• Journal of Neurogastroenterology and Motility
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• 제24권4호
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• pp.512-527
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• 2018

This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses in regions related to sensory processing of the homeostatic condition of the gut (homeostatic afferent) and responses to salience stimuli (salience network), as well as increased and decreased brain activity in the emotional response areas and reduced activation in areas associated with the top-down modulation of visceral afferent signals. Altered central regulation of the endocrine and autonomic nervous responses, the key mediators of the brain-gut axis, has been demonstrated. Studies using resting-state functional magnetic resonance imaging reported abnormal local and global connectivity in the areas related to pain processing and the default mode network (a physiological baseline of brain activity at rest associated with self-awareness and memory) in FGIDs. Structural imaging with brain morphometry and diffusion imaging demonstrated altered gray- and white-matter structures in areas that also showed changes in functional imaging studies, although this requires replication. Molecular imaging by magnetic resonance spectroscopy and positron emission tomography in FGIDs remains relatively sparse. Progress using analytical methods such as machine learning algorithms may shift neuroimaging studies from brain mapping to predicting clinical outcomes. Because several factors contribute to the pathophysiology of FGIDs and because its population is quite heterogeneous, a new model is needed in future studies to assess the importance of the factors and brain functions that are responsible for an optimal homeostatic state.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.422-433
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• 2018

Objective: Neuropsychiatric manifestations like depression and cognitive dysfunction commonly occur in inflammatory bowel disease (IBD). In the context of the brain-gut axis model, colitis can lead to alteration of brain function in a bottom-up manner. Here, the changes in the response of the hypothalamic-pituitary-adrenal axis and inflammation-related markers in the brain in colitis were studied. Methods: Dextran sodium sulfate (DSS) was used to generate a mouse model of colitis. Mice were treated with DSS for 3 or 7 days and sacrificed. We analyzed the gene expression of brain-derived neurotrophic factor (BDNF), cyclooxygenase 2 (COX-2), and glial fibrillary acidic protein (GFAP), and the expression of GFAP, in the hippocampus, hypothalamus, and amygdala. Additionally, the levels of C-reactive protein (CRP) and serum cortisol/corticosterone were measured. Results: Alteration of inflammatory-related markers varied depending on the brain region and exposure time. In the hippocampus, COX-2 mRNA, GFAP mRNA, and GFAP expression were upregulated during exposure to DSS. However, in the hypothalamus, COX-2 mRNA was upregulated only 3 days after treatment. In the amygdala, BDNF and COX-2 mRNAs were downregulated. CRP and corticosterone expression increased with DSS treatment at day 7. Conclusion: IBD could lead to neuroinflammation in a bottom-up manner, and this effect varied according to brain region. Stress-related hormones and serum inflammatory markers, such as CRP, were upregulated from the third day of DSS treatment. Therefore, early and active intervention is required to prevent psychological and behavioral changes caused by IBD, and region-specific studies can help understand the precise mechanisms by which IBD affects the brain.

• 동의생리병리학회지
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• 제32권6호
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• pp.375-383
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• 2018

This study was conducted to investigate the cognitive improvement and memory recovery effects of Korean and Chinese Crataegus pinnatifida ethanolic extracts on scopolamine-induced memory impairment in mice. In vivo studies were carried out with mice treated with Korean Crataegus pinnatifida extracts (KCF) and Chinese Crataegus pinnatifida extracts (CCF) in doses of 5 and 50 mg/kg (p.o.) and scopolamine was injected 30 min before the behavioral testing. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase inhibition by Ellman's modified method. The chlorogenic acid and hyperoside as marker compounds of KCF and CCF was quantified by ultra-performance liquid chromatography analysis (UPLC). Results showed that KCF was more contained high content of chlorogenic acid and hyperoside than CCF. In addition, KCF was more exerted free radical (DPPH and ABTS) scavenging activity and blocked AChE activity than CCF. In vivo studies also showed that KCF administration has a further improved the memory of scopolamine-treated mice than CCF in Y-maze test, passive avoidance test and Morris water maze test. These results revealed that KCF more prevents scopolamine-induced memory impairments through antioxidant and acethylcholinesterase inhibition effect compared CCF.

