• Title/Summary/Keyword: clinical statistics

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Statistical Analysis of Bioequivalence Study in $3{\times}2$ Crossover Design ($3{\times}2$ 교차설계법에서 생물학적 동등성 시험의 통계분석)

  • Park, Sang-Gue;Kim, Jeong-Il;Chae, Sung-San;Ko, Seoung-Gon;Oh, Hyun-Sook;Yang, Wan-Youn;Kim, Dong-Sup;Choi, Young-Wook
    • Journal of Pharmaceutical Investigation
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    • v.28 no.4
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    • pp.231-239
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    • 1998
  • A $3{\times}2$ crossover design is considered for the bioequivalence of two test formulations with a control. It could be considered as a better choice over $3{\times}3$ crossover design because of the cost and experimental duration. Oh et al.(1998) derived $3{\times}2$ crossover design and discussed its benefits over the typical crossover designs. We consider here the statistical models for $3{\times}2$ crossover design and show its statistical properties. The statistical procedures for the bioequivalence in $3{\times}2$ crossover design are shown through an example and the results are summarized by satisfying the 3 standards that proposed by the Korea Food and Drug Administration Guidelines for Bioequivalence.

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Self-Efficacy, Self-Concept of Professional Nursing, and Clinical Practice Satisfaction to Clinical Practice Education in Nursing Students (간호대학생의 임상실습교육에 대한 자기효능감, 전문직 자아개념 및 임상실습만족도)

  • Kim, Nam-Hee;Kim, Kyung-Won
    • The Korean Journal of Health Service Management
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    • v.5 no.4
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    • pp.41-51
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    • 2011
  • The purpose of this study was to identify self-efficacy and self-concept of professional nursing which might influence clinical practice satisfaction in nursing students. The participants were 278 nursing students in U city. Date were collected from November 29 to December 17, 2010. The collected data was analyzed with the PASW 18.0 statistics program. Self-efficacy had significant positive correlation with self-concept of professional nursing(r=.595, p<.001) and self-concept of professional nursing had significant positive correlation with clinical practice satisfaction(r=.396, p<.001). In multiple regression analysis, self-concept of professional nursing is most influential factor explained 21% of variance of clinical practice satisfaction. The results indicate that to develop a more reasonable and effective curriculum and teaching program for enhancement of students' self-concept of professional nursing.

Critical Thinking Disposition, Professional Self-Concept and Clinical Competence in Nursing Students (간호대학생의 비판적 사고성향, 전문직 자아개념 및 임상수행능력)

  • Park, In-Soon;Kim, Ran
    • The Korean Journal of Health Service Management
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    • v.7 no.4
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    • pp.105-117
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    • 2013
  • The purpose of this study was to identify the relationships among critical thinking disposition, professional self-concept and clinical competence in nursing students. The participants were 291 nursing students in Gwangju Province. A questionnaire survey was conducted from March 02 to 16, 2013. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheffe test, pearson's correlation coefficients, and stepwise multiple regression analysis with SPSS/WIN 20.0 version. There was a significant positive correlations among critical thinking disposition, professional self-concept, and clinical competence. The variable predicting clinical competency were professional self-concept and critical thinking disposition. These factors accounted for 44.1% of the variance. The findings of this study suggest that the most influential factor for clinical competence was professional self-concept. Therefore it is necessary to improve professional self-concept through effective education program.

Effect of the Erimental Design on the Determination of MTD in Phase I Clinical Trial (약물독성시험에서 실험설계가 MTD의 결정에 미치는 영향)

  • Lee, Yoon-Dong;Lee, Eun-Kyung
    • Journal of Korean Society for Quality Management
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    • v.39 no.2
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    • pp.329-336
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    • 2011
  • The purpose of Phase I clinical trial is to identify the maximum tolerated dose with specific toxicity rate. The standard TER design does not guarantee the pre-specified toxicity rate. It depends on the dose-toxicity curves. Therefore it is necessary to check the expected toxicity rate of various dose-toxicity curves before we conduct clinical trials. We developed TERAplusB library to help this situation, especially in cancer research. This package will help design the cancer clinical trial. We can compare the expected toxicity rates, the expected number of patients, and the expected times calculated with various dose-toxicity curves. This process will help find the best clinical trial design of the proposed drug.

Influence of Cultural competency and Intercultural Communication on Clinical competence of Emergency Unit Nurses Caring for Foreign Patients (응급실 간호사의 문화역량과 문화간 의사소통역량이 외국인 환자 임상간호수행능력에 미치는 영향)

  • Ryu, Yoon Ji;Lee, Yun Mii
    • Journal of Korean Critical Care Nursing
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    • v.14 no.1
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    • pp.40-49
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    • 2021
  • Purpose : This study identified the factors affecting the clinical competence of emergency unit nurses caring for foreign patients. Methods : This study utilized a descriptive correlation design. Participants were 112 emergency unit nurses working in different hospitals designated as the government's emergency medical centers and agencies in 2018. The collected data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson's correlation coefficients, and multiple linear regression analysis. Results : Subjects' clinical competence showed positive relationships with cultural competency (r=.45, p<.001) and intercultural communication (r=.53, p<.001). Factors that affect the clinical competence of subjects showed intercultural communication (β=0.38, p=.001). Conclusion : It is necessary to develop programs to improve intercultural communication, factors that influence clinical competence of emergency unit nurses, and apply them to practical fields.

