• 대한두개안면성형외과학회지
• /
• 제22권2호
• /
• pp.71-77
• /
• 2021

Hypopharyngeal reconstruction is a surgically challenging procedure, and postoperative management is important due to a high rate of complications following surgery. In particular, stricture and fistula formation is the most common long-term postoperative complication. Through systematic review and meta-analysis of 21 studies, a significant radiation effect of stricture and fistula formation was found in patients who underwent hypopharyngeal reconstruction. The perioperative radiation must be seen as a critical factor for stricture and fistula formation in hypopharyngeal reconstruction.

• Advances in aircraft and spacecraft science
• /
• 제10권5호
• /
• pp.473-494
• /
• 2023

This article introduces a formalism for the analysis of airplane trajectories on which the motion is determined by specifying the power of the engines. It explains a procedure to solve the equations of motion to obtain the value of the relevant flight parameters. It then enumerates the constraints that the dynamical abilities of the airplane impose on the amount of fuel used, the speed, the load factor, the lift coefficient, the positivity and upper boundedness of the power available. Examples of analysis are provided to illustrate the method proposed, with rectilinear and circular trajectories. Two very different types of airplanes are used in the examples: a Silver Fox-like small UAV and a common Cessna 182 Skylane.

• 대한치과의료관리학회지
• /
• 제10권1호
• /
• pp.22-32
• /
• 2022

This study investigated factors affecting care for elderly patients, management of systemic disease, infection management, improvement of medical care quality, and educational requirements, and provide basic data for quality care for elderly patients with systemic diseases. An online survey was conducted among dental hygienists working at dental institutions and data of 172 individuals were analyzed using the SPSS 21.0 program. Descriptive statistics was performed for general characteristics. For factor analysis by general characteristics, t-test and ANOVA were performed. For differences between groups Scheffe verification was performed. A correlation analysis between factors was performed using Pearson's correlation analysis, and a factor analysis affecting the improvement of healthcare quality was performed using multiple linear regression analysis. Care for elderly patients was 52.33/75, management of systemic disease was 12.65/17, and infection management was 96.92/130. Improvement of medical quality (institutional effort) was 22.87/35, and improvement of medical quality (personal effort) was 22.72/35. The most common educational needs were "necessary". Analysis revealed a positive correlation between factors.. Factors affecting improvement of medical quality (personal effort) were age, final academic background, place of work, and the presence or absence of annual medical examinations. The findings of this study indicate that there is a significant correlation between factors. For the qualitative care of elderly patients, education programs related to elderly characteristics, systemic diseases, and infection management should be actively conducted by dental hygienists, and interest and research on geriatric dental hygiene is needed, centering on associations and educational institutions.

• Structural Monitoring and Maintenance
• /
• 제10권3호
• /
• pp.207-220
• /
• 2023

The safety of bridges are critical in our transportation infrastructure. Bridge design and analysis require complex structural analysis procedures to ensure their safety and stability. One common method is to calculate the maximum moment in the girders to determine the appropriate bridge section. Girder distribution factors (GDFs) provide a simpler approach for performing this analysis. A GDF is a ratio between the response of a single girder and the total response of all girders in the bridge. This paper explores the significance of GDFs in bridge analysis and design, including their importance in the evaluation of existing bridges. We utilized Bridge Weigh-in-motion (B-WIM) measurements of five simple supported girder bridge in Indonesia to develop a simple GDF provisions for the Indonesia's bridge design code. The B-WIM measurements enable us to know each girder strain as a response due to vehicle loading as the vehicle passes the bridge. The calculated GDF obtained from the B-WIM measurements were compared with the code-specified GDF and the American Association of State Highway and Transportation Officials (AASHTO) Load and Resistance Factor Design (LRFD) bridge design specification. Our study found that the code specified GDF was adequate or conservative compared to the GDF obtained from the B-WIM measurements. The proposed GDF equation correlates well with the AASHTO LRFD bridge design specification. Developing appropriate provisions for GDFs in Indonesian bridge design codes can provides a practical solution for designing girder bridges in Indonesia, ensuring safety while allowing for easier calculations and assessments based on B-WIM measurements.