• 대한한의학방제학회지
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• 제27권2호
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• pp.121-136
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• 2019

Objective : To investigate the effect of sihogayonggolmoryeotang (SY) on Single Prolonged Stress(SPS)-induced Post Traumatic Stress Disorder(PTSD). Method : To confirm the effects of SY on SPS-induced PTSD, Changes in body weight, sucrose intake open field test(OFT) and forced swimming test(FST)were observed. After behavioral tests, the plasma corticosterone(CORT) from the abdominal aorta, serotonin(5-HT) from prefrontal cortex, hippocampus, amygdala and striatum, norepinephrine(NE) and dopamine(DA) from hippocampus was measured by ELISA. mRNA expression of brain-derived neurotrophic factor(BDNF) and cAMP response element-binding protein(CREB) in hippocampus was measured by RT-PCR. Result : Weight change and sucrose intakes of rats in 14th day after the administration of SY were significantly increased in the SPS + SY450 group compared to the SPS group (p<0.05). Numbers of crossing in the central zone in the OFT were significantly increased in the SPS + SY450 group (p<0.05) compared with the SPS group. The immobility time of FST was significantly decreased in SPS + SY450 group compared with SPS group (p<0.05). The change of plasma CORT concentration was significantly decreased in SPS + SY450 group compared with that in SPS group (p<0.05). The change of 5-HT concentration was significantly increased in the SPS + SY450 group at hippocampus and amygdala compared with the SPS group (p<0.05). The concentration of DA was significantly increased in the SPS + SY450 group compared with the SPS group (p<0.05). The expression of BDNF and CREB were significantly increased in SPS + SY450 group compared with the SPS group (p<0.05). Conclusion : SY administration lowered the increase of CORT caused by PTSD and increases the 5-HT concentration and reversed the decreased expression of NE and DA and BDNF and CREB by PTSD. It is postulated that SY is effective in treating PTSD by restoring cognitive function, memory impairment, unstable emotional disturbances.

• Journal of Information Science Theory and Practice
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• 제7권2호
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• pp.40-53
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• 2019

Although fake news has been present in human history at any time, nowadays, with social media, deceptive information has a stronger effect on society than before. This article answers two research questions, namely (1) Is the dissemination of fake news supported by machines through the automatic construction of filter bubbles, and (2) Are echo chambers of fake news manmade, and if yes, what are the information behavior patterns of those individuals reacting to fake news? We discuss the role of filter bubbles by analyzing social media's ranking and results' presentation algorithms. To understand the roles of individuals in the process of making and cultivating echo chambers, we empirically study the effects of fake news on the information behavior of the audience, while working with a case study, applying quantitative and qualitative content analysis of online comments and replies (on a blog and on Reddit). Indeed, we found hints on filter bubbles; however, they are fed by the users' information behavior and only amplify users' behavioral patterns. Reading fake news and eventually drafting a comment or a reply may be the result of users' selective exposure to information leading to a confirmation bias; i.e. users prefer news (including fake news) fitting their pre-existing opinions. However, it is not possible to explain all information behavior patterns following fake news with the theory of selective exposure, but with a variety of further individual cognitive structures, such as non-argumentative or off-topic behavior, denial, moral outrage, meta-comments, insults, satire, and creation of a new rumor.

• Journal of Korean Biological Nursing Science
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• 제21권3호
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• pp.217-223
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• 2019

Purpose: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction of energy drinks. However, little is known about the time-dependent effect of high doses of caffeine consumption in adolescents. The present study aims to examine the short- and long-term influence of high-dose caffeine on behavior of adolescence. Methods: The animals were divided into three groups: a "vehicle" group, which was injected with 1 ml of phosphate-buffered saline for 14 days; a "Day 1" group, which was injected with caffeine (30 mg/kg), 2 h before the behavioral tests; and a "Day 14" group, which was infused with caffeine for 14 days. An open-field test, a Y-maze test, and a passive avoidance test were conducted to assess the rats'activity levels, anxiety, and cognitive function. Results: High-dose caffeine had similar effects in short-and long-term treatment groups. It increased the level of locomotor activity and anxiety-like behavior, as evidenced by the increase in the number of movements and incidences of rearing and grooming in the caffeine-treated groups. No significant differences were observed between the groups in the Y-maze test. However, in the passive avoidance test, the escape latency in the caffeine-treated group was decreased significantly, indicating impaired memory acquisition. Conclusion: These results indicate that high-dose caffeine in adolescents may increase locomotor activity and anxiety-like behavior and impair learning and memory, irrespective of the duration of administration. The findings will be valuable for both evidence-based education and clinical practice.

