• Genomics & Informatics
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• v.9 no.3
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• pp.114-120
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• 2011

Chronic inflammation has been implicated as one of the important etiological factors in insulin resistance and type 2 diabetes mellitus (T2DM). To investigate the role of anti-inflammatory cytokines in the development of T2DM, we conducted a case-control study to assess the association between IL4/IL4R polymorphisms and disease risk. We firstly identified single nucleotide poly-morphisms (SNP) at IL4 and IL4RA loci by sequencing the loci in Korean participants. Case-control studies were conducted by genotyping the SNPs in 474 T2DM cases and 470 non-diabetic controls recruited from community-based cohorts. Replication of the associated signals was performed in 1,216 cases and 1,352 controls. We assessed effect of IL4 -IL4RA interaction on T2DM using logistic regression method. The functional relevance of the SNP associated with disease risk was determined using a reporter expression assay. We identified a strong association between the IL4 promoter variant rs2243250 and T2DM risk (OR=0.77; 95% CI, 0.67~0.88; p=$1.65{\times}10^{－4}$ in the meta-analysis). The reporter gene expression assay demonstrated that the presence of rs2243250 might affect the gene expression level with ~1.5-fold allele difference. Our findings contribute to the identification of IL4 as a T2D susceptibility locus, further supporting the role of anti-inflammatory cytokines in T2DM disease development.

• Mass Spectrometry Letters
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• v.13 no.4
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• pp.177-183
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• 2022

The monomer and dimer structures of the amyloid fragment Aβ(1-16) sequence formed in H₂O were investigated using electrospray ionization mass spectrometry (MS) and tandem MS (MS/MS). Aβ16 monomers and dimers were indicated by signals representing multiple proton adduct forms, [monomer+zH]ⁿ⁺ (=M^z+, z = charge state) and [dimer+zH]^z+ (=D^z+), in the MS spectrum. Fragment ions of monomers and dimers were observed using collision-induced dissociation MS/MS. Peptide bond dissociation was mostly observed in the D1-D7 and V11-K16 regions of the MS/MS spectra for the monomer (or dimer), regardless of the monomer (or dimer) charge state. Both covalent and non-covalent bond dissociation processes were indicated by the MS/MS results for the dimers. During the non-covalent bond dissociation process, the D³⁺ dimer complex was separated into two components: the M¹⁺ and M²⁺ subunits. During the covalent bond dissociation of the D³⁺ dimer complex, the b and y fragment ions attached to the monomer, (M+b_10-15)^z+ and (M+y_9-15)^z+, were thought to originate from the dissociation of the M²⁺ monomer component of the (M¹⁺+M²⁺) complex. Two different D³⁺ complex geometries exist; two distinguished interaction geometries resulting from interactions between the M¹⁺ monomer and two different regions of M²⁺ (the N-terminus and C-terminus) are proposed. Intricate fragmentation patterns were observed in the MS/MS spectrum of the D⁵⁺ complex. The complicated nature of the MS/MS spectrum is attributable to the coexistence of two D⁵⁺ configurations, (M¹⁺+M⁴⁺) and (M²⁺M³⁺), in the Aβ16 solution.

• Korean Journal of Clinical Laboratory Science
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• v.37 no.2
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• pp.123-128
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• 2005

Magnetoencephalography (MEG) is the measurement of the magnetic fields produced by electrical activity in the brain, usually conducted externally, using extremely sensitive devices such as Superconducting Quantum Interference Device (SQUID). MEG needs complex and expensive measurement settings. Because the magnetic signals emitted by the brain are on the order of a few femtoteslas (1 fT = 10-15T), shielding from external magnetic signals, including the Earth's magnetic field, is necessary. An appropriate magnetically shielded room is very expensive, and constitutes the bulk of the expense of an MEG system. MEG is a relatively new technique that promises good spatial resolution and extremely high temporal resolution, thus complementing other brain activity measurement techniques such as electroencephalography (EEG), positron emission tomography (PET), single-photon emission computed tomography (SPECT) and functional magnetic resonance imaging (fMRI). MEG combines functional information from magnetic field recordings with structural information from MRI. The clinical uses of MEG are in detecting and localizing epileptic form spiking activity in patients with epilepsy, and in localizing eloquent cortex for surgical planning in patients with brain tumors. Magnetoencephalography may be used alone or together with electroencephalography, for the measurement of spontaneous or evoked activity, and for research or clinical purposes.

• IEIE Transactions on Smart Processing and Computing
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• v.1 no.2
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• pp.117-124
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• 2012

A client collaboration (CC) system is proposed for a user relay system. The proposed scheme focuses on the management of transmit power and leakage interference. In the proposed CC system, edge users transmit signals to the masters considered as user relays. The masters relay the signals of the edge users to the base station using the resource blocks (RBs) that are assigned to the edge users. The leakage interference and power consumption were analyzed in the CC system. In addition, an optimal master location problem was formulated based on the signal-to-leakage-plus-noise ratio (SLNR). Because the optimal master location problem is quite complex, a sub-optimal master location problem was proposed and a closed-form sub-optimal master location was obtained. The edge users generate smaller leakage interference and power consumption in the proposed CC system compared to the system without the CC. The numerical results showed that the edge users generate smaller leakage interference and power consumption in the proposed CC system compared to the system without the CC, and the average throughput increases.

