• Steel and Composite Structures
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• v.29 no.1
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• pp.77-90
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• 2018

This paper presents a combined numerical, experimental, and theoretical study on the behavior of the concrete-filled double circular steel tubular (CFDT) stub columns under axial compressive loading. Four groups of stub column specimens were tested in this study to find out the effects of the concrete strength, steel ratio and diameter ratio on the mechanical behavior of CFDT stub columns. Nonlinear finite element (FE) models were also established to study the stresses of different components in the CFDT stub columns. The change of axial and transverse stresses in the internal and external steel tubes, as well as the change of axial stress in the concrete sandwich and concrete core, respectively, was thoroughly investigated for different CFDT stub columns with the same steel ratio. The influence of inner-to-outer diameter ratio and steel ratio on the ultimate bearing capacity of CFDT stub columns was identified, and a reasonable section configuration with proper inner-to-outer diameter ratio and steel ratio was proposed. Furthermore, a practical formula for predicting the ultimate bearing capacity was proposed based on the ultimate equilibrium principle. The predicted results showed satisfactory agreement with both experimental and numerical results, indicating that the proposed formula is applicable for design purposes.

• Journal of the Ergonomics Society of Korea
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• v.30 no.3
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• pp.419-426
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• 2011

Objective: The objective of this study was to evaluate a work of guards, using an ergonomic method(work analysis and posture analysis). Background: Most studies about guards were conducted in the field of medical, problems of shift, and the physical problems of old workers and social problems. But, guards consist of vulnerability group so it needs an ergonomic research in musculoskeletal disorders. Method: A head of an ergonomic estimation was work analysis(determination of combined task, work tool, work time and frequency of combined task) and posture analysis(upper body and lower body) of workers based on the video. Results: The result showed that combined task of guards was classification of patrolling, security, cleaning and waiting. The security indicated the highest ratio in the work time of combined tasks. The results of posture analysis for guards indicated high value in neutral. But, lower arm indicated high value in bending(left: 59%, right: 50%). Conclusion: The results of ergonomic methods indicated that guards' physical work load was not high during work, but comfortable work environment would be required for old guards. Application: If an ergonomic rule can be integrated into existing work environments, the risk of occupational injuries and stress will be reduced.

• Journal of Biomedical Engineering Research
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• v.30 no.1
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• pp.89-93
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• 2009

Bone remodeling is a continuous process of skeletal renewal during which bone formation is tightly coupled to bone resorption. Mechanical loading is an important regulator of bone formation and resorption. In recent studies, neurotransmitters such as vasoactive intestinal peptide (VIP) were found to be present inside bone tissue and have been suggested to potentially regulate bone remodeling. In this study, our objective was to use a pre-established in vitro oscillatory fluid flow-induced shear stress mechanical loading system to quantify the effect of VIP on bone resorptive activity and investigate its combined effect with mechanical loading. VIP decreased osteoclastogenesis significantly decreased RANKL/OPG mRNA ration by approximately 90%. Combined VIP and mechanical loading further decreased RANKL/OPG ratio to approximately 95%. These results suggest that VIP present in bone tissue may synergistically act with mechanical loading to regulate bone remodeling via suppression of bone resorptive activities.

• Korea-Australia Rheology Journal
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• v.13 no.1
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• pp.1-12
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• 2001

This paper describes the application of our recently developed two-phase model for flow-induced crystallization (FIC) to the simulation of fiber spinning and film blowing. 1-D and 2-D simulations of fiber spinning include the combined effects of (FIC), viscoelasticity, filament cooling, air drag, inertia, surface tension and gravity and the process dynamics are modeled from the spinneret to the take-up roll device (below the freeze point). 1-D model fits and predictions are in very good quantitative agreement with high- and low-speed spinline data for both nylon and PET systems. Necking and the associated extensional softening are also predicted. Consistent with experimental observations, the 2-D model also predicts a skin-core structure at low and intermediate spin speeds, with the stress, chain extension and crystallinity being highest at the surface. Film blowing is simulated using a "quasi-cylindrical" approximation for the momentum equations, and simulations include the combined effects of flow-induced crystallization, viscoelasticity, and bubble cooling. The effects of inflation pressure, melt extrusion temperature and take-up ratio on the bubble shape are predicted to be in agreement with experimental observations, and the location of the frost line is predicted naturally as a consequence of flow-induced crystallization. An important feature of our FIC model is the ability to predict stresses at the freeze point in fiber spinning and the frost line in film blowing, both of which are related to the physical and mechanical properties of the final product.l product.

• Journal of the Korean Society of Safety
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• v.29 no.2
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• pp.53-61
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• 2014

This study evaluated wind loads considering a local basic wind velocity and construction periods to define the level of applied wind loads for system supports. Structural responses of system supports were examined and compared to those of system supports with the level of wind loads following various standards and specifications for permanent and temporary structures. And, the maximum combined stress ratios were estimated to evaluate the structural safety of a considered system support. From results, it was found that the wind load level should be applied in accordance with construction periods when estimating the safety of system supports. Looking into the response by change of the basic wind velocity according to local regions, it is no need to consider wind loads in regions with the basic wind velocity of 30 m/s. However, it was analyzed that wind loads should be considered in the regions with the basic wind velocity of 40 m/s or above. In addition, wind loads should be considered in designing system supports located at the region with the basic wind velocity of 35 m/s starting from construction period of 1.5 years. The standard specification for temporary work was analyzed as an incorrect standard in evaluating wind loads, since it underestimated the response of system supports in accordance with the local basic wind velocity and construction periods.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.7
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• pp.629-636
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• 2009

