• 대한수의학회지
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• 제37권2호
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• pp.291-299
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• 1997

In order to establish optimal dosage schedules and withdrawal times for sulfamethazine(SMZ) in pigs, pharmacokinetic and tissue distribution experiments were conducted in pigs. For comparative purposes, tissue depletion kinetics are also studied in rats. From three pigs administered with SMZ i.v., the pharmacokinetic profile of SMZ in two pigs was adequately described by a one-compartment open model whereas that in one pig was patterned after a two-compartment open model. Volume of distribution(Vd) was 0.48~0.57 L/kg and biological half-life($t_{1/2}$) was 11.8-16.8 h. From three pigs dosed with SMZ p.o., pharmacokinetic profile was explainable with a one-compartment open model. Time to reach maximum SMZ concentration in serum (Tmax) was 2.8 h, 3.2 h and 7.5 h. Elimination half-life was 2.8-7.5 h. The descending order in concentration of SMZ was plsama > kidney > liver > lung > heart > pancreas > spleen > duodenum > ileum > brain > adipsoe tissue from three pigs sacrificed at 5h, 29h and 54h after the administration of SMZ, p.o.. The protein binding of SMZ in pigs was 55.2%($2.5{\mu}g/ml$), 71.5% ($5{\mu}g/kg$) and 71.5%($10{\mu}g/ml$). The mean systemic bioavailability (F) of SMZ p.o. was 49.1 %. Meanwhile the pharmacokinetic profile of SMZ in rats was adequately described by a one-compartment open model. Absorption of SMZ p.o. in the rat was very rapid. In conclusion, the oral optimal dosage regimen of SMZ for pigs was the initial dose of 45.7 mg/kg followed by the maintenance dose of 30.2 mg/kg for high specific pathogens to SMZ. The time to reach below the stipulated residual allowable concentration (0.1 ppm) was calculated 93 h after oral administration of 200 mg/kg recommended by manufactureres.

• 천문학회지
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• 제38권2호
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• pp.191-195
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• 2005

We used Subaru observations of A1689 (z = 0.183) to derive an accurate, model-independent mass profile for the entire cluster, r$\le$2Mpc/h, by combining magnification bias and distortion measurements. The projected mass profile steepens quickly with increasing radius, falling away to zero at r${\~}$1.0Mpc/h, well short of the anticipated virial radius. Our profile accurately matches onto the inner profile, r $\le$200kpc/ h, derived from deep HST / ACS images. The combined ACS and Subaru information is well fitted by an NFW profile with virial mass, $(1.93 \pm 0.20) {\times}10^{15} M_{\bigodot}$, and surprisingly high concentration, $C_{vir} = 13.7^{+1.4}_{-1.1}$, significantly larger than theoretically expected ($C_{vir} {\le}4$), corresponding to a relatively steep overall profile. These results are based on a reliable sample of background galaxies selected to be redder than the cluster E/SO sequence. By including the faint blue galaxy population a much smaller distortion signal is found, demonstrating that blue cluster members significantly dilute the true signal for r $\le$ 400kpc/ h. This contamination is likely to affect most weak lensing results to date.

• 한국유기농업학회지
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• 제22권3호
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• pp.483-490
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• 2014

본 연구는 키토산올리고당의 음수 내 급여가 따른 육계의 혈액성상, 면역력 및 항산화효소계에 미치는 영향을 알아보기 위해 1일령 Arbor Acre종 약 2만 8천수를 대조구와 키토산 음수 급여구로 나누어 5주 동안 실시하였다. 육계의 혈액 성상에서 Glucose의 농도는 대조구보다 키토산올리고당 음수 급여구가 유의적으로 감소하였으나, Triglyceride, Total cholesterol, HDL-cholesterol 및 LDL-cholesterol 농도에는 대조구와 키토산올리고당 음수 급여구간에 차이를 보이지 않았고 간 손상에 대한 인자인 GOT농도는 시험구간에 차이가 없었지만 GPT농도는 대조구보다 키토산올리고당 음수 급여구가 유의적으로 감소하였다(P<0.05). 혈액 내 면역글로블린 농도 중, IgG 농도는 대조구와 키토산올리고당 음수 급여구간에 차이가 없었으나, IgM 농도는 대조구보다 키토산올리고당 음수 급여구가 유의적으로 증가하였다(P<0.05). 항산화력과 SOD의 농도는 시험구간에 차이가 없었으며, Catalase와 Glutathione peroxidase의 농도는 대조구보다 키토산올리고당 음수 급여구가 유의적으로 증가하였다(P<0.05). 따라서, 키토올리고당의 음수 급여로 인해 육계의 당대사, 면역기능 및 1차 항산화 효소계의 활성을 증가시켜 육계의 강건성에 영향을 미칠 수 있음을 보여주었다.

