Korean Journal of Poultry Science (한국가금학회지)

The Korean Society of Poultry Science (한국가금학회)
권호 표지

Avian Gut Immune System and Local Responses to Eimerial Parasites

조류의 장내 면역체계와 콕시듐(Eimeria)기생충들에 대한 국소면역 반응

  • Lillehoj, H.S. (Immunology and Disease Resistance Laboratory, Livestock and Poultry Sciences Institute, U. S. Department of Agriculture, Agricultural Research Service, Beltsville)
  • Published : 1999.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Coccidiosis, an intestinal infection caused by intracellular protozoan parasites belonging to several different species of Eimeria seriously impairs the growth and feed utilization of livestock and poultry. Due to complex life cycle of organism and intricate host immune responses to Elmeria, coccidia vaccine development has been difficult. Understanding of basic imunobiology of pertinent host-parasite interactions is necessary for the development of novel control strategy. Although chickens infected with Eimeria spp. produce parasite-specific antibodies in both the circulation and mucosal secretions, antibody mediated responses play a minor role in protection gainst coccidiosis. Rather, increasing evidence show that cell-mediated immunity plays a major role in resistance to coccidiosis. T-lymphocytes appear to respond to coccidiosis both through cytokine production and a direct cytotoxic attack on infected cells. The exact mechanisms by which T-cells eliminate the parasites, however, remain to be investigated. Since it is crucial to understand the intestinal immune system in order to develop an immunological control strategy against any intestinal immune system in order to develop an immunological control strategy against any intestinal diseases, this presentation will summarize our current understanding of the avian intestinal immune system and mucosal immune responses to Eimeria, to provide a conceptual overview of the complex molecular and cellular events involved in intestinal immune responses to enteric pathogens.

