• Investigative Magnetic Resonance Imaging
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• 제22권1호
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• pp.65-70
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• 2018

The objective of this study was to describe a radiofrequency (RF) coil design for in vivo sodium magnetic resonance imaging (MRI) for use in small animals. Accumulating evidence has indicated the importance and potential of sodium imaging with improved magnet strength (> 7T), faster gradient, better hardware, multi-nucleus imaging methods, and optimal coil design for patient and animal studies. Thus, we developed a saddle-shaped sodium volume coil with a diameter/length of 30/30 mm. To evaluate the efficiency of this coil, bench-level measurement was performed. Unloaded Q value, loaded Q value, and ratio of these two values were estimated to be 352.8, 211.18, and 1.67, respectively. Thereafter, in vivo acquisition of sodium images was performed using normal mice (12 weeks old; n = 5) with a two-dimensional gradient echo sequence and minimized echo time to increase spatial resolution of images. Sodium signal-to-noise ratio in mouse kidneys (renal cortex, medulla, and pelvis) was measured. We successfully acquired sodium MR images of the mouse kidney with high spatial resolution (approximately 0.625 mm) through a combination of sodium-proton coils.

• Investigative Magnetic Resonance Imaging
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• 제23권2호
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• pp.100-113
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• 2019

Sarcoidosis is a multisystem disease characterized by noncaseating granulomas. Cardiac involvement is known to have poor prognosis because it can manifest as a serious condition such as the conduction abnormality, heart failure, ventricular arrhythmia, or sudden cardiac death. Although early diagnosis and early treatment is critical to improve patient prognosis, the diagnosis of CS is challenging in most cases. Diagnosis usually relies on endomyocardial biopsy (EMB), but its diagnostic yield is low due to the incidence of patchy myocardial involvement. Guidelines for the diagnosis of CS recommend a combination of clinical, electrocardiographic, and imaging findings from various modalities, if EMB cannot confirm the diagnosis. Especially, the role of advanced imaging such as cardiac magnetic resonance (CMR) imaging and positron emission tomography (PET), has shown to be important not only for the diagnosis, but also for monitoring treatment response and prognostication. CMR can evaluate cardiac function and fibrotic scar with good specificity. Late gadolinium enhancement (LGE) in CMR shows a distinctive enhancement pattern for each disease, which may be useful for differential diagnosis of CS from other similar diseases. Effectively, T1 or T2 mapping techniques can be also used for early recognition of CS. In the meantime, PET can detect and quantify metabolic activity and can be used to monitor treatment response. Recently, the use of a hybrid CMR-PET has introduced to allow identify patients with active CS with excellent co-localization and better diagnostic accuracy than CMR or PET alone. However, CS may show various findings with a wide spectrum, therefore, radiologists should consider the possible differential diagnosis of CS including myocarditis, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy, amyloidosis, and arrhythmogenic right ventricular cardiomyopathy. Radiologists should recognize the differences in various diseases that show the characteristics of mimicking CS, and try to get an accurate diagnosis of CS.

• Journal of Power Electronics
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• 제18권5호
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• pp.1555-1566
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• 2018

Proportional capacitor-current-feedback active damping (AD) is a common damping method for the resonance of LCL-type grid-connected inverters. Proportional capacitor-current-feedback AD behaves as a virtual resistor in parallel with the capacitor. However, the existence of delay in the actual control system causes impedance in the virtual resistor. Impedance is manifested as negative resistance when the resonance frequency exceeds one-sixth of the sampling frequency ($f_s/6$). As a result, the damping effect disappears. To extend the system damping region, this study proposes a virtual resistor-inductor-capacitor (RLC) AD method. The method is implemented by feeding the filter capacitor current passing through a band-pass filter, which functions as a virtual RLC in parallel with the filter capacitor to achieve positive resistance in a wide resonance frequency range. A combination of Nyquist theory and system close-loop pole-zero diagrams is used for damping parameter design to obtain optimal damping parameters. An experiment is performed with a 10 kW grid-connected inverter. The effectiveness of the proposed AD method and the system's robustness against grid impedance variation are demonstrated.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2001년도 춘계학술대회논문집
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• pp.942-947
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• 2001

This paper provides a stability analysis of the transverse vibration of a spinning disk under the torque fluctuation from a permanent magnetic motor. An analytical model has been formulated for a flexible annular disk with its spinning velocity varying harmonically with the same frequency as the cogging torque. A perturbation method based on multiple time scales is applied to perform the stability analysis. Based on expressions for the amplitude and frequency of the parametric excitation, stability boundaries are determined in terms of a nominal spindle velocity, the least common multiple of poles and slots, the magnitude of torque fluctuation and the modal characteristics of. the disk. The stability diagrams predicted by perturbation have been verified numerically using the Floquet theory, which is in good agreement. In conclusion, the fluctuation in spinning velocity is found to affect the stability of the transverse vibration of a rotating disks. The results of this work can be applied to high precision spindle systems such as computer storage systems.

