• 한국자기공명학회논문지
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• 제20권4호
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• pp.102-108
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• 2016

With the rapid increase of data on protein-protein interactions, the need for delineating the 3D structures of huge protein complexes has increased. The protocols for determining nuclear magnetic resonance (NMR) structure can be applied to modeling complex structures coupled with sparse experimental restraints. In this report, I suggest the use of multiple rigid bodies for improving the efficiency of NMR-assisted structure modeling of huge complexes using CYANA. By preparing a region of known structure as a new type of residue that has no torsion angle, one can facilitate the search of the conformational spaces. This method has a distinct advantage over the rigidification of a region with synthetic distance restraints, particularly for the calculation of huge molecules. I have demonstrated the idea with calculations of decaubiquitins that are linked via Lys6, Lys11, Lys27, Lys29, Lys33, Lys48, or Lys63, or head to tail. Here, the ubiquitin region consisting of residues 1-70 was treated as a rigid body with a new residue. The efficiency of the calculation was further demonstrated in Lys48-linked decaubiquitin with ambiguous distance restraints. The approach can be readily extended to either protein-protein complexes or large proteins consisting of several domains.

• Asian-Australasian Journal of Animal Sciences
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• 제15권3호
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• pp.421-426
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• 2002

The pyruvate dehydrogenase complex (PDC), a member of $\alpha$-keto acid dehydrogenase complex, catalyzes the oxidative decarboxylation of pyruvate with the formation of $CO_2$, acetyl-CoA, NADH, and $H^+$. This complex contains multiple copies of three catalytic components including pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Two regulatory components (E1-kinase and phospho-E1 phosphatase) and functionally less-understood protein (protein X, E3BP) are also involved in the formation of the complex. In this study, we have partially cloned the gene for E3BP in human. Nine putative clones were isolated by human genomic library screening with 1.35 kb fragment of E3BP cDNA as a probe. For investigation of cloned genes, Southern blot analysis and the construction of the restriction map were performed. One of the isolated clones, E3BP741, has a 3 kb-SacI fragment, which contains 200 bp region matched with E3BP cDNA sequences. The matched DNA sequence encodes the carboxyl-terminal portion of lipoyl-bearing domain and hinge region of human E3BP. Differences between yeast E3BP and mammalian E3BP coupled with the remarkable similarity between mammalian E2 and mammalian E3BP were confirmed from the comparison of the nucleotide sequence and the deduced amino acid sequence in the cloned E3BP. Cloning of human E3BP gene and analysis of the gene structure will facilitate the understanding of the role(s) of E3BP in mammalian PDC.

• Bulletin of the Korean Chemical Society
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• 제26권7호
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• pp.1065-1070
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• 2005

$[Mn_{12}O_{12}(O_2CPh-4-SMe)_{16}(H_2O)_4]{\cdot}7CH_2Cl_2$ (1), a new single-molecule magnet complex has been successfully synthesized by substitution of acetate ligand of Mn12ac with 4-(methylthio)benzoic acid. Complex 1 crystallizes into triclinic P$\overline{1}$ with a = 18.321(3) $\AA$, b = 19.011(3) $\AA$, c = 27.230(4) $\AA$, $\alpha$ = 86.973(3)$^{\circ}$, $\beta$ = 76.919(3)$^{\circ}$, $\gamma$ = 87.613(3)$^{\circ}$, and Z = 2. In complex 1, one Mn(III) ion has an abnormal Jahn-Teller elongation axis oriented at an oxide ion. Complex 1 has two out-of-phase ac susceptibility peaks in the 2-4 K and 4-7 K regions. Effective anisotropy energy barrier and pre-exponential factor are $U_{eff}$ = 45.95 K, 1/$\tau$0 = 8.6 ${\times}\;10^9s^{-1}\;for\;{\chi}_M$'' peaks in the lower temperature region and $U_{eff}$ = 59.45 K, 1/$\tau_0$ = 2.2 ${\times}\;10^8\;s^{-1}$ for $\chi_M$'' peaks in the higher temperature region. The parameters of S = 10, g = 1.87, D = -0.40 $cm^{-1}$, and E = 0.00034 $cm^{-1}$ were obtained from the M/N${\mu}_B$ vs. H/T plot of complex 1.