Keywords

References

  1. Avian Cellular Immunology Cell-mediated immunity in parasitic and bacterial diseases Lillehoj HS;Sharma,J.M.(ed.)
  2. Clin Microbiol Review v.9 Avian gut-associated lymphoid tissues and intestinal immune responses to Elimeria parasites Lillehoj HS;Trout JM
  3. Int J Prasitol v.28 Role of T lymphocytes and cytokines in coccidiosis Lillehoj HS
  4. Sur Immunol Res v.3 Gut bacterial endotoxin:influence on gut-associated lymphoreticular tissue and host immune function McGhee JR;Kiyono H;Alley CD
  5. Digest Dis Sci. v.25 Lymphoid populations of gut mucosa in chickens Arnaud-Battandier F;Lawrence EC;Blaese RM
  6. I.Morphology, ontogeny and some functional characteristics of Peyer's patches J Immnol v.125 Gut-associated lymphoid tissue in the chicken Befus AD;Johnston N;Leslie GA;Bienenstock J
  7. J Immunol v.140 Identification of the avian homologue of mammalian CD4 and CD8 antigens. Chan MM;Chen CL;Ager LL;Cooper MD
  8. Eur J Immunol v.18 Differential expression of two T cell receptors, TCR1 and TCR2, on chicken lymphocytes Chen CH;Cihak J;Losch U;Cooper MD
  9. Eur J Immunol v.18 Functional and biochemical characterization of chicken T lymphocyte antigens Lillehoj HS;Lillehoj EP;Weinstock D;Schat K
  10. J Immunol v.141 Avian T Cells expresses gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium Bucy RP;Chen CL; Cihak J;Losch U;Cooper MD
  11. Crit. Rev Poul Biol v.2 Chicken T cells : Differentation antigens andcell-cell interactions Vainio O;Lassila O
  12. Adv Can Res v.27 Natural cell-mediated immunity Herberman RB;Holden HT
  13. J Exp Med v.155 Characteristics of natural killer cells in the murine intestinal epithelium and lamina propria Tagliabue A;Befus D;Clark DA;Bienenstock J
  14. Des Comp Immunol v.12 Comparative natural killer cell activities of thymic, bursal, splenic and intestinal intraepithelial lymphocytes Lillehoj HS;Chai JY
  15. Eur J Immunol v.20 Development of cytoplasmic CD3+/T cell receptor negative cells in the peripheral lymphoid tissues of chickens Bucy RP;Chen CH;Cooper MD
  16. Advances in host defense mechanisms Intraepithelial lymphocytes in birds Kasahara Y;Chen CH;Global TWF;Bucy RP;Cooper MD;Gallian J(ed)I;Fauci AS(ed)
  17. Immunology v.52 Functional properties of lymphocytes isolated from murine small interestinal epithelium Dillon SB;MacDonald TT
  18. J Parasitol v.71 Capping of immune complexes by sporozoties of EImeria tenella Speer CA;Wong RB;Blixt JA;Schenkel RH
  19. Immunology v.48 Natural cytotoxicity, responsiveness to interferon and morphology of intraepithelial lymphocytes from the small intestine of the rat Flexman JP;Shellam GR;Mayrhofer G
  20. J Immunol v.121 Cytotoxic activities of gut mucosal lymphoid cells in guines pigs Arnaud-Battandier- F;Bundy BM;O'Neill M;Bienenstock J;Nelson DL
  21. J Immunol v.125 Transfer of natural resistance to Marek's disease(JMV) with nonimmune spelen cells,Ⅱ.Further characterization of protecting cell population Lam KM;Linna TJ
  22. J Immunol v.125 Effector cells in avian spontaneous and antibody dependent, cell-mediated cytotoxicity Fleischer B
  23. Scand J Immunol v.11 Spontaneous cell mediated cytotoxicity(SCMC) in various mammalian species and chickens:selective reaction pattern and different mechanisms Leibold W;Janotte G;HH Peter HH
  24. Immunology v.63 Isolation and functional characterization of chicken intestinal intra-epithelial lymphocytes showing natural killer cell activity against tumour target cells Chai JY;Lillehoj HS
  25. Vet Immunol. Immunapathol v.31 Postnatal development of T lymphocyte subpopulations in the intestinal intraepithelium and lamina propria in chickens Lillehoj HS;Cheung KS
  26. Immunology of the Gastrointestinal Tract. Nature and properties of the human gastrointestinal immune system Brandtzaeg P;Baklien K;Barklien K;Bjerke K;Rognum TO;Scott H;Valnes K;Miller K;Miller K(ed);Nicklin S(ed)
  27. Eur J Immunol v.13 A functional homologue of mammalian SC exists in chickens Parrard JV;Ross ME;Hesketh P
  28. Infect Immun v.55 Effects of immunosuppression on avian coccidiosis:cyclosporin A but not hormonal bursectomy abrogates host protective immunity Lillehoj HS
  29. Changes in intestinal lymphocyte subpopulation and cytokine expression following E. acervulina infection Choi KD;Lillehoj HS;Zalenga DS
  30. Dev Biol v.143 Expression of Transforming Growth Factor-as 1-4 in Chicken Embryo Chondrocytes and Myocytes Jakowlew SB;Dillard PJ;Winokur TS;Flanders KC;Sporn MB;Roberts AB
  31. Handbook of Experimental Pharmacology. Peptide Growth Factors and Their Receptions v.95 no.1 The Multifunctional Nature of Peptide Growth Factors Sporn MB;Roberts AB;M.B.Sporn(ed.);A.B.Roberts(ed.)
  32. Develo & Comp Immunol. Molecular and functional characterization of chicken IL-15 and IL-15 dependent gdTCR+lymphocytes. Choi KD;Lillehoj HS;Song KD;Han JY
  33. Poul Sci v.74 Eimeria acervulina: Evidence for the involvement of CD8+ T lymphocytes in sporozoite transport and host protection Trout JM;Lillehoj HS
  34. Avian Dis v.29 no.43 Effects of hybridoma antibodies on invasion of cultured cells by sporpzoites of Eimeria Augustine PC;HD Danforth
