• 한국임상약학회지
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• 제30권1호
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• pp.1-10
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• 2020

Objective: The aim of the study was to perform a meta-analysis of randomized clinical trials to compare the clinical efficacy and safety between combination of cyclin-dependent kinase (CDK) 4/6 inhibitors with aromatase inhibitors (AIs) and AIs alone in patients with hormone receptor+/human epidermal growth factor receptor type2-(HR+/HER2-) advanced breast cancer. Methods: Published clinical studies were identified through electronic database searches until February 2019. Literature qualities were assessed by the Scottish Intercollegiate Guidelines Network Checklist. Key endpoints of efficacy were progression-free survival (PFS), objective response rate (ORR), and clinical benefit (CB). Endpoints of safety were adverse events (AEs) (neutropenia, leukopenia, any grade 3/4 AEs, and serious AEs) and on-treatment death. Meta-analysis was performed using the RevMan 5.3 software. Results: The selected five studies were evaluated as "good" in quality assessment. Compared to AIs alone, the combination therapy significantly improved PFS (pooled hazard ratio=0.55; 95% confidence interval (CI) 0.49-0.62), ORR (odds ratio=1.78; 95% CI=1.49-2.13), and CB (odds ratio=1.86; 95% CI=1.51-2.28). The prevalence of AEs was significantly higher in the combination group than in the AIs alone group. On-treatment death was greater in the combination group than in the AIs alone group, although insignificant. Conclusion: The combination therapy of CDK4/6 inhibitors with AIs was more effective for the treatment of HR+/HER2- advanced breast cancer, but less safe than AIs alone. The combination therapy should be effectively managed through patient monitoring, and further studies are needed to reduce AEs in the combination therapy of CDK4/6 inhibitors with AIs.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2014년도 춘계 학술논문 발표대회
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• pp.270-271
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• 2014

In this study, a replacement ratio of blast furnace slag coarse aggregate and a water binder ratio by an optimum combination of PHC file was investigated. As a results, the target strength 78.5MPa was altogether satisfied in a mix proportion 28-G100-SG0 and W/B ratio 26 %. The surface rupture was generated in 28-G0-SG100 combination after curing with the autoclave. According to the result of measuring the ingredient, the majority were the MgOH2 hydrate.

• 유통과학연구
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• 제12권3호
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• pp.33-41
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• 2014

Purpose - The purpose of this study was to predict the selection of independent auditors in the companies listed on the Tehran Stock Exchange (TSE) using a combination of PSO algorithm and CART. This study involves applied research. Design, approach and methodology - The population consisted of all the companies listed on TSE during the period 2005-2010, and the sample included 576 data specimens from 95 companies during six consecutive years. The independent variables in the study were the financial ratios of the sample companies, which were analyzed using two data mining techniques, namely, PSO algorithm and CART. Results - The results of this study showed that among the analyzed variables, total assets, current assets, audit fee, working capital, current ratio, debt ratio, solvency ratio, turnover, and capital were predictors of independent auditor selection. Conclusion - The current study is practically the first to focus on this topic in the specific context of Iran. In this regard, the study may be valuable for application in developing countries.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2017년도 춘계 학술논문 발표대회
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• pp.88-89
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• 2017

Due to the increase in the usage of explosive materials and terrorism, the interest towards the superior explosion protective HPFRCC has risen. In existing research, the optimum ratio for solving the problematic problems such as the optimum fiber incorporation rate and the self-shrinkage crack of HPFRCC had been derived. However, there had been few or even no research upon how effective HPFRCC would perform protective explosion-proof in actual explosion. Therefore, this research compared the explosion-proof performance of HPFRCC according to fiber commination and mixing ratio. As a result, the combination of steel fiber and organic fiber showed excellent flow and strength, and it also improved the explosion resistance.

• 전기학회논문지P
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• 제59권3호
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• pp.330-334
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• 2010

We tried to combine a transformer with a superconducting element and investigated the current limiting characteristics. When a superconducting element was connected to third winding of the transformer, the fault current was limited to about 90 % effectively. The fault current and consumption power were able to be controlled by the turn's ratio of secondary and third windings. It gives flexibility of the rating of a transformer in the power grid. As a result, power burden of a superconducting element was reduced by the decrease of turn's ratio in third winding of a transformer. It was because the voltage behavior of a superconducting element was dependent on turn's ratio of a transformer while the current characteristic was independent.

• Biomolecules & Therapeutics
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• 제20권1호
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• pp.62-67
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• 2012

TNF-related apoptosis-inducing ligand (TRAIL) is a promising agent for management of cancer because of its selective cytotoxicity to cancer cells. However, some cancer cells have resistance to TRAIL. Accordingly, novel treatment strategies are required to overcome TRAIL resistance. Here, we examined the synergistic apoptotic effect of apigenin in combination with TRAIL in Huh-7 cells. We found that combined treatment of TRAIL and apigenin markedly inhibited Huh-7 cell growth compared to either agent alone by inducing apoptosis. Combined treatment with apigenin and TRAIL induced chromatin condensation and the cleavage of poly (ADP-ribose) polymerase (PARP). In addition, enhanced apoptosis by TRAIL/apigenin combination was quantified by annexin V/PI flow cytometry analysis. Western blot analysis suggested that apigenin sensitizes cells to TRAIL-induced apoptosis by activating both intrinsic and extrinsic apoptotic pathway-related caspases. The augmented apoptotic effect by TRAIL/apigenin combination was accompanied by triggering mitochondria-dependent signaling pathway, as indicated by Bax/Bcl-2 ratio up-regulation. Our results demonstrate that combination of TRAIL and apigenin facilitates apoptosis in Huh-7 cells.

