• Asian-Australasian Journal of Animal Sciences
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• v.28 no.12
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• pp.1784-1793
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• 2015

This study was carried out to investigate the effects of tributyrin (TB) on the growth performance, pro-inflammatory cytokines, intestinal morphology, energy status, disaccharidase activity, and antioxidative capacity of broilers challenged with lipopolysaccharide (LPS). A total of 160 one-day-old Cobb broilers were allocated to 1 of 4 treatments, with 4 replicated pens per treatment and 10 birds per pen. The experiment consisted of a $2{\times}2$ factorial arrangements of treatments with TB supplementation (0 or 500 mg/kg) and LPS challenge (0 or $500{\mu}g/kg$ body weight [BW]). On days 22, 24, and 26 of the trial, broilers received an intraperitoneal administration of $500{\mu}g/kg$ BW LPS or saline. Dietary TB showed no effect on growth performance. However, LPS challenge decreased the average daily gain of broilers from day 22 to day 26 of the trial. Dietary TB supplementation inhibited the increase of interleukin-$1{\beta}$ (in the jejunum and ileum), interleukin-6 (in the duodenum and jejunum), and prostaglandin $E_2$ (in the duodenum) of LPS-challenged broilers. Similar inhibitory effects of TB in the activities of total nitric oxide synthase (in the ileum) and inducible nitric oxide synthase (in the jejunum) were also observed in birds challenged with LPS. Additionally, TB supplementation mitigated the decrease of ileal adenosine triphosphate, adenosine diphosphate and total adenine nucleotide and the reduction of jejunal catalase activity induced by LPS. Taken together, these results suggest that the TB supplementation was able to reduce the release of pro-inflammatory cytokines and improve the energy status and anti-oxidative capacity in the small intestine of LPS-challenged broilers.

• The Transactions of the Korea Information Processing Society
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• v.6 no.4
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• pp.1009-1021
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• 1999

This paper describes the design principles and structure of a prototype system for collaborative authoring over a wide area network. The system includes extensive support for commenting and comment review, facilities for document space navigation, and tools for controlling and monitoring work group activity, including document locking and activity recording. The operational prototype provides a testbed for the examination of human computer interaction, group interaction, group support, document structures, and the problem and the history of efforts to address it.

• English Language & Literature Teaching
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• v.17 no.4
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• pp.75-95
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• 2011

The purpose of this study was to evaluate a group activity, reciprocal peer tutoring (RPT), in order to investigate advantages and challenges of RPT in promoting cooperative and collaborative learning environment for EFL University reading instruction. The participants in this study were 89 students taking an English reading course at a Korean university. RPT is a learning strategy whereby learners help each other and learn by teaching. This program was supported by a Vygotskyan perspective which assumes that learners gain mastery and develop cognitive skills through social interaction with more proficient others and their environment. This study relied particularly on participant perceptions through questionnaire survey and Anonymous Online class Report of the course. This study showed various advantages for tutors such as learning through teaching and becoming more autonomous and responsible for their own learning. Non-threatening and highly motivating learning atmosphere are parts of benefits for tutees. Other advantages for tutees included improved level of academic self-confidence, and motivation. This study also revealed several drawbacks associated with the problem of inaccuracy in students' production and students' demand for more direct teacher role. (182 words).

• KIISE Transactions on Computing Practices
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• v.22 no.10
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• pp.504-512
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• 2016

In this paper, we propose a personalized event recommendation scheme using user's activity analysis and collaborative filtering in social network environments. The proposed scheme predicts un-evaluated attribute values through analysis of user activities, relationships, and collaborative filtering. The proposed scheme also incorporates a user's recent preferences by considering the recent history for the user or context-aware information to precisely grasp the user's preferences. As a result, the proposed scheme can recommend events to users with a high possibility to participate in new events, preventing indiscriminate recommendations. In order to show the superiority of the proposed scheme, we compare it with the existing scheme through performance evaluation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.8C
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• pp.713-719
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• 2010

Collaborative spectrum sensing has been found to be an effective means for detecting the activity of primary users in a fading environment. Most previous works on collaborative spectrum sensing are based on the assumption that the local spectrum sensing decisions of secondary users are statistically independent. However, it may not hold in some practical situations. In this paper, we consider a cognitive radio network where the local spectrum sensing decisions of secondary users are statistically correlated with the same level of correlation if they are next to each other in location and statistically independent, otherwise. Then, for the system, we analyzed the performance of the collaborative spectrum sensing with the AND and the OR fusion rules and found that the scheme with the AND fusion rule performs better than the one with OR fusion rule when the degree of correlation is significant.