• 마이크로전자및패키징학회지
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• 제7권3호
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• pp.13-17
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• 2000

ECR (Electron Cyclotron Resonance) 식각 공정에 따른 층간 절연막 폴리이미드의 전기적 특성에 관하여 연구하였다. 알루미늄 식각시 일반적으로 사용되는 $Cl_2$플라즈마는 폴리이미드의 유전상수 값을 증가시킨 반면에 $SF_{6}$플라즈마의 경우는 높은 식각률과 유전상수 값의 감소를 가져왔다. 폴리이미드의 누설 전류는 ECR 식각 공정 후에 감소되었다. 다중 금속화 구조를 구현하는데 있어 $Cl_2$플라즈마를 사용하여 알루미늄을 식각하고 $SF_{6}$ 플라즈마를 사용하여 폴리이미드를 식각하는 것이 최적일 것으로 판단된다.

• 한국군사과학기술학회지
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• 제17권1호
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• pp.57-63
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• 2014

In this paper, we have proposed a wide band antenna for manpack SDR(Software Defined Radio). The proposed antenna consists of feeding post, flexible gooseneck and two radiating elements composed of a upper and lower radiators. The upper radiator has a longer electrical length than the lower radiator in order to operate in the lower frequency. Also, the resonant frequency and impedance characteristics of the antenna can be adjusted independently for two radiators. Therefore, the proposed antenna can be achieved wide impedance bandwidth by the combination of two independent resonance modes. To analyze the characteristics of the antenna in the design process is employed the equivalent circuit theory and EM(Electro-Magnetic) simulation. The measurement results show that the proposed antenna have the sufficient wide bandwidth, above -3.4dBi of the gain and fairly good radiation pattern over the wide bandwidth.

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.10-26
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• 2019

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging guidance, transcranial sonication of precise cerebral targets has become a therapeutic option. Intensity is a key determinant of ultrasound effects. High-intensity focused ultrasound can produce targeted lesions via thermal ablation of tissue. MRgFUS-mediated stereotactic ablation is non-invasive, incision-free, and confers immediate therapeutic effects. Since the US Food and Drug Administration approval of MRgFUS in 2016 for unilateral thalamotomy in medication-refractory essential tremor, studies on novel indications such as Parkinson's disease, psychiatric disease, and brain tumors are underway. MRgFUS is also used in the context of blood-brain barrier (BBB) opening at low intensities, in combination with intravenously-administered microbubbles. Preclinical studies show that MRgFUS-mediated BBB opening safely enhances the delivery of targeted chemotherapeutic agents to the brain and improves tumor control as well as survival. In addition, BBB opening has been shown to activate the innate immune system in animal models of Alzheimer's disease. Amyloid plaque clearance and promotion of neurogenesis in these studies suggest that MRgFUS-mediated BBB opening may be a new paradigm for neurodegenerative disease treatment in the future. Here, we review the current status of preclinical and clinical trials of MRgFUS-mediated thermal ablation and BBB opening, described their mechanisms of action, and discuss future prospects.

• Animal Bioscience
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• 제34권4호
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• pp.724-733
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• 2021

Objective: The objectives of this study were to investigate the direct antioxidative effect of 90 Kda heat shock protein (Hsp90) obtained from duck muscle. Methods: The interaction of Hsp90 with phospholipids and oxidized phospholipids was studied with surface plasmon resonance (SPR), and their further oxidation in the presence of Hsp90 was evaluated with thiobarbituric acid reactive substances (TBARS) assay. The scavenging effect on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis (3-ethylbenzthiazoline-6-sulfonic acid (ABTS) was measured, and the electron paramagnetic resonance (EPR) spectroscopy in combination with 5-tert-Butoxycarbonyl-5-methyl-1-pyrroline-N-oxide and 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide (PTIO) was utilized to determine the abilities of Hsp90 in scavenging hydroxyl and PTIO radicals. Results: SPR showed Hsp90 could bind with both phospholipids and oxidized phospholipids, and prevent their further oxidation by the TBARS assay. The DPPH and ABTS scavenging activity increased with Hsp90 concentration, and could reach 27% and 20% respectively at the protein concentration of 50 μM. The EPR spectra demonstrated Hsp90 could directly scavenge ·OH and PTIO· radicals. Conclusion: This suggests that Hsp90, a natural antioxidant in meat, may play an important role in cellular defense against oxidative stress, and may have potential use in meat products.

• 대한기계학회논문집A
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• 제22권4호
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• pp.916-923
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• 1998

In this paper, an infinite determinant method is presenstd for stability analysis of parametrically excited systems. Unstable regions of the combination parametric resonance as well as principal resonance can be identified with the method. A numerical problem of relatively large amplitude of excitation is solved, and the results of the presented method are compared to those of the multiple scales perturbation method. It is found that the presented method obtains more accurate transition curves which divide stable and unstables in the parameter plane than those of the multiple scales perturbation method.

• 한국자기공명학회논문지
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• 제18권2호
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• pp.47-51
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• 2014

Larger proteins (above molecular weight 50 kDa) usually show slow motional tumbling in solution, which facilitates the decay of NMR signal, resulting in poor signal-to-noise. In the past twenty years, researchers have tried to overcome this problem with higher molecular weight by improvement of hardware (higher magnetic field and cryoprobe), optimization of pulse sequences for lager molecules, and development of isotope-labeling techniques. Actually, GroEL/ES complex (${\approx}$ 900 kDa) was successfully studied using combination of above techniques. Among the techniques used in large molecular studies, the impact of isotope-labeling for large molecules study is summarized and discussed here.