• Korean Journal of Poultry Science
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• v.26 no.2
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• pp.131-144
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• 1999

Coccidiosis, an intestinal infection caused by intracellular protozoan parasites belonging to several different species of Eimeria seriously impairs the growth and feed utilization of livestock and poultry. Due to complex life cycle of organism and intricate host immune responses to Elmeria, coccidia vaccine development has been difficult. Understanding of basic imunobiology of pertinent host-parasite interactions is necessary for the development of novel control strategy. Although chickens infected with Eimeria spp. produce parasite-specific antibodies in both the circulation and mucosal secretions, antibody mediated responses play a minor role in protection gainst coccidiosis. Rather, increasing evidence show that cell-mediated immunity plays a major role in resistance to coccidiosis. T-lymphocytes appear to respond to coccidiosis both through cytokine production and a direct cytotoxic attack on infected cells. The exact mechanisms by which T-cells eliminate the parasites, however, remain to be investigated. Since it is crucial to understand the intestinal immune system in order to develop an immunological control strategy against any intestinal immune system in order to develop an immunological control strategy against any intestinal diseases, this presentation will summarize our current understanding of the avian intestinal immune system and mucosal immune responses to Eimeria, to provide a conceptual overview of the complex molecular and cellular events involved in intestinal immune responses to enteric pathogens.

• Parasites, Hosts and Diseases
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• v.54 no.6
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• pp.719-724
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• 2016

The present study was designed to assess the dynamic patterns of pro-inflammatory cytokines, including $IFN-{\gamma}$, $TNF-{\alpha}$, IL-4, IL-6, acute phase protein (${\alpha}1$-acid-glycoprotein, AGP), and an inflammation associated factor (adenosine deaminase; ADA) following experimental caprine coccidiosis. Ten kids aging from 2 to 4 months were infected orally with $5{\times}10^4$ sporulated oocysts and 10 animals served as controls. Blood samples were collected in both groups before infection and at days 3, 7, 14, 21, 28, and 35 post-infection (PI), and the levels of above-mentioned factors were measured. $IFN-{\gamma}$, $TNF-{\alpha}$, IL-4, IL-6, AGP, and ADA activities were significantly higher in infected animals from day 7 PI (P<0.05). In conclusion, the circulatory levels of most systemic inflammatory markers, including pro-inflammatory cytokines ($IFN-{\gamma}$, $TNF-{\alpha}$, IL-4, IL-6), AGP, and ADA increased significantly starting from day 3 to day 7 PI in caprine coccidiosis.

• Korean Journal of Veterinary Service
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• v.17 no.1
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• pp.44-53
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• 1994

The result that investigated aberage weekly oocyst nymbers in faeces from 16 broiler farms, Oocyst can be found in the highest during the 5 weeks age. The 3 of the 16 farms have clinical sign of the coccidiosis at the faeces collection. Anticoccidial drug sensitivity against Oocyst isolated in 2 farms to have clinical coccidiosis was tested for the drug susceptibility and resistance in order to prevention coccidiosis effectively. Maduramicin, Salynomicif Narasin Lasalocid, Monensin, Robenidine and Dicrazulir were used an anticoccidial drugs. The results ; Anticoccidial index(ACI) of the A farm were 201.50 in a chicken group treated with Dicrazulir, 194.84 with Robenidine. 172.79 with Maduramicin 6ppm 170.49 with Salynomicin, 168.02 with maduramicin 5ppm 165.77 with Lasalocid, 143.34 with Monensin and 140.63 with Narasin. ACI of the B farm were 193.40 in a chicken group treated Robenidine, 190.64 with Dicrazuril, 158.75 with Maduramic in 6ppm, 151.62 with Maduramicin 5ppm, 149.44 with Salynomicin, 143.10 with lasalocid, 138.11 with Monensin and 137.50 with Narasin. According to interpretation of ACI from Kawasae et al, the drug resistance(less than 120 of ACI) not appeared in two farms, vut the drug tolerance(120-160 of ACI) appeared in two group treated with Monesin and Nalacin in csae of A farm and in all group with treated anticoccidial drug in case of B farm.

• Parasites, Hosts and Diseases
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• v.59 no.5
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• pp.439-445
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• 2021

Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. Therefore, this study aims to investigate the expression of cNK-lysin in E. necatrix-infected chickens and its role in E. necatrix infection. The expression of cNK-lysin transcript was significantly increased in E. necatrix sporozoites-treated lymphocytes. In E. necatrix infection, cNK-lysin transcript was induced in intestinal lymphocytes but not in the spleen. The recombinant cNK-lysin exhibited anticoccidial activity against E. necatrix sporozoites as well as immunomodulatory activity on macrophages by inducing proinflammatory cytokines. These results indicated that E. necatrix infection induces high local expression of cNK-lysin and the secreted cNK-lysin helps protect coccidiosis.

• KOREAN POULTRY JOURNAL
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• v.6 no.3 s.53
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• pp.93-94
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• 1974

• KOREAN POULTRY JOURNAL
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• v.6 no.5 s.55
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• pp.100-103
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• 1974

• KOREAN POULTRY JOURNAL
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• v.4 no.11 s.37
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• pp.79-80
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• 1972

• Journal of Veterinary Clinics
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• v.12 no.1
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• pp.917-924
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• 1995

I suis cocciosis in piglets seems to occur in the majority of Korean sow herds. Cocci야osis is characterized by a pasty diarrhea in piglets appearing at 5 to 11 days old. Morbidity is variable, Mortality is usually low but piglets growth is always retarded. And, the principal source of infection is the environment because of the high resistance of oocysts. Control of coccidiosis is usually frustrated since the majority of treatment have not constant results. Mundt et al(1990) developed a new strategy by administrating toltrazuril as an oral suspension. This new anticoccidial drug reduced clinical signs and mortality. Therefore, we will try to medicate piglets with Baycox(Bay Vi 9142) suspension in a sow herd, having a problem of I suis coccidiosis. The incidences of coccidiosis in suckling piglets in C and D bleeding stock farm were from 28.6 to 42.3 and 21.1~57.9 % during 3 to 21 day-old. The body weights of suckling piglets in treated groups were higher than those of control groups at 11 and 18 day-old. Also, those of C breeding stock firm were higher than those of D farm. The body weight gains of suckling piglet of treated groups were higher than those of control groups. Also, those of C breeding stock firm were higher than those of D farm. There was no dead piglet in all experimental groups. Some atrophic piglets were done away with. In C breeding stock farm, the incidences of diarrhea in treatment groups were significantly lower an those of control groups. Also, the degrees of diarrhea in treated groups were significantly lower than those in control groups. In D breeding stock farm, the incidences of diarrhea in treated groups were a little lower than those in control groups. Also the degrees of diarrhea in treated groups were a little lower than those in control groups. In the treated groups, the incidences and degrees of diarrhea were reduced at the 4th day and increased at the 13th day after treatment. The number of litters excreted oocysts in treated groups wert lower than those in control groups after treatment. Also, the OPG in treated groups were lower than those in control groups. According to above results, the effect of Baycox suspension against swine coccidiosis was very good. If we will treat with Barcox suspension swine coccidiosis in swine stock farms, we can get good effects of the improvement of body weight gains and diarrhea and e reduce of excreted costs in faeces.

• KOREAN POULTRY JOURNAL
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• v.13 no.8 s.142
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• pp.122-123
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• 1981

• KOREAN POULTRY JOURNAL
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• v.35 no.9 s.407
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• pp.134-135
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• 2003