• 박물관보존과학
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• 제18권
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• pp.93-114
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• 2017

현재 베트남에는 ①탕롱 유적, ②호 왕조의 성채, ③미선 유적, ④호이안 고도시, ⑤후에 유적 등 5곳의 세계문화유산, ⑥하롱 베이, ⑦퐁나케방 국립공원 등 2곳의 세계자연유산, 세계복합유산인 ⑧짱안 경관유적 1곳 등 총 8곳의 유네스코 세계유산이 등재되어 있다. 지역적으로 보면 북부지역에 4곳, 중부지역에 4곳으로 분포하며, 남부지역에는 하나도 없다. 베트남의 자연유산은 모두 전형적인 석회암 카르스트 지형 경관이며, 2000년대 이후 등재된 문화유산 지역들은 대부분 북부지역의 옛 왕조들의 수도였던 도성 유적이다. 지금까지 베트남의 세계문화유산 등재 정책은 북부지역의 역사적 정통성을 강조한 유적을 중심으로 진행되어 왔으나, 향후 베트남 정부의 문화 정책이 좀더 남북 지역간 격차를 줄이고 통합적으로 진행될 수 있기를 기대한다.

• 정보처리학회논문지B
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• 제12B권3호
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• pp.223-232
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• 2005

본 논문에서는 블록 기반으로 부호화된 영상에 대하여 블록 경계 영역 특성에 따른 적응적 필터링을 이용한 양자화 잡음 제거 알고리즘을 제안하였다 제안한 방법에서는 블록 경계에 인접한 네 개 화소들의 통계적 특성을 이용하여 각 블록 경계 영역을 평탄 부영역(smooth sub-region)과 복잡 부영역(complex sub-region)으로 분류한 후, 인접 블록간 영역 특성을 이용하여 서로 다른 블록간 필터링을 수행한다. 먼저 인접 블록 모두 평탄 부영역인 경우에는 평탄 블록 경계 영역 중 블록화 현상이 발생하지 않은 영역도 존재하기 때문에 계산량을 줄이기 위하여 평탄 영역 중 블록화 현상이 발생한 영역만을 검출하여 필터링을 수행한다. 그리고, 두 부영역이 서로 다른 부영역인 경우에 대하여서는 기존의 방법들과는 달리 실제 에지 성분을 보존하면서 블록화 현상과 에지 주위에서 발생하는 링잉 현상을 동시에 제거하기 위하여 인접 블록의 영역 특성에 따라 적응적으로 일차원 필터링을 수행한다. 두 부영역이 모두 복잡 부영역일 경우에는 블록화 현상을 제거하면서 실제 에지를 보존하기 위하여 블록화 강도 및 양자화 파라미터에 따라 블록 경계 영역의 두 화소에 대하여 필터링을 수행한다. 모의실험 결과를 통하여 제안한 방법이 객관적 화질 및 주관적 화질 측면에서 기존의 방법보다 그 성능이 우수함을 확인하였다.

• Journal of Korean Neurosurgical Society
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• 제61권2호
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• pp.277-281
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• 2018

Objective : Craniovertebral junctional anomalies constitute a technical challenge. Surgical opening of atlantoaxial joint region is a complex procedure especially in patients with nuchal deformity like basilar invagination. This region has actually very complicated anatomical and functional characteristics, including multiple joints providing extension, flexion, and wide rotation. In fact, it is also a bottleneck region where bones, neural structures, and blood vessels are located. Stabilization surgery regarding this region should consider the fact that the area exposes excessive and life-long stress due to complex movements and human posture. Therefore, all options should be considered for surgical stabilization, and they could be interchanged during the surgery, if required. Methods : A 53-year-old male patient applied to outpatients' clinic with complaints of head and neck pain persisting for a long time. Physical examination was normal except increased deep tendon reflexes. The patient was on long-term corticosteroid due to an allergic disease. Magnetic resonance imaging and computed tomography findings indicated basilar invagination and atlantoaxial dislocation.The patient underwent C0-C3-C4 (lateral mass) and additional C0-C2 (translaminar) stabilization surgery. Results : In routine practice, the sites where rods are bound to occipital plates were placed as paramedian. Instead, we inserted lateral mass screw to the sites where occipital screws were inserted on the occipital plate, thereby creating a site where extra rod could be bound.When C2 translaminar screw is inserted, screw caps remain on the median plane, which makes them difficult to bind to contralateral system. These bind directly to occipital plate without any connection from this region to the contralateral system.Advantages of this technique include easy insertion of C2 translaminar screws, presence of increased screw sizes, and exclusion of pullout forces onto the screw from neck movements. Another advantage of the technique is the median placement of the rod; i.e., thick part of the occipital bone is in alignment with axial loading. Conclusion : We believe that this technique, which could be easily performed as adjuvant to classical stabilization surgery with no need for special screw and rod, may improve distraction force in patients with low bone density.