• 한국인구학
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• 제7권1호
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• pp.78-123
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• 1984

This study is attempting to examine the possible determinants of the rise of the sex ratio at birth from 106 to 110 in past decade in Taiwan. The basic hypothesis for the sudden rise of the sex ratio at birth is due to a combination of prenatal sex determination and abortion. The reasoning for this hypothesis involves three types of considerations - motivation, norm, and access. The theory is evaluated by analyzing data from birth registration and a large and representative sampie of Taiwanese wives of childbearing age. The empirical data seem to support the theoretical preposition and the basic hypothesis that the rise of the sex ratio at birth in Taiwan is due to a combination of prenatal sex determination and abortion. There is striking evidence of son-preference in the rise of the sex ratio at birth in higher birth order. In 1990 the sex ratio was 119 for third births and 128 for fourth and fifth births compared to the expected 106. Also, the 1991 KAP data indicated that women who have only daughters but no any son are more likely to make prenatal sex screening and terminate their pregnancies in male live births at higher birth order. Obviously, genetic diagnosis through chorionic villus sampling which was available in recent years was misused for prenatal sex determination and sex selective abortion.

• Asian-Australasian Journal of Animal Sciences
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• 제20권2호
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• pp.252-256
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• 2007

This study was carried out to determine the effect of vitamin E and vitamin C on the performance of Japanese quails (Coturnix coturnix japonica) reared under heat stress during the growth and egg production period. A total of 810 seven-day-old Japanese quails were used in the trial. The birds received a diet with either three levels of vitamin E (DL-${\alpha}$Tocopheryl acetate) (60, 120 and 240 mg/kg of diet) and vitamin C (ROVIMIX STAY-C 35) (60, 120 and 240 mg/kg of diet). Live weight on day 35 and weight gain were the lowest in the group of chicks on a combination of 60 mg of vitamin E and 60 mg of vitamin C, whereas the highest live weight was demonstrated in chicks on a combination of 240 mg of vitamin E and 240 mg of vitamin C (p<0.01). The effects of treatments on cumulative feed consumption, feed conversion ratio, age at 5% lay, sexual maturity weight, rate of lay and mean egg weight values were found to be significant (p<0.01). The highest feed consumption, feed conversion ratio, age at 5% lay, sexual maturity weight, rate of lay and mean egg weight values were found in the group on a combination of 240 mg of vitamin E and 240 mg of vitamin C. The effect of treatments on the mortality ratio was found to be insignificant (p>0.01). The cost of supplementing diets with vitamin E and vitamin C is very low. Therefore such a combination of supplement can offer a potential protective management practice in preventing heat stress related losses in performance of Japanese quails.

• 한국구조물진단유지관리공학회 논문집
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• 제14권5호
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• pp.87-92
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• 2010

본 연구에서는 실리카흄 대체재로 활용 가능한 실리카 흄 무혼입 결합재(SFFB)의 치환율에 따른 고강도 콘크리트의 품질특성을 비교 분석하기 위하여, 실리카흄, SFFB의 2수준과 물-결합재비는 25, 35% 치환율은 실리카 흄 10%, SFFB 5, 10, 15(%)의 4수준으로 설정하였다. 실험을 실시한 결과, 목표 유동성을 확보하기 위한 고성능감수제의 첨가율은 물-결합재비가 낮을수록 증가하였으며, SFFB가 실리카 흄 보다 저흡수성을 갖는 재료적 특성으로 인해 고성능감수제의 첨가율이 감소하는 경향을 나타내었다. 압축강도에서는 SFFB 치환율이 10%일 경우 인장강도에서는 치환율이 15%일 경우 가장 우수한 강도를 나타내었으며, 자기수축에서는 W/B와 SFFB의 치환율과 상관없이 Plain(SF)에 비해 수축이 저감하는 것으로 나타났다.

• 한국콘텐츠학회논문지
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• 제19권12호
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• pp.517-526
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• 2019

본 연구는 자동노출제어장치 사용 시 파라미터 조합에 따른 영상 화질과 방사선 출력을 분석하여 임상에 적용할 수 있는 최적의 방법을 모색하고자 하였다. 실험방법은 관전압 70, 81 kVp와 자동노출제어장치(Automatic Exposure Control, AEC)의 감도 S200, S400, S800, S1000을 조합해서 복부와 골반부의 입사표면선량, 관전류량, 신호 대 잡음비(Signal to Noise Ratio, SNR), 대조도 대 잡음비(Contrast to Noise Ratio, CNR), 시간-방사선량 곡선을 구하였다. 그 후 영상 화질과 출력의 안정성을 평가하였다. 그 결과 입사표면선량, 관전류량, 신호 대 잡음비, 대조도 대 잡음비는 관전압과 감도가 높게 설정될수록 감소하였다. 또한 관전압과 감도가 높게 설정될수록 시간-방사선량 곡선은 출력의 안정성이 줄어드는 양상을 보였다. 결론적으로 복부와 골반부 검사 시 관전압과 감도를 높게 조합할수록 검출기는 영상 화질과 방사선 출력을 정상적으로 재현해내지 못하였다. 따라서 비교적 낮은 관전압과 감도를 조합하여 검출기가 파라미터의 조합을 인식할 때 발생하는 오차 범위를 최소화해야 영상 화질과 방사선 출력의 안정성을 최적화할 수 있다는 것을 알 수 있었다.