• Asian-Australasian Journal of Animal Sciences
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• 제27권8호
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• pp.1114-1123
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• 2014

The study was designed to evaluate the effect of 2% seamustard (Undaria pinnatifida) by-product (SW) on growth performance, immunity, carcass characteristics, cholesterol content and fatty acid profile in Hanwoo steers. A total of 20 Hanwoo steers (ave. 22 months old; 619 kg body weight) were randomly assigned to control (basal diet) and 2% SW supplemented diet. Dietary SW supplementation significantly (p<0.05) improved average daily gain and gain:feed ratio as well as serum immunoglobulin G concentration. Chemical composition and quality grade of meat and carcass yield grades evaluated at the end of the trial were found to be unaffected by SW supplementation. Dietary SW significantly reduced meat cholesterol concentration (p<0.05). Dietary SW supplementation significantly reduced the myristic acid (C14:0) and palmitoleic acid (C16:ln-7) concentration, while SW increased the concentration of stearic acid (C18:0) and linolenic acid (C18:3n-3) compared to control (p<0.05). Dietary SW supplementation had no effect on saturated fatty acids (SFA), unsaturated fatty acids, poly unsaturated fatty acid (PUFA) or mono unsaturated fatty acid content in muscles. A reduced ratio of PUFA/SFA and n-6/n-3 were found in SW supplemented group (p<0.05). In conclusion, 2% SW supplementation was found to improve growth, immunity and fatty acid profile with significantly reduced cholesterol of beef.

• 대한기계학회논문집B
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• 제21권11호
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• pp.1422-1436
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• 1997

Numerical investigations were conducted to study the convective phenomena of an initially stably stratified salt water solution with lateral heating in a uniformly rotating annulus. The method of investigation is the finite difference analysis of the basic conservation equation for an axisymmetric, unsteady, double-diffusive convection and calculation is made for R $a_{\eta}$=2*10$^{5}$ and Ta=10$^{7}$ ~ 2.5*10$^{8}$ . Formation of layered flow structure, merging process of layers, the corresponding temperature and concentration distributions, Nu variation with time are examined. Numerical results show that in each layer, the temperature profile looks 'S'-shaped and the concentration profile is uniform due to the convective mixing. At the interface between adjacent layers, the temperature changes smoothly but the concentration changes rapidly. As the effect of the rotation increases, the generation of rolls at hot wall, the formation and merging of layers are delayed. The average Nu shows the trend of conduction heat transferees the effect of the rotation increases.n increases.

• Asian-Australasian Journal of Animal Sciences
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• 제15권1호
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• pp.38-44
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• 2002

Nine crossbred castrated lambs fitted with rumen and duodenum cannula and fed a diet of hay and concentrate formulated with ground corn and soybean meal as main ingredients were used to assess the duodenal ideal amino acid pattern. Three synthetic amino acid mixtures with different profile of essential amino acids were duodenally infused in order to get three different amino acid patterns flowing into the duodenum. The mixtures were designed to have similar amino acid profile as rumen microbial protein (Pm), casein (Pc) and modified muscle amino acid (Pmm). Results showed a lower urine nitrogen excretion (p=0.05), a higher nitrogen retention (p=0.04) and bodyweight gain with treatment Pmm. The modified muscle amino acid pattern also promoted a lower ratio of Gly to other amino acids in plasma (Gly/OAA) and a higher RNA and RNA/DNA concentration in the liver of the sheep. Meanwhile, the urea concentration in plasma was reduced and the insulin concentration was increased with Pmm treatment. No differences in glucose and growth hormone concentration in plasma were found among three treatments. All results obtained indicate that the modified muscle amino acid pattern (Lys 100%, Met+Cys 39%, Thr 76%, His 41%, Arg 72%, Leu 158%, Ile 81%, Val 105%, Phe 81% and Trp 13%) was the best for growing sheep.

