• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제25권6호
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• pp.500-509
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• 2022

Purpose: We compared the health-related quality of life (HRQOL) of children and adolescents with functional abdominal pain disorders (FAPDs) and organic abdominal pain disorders (ORGDs). Methods: This was a single-center, cross-sectional, observational study. The PedsQL 4.0 generic cores scales parent proxy-report was administered to parents/caregivers of 130 and 56 pediatric patients with FAPDs and ORGDs respectively on their first visit. The self-reported pain intensity in the patients was assessed using a visual analog scale (VAS) and facial affective scale (FAS). Results: Irritable bowel syndrome was the most prevalent FAPDs, and the most prevalent ORGDs were reflux esophagitis (41.1%) and gastritis associated with Helicobacter pylori (21.4%). There was no difference in HRQOL among patients diagnosed with ORGDs and FAPDs (p>0.05). Patients with ORGDs and FAPDs had lower HRQOL Scale scores than healthy Brazilian and American children's references, with a high proportion of children at risk for impaired HRQOL (p<0.0001). There was no difference in the VAS and the FAS scores between the ORGDs and the FAPDs. FAPDs had a higher prevalence of girls' and couples' disagreement (p<0.02), although poor school performance (p<0.0007) and bullying (p<0.01) were higher in patients with ORGD. Conclusion: This study revealed that there was a difference in impaired HRQOL between patients with ORGDs and FAPDs. Thus, considering the high prevalence of chronic abdominal pain in children, a well-founded treatment plan is necessary for a multidisciplinary cognitive-behavioral Pain management program.

• BMB Reports
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• 제56권3호
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• pp.178-183
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• 2023

Huntington's disease (HD) is a neurodegenerative disorder, of which pathogenesis is caused by a polyglutamine expansion in the amino-terminus of huntingtin gene that resulted in the aggregation of mutant HTT proteins. HD is characterized by progressive motor dysfunction, cognitive impairment and neuropsychiatric disturbances. Histone deacetylase 6 (HDAC6), a microtubule-associated deacetylase, has been shown to induce transport- and release-defect phenotypes in HD models, whilst treatment with HDAC6 inhibitors ameliorates the phenotypic effects of HD by increasing the levels of α-tubulin acetylation, as well as decreasing the accumulation of mutant huntingtin (mHTT) aggregates, suggesting HDAC6 inhibitor as a HD therapeutics. In this study, we employed in vitro neural stem cell (NSC) model and in vivo YAC128 transgenic (TG) mouse model of HD to test the effect of a novel HDAC6 selective inhibitor, CKD-504, developed by Chong Kun Dang (CKD Pharmaceutical Corp., Korea). We found that treatment of CKD-504 increased tubulin acetylation, microtubule stabilization, axonal transport, and the decrease of mutant huntingtin protein in vitro. From in vivo study, we observed CKD-504 improved the pathology of Huntington's disease: alleviated behavioral deficits, increased axonal transport and number of neurons, restored synaptic function in corticostriatal (CS) circuit, reduced mHTT accumulation, inflammation and tau hyperphosphorylation in YAC128 TG mouse model. These novel results highlight CKD-504 as a potential therapeutic strategy in HD.

• 동의신경정신과학회지
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• 제34권3호
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• pp.213-234
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• 2023

Objectives: To investigate current status of randomized controlled clinical trial (RCT) registration for suicide attempters. Methods: The World Health Organization International Clinical Trials Registry Platform (WHO-ICTRP) was used to search for data using 'suicide' as a search term. All registration information of RCTs registered up to April 2023 were collected. Results: Among a total of 68 RCTs registered, the United States ranked the highest in terms of quantity in this field (n=30, 46.15%), whereas Asia had only six (8.82%). A total of 62 (91.18%) RCTs involved individual interventions, while nine (13.24%) RCTs involved group interventions. Among individual interventions, 11 (16.18%) and 54 (79.41%) RCTs were on pharmacotherapy and psychotherapy, respectively. Within psychotherapy, there were a total of 17 (25%) studies utilizing digital media, with cognitive behavioral therapy (CBT) via phone being the most common approach. Among non-digital media-based studies, CBT was used the most frequently (n=11, 16.18%), followed by attempted suicide short intervention program (n=6, 8.82%). There were no studies using interventions from East Asian traditional medicine, including Korean medicine (KM). The most frequently used main outcome was the Beck scale for suicidal ideation. Conclusions: Studies on suicide attempts in Asia, especially in South Korea, are very scarce. Despite vigorous psychotherapeutic research in this field, KM psychotherapy has not been used. Thus, KM clinical trial for suicide attempters might be planned in the future based on our findings.