  35. Avan Dis v.30 A study of the dynamics of the invasion of immunized birds by Eimeria sporozoites Augustine PC;HD Danforth
  36. J Parasitol Characterization of a chicken monoclonal antibody that recognizes the apical comples of Eimeria acervulina sporozoites and partially inhibits sporozoite invasion of CD8+ T lymphocytes in vitro Sasai K;Lillehoj HS;Matsuda H
  37. Rev Infectious Dis v.7 How does Toxoplasma gondii enter host cells? Werk R
  38. J Parasitol v.84 A chicken anti-conoid monoclonal antibody identifies a common epitope which is present on motile stages of Eimeria, Neospora and Toxoplasma Sasai K;Lillehoj HS;Hemphill A;Matsuda H;Hanioka Y;Fukata T;Baba E;Arakawa A
  39. Parasitol v.88 The effect of immunity on the early events in the life-cycle of Eimeria tenella in the caesal mucosa of the chicken Rose Me;Lawn AM;Millard BJ
  40. Parasitol v.102 Emeria tenella:localization of the sporozoites in the caecum of the domestic fowl Rose Me;Hesketh P
  41. J Parasitol v.43 Transport of sporozoites of Eimeria necatrix in macrophages Van Doorninck WM;Becker ER
  42. J Protozool v.13 The migration of Eimeria acervulina sporozoites to the duodenald lands of Lieberkuhn Doran DJ
  43. J Parasitol v.73 Transport of Eimeria necatrix sporozoitesin the chicken:effects of irritants injected intraperitioneally Al-Atar MA;Fernando MA
  44. J Parasitol v.73 Eimeria spp. of domestic fowl: the migration of sporozoties intra- and extra- enterically Fernando MA;Rose ME;Millard BJ
  45. J Parasitol v.68 Mucosal transport of Eimeria tenella in the cecum of the chicken Lawm AM;Rose Me
  46. Poul Sci. v.74 Eimeria acervulina infection: Evidence for the involvement of CD8+ T Lymphocytes in sporozoite transport Trout JM;Lillehoj HS
  47. Vet. Immunol. Immunopathol v.53 T Lymphocyte roles during Eimeria acervulina and Eimeria tenella infections Trout JM;Lillehoj HS
  48. Avian Dis. v.31 Comparison of disease susceptibility and subclass specific antibody response in SC and FP chickens experimentally inoculated with E.tenella, Eacervulina or E.maxima Lillehoj HS;Ruff MD
  49. J Parasitol v.74 B-lymphocytes responses in the large intestine and mesenteric lymph nodes of mice infected with Eimeria falciformis(Apicomplexa) Nash PV;Speer CA
  50. Vecter.Parasitol v.18 Class-specific circulating antibodies in infections with Eimeria tenella Trees AJ;Crozier SJ;Mckellar SB;Wachira TM
  51. Vet Immunol Immunopathol v.39 Dexamerhasone suppresses T-cell-mediated immunity and enhances disease susceptibility to Eimeria mivati infection Isobe T;Lillehoj HS
  52. Res Vet Sci. v.56 Analysis of Eimeia acervulina induced changes in intestinal T lymphocyte subpopulations in two inbred chickens showing different levels of disease susceptibility to coccidia Lillehoj HS
  53. Prasite Immunol v.13 Interferon-gamma-mediated effects upon immunity to coccidial infections in the mouse Rose ME;Wakelin D;Hesketh P
  54. Avan Dis. v.38 Mitogen-induced lymphocyte proliferation and interferon production induced by coccidia infection Martin A;Lillehoj HS;Kasper B;Bacon LD
  55. Poul Sci. v.72 Antigen-specific proliferation and interferon production induced by coccidia infection Martin HS;Lillehoj HS;Kaspers B;Bacon LD
  56. Avian Dis. v.42 Recombinant chicken interferon-g inhibits Eimeria tenella development in vitro and reduces oocyst production and body weight loss following challenge with E. acervulina Lillehoj HS;Choi KD
  57. Vet Immunol Immulnopathol v.55 Transformimg growth factor-b isoforms in the developing chicken intestine and spleen:Increase in transforming growth factor b4 with coccidia infection Jakelow S;Mathias A;Lillehoj HS
  58. J Exp Med v.174 Regulation of Trypanosoma Cruzi Infections In Vitro and In Vivo by Transforming Growth Factor A(TGF-a) Silva JS;Twaedzik DR;Reed SG
  59. Proc Natl Acad Sci USA v.90 Transforming Growth Factor-a as a Virulence Mechanism for Leishmania braziliensis Barral A;Barral-Netto M;Yong EC;Brownell CE;Twardzik DR;Reed SG
  60. Poul Sci. v.74 Chicken tumor necrosis factor: In vitro production by macrophases co-cultured with Eimeria tenalla or stomulated with bacterial lipopolysaccharides Zhang S;Lillehoj HS;Ruff M
  61. Avian Diseases v.39 In vivo role of tumor necrosis factor in Eimeria tenella infection Zhang S;Lillehoj HS;Ruff MD
  62. Avian Dis. v.35 Increased of Intestinal intraepithelial lymphocytes expressing CD8 antigen following challenge with Eimeria acervulina Lillehoj HS;Bacon LD
  63. Handbook of Vertebrate Immunology Macosal gut immunity Lillehoj HS;Jakolew S;Pastoret P(ed);Griebel P(ed);Bazin H(ed);Govaert A.(ed)
  64. Immunol Today v.9 Specificity and function of T cell bearing gamma delta receptors Janeway CA;Jones B;Hayday A
  65. Infect Immunity v.57 Intestinal intraepithelial and splenic natural killer cell responses to Eimeria infections in inbred chickens Lillehoj HS
  66. Vet Immunol Immunopathol v.58 Expression and funtional characterization of recombinant chicken interferon-gamma Song KD;Lillehoj HS;Choi KD;Zalenga D;Han JY