• Clinical and Experimental Pediatrics
• /
• 제64권7호
• /
• pp.355-363
• /
• 2021

Background: Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity. Purpose: This study aimed to explore the molecular responses of podocytes to nephrotic plasma to identify specific genes and signaling pathways differentiating various clinical NS groups as well as biological processes that drive injury in normal podocytes. Methods: Transcriptome profiles from immortalized human podocyte cell line exposed to the plasma of 8 subjects (steroid-sensitive nephrotic syndrome [SSNS], n=4; steroid-resistant nephrotic syndrome [SRNS], n=2; and healthy adult individuals [control], n=2) were generated using microarray analysis. Results: Unsupervised hierarchical clustering of global gene expression data was broadly correlated with the clinical classification of NS. Differential gene expression (DGE) analysis of diseased groups (SSNS or SRNS) versus healthy controls identified 105 genes (58 up-regulated, 47 down-regulated) in SSNS and 139 genes (78 up-regulated, 61 down-regulated) in SRNS with 55 common to SSNS and SRNS, while the rest were unique (50 in SSNS, 84 genes in SRNS). Pathway analysis of the significant (P≤0.05, -1≤ log2 FC ≥1) differentially expressed genes identified the transforming growth factor-β and Janus kinase-signal transducer and activator of transcription pathways to be involved in both SSNS and SRNS. DGE analysis of SSNS versus SRNS identified 2,350 genes with values of P≤0.05, and a heatmap of corresponding expression values of these genes in each subject showed clear differences in SSNS and SRNS. Conclusion: Our study observations indicate that, although podocyte injury follows similar pathways in different clinical subgroups, the pathways are modulated differently as evidenced by the heatmap. Such transcriptome profiling with a larger cohort can stratify patients into intrinsic subtypes and provide insight into the molecular mechanisms of podocyte injury.

• Clinical and Experimental Reproductive Medicine
• /
• 제12권1호
• /
• pp.47-70
• /
• 1985

This study was presented of the 1,872 cases of infertile couples who visited and examined at the sterility clinic of Department of Obstetrics & Gynecology, Seoul National University Hospital from Sept., 1980 to Dec., 1983. Age, duration of infertility, past medical history, and other general factors were analyzed, and the factors responsible for infertility were classified and discussed. Mode of treatment, outcome of pregnancy, pregnancy rate responsible for each factor were also presented. The results were as follows: 1) The infertility was primary in 1,128, or 60.3% and secondary in 744, or 39.7%. 2) The age between 26 and 30 years of age comprised about one half of the total patients. 3) The duration of infertility between 1 and 4 years comprised about three quarters of the total patients, and the mean duration was 3.8 years. 4) The most common medical history in primary infertility was tuberculous disease, and that in secondary infertility was history of previous laparotomy. 5) About two thirds of antecedent pregnancies were abortion. 6) The major etiologic factor of infertility were male factor in 12.3%, tubal factor in 38.8%, ovulatory failure in 25.4%, uterine factor in 8.8%, cervical factor in 5.2%, peritoneal factor in 9.5%, and no demonstrable cause in 11.3%. 7) The types of male factor were azoospermia in 61.6%, oligospermia in 25.8%, low motility in 11.6%, and other abnormality in 1.0%. 8) The types of ovulatory failure were ovarian failure in 7.4%, hypothalamo-pituitary failure in 8.1 %, hypothalamo-pituitary dysfunction (including Polycystic ovarian syndrome) in 30.2%, and hyperprolactinemia in 22.4%. 9) The types of uterine factor were endometrial tuberculosis in 27.5%, uterine synechia in 33.8%, uterine anomaly in 19.7%, myoma and polyp in 9.1 %, and luteal phase defect in 9.9%. 10) The types of peritoneal factor were pelvic adhesion in 80.9% and endometriosis in 19.6%. 11) Surgeries were done in 408 patients, and they were salpingolysis, lysis of extraadnexal adhesion, salpingostomy, fimbrioplasty, ovarian wedge resection for polycystic ovarian disease, tubo-tubal anastomosis, and tubo-uterine implantation in orders. 12) 243 pregnancies were achieved during the infertility work-up, of which livebirth was 46.5%, ectopic pregnancy was 7.4%, spontaneous abortion was 7.8%, and on-going pregnancy or lost to follow-up was 36.2%. 13) Pregnancy rates in various factors were male factor in 18.7%, ovulatory factor in 31.7%, tubal factor in 24.2%, uterine factor in 34.6%, cervical factor in 19.0%, peritoneal factor in 29.0%, combined factors in 10.5%, and unexplained infertility in 37.1%. Pregnancy rate in whole patients was 25.2%.