• 대한통합의학회지
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• 제11권2호
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• pp.77-86
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• 2023

Purpose : This study systematically assessed 9 emotion-function programs for schizophrenic individuals that have been implemented over the past 10 years in Korea and abroad, with the objective of providing clinical grounds and data for further programs. Methods : This study identified 2,558 studies from among those registered in the RISS, KISS, EMbase, PubMed and Scopus databases from 2013 to September 2023, using 'schizophrenia' AND 'emotion' AND ('program' OR 'therapy') as keywords. Of the 2,558 studies retrieved from electronic databases, 602 duplicate papers were excluded. After this process, 1,915 papers that did not meet the study's inclusion and exclusion criteria were excluded based on their titles and abstracts. Following a review of the texts of the remaining 41 papers, nine papers were finally selected, excluding 32 papers according to the selection and exclusion criteria. Results : Programs for the emotional function of patients with schizophrenia have continued to be researched. The results of an evaluation on the quality of the selected literature confirmed that a majority of the reviewed items were "uncertain", confirming that there was a risk of bias. The interventions for emotions included art, cognitive-behavioral, and physical programs, of which art programs were frequently applied. Most of the interventions were implemented in hospitals. The dependent variables for evaluating emotions included emotional expression, depression, anxiety, and positive emotions, and among them, emotional expression was used most frequently. Accordingly, the Berkeley expressivity questionnaire was commonly used as an evaluation tool. Conclusion : This study is significant for intending to analyze domestic and overseas programs for the emotions of patients with schizophrenia, thereby proposing the direction for planning and applying interventions in clinical settings. In follow-up studies, it will be necessary to develop a protocol that confirms interventions according to the settings and patient characteristics of programs and expands the scope of literature reviews.

• 동의신경정신과학회지
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• 제33권1호
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• pp.79-111
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• 2022

Major depressive disorder (MDD) causes a persistent feeling of sadness and loss of interest. It can lead to emotional and physical problems. Treatments such as antidepressant and cognitive behavioral therapy for MDD have many limitations. Traditional East Asian Herbal Medicine (TEAM) is a representative modality of Complementary and Integrative Medicine (CIM) which can be used for MDD. However, no study has systematically reviewed the efficacy or safety of TEAM for MDD so far. Therefore, we performed a systematic review and meta-analysis to evaluate effectiveness and safety of TEAM as a monotherapy for MDD. We only included TEAM that could be used in context of clinical setting in Korean Medicine. Outcomes were the Hamilton Depression Rating Scale (HAMD) and total effective rate (TER). After comprehensive electronic search of 11 databases, we included 28 randomized controlled trials (RCTs) that compared HM as monotherapy with antidepressant for MDD. Meta-analysis showed that TEAM had significant benefits in reducing HAMD (MD=-0.40, 95% CI: -0.67 to -0.13, p=0.003, I²=85%) and improving TER (RR=1.06, 95% CI: 1.02 to 1.10, p=0.003, I²=0%). It also appeared to be safer than antidepressant in terms of adverse effects. Methods used for RCTs were poor and the quality of evidence was graded 'low' or 'moderate'. These findings indicate that the use of HM as a monotherapy might have potential benefits in MDD treatment as an alternative to antidepressant. However, considering the methodological quality of included RCTs, the clinical evidence is uncertain. Further well-designed RCTs are required to confirm these findings.

• 대한중풍순환신경학회지
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• 제15권1호
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• pp.50-56
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• 2014

The prevalence rate of plant poisoning is growing up gradually. However, it could be difficult to get proper treatment without detail medical history taking due to the diversity of poisonous plants and their various symptoms. Scopolia Japonica, which grows naturally in Korea, is reported to cause severe toxicity which could be lethal. A few therapeutic measures have been reported in Traditional Korean Medicine (TKM), but it has not been reported yet that those measures have been successfully proven in the clinical practice in modern times. This is a case report of toxicity caused by scopolia japonica ingestion. A 65years-old male patient with cognitive impairment, behavioral disorder, gait difficulty, dysarthria, dysphagia and abnormal pupil reflex recovered from those symptoms during taking Gamigamdu-tang and getting acupuncture. This study shows the clinical aspects of Scopolia Japonica toxicity and the possibility of TKM treatments as one of plant poisoning treatments.

• 인간행동과 음악연구
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• 제19권2호
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• pp.1-26
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• 2022

본 연구는 중등도 및 중증 치매 노인을 대상으로 한 국내·외 음악 중재 연구를 고찰하여 연구 동향을 알아보고, 참여자의 임상적 특성이 고려된 음악 중재의 특징을 알아보고자 시행되었다. 검색을 통해 선정된 17편의 문헌을 분석한 결과, 종속 변인은 행동심리증상 등 심리·정서적 변인이 주를 이루는 것으로 나타났다. 중재 참여유형을 살펴보면 내담자의 활동 참여가 요구되는 적극적 유형이 감상만 하는 수용적 유형보다 많았다. 중재의 일반적 특성으로는 과반수가 라이브 음악, 친숙하고 선호하는 음악 선곡, 리듬기반 연주활동을 제공한 것으로 나타났다. 적극적 유형의 음악중재 내용을 살펴보면 음악에 맞춰 그룹 연주나 노래를 하며 유발되는 감정을 말하도록 하는 것으로 참여자가 중등도와 중증이 혼합된 경우와 중증 치매만인 경우 차이점이 없어 중증 치매가 지닌 기능적 한계가 충분히 반영되지 않은 것으로 나타났다. 추후 연구에서는 중증 치매 노인의 의미있는 음악경험을 위한 중재구성과 내담자의 치매 진행 정도에 따른 음악치료 전략 개발이 필요하다.