Mechanical stimulation is known to play a vital role on the differentiation of mesenchymal stem cells (MSCs) to pre-osteoblasts. In this research, we developed a tensile cell stimulator, composed of a DC motor-driven actuator and LVDT sensor for measuring linear displacement, to study the effects of tensile stress on osteogenic differentiation of MSCs. First, we demonstrated the reliability of this device by showing the uniform strain field in the silicon substrate. Secondly, we investigated the effects of tensile stretching on osteogenic differentiation. We imposed a pre-set cyclic strain at a fixed frequency on cell monolayer cultured on a flexible silicon substrate while varying its amplitude and duration. 60 min of resting period was allowed between 30 min of cyclic stretching and this cycle is repeated up to 7 days. Under the combined stimulation with osteogenic media and mechanical stretching, the osteogenic markers such as alkaline phosphatase (ALP), osterix, and osteopontin began to get expressed as early as 4 days of stimulation, which is much shorter than what is typically required for osteogenic media induced differentiation. Moreover, different markers were induced at different magnitudes of the applied strains. Lastly, for the case of ALP, we observed the antagonistic effects of osteogenic media when combined with mechanical stretching.

• 한국전산유체공학회:학술대회논문집
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• 2009.11a
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• pp.88-92
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• 2009

When exposed to uniform magnetic fields externally applied, paramagnetic particles acquire dipole moments and the induced moments interacting with each other lead to the formation of chainlike structures or clusters of particles aligned with the field direction. A direct simulation method, based on the Maxwell stress tensor and a fictitious domain method, is applied to solve flows with magnetic chains in simple shear flow. We assumed that the particles constituting the chains are paramagnetic, and inertia of both flow and magnetic particles is negligible. The numerical scheme enables us to take into account both hydrodynamic and magnetic interactions between particles in a fully coupled manner, enabling us to numerically visualize breakup and reformation of the chains by the combined effect of the external field and the shear flow. Simple shear flow with suspended magnetic chains is solved in a periodic domain for a given magnetic field. Dynamics of interacting magnetic chains is found to be significantly affected by a dimensionless parameter called the Mason number, the ratio of the viscous force to the magnetic force in the shear flow. The effect of particle area fraction on the chain dynamics is investigated as well.

• Genomics & Informatics
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• v.10 no.4
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• pp.244-248
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• 2012

Oxidative stress, which results in an excessive product of reactive oxygen species (ROS), is one of the fundamental mechanisms of the development of hypertension. In the vascular system, ROS have physical and pathophysiological roles in vascular remodeling and endothelial dysfunction. In this study, ROS-hypertension-related genes were collected by the biological literature-mining tools, such as SciMiner and gene2pubmed, in order to identify the genes that would cause hypertension through ROS. Further, single nucleotide polymorphisms (SNPs) located within these gene regions were examined statistically for their association with hypertension in 6,419 Korean individuals, and pathway enrichment analysis using the associated genes was performed. The 2,945 SNPs of 237 ROS-hypertension genes were analyzed, and 68 genes were significantly associated with hypertension (p < 0.05). The most significant SNP was rs2889611 within MAPK8 (p = $2.70{\times}10^{-5}$; odds ratio, 0.82; confidence interval, 0.75 to 0.90). This study demonstrates that a text mining approach combined with association analysis may be useful to identify the candidate genes that cause hypertension through ROS or oxidative stress.

• 한국지구물리탐사학회:학술대회논문집
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• 2006.06a
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• pp.195-200
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• 2006

Laboratory creep experiments show that compaction of unconsolidated shale is an irrecoverable process caused by viscous time-dependent deformation. Using Perzyna's viscoplasticity framework combined with the modified Cam-clay theory, we found the constitutive equation expressed in the form of strain rate as a power law function of the ratio between the sizes of dynamic and static yield surfaces. We derived the volumetric creep strain at a constant hydrostatic pressure level as a logarithmic function of time, which is in good agreement with experimental results. The determined material constants indicate that the yield stress of the shale increases by 6% as strain rate rises by an order of magnitude. This demonstrates that the laboratory-based prediction of yield stress (and porosity) may result in a significant error in estimating the properties in situ.

• Geomechanics and Engineering
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• v.12 no.4
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• pp.611-626
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• 2017

The research reported herein is concerned with the model testing of piles socketed in soft rock which was simulated by cement, plaster, sand, water and concrete hardening accelerator. Model tests on a single pile socketed in simulated soft rock under axial cyclic loading were conducted and the bearing capacity and accumulated deformation characteristics under different static, and cyclic loads were studied by using a device which combined oneself-designed test apparatus with a dynamic triaxial system. The accumulated deformation of the pile head, and the axial force, were measured by LVDT and strain gauges, respectively. Test results show that the static load ratio (SLR), cyclic load ratio (CLR), and the number of cycles affect the accumulated deformation, cyclic secant modulus of pile head, and ultimate bearing capacity. The accumulated deformation increases with increasing numbers of cycles, however, its rate of growth decreases and is asymptotic to zero. The cyclic secant modulus of pile head increases and then decreases with the growth in the number of cycles, and finally remains stable after 50 cycles. The ultimate bearing capacity of the pile is increased by about 30% because of the cyclic loading thereon, and the axial force is changed due to the applied cyclic shear stress. According to the test results, the development of accumulated settlement is analysed. Finally, an empirical formula for accumulated settlement, considering the effects of the number of cycles, the static load ratio, the cyclic load ratio and the uniaxial compressive strength, is proposed which can be used for feasibility studies or preliminary design of pile foundations on soft rock subjected to cyclic loading.