• World Technopolis Review
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• 제6권2호
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• pp.148-158
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• 2017

Sejong City, which has been chosen as a new administrative capital of South Korea, has completed the first phase of its development plan with the construction of the facilities needed to accommodate central administrative organizations and the required accompanying population. Now, it is undergoing the second phase of development with a focus on strengthening the region's innovation capacity to catalyze endogenous development. The strategy for phase II is to establish a regional innovation system including building necessary infrastructure and attracting innovation agents such as universities, businesses, and research institutes. The first step for this is developing a research complex, tentatively named Tech Valley, that includes universities, research institutes, and businesses, and building infrastructure comprising a science complex, a knowledge industry center, and support facilities. Phase II of the city's development initiative includes the establishment of a joint university campus, which is to serve as a center to promote cooperation among industry actors, universities, and research institutes. The concept of a joint campus has been drawn from a need to enhance capacity for innovation and specialization in the region's industries and to maximize synergy among participating universities through the sharing of research equipment, facilities, and programs. The joint campus is expected to play a key role in creating an innovation system in the region by enhancing research capacity for strategic industries, cultivating highly skilled human resources, and leading industry-academia-research cooperation. In order to ensure the sustainable development of the new city, there is a growing need to have a main player in place that could lead the region's economic development. The joint campus will propel industrial specialization and serve as a catalyst to attract competent universities to the region. This paper will examine the concept, major functions, and the establishment and operation of the joint campus.

• 한국수자원학회논문집
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• 제39권9호
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• pp.737-744
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• 2006

난류의 내부 영역의 유속은 단순한 공식으로 표현하기 매우 어려운 형태를 가지고 있다. 이 속도 분포를 기술하는 여러 가지 공식들이 제안된 바 있지만, 모든 공식들은 많은 항들을 가지거나 적분형 또는 음함수꼴을 가지고 있다. 이것은 이 식들이 적용하기 힘들거나, 매개 변수들을 추정하기 어렵다는 것을 의미한다. 이 연구에서는 매끄러운 바닥 위를 흐르는 난류 내부 영역의 유속 분포를 표현할 수 있는 간단한 형태의 새로운 공식을 제안하였다. 이 공식은 전통적인 대수 법칙에 감쇄 함수를 곱한 형태이다. 단 하나의 추가적인 매개 변수를 도입하여, 전체 내부 영역의 유속 분포를 적절하게 표현할 수 있었다. 이 공식은 벽법칙이 성립하는 바닥 근처의 유속과 대수 법칙이 성립되는 중복 영역의 유속 분포까지를 적절하게 나타낼 수 있다. 또한, 추가된 매개 변수인 감쇄 계수는 쉽게 추정할 수 있다. 이 변수는 Reynolds 수의 변화에 민감하지 않으며, 공식에 의하여 계산된 유속 분포도 또한 이 매개 변수의 변화에 대해서 민감하지 않다.

• 한국가구학회지
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• 제24권4호
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• pp.433-443
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• 2013

The furniture industry of the northern region of Gyeonggi Province consists of several regional complexes which was just autogenously, that is, not based on the organized and planned movements cultivated and clustered, so it stays small businesses. This fact certainly requires to find right courses for future policy direction, in order to develop the furniture industry centering in the northern region of Gyeonggi Province internationally competitive. Consequently the aim of the present study was to investigate the characteristics of the furniture industry in the northern region of Gyeonggi Province first and to present right development directions for the innovation of the structure of furniture industry according to the change of the times, i.e. to connect the industry, university and the authorities concerned well and to strengthen the technology level of furniture industry accordingly. In addition, this requires education and training of the excellent designers being able to create high added-value industrial sectors, including finding a new Korean national brand which should preoccupy the global market. Furthermore, the high-tech furniture industrial complex specialized in manufacture, distribution and marketing such as the division of work between business to business should be built and finally a Korean traditional & unique furniture culture should be created on the basis of a cultural approach of furniture industry. It would be the timing for entire business sectors related to Korea's furniture industry to establish an international standard certification like ISO, in order to upgrade the quality of furniture steadily while keeping our own tradition, and this belongs to a meaningful attempt for the high-tech lifestyles and the improvement in the quality of life of customers.

• 한국환경과학회지
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• 제17권5호
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• pp.525-535
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• 2008

5 public complaint areas against odor in Changwon Industrial Complex were selected and investigated to clear up the cause of the complaint. 16 companies operated in public complaint areas were visited and had a grip of their situation about odor generation and treatment. Two samples at it's site boundary of each company were taken to measure complex odor unit. Complex odor unit at the site boundary of investigated companies in the public complaint areas, for the most part, exceeded standard(odor unit 20) in industrial area. It was due to that this area was not designated as odor control region and that there are also many problems in current laws of Odor Protection Act, Air Quality Act and regional legislation. Accordingly, It will be necessary to revise the related legislation, to organize governance, to financially support the improvement of environmental facilities and to enforce guidance and the regulation rigidly for the odor emission reduction in Changwon Industrial Complex.