• 한국식생활문화학회지
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• 제24권6호
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• pp.784-792
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• 2009

This study was conducted to investigate the effects of weight control programs on BMI, serum profiles, nutrition knowledge and eating behaviors of adult obese women. The subjects of this study were 33 adult obese women aged 30-65 years residing in Seoul. The weight control program for obese women included nutritional education, cognitive behavioral therapy and exercise for 12 weeks. The weight control experience of the subjects was 60.6%. They preferred physical exercise and diet restriction to weight control and 72.7% of subjects answered that the reasons for wanting to control their weight was health. The BMI of test subjects significantly decreased (p<0.001) from 28.3 to 27.1 after the 12 weeks of the weight control program. In addition, the % body fat significantly decreased (p<0.001) from 36.4% to 34.5% after completion of the weight control program. SGPT levels in the serum were also significantly decreased (p<0.05) after the program. Triglyceride levels significantly decreased from 194.9 mg/dL to 98.1 mg/dL (p<0.01) and the HDL cholesterol level significantly increased (p<0.01) from 55.8 mg/dL to 60.0 mg/dL after completion of the weight control program. Nutritional knowledge and eating behavior scores were significantly increased (p<0.001). In addition, the eating self-efficacy of the subjects was significantly increased (p<0.01); however, the food diversity scores were not changed after the program. These results suggest that the weight control program for adult obese women may be effectively used to promote weight reduction and improve nutritional knowledge and eating behavior.

• 한국심리학회지 : 문화 및 사회문제
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• 제24권4호
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• pp.637-655
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• 2018

본 연구는 내현적 자기애가 대인공포(Taijin Kyofusho) 증상에 미치는 영향에서 편집 사고와 사회적 고립의 연속매개 효과를 탐색하고자 하였다. 이를 위해 경기도 소재의 334명의 대학생을 대상으로 (남성 163명, 여성 171명) 내현적 자기애, 편집 사고, 사회적 고립, 대인공포증에 대한 자기보고식 설문지를 실시하였고, 구조방정식을 활용한 경로분석을 시행하였다. 적합도 분석 결과 이론적으로 가정된 모형이 수집된 자료에 의해 잘 설명되었고, 경로분석에 서 편집 사고와 사회적 고립이 내현적 자기애와 대인공포증 간의 관계를 연속 매개함이 확인되었다. 이와 같은 발견은 대인공포증을 이해하고 개입함에 있어 내현적 자기애와 같은 성격적 변인, 편집 사고와 같은 인지적 과정 변인, 사회적 고립과 같은 행동적 변인들을 함께 고려해야 함을 제안한다.

• 한국심리학회지 : 문화 및 사회문제
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• 제22권2호
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• pp.183-202
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• 2016

주관적 안녕감이 소수집단에 대한 태도의 측면에서 어떠한 결과를 산출하는지 검토했다. 이를 위해서 먼저 주관적 안녕감과 소수집단에 대한 태도의 횡단적 관계를 검토하는 예비연구를 실시했다. 그 결과, 주관적 안녕감이 높은 청소년은 외국인 노동자나 국제결혼 가정의 자녀들에 대해서 우호적인 생각과 느낌, 행동을 보이는 것으로 나타났다. 이에 본 연구에서는 한국아동·청소년패널조사(KCYPS) 자료를 활용하여 주관적 안녕감과 소수집단에 대한 태도의 종단적 관계를 검토했다. 그 결과, 주관적 안녕감의 초기값과 변화율은 2년 후 소수집단에 대한 태도를 예측했다. 구체적으로 초등학교 5학년 시기에 주관적 안녕감이 높은 청소년은 동일시기(초5) 뿐 아니라 2년 후 중1이 되었을 때에도 소수집단에 대한 태도가 우호적이었다. 또한 이 기간 동안 주관적 안녕감은 감소하는 추세였으며, 주관적 안녕감이 적게 감소한 청소년들이 중1이 되었을 때 소수집단에 대한 태도가 더 긍정적이었다. 이러한 결과는 행복이 긍정적인 다문화 태도를 형성하는데 기여할 가능성이 있으며, 현재 행복을 통해 미래 한국 사회의 특징이 예측될 수 있음을 시사한다.