• Genomics & Informatics
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• v.19 no.4
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• pp.36.1-36.11
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• 2021

Predicting individual traits and diseases from genetic variants is critical to fulfilling the promise of personalized medicine. The genetic variants from genome-wide association studies (GWAS), including variants well below GWAS significance, can be aggregated into highly significant predictions across a wide range of complex traits and diseases. The recent arrival of large-sample public biobanks enables highly accurate polygenic predictions based on genetic variants across the whole genome. Various statistical methodologies and diverse computational tools have been introduced and developed to computed the polygenic risk score (PRS) more accurately. However, many researchers utilize PRS tools without a thorough understanding of the underlying model and how to specify the parameters for the best performance. It is advantageous to study the statistical models implemented in computational tools for PRS estimation and the formulas of parameters to be specified. Here, we review a variety of recent statistical methodologies and computational tools for PRS computation.

• Journal of the Korean Society for Precision Engineering
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• v.29 no.10
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• pp.1056-1061
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• 2012

FEM analysis is essential to shorten the development time and reduce the cost for developing high-performance machine tools. Mount joint parts play important role to ensure static and dynamic stability of machine tools. This paper suggests a computational modeling of mount joint part of machine tools. MATRIX27 element of ANSYS is adopted to model mount joint parts. MATRIX27 allows the definition of stiffness and damping matrices in matrix form. The matrix is assumed to relate two nodes, each with six degrees of freedom per node. Stiffness and damping values of commercial mount products are measured to build a database for FEM analysis. Jack mounts with rubber pad are exemplified in this paper. The database extracted from the experiments is also used to estimate of stiffness and damping of untested mounts. FEM analysis of machine tools system with the suggested mount computational model is performed. Static and dynamic results prove the feasibility of the suggested mount model.

• Journal of the Korean Society for Precision Engineering
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• v.29 no.10
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• pp.1070-1077
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• 2012

Virtual machine tools have been magnified recently as manufacturers could estimate performances of machine tools before design and manufacturing of them. However, it requires much time and efforts to make FEM models and predict precision of machine tools well because machine tools are composed of many joints such as bolt joints, LM joints, rotational bearing joints and mounts. Especially, we have studied computational modeling methods of bolt joints to predict precision of machine tools well in this paper. Stiffness and damping coefficients of bolt joints are investigated and generalized with respect to fasten forces through experiments and FEM analysis. Matrix 27 element of ANSYS is used and bolt joints are simplified as square areas with 8 nodes to apply stiffness and damping simultaneously. Additionally, coordinate transformation of matrix 27 for bolt joints is induced to apply to skewed bolt joints of machine tools and evaluate it using FEM analysis.

• Korean Journal of Computational Design and Engineering
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• v.6 no.4
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• pp.236-243
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• 2001

A key factor far realizing the internet-based virtual manufacturing system(VMS) and virtual enter-prise(VE) is how to precisely and effectively represent the machine elements and mechanics. In this paper, we present methods to represent the numerically controlled machine tools in the internet environment. The method is composed of: 1) geometrical modeling of the machine tools, 2) kinematic modeling for the movements of the machine tools, and 3) representing the developed model in the internet infrastructure. Based on the models. a web-based virtual machine tools (WVMT) is developed, and it can be accessed at hrrp://wvmt.postech.ac.kr. The WVMT can be used for various purposes: 1) web-based virtual manufacturing system, 2) web-based CAM system, and 3) CNC educational tools for the vocational school through internet.

• Korean Journal of Computational Design and Engineering
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• v.5 no.2
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• pp.136-143
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• 2000

The appearance of new machine tools with higher flexibility is in need of a basic structure design system for establishing the systematic and rationalized design and manufacturing procedures. In this study. the basic structure design system for machine tools is realized based on the modular construction method. Machine tools are represented as a whole and modular complex with the directed graph, and all possible structural configurations and codes of machine tools for satisfying the machining requirement are derived from the DNA data and connecting patterns of basic structural elements. Especially the structural configurations of machine tools are visualized by the solid modeling techniques and 3-D graphics techniques.

• Korean Journal of Computational Design and Engineering
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• v.10 no.4
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• pp.293-302
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• 2005

The research focused quantitative comparisons of protocols occurring in the architectural massing process using two different tools, three-dimensional(3D) modeler and traditional design tools, to aid architectural massing education. Through the protocol analysis from some experiments, the research identified the following conclusions: 1) Usage of traditional tools produced much higher protocol rate in proposing solution, evaluating proposed solution, explicitness of strategies. This result seemed to be from convenience of traditional tools causing faster visual cognitive cycle. 2) Usage of 3D modeler produced much higher protocol rate concerning attempts of making design vocabulary. The result indicated 3D modeler has relatively effective functions for mass generation and orientation, however it still has some weaknesses on display interface which cause designer's lower idea generations compared to traditional design tools.

• Proceedings of the KSME Conference
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• 2005.11a
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• pp.257-261
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• 2005

Over the past 30 years, numerical methods and simulation tools for fluid dynamic problems have advanced as a new discipline, namely, computational fluid dynamics (CFD). Although a wide spectrum of flow regimes are encountered in many areas of science and engineering, simulation of compressible flow has been the major driver for developing computational algorithms and tools. This Is probably due to a large demand for predicting the aerodynamic performance characteristics of flight vehicles, such as commercial, military, and space vehicles. As flow analysis is required to be more accurate and computationally efficient for both commercial and mission-oriented applications (such as those encountered in meteorology, aerospace vehicle development, general fluid engineering and biofluid analysis) CFD tools for engineering become increasingly important for predicting safety, performance and cost. This paper presents the author's perspective on the maturity of CFD, especially from an aerospace engineering point of view.

• Computational Structural Engineering
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• v.35 no.1
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• pp.4-10
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• 2022

• Journal of Ship and Ocean Technology
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• v.12 no.4
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• pp.1-6
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• 2008

Nowadays, the computational capability and graphical power based on PCs increase very rapidly every year. As a result, the complicated engineering or scientific problems that could have only been handled by supercomputers a couple of decades ago can now be routinely run on PCs. Besides, the PCs can be assembled in parallel to increase its computational capability theoretically without limitation. The Web-based interface and communication tools are also being enhanced very rapidly and the real-time distance learning (E-Learning) and project cooperation on web get increasing attention. Using the-state-of-the-art computational method, a number of complicated and computationally intensive problems are being solved by PCs. The results can be well demonstrated on screen by graphics and animation tools. Those examples include the simulations of fully nonlinear waves, their interactions with floating bodies, global-motion analysis of multi-unit floating production system including complicated mooring lines and risers. Several examples will be presented in this regard. Also, Web and java-applet based educational tools have been developed at Texas A&M University for better understanding of waves and wave-body interactions. The background and examples of such Web-based educational tools published in Kim et al. (2003) are briefly introduced here.

• Proceedings of the KIEE Conference
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• 2008.11a
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• pp.299-301
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• 2008

For an efficient operation of today's power system, power engineers are required to analyze enormous amount of data. Owing to the development of technology, a variety of power systems computational tools have been developed and commercialized. However, the practical use of computational tools not only requires that people be able to understand the results the tools produce but also extract the required information from the simulation results which generally involves massive amount of information. This paper introduces a novel interface that would complement the drawbacks in the visualization of data of the pre-existing tools and assist the user in readily retrieving the required information, in this case the rotor angle data, of the simulated system thereby making power system analysis more feasible to be effectuated.