• Korean Journal of Childcare and Education
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• v.15 no.3
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• pp.61-81
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• 2019

Objective: This study aimed to examine the effects of collaborative activities by utilizing picture books in order to improve the self-regulation and perspectivetaking abilities among four-year-olds. Methods: A total of 52 four-year-olds(control group 26, experimental group 26) attending two classes at D kindergarten located in B city participated in this study. Before and after the activities, all participants individually took a social perspective taking ability instrument and rated their self-regulation with a teacher. Data were analyzed by conducting ANCOVA in the way of setting pre-test scores as the covariate and post-test scores as the dependent variable. Results: First, the total and subarea of self-regulation in the experimental group was higher than the control group. Second, the cognitive and emotional perspective taking abilities in the experimental group were higher than the control group in all cares. Conclusion/Implications: The results of this study suggest that collaborative activities using picture books are effective in improving young children's selfregulation and perspective-taking abilities.

• Educational Technology International
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• v.13 no.1
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• pp.207-231
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• 2012

The purpose of this study is to analyze the effects of Critical Thinking Strategy supporting argumentation activities between learners. The research question is whether the form of Critical Thinking Strategy offered to support meaningful interaction of collaborative argumentation between learners influences the knowledge acquisition, learning outcome, and student satisfaction. For this, the collaboration outcome of the group, the level of individual knowledge acquisition, the level of students satisfaction were measured as outcome of argumentation activity and their differences analyzed. This study concludes the following: A comparison of the group that was provided with Critical Thinking Strategy (test group) and the group provided with general argumentation scaffolds (compared group) showed there wasn't statistically significant differences in the quality of the learning outcome of collaboration between the groups and in students satisfaction. But there was significant difference in the degree of individual acquisition depending on the offering of scaffolding for Critical Thinking. Therefore, as premised in this study, supporting meaningful mutual interaction between learners during collaborative argumentation using Critical Thinking Strategy has a positive influence on the individual acquisition of domain knowledge. The group provided with scaffolding for Critical Thinking gained higher effect in the degree of knowledge sharing and individual acquisition of domain knowledge compared to the group provided with general argumentation scaffolding.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3805-3810
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• 2015

Arsenic trioxide (ATO) has been found to exert anti-cancer activity in various human malignancies. However, the molecular mechanisms by which ATO inhibits tumorigenesis are not fully elucidated. In the current study, we explored the molecular basis of ATO-mediated tumor growth inhibition in pancreatic cancer cells. We used multiple approaches such as MTT assay, wound healing assay, Transwell invasion assay, annexin V-FITC, cell cycle analysis, RT-PCR and Western blotting to achieve our goal. We found that ATO treatment effectively caused cell growth inhibition, suppressed clonogenic potential and induced G2-M cell cycle arrest and apoptosis in pancreatic cancer cells. Moreover, we observed a significant down-regulation of Skp2 after treatment with ATO. Furthermore, we revealed that ATO regulated Skp2 downstream genes such as FOXO1 and p53. These findings demonstrate that inhibition of Skp2 could be a novel strategy for the treatment of pancreatic cancer by ATO.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.7C
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• pp.642-650
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• 2010

Collaborative spectrum sensing allows secondary users scattered in location to work together to detect the activity of primary users and has been shown to significantly reduce the performance degradation due to fading phenomenon. Most previous works on collaborative spectrum sensing are based on the assumption that local spectrum sensing decisions of secondary users are statistically independent. However, it may not hold in some practical situations with shadowing effect. In this paper, we consider the case that the secondary users are evenly spaced in the form of a linear array and only adjacent secondary users are statistically correlated, and analyze the effect of the statistical correlation on the performance of collaborative spectrum sensing and the throughput of a cognitive radio network. Here we assumed the AND and OR fusion rules for combining the local decisions of secondary users. The analysis showed that the AND fusion rule achieves higher throughput than the OR fusion rule.

• Journal of Ginseng Research
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• v.44 no.1
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• pp.14-23
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• 2020

Ginseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20(R)-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20(R)-ginseng saponins are generally prepared by chemical epimerization and microbial transformation from 20(S)-isomers. The C20 configuration of 20(R)-ginseng saponins are usually determined by ¹³C NMR and X-ray single-crystal diffraction. 20(R)-ginseng saponins have antitumor, antioxidative, antifatigue, neuroprotective, and osteoclastogenesis inhibitory effects, among others. Owing to the chemical structure and pharmacological and stereoselective properties, 20(R)-ginseng saponins have attracted a great deal of attention in recent years. In this study, the discovery, identification, chemical epimerization, microbial transformation, pharmacological activities, and metabolism of 20(R)-ginseng saponins are summarized.