• Journal of Hospice and Palliative Care
• /
• 제8권2호
• /
• pp.200-208
• /
• 2005

목적: 악성 위장관 폐색 환자에서 완화적 시술이나 수술은 폐색의 다양한 증상을 조절할 뿐만 아니라 삶의 질을 향상시킨다. 본 연구는 완화적인 시술을 받았던 악성 위장관 폐색 말기암 환자의 임상적 특징과 예후인자를 알아보고자 하였다. 방법: 2002년 5월부터 2005년 5월까지 본원에서 악성 위장관 폐색으로 진단받아 완화적인 시술을 받았던 48명의 말기암 환자를 대상으로 후향적으로 조사하였다. 완화적인 암절제 환자는 제외하였다. 임상적 특성과 시술내용을 조사하였고 예후인자는 log-rank test를 이용한 단변량 분석을 하고 통계적으로 의미 있는 인자는 Cox's proportional hazard model을 사용하여 다변량 분석을 하였다. 결과: 연령의 중앙값은 65세이고 남자가 25명(52%), 여자가 23명(48%)이었다. 가장 많은 암은 대장직장암으로 26명(55%)이고 다음으로 10명(21%)의 위암이었다. 치료를 전혀 받지 않았던 환자는 25명(58%)이었고 20명(42%)은 치료를 받았으며 이 중 18명은 항암 치료를 받은 과거력이 있었다. 가장 흔한 증상은 통증으로 15명(31%)이었다. 활동도 1점 혹은 2점이 23명(48%), 3점 혹은 4점이 25명(52%)이었다. 가장 많은 완화적인 시술은 대장루술로 19명이 받았다. 완화적 시술로 인한 사망은 없었다. 단변량과 다변량 분석에 의해서 전체 생존기간과 무증상 생존기간에 대하여 활동도 만이 의미있는 독립 예후인자였다. 전체 중간 생존기간은 150일이었으며 무증상 중간 생존기간은 90일이었다. 결론: 완화적 시술을 받은 악성 위장관 폐색 환자의 전체 중간 생존기간과 무증상 중간 생존기간에 대하여 활동도만이 유일한 독립 예후인자였다.

• Journal of Korean Neurosurgical Society
• /
• 제60권5호
• /
• pp.584-590
• /
• 2017

Objective : Traumatic brain injury (TBI) in children under age 24 months has characteristic features because the brain at this age is rapidly growing and sutures are opened. Moreover, children this age are completely dependent on their parents. We analyzed the demographic data and risk factors for outcomes in TBI patients in this age group to elucidate their clinical characteristics. Methods : We retrospectively reviewed the medical records and radiological films of children under 24 months who were admitted to Kyungpook National University Hospital from January 2004 to December 2013 for TBI. Specifically, we analyzed age, cause of injury, initial Glasgow coma scale (GCS) score, radiological diagnosis, seizure, hydrocephalus, subdural hygroma, and Glasgow outcome scale (GOS) score, and we divided outcomes into good (GOS 4-5) or poor (GOS 1-3). We identified the risk factors for post-traumatic seizure (PTS) and outcomes using univariate and multivariate analyses. Results : The total number of patients was 60, 39 males and 21 females. Most common age group was between 0 to 5 months, and the median age was 6 months. Falls were the most common cause of injury (n=29, 48.3%); among them, 15 were falls from household furniture such as beds and chairs. Ten patients (16.7%) developed PTS, nine in one week; thirty-seven patients (61.7%) had skull fractures. Forty-eight patients had initial GCS scores of 13-15, 8 had scores of 12-8, and 4 had scored 3-7. The diagnoses were as follows : 26 acute subdural hematomas, 8 acute epidural hematomas, 7 focal contusional hemorrhages, 13 subdural hygromas, and 4 traumatic intracerebral hematomas larger than 2 cm in diameter. Among them, two patients underwent craniotomy for hematoma removal. Four patients were victims of child abuse, and all of them had PTS. Fifty-five patients improved to good-to-moderate disability. Child abuse, acute subdural hematoma, and subdural hygroma were risk factors for PTS in univariate analyses. Multivariate analysis found that the salient risk factor for a poor outcome was initial GCS on admission. Conclusion : The most common cause of traumatic head injury in individuals aged less than 24 months was falls, especially from household furniture. Child abuse, moderate to severe TBI, acute subdural hematoma, and subdural hygroma were risk factors for PTS. Most of the patients recovered with good outcomes, and the risk factor for a poor outcome was initial mental status.