• 대한기계학회논문집B
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• 제22권2호
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• pp.173-183
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• 1998

An optimization procedure to find the inlet concentration profile that yields the most uniform deposition rate in a cylindrical CVD chamber has been developed. Assuming that the chemical reaction time is negligibly small, a SIMPLE based finite-volume method is adopted to solve the fully elliptic equations for momentum, temperature, and concentration. The inlet concentration profile is expressed by a linear combination of Chebyshev polynomials and the coefficients of which are determined by the local random search technique. It is shown that the present method is very effective in improving the uniformity of the deposition rate, especially when Re is high and/or the wafer is placed close to the inlet. The optimal profiles have been obtained for various Re, Gr, and geometry combinations.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 1998년도 추계 학술대회논문집
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• pp.121-126
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• 1998

A numerical optimization procedure is developed to find the inlet velocity profile that yields the most uniform epitaxial layer in a vertical MOCVD reactor. It involves the solution of fully elliptic equations of motion, temperature, and concentration; the finite volume method based on SIMPLE algorithm has been adopted to solve the Navier-Stokes equations. The overall optimization process is highly nonlinear and has been efficiently treated by the sequential linear programming technique that breaks the non-linear problem into a series of linear ones. The optimal profile approximated by a 6th-degree Chebyshev polynomial is very successful in reducing the spatial non-uniformity of the growth rate. The optimization is particularly effective to the high Reynolds number flow. It is also found that a properly constructed inlet velocity profile can suppress the buoyancy driven secondary flow and improve the growth-rate uniformity.

• 한국진공학회지
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• 제10권2호
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• pp.225-233
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• 2001

Oxygen flooding을 이용한 Secondary ion Mass Spectrometry(SIMS) 분석에 있어서 표면에 산화막이 있을 때 발생하는 SIMS depth profile의 왜곡현상에 대한 원인을 분석하고 이를 보정하였다. 이러한 왜곡현상은 표면 산화막에서와 Si 매질에서의 sputter rate이 다른 데서 발생하는 깊이 보정 오류와 상대감도인자(relative sensitivity factor, RSF)가 다른 데서 발생하는 농도보정 오류로부터 발생됨이 밝혀졌다. 깊이보정 오류를 바로잡기 위하여 $N^a+$ 이온을 산화막과 Si 매질의 계면에 대한 marker로 사용하였으며 산화막 두께는 SEM 및 XPS로 측정하였다. 산화막과 Si 매질에서의 sputter rate 및 RSF의 차이는 주로 oxygen flooding이 유발한 산화막 형성시의 부피팽창에 의한 것으로 해석되었으며 이를 보정한 depth profile은 oxygen flooding없이 분석한 경우와 거의 동일한 결과를 보여주었다.

• 상하수도학회지
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• 제20권3호
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• pp.443-450
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• 2006

For understanding sludge concentration profile as a function of time, sludge was sampled at each sampling port. When sludge concentration was 3g/L, the vertical sludge concentration distribution was similar to that of 2g/L of sludge concentration. During the early stage of sludge settling, sludge concentration increased remarkably as the sludge interface height in batch column became lower. The higher sludge concentration became, the worse sludge setteability became. Also, the type of sludge settling was influenced with sludge concentration gradient in batch column. In the same concentration, the greater sludge concentration gradient was, the faster sludge interface settled down. And the changing sludge concentrations in a batch settling or a continuous settling were simulated by using the equation of sludge interface height change model.