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http://dx.doi.org/10.15188/kjopp.2018.12.32.6.375

Comparative Study on the Effects of Korean and Chinese Crataegus pinnatifida on Scopolamine-induced Memory Impairment in Mice  

Lee, Jihye (Department of Pharmacology, Daegu Haany University)
Kim, Hye-Jeong (Department of Pharmacology, Daegu Haany University)
Lee, Chanhee (Department of Pharmacology, Daegu Haany University)
Park, Sang Hyeok (Department of Pharmacology, Daegu Haany University)
Jung, Chul Jong (Okchundang Corporation)
Beik, Gyung Yun (Okchundang Corporation)
Shin, Jin Gi (Okchundang Corporation)
Jung, Ji Wook (Department of Pharmacology, Daegu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.32, no.6, 2018 , pp. 375-383 More about this Journal
Abstract
This study was conducted to investigate the cognitive improvement and memory recovery effects of Korean and Chinese Crataegus pinnatifida ethanolic extracts on scopolamine-induced memory impairment in mice. In vivo studies were carried out with mice treated with Korean Crataegus pinnatifida extracts (KCF) and Chinese Crataegus pinnatifida extracts (CCF) in doses of 5 and 50 mg/kg (p.o.) and scopolamine was injected 30 min before the behavioral testing. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase inhibition by Ellman's modified method. The chlorogenic acid and hyperoside as marker compounds of KCF and CCF was quantified by ultra-performance liquid chromatography analysis (UPLC). Results showed that KCF was more contained high content of chlorogenic acid and hyperoside than CCF. In addition, KCF was more exerted free radical (DPPH and ABTS) scavenging activity and blocked AChE activity than CCF. In vivo studies also showed that KCF administration has a further improved the memory of scopolamine-treated mice than CCF in Y-maze test, passive avoidance test and Morris water maze test. These results revealed that KCF more prevents scopolamine-induced memory impairments through antioxidant and acethylcholinesterase inhibition effect compared CCF.
Keywords
Crataegus pinnatifida; Scopolamine; Amnesia; Memory; Chlorogenic acid; Hyperoside;
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