• 한국과학교육학회지
• /
• 제39권2호
• /
• pp.249-261
• /
• 2019

본 연구의 목적은 과학자들의 문제 해결 과정에서 공감요소를 추출하고 그 공감요소가 과학자들의 문제 해결 상황에서 어떤 영향을 주고 있는지 확인해보고자 한다. 이에 본 연구는 창의성 연구자들이 언급한 과학자들 중 공통인물 6명을 분석대상으로 선정하고 그들의 자서전 및 그들의 일대기에 관련한 논문을 통해 그들의 문제 해결 사례에서 공감요소를 추출하여 이를 유목화 하였다. 총 12개의 서적과 50여개의 논문에서 제시한 사례를 Davis의 공감척도를 분석틀로 분석하였고 공통요인을 추출하였다. 그 결과 총 182개의 사례에서 과학 공감요소가 추출되었고, 이 중 33개의 공통요소가 발견되었다. 과학교육전문가집단의 내용타당도 검사를 통하여 본 사례의 타당도를 확인한 결과, 전문가의 내용타당도 I-CVI 평균은 .86, S-CVI 평균 .90값이 확인되었다. 과학자들이 문제 해결사례에서 활용하고 있는 공감요소는 인지적 공감으로 관점 취하기 측면에서 3가지(다른 학문 분야를 통한 공감, 연구대상의 관점에서 공감, 다른 사람의 의견 수용), 상상하기 측면에서 3가지(관찰 근거의 상상, 사고 실험, 연구 대상에 대한 유기체적 느낌), 정서적 공감으로 공감적 관심측면에서 3가지(동료 연구자의 의욕에 따른 반응, 연구대상에 대한 감동, 더 연구하고 싶은 흥분), 개인적 각성 측면에서 2가지(타인의 연구실패에 대한 불편한 감정, 문제에 대한 민감성)가 추출되었다. 이는 Davis의 공감요소와 완벽하게 일치한다고 할 수 없었으나 과학자들의 사례에서 발견되는 이러한 공통되는 요소를 기초로 과학 공감요소에 대한 정의가 가능할 것이다.

• 한국항해항만학회:학술대회논문집
• /
• 한국항해항만학회 2002년도 춘계학술대회논문집
• /
• pp.1-11
• /
• 2002

As the competition among the ports is extreme, the purpose of this study which intendsto keep sustainable competitive advantage in Busan Container Terminals through the quality management of port service is shown as the followings. First, the common factor of quality management activities In the part of domestic container port is to be analysed. secondly, the efforts for enhancing the standard of quality management is to be confirmed lastly the relationship of cause-effect among the source of quality management, quality management activities and quality management is to be clarified. An empirical study was carried out to examine how Busan Container Terminals view quality management activities by the provision of statistical evidence showing the efforts to enhance the standard of quality management, common factors of quality management activities and causal relationship among these factors. The data investigating the quality management for Busan Container Terminals were collected from 170 persons in charge of quality management for port services in Busan Container Terminals the use of questionnaire method and personal interviews. The Cronbach's $\alpha$ coefficient and factor analysis were used to analyze the reliability and the propriety of measured variables. Furthermore SEM method using AMOS 4.0 was used to analyze the cause-effect relationship among the source. activities and accomplishments of quality management representing the core concept of quality management system. The importance of this study is placed in the description of the theoretical and general system on the quality management when the domestic container terminals have activated to promote the quality management, and in suggesting the actual problem and settlement method which are directly helpful to the field, and It can be indicated as having its meaning on future research obect.