• Journal of IKEEE
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• v.8 no.2 s.15
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• pp.166-171
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• 2004

This paper describes a CMOS time to digital converter (TDC) that measures the interval between two signals and converts to a digital signal. There are various methods to measure the time interval. But several architectures have a limitation in resolution and in conversion time. Moreover, they have complex algorithms. But the proposed TDC circuit has achieved a high resolution (25ps) by using a high-speed digital sampler and simple algorithm. The sampler detects when input signals comes into the TDC and output is coded. The proposed multiphase clock generator was also implemented to achieve 25p resolution.

• Proceedings of the KOSOMBE Conference
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• v.1992 no.05
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• pp.175-178
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• 1992

This paper proposes a method called linear prediction (a high performant technique in digital speech processing) for analyzing digital ECG signals. There are several significant properties indicating that ECG signals have an important feature in the residual error signal obtained after processing by Durbin's linear prediction algorithm. The ECG signal classification puts an emphasis on the residual error signal. For each ECG's QRS complex. the feature for recognition is obtained from a nonlinear transformation which transforms every residual error signal to set of three states pulse-cord train relative to the original ECG signal. The pulse-cord train has the advantage of easy implementation in digital hardware circuits to achive automated ECG diagnosis. The algorithm performs very well feature extraction in arrythmia detection. Using this method, our studies indicate that the PVC (premature ventricular contration) detection has a at least 90 percent sensityvity for arrythmia data.

• Proceedings of the KIEE Conference
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• 2006.10c
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• pp.391-393
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• 2006

In this paper, we develop a portable game device with uncompressed HD video and high quality sound output. Portable game devices support not only game function but also various complex functions recently. It especially supports TV-Out port to play realistic game, connecting a large screen display device. But the video and audio output signals of conventional TV-out port have the low performance and these signals are analog output. So, it is difficult that the users enjoy realistic game with benefit of high resolution digital TV. We propose the game device output with uncompressed digital signal, which has no delay of video/audio signal, also has strong immunity to external noise. Since it supports a high resolution video and high quality sound, users can playa realistic game. First, we implement the HDMI to the game device and we test reliability with the various resolutions video inputs and audio inputs. The proposed method can be applied multimedia devices requiring high performance output function as well as portable devices.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.5C
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• pp.556-561
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• 2006

In this study, an ultra-wideband(UWB) signal model is considered to estimate the angle-of-arrivals(AOAs) of clusters in an UWB indoor-to-outdoor communication environment having random angle spreads. A conventional AOA algorithm for UWB estimates the directions of both clusters and multipath signals together and so has complex estimation procedure. In order to solve that problem, we propose a new clustered AOA estimation algorithm. The estimation technique based a well-known MUSIC algorithm is proposed and the estimates of the AOA on received clusters are obtained using the proposed technique. The proposed model and estimation technique are verified through computer simulations.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.8A
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• pp.1187-1194
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• 1999

In general wireless mobile channel is modeled as complex random processes having a narrowband spectrum. In this paper, a real-time feneration of fading signals using a DSP chip is described. Real-time simulator is designed so that simulation parameters such as mobile terminal speed, carrier frequency, power ratio of line-of-sight component versus multipath, and variance of received power can be chosen in the window. Design algorithms for the generation of ideal fading signals with a minimum DSP computation and trade-offs are investigated. The accuracy of the statistical characteristics is verified through the comparison of measured results with the theoretical prediction.

• 제어로봇시스템학회:학술대회논문집
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• 1988.10b
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• pp.794-797
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• 1988

G. Binnig and H. Rohrer introduced the Scanning Tunneling Microscope (STM) in 1982 and developed it into a powerful and not to be missed physical tool. Scanning tunneling Microscopy is a real space surface imaging method with the atomic or subatomic resolution in all three dimensions. The tip is scanned over the surface by two piezo translators mounted parallel (X-piezo and Y-piezo) to the surface and perpendicular to each other. The voltage applied to the third piezo (Z-piezo) translator mounted perpendicular to the surface to maintain the tunneling current through the gap at a constant level reflects then the topography of the surface. The feed back control loop for the constant gap current is designed using the automatic control technique. In the designing process of the feed back loop, the identification of the gap dynamics is very complex and has difficulty. In this research, using some suitable test signals, the system dynamics of the gap including the Z-piezo are investigated. Especially, in this paper, a system model is proposed for the gap and Z-piezo series system. Indicial response is used to find out the model. The driving voltage of the Z-piezo and the tunneling current are considered as input and output signals respectively.