• 한국융합학회논문지
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• 제10권4호
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• pp.219-227
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• 2019

본 연구는 심리적 과정에 따른 운동행동의 변화를 알아보기 위해 운동변화단계와 운동자기도식, 운동중단유혹의 관계를 분석하는데 목적이 있다. 연구목적 달성을 위하여 공공스포츠센터를 이용하는 성인을 대상으로 총 297부의 최종자료를 사용하였다. 자료처리는 SPSS 18.0을 이용하여 탐색적 요인분석 후 다변량분석, 중다회귀분석, 판별분석을 통해 검증하였다. 연구결과는 첫째, 운동변화단계에 따라서 운동자기도식은 차이가 있는 것으로 나타났다. 둘째, 운동변화단계에 따라서 운동중단유혹은 지도자와 의욕상실에서 차이가 있는 것으로 나타났다. 셋째, 행동적 자기도식과 의욕상실은 운동변화단계를 판별하는데 주요 요인인 것으로 나타났다. 넷째, 운동자기도식은 의욕상실에 부적 영향을 미치는 것으로 나타났고, 감정에는 인지-감정적 자기도식이 부적 영향을 미치는 것으로 나타났다.

• 한국콘텐츠학회논문지
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• 제21권3호
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• pp.114-120
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• 2021

인간의 주거 영역에 있어서 가구는 필수적인 요소이며 특히 다양하고 유연한 배치와 공간의 성격을 명확하게 구분하고 디자인의 통일성 추구에 적합한 시스템가구의 필요성은 점차 확대되어 가고 있다. 우리나라의 고령인구는 현재 15%를 상회하고 있으며 2050년에는 약 40% 가까이 될것으로 전망되고 있다. 증가하고 있는 노인세대는 정보의 공유와 건강관리, 자녀로부터의 독립을 추구하는 등의 기존과는 다른 행동적 양식을 보여주고 있다. 독립적인 일상 생활의 유지를 위해 안정적 주거환경은 필수가 되었으나 인지능력 및 신체적 능력의 저하로 인해 가구로 인한 안전사고가 증가한다는 연구결과로 볼 때 이에 맞는 가구의 필요성이 증가하였다. 따라서 고령인의 생물학적 변화와 특성을 파악하고 시스템가구의 개념정의, 범위 및 한계를 연구하였다. 또한 가전시장의 변화와 가전시장의 트렌드를 파악하여 고령세대가 요구하는 시스템가구의 디자인 방향성을 제시하였다.

• 문화기술의 융합
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• 제8권4호
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• pp.271-276
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• 2022

본 연구는 대학 운동선수의 완벽주의성향이 운동몰입에 미치는 영향을 규명하고자 하는데 목적이 있으며, 궁극적으로는 우수한 운동선수 양성을 위한 심리적 요인의 중요성을 제공하는데 그 목적이 있다. 중국 하남성과 한국 수원시 대학에 재학중인 운동선수 170명을 대상으로 설문조사를 실시하였다. 이 연구의 목적을 달성하기 위하여 SPSS 22.0을 사용하여 분석하였다. 분석 방법은 빈도 분석, 탐색적 요인분석, 내적일치도, pearson 상관분석, 중다회귀분석을 실시하였다. 그 결과 중국 대학 운동선수의 완벽주의성향이 운동 몰입에 미치는 영향에서는 대학 운동선수의 완벽주의성향 중 행동몰입, 인지몰입에 유의한 영향을 미쳤다. 이 연구를 통해서 대학 운동 선수의 완벽주의성향과 운동몰입의 관계를 규명하여 기초자료를 제공한 점은 대학 운동선수들에게 의미가 있을 것이다.

• Journal of Microbiology and Biotechnology
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• 제32권9호
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• pp.1168-1177
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• 2022

Parkinson's disease (PD) is the second-most prevalent neurodegenerative disease and is characterized by dopaminergic neuronal death in the midbrain. Recently, the association between alterations in PD pathology and the gut microbiota has been explored. Microbiota-targeted interventions have been suggested as a novel therapeutic approach for PD. Agathobaculum butyriciproducens SR79^T (SR79) is an anaerobic bacterium. Previously, we showed that SR79 treatment induced cognitive improvement and reduced Alzheimer's disease pathologies in a mouse model. In this study, we hypothesized that SR79 treatment may have beneficial effects on PD pathology. To investigate the therapeutic effects of SR79 on PD, 6-hydroxydopamine (6-OHDA)-induced mouse models were used. D-Amphetamine sulfate (d-AMPH)-induced behavioral rotations and dopaminergic cell death were analyzed in unilateral 6-OHDA-lesioned mice. Treatment with SR79 significantly decreased ipsilateral rotations induced by d-AMPH. Moreover, SR79 treatment markedly activated the AKT/GSK3β signaling pathway in the striatum. In addition, SR79 treatment affected the Nrf2/ARE signaling pathway and its downstream target genes in the striatum of 6-OHDA-lesioned mice. Our findings suggest a protective role of SR79 in 6-OHDA-induced toxicity by regulating the AKT/Nrf2/ARE signaling pathway and astrocyte activation. Thus, SR79 may be a potential microbe-based intervention and therapeutic strategy for PD.