A study on the comparison of preclinical and post-training satisfaction of dental technology students in COVID-19 (코로나19 상황에서 치기공과 학생들의 임상실습 전 기대도 및 실습 후 만족도 비교에 관한 연구)

  • Hwang, Jae-Sun
    • Journal of Technologic Dentistry
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    • v.44 no.2
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    • pp.38-46
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    • 2022
  • Purpose: This study aims to confirm the effect of clinical practice on dental technology students by comparing preclinical expectations and post-training satisfaction of dental technology students in Suwon-si, Gyeonggi-do during the coronavirus disease pandemic. Methods: This study included students enrolled in the Department of Dental Technology of D University in Suwon-si, Gyeonggi-do. The purpose of the study was explained in advance and 70 students agreed to participate in the survey. IBM SPSS Statistics version 18.0 was used for data analysis and the significance level was tested at p=0.05. Results: There were significant differences in clinical practice content, operation, institutional expectations, and satisfaction. Conclusion: Based on the differences in expectations and satisfaction in this study, schools, industries, and associations can study ways to increase satisfaction in terms of clinical practice content, operation, and institution to present directions for dental technology and clinical practice.

Relationship of Self-leadership, Stress and Satisfaction in Clinical Practice of Nursing Students (간호대학생이 지각한 셀프리더십, 임상실습 스트레스 및 임상실습 만족도 간의 관계)

  • Yang, Nam-Young;Moon, Sun-Young
    • Journal of Korean Academy of Nursing Administration
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    • v.17 no.2
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    • pp.216-225
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    • 2011
  • Purpose: In this study, the relationship between self-leadership, stress, and satisfaction among nursing students in clinical practice was examined. Method: The participants were 273 nursing students. Data collected from September to December 2010 were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and stepwise multiple regression. Results: The mean scores for self-leadership ($3.72{\pm}.41$), stress ($3.45{\pm}.59$), and satisfaction ($3.11{\pm}.38$) in clinical practice were above average. Self-leadership was significantly different according to year, interpersonal relationships, and satisfaction with nursing as a major. Stress in clinical practice was significantly different according to gender, year, and health status. Satisfaction in clinical practice was significantly different according to year, interpersonal relationships, and satisfaction with nursing as a major. Significant correlations were found between self-leadership and satisfaction in clinical practice, and stress and satisfaction in clinical practice. Year, self-leadership, interpersonal relationships, and stress in clinical practice were factors influencing satisfaction in clinical practice (20.0%). Conclusion: These findings indicate that there is a need to improve self-leadership, and to lessen stress in clinical practice to improve nursing students' satisfaction with clinical practice. The above-mentioned results should be reflected in the development of effective teaching methods for clinical practice.

Effect on Preference of Clinical Practice Subjects

  • Jungae Kim
    • International Journal of Advanced Culture Technology
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    • v.11 no.1
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    • pp.27-35
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    • 2023
  • This study was a cross-sectional descriptive survey study that confirms the effect on subjects that prefer clinical practice in order to prepare basic data for efficient clinical practice guidance for nursing college students. The study participants were 201 students attending C University, and the data collection period was from October 1 to October 15, 2022. The collected data were analyzed using SPSS 18.0 as descriptive statistics, Pearson correlation, Chi square test, ANOVA test, and Multiple regression test. As a result of the analysis, it was found that clinical decision-making and critical thinking were correlated under the statistical significance level (r=.730, p<0.01). The most favorite clinical practice department was community nursing, and male students preferred community nursing the most (Male=45.6%, χ2=.000), female students were found to prefer similar levels of practical subjects with child nursing , adult nursing, and maternal nursing(χ2=000).Clinical decision-making was found to be higher in students who preferred community nursing at a statistical significance level than those who preferred child nursing (F=4.91, p<0.01). Critical thinking was higher among students who preferred adult nursing than those who preferred other subjects (F=4.65, p<0.01). Through the analysis results, it was found that general characteristics vary, but clinical decision-making ability and critical thinking affect the preference of clinical practice subjects. Therefore, based on the results of this study, the professor of clinical practice suggests the development of a program to foster clinical decision-making and critical thinking to make students interested in clinical practice subjects.

Assessing Cure Rates via Piecewise Gompertz model with Covariates

  • Chung, Dae-Hyun;Won, Dong-Yu
    • Journal of the Korean Data and Information Science Society
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    • v.10 no.2
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    • pp.445-455
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    • 1999
  • We modify the Gompertz regression model for estimation of cure rates from pediatric clinical trials by assuming different hazard rates on the different periods. A treatment period may be divided by the stages of treatments under the different treatment arms. The piecewise Gompertz models provide an efficient method for estimation of the cure rates and a method for testing the difference of the treatment effects in the given interval.

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Family Support and Job Stress of Clinical Nurses (임상간호사의 가족지지도가 직무 스트레스에 미치는 영향)

  • Lee, Inhee;Lee, Mihee;Im, Junga;Bae, Kyungeui
    • Korean Parent-Child Health Journal
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    • v.19 no.1
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    • pp.1-8
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    • 2016
  • Purpose: This study was done to investigate the level of family support, job stress in clinical nurses end identify the participant's individual characteristics that influenced each of them. Methods: This study was a descriptive correlational study. The participants were 192 clinical nurses working in local middle range hospitals. The data were collected from May to June, 2013 and analyzed using descriptive statistics, t-test and Pearson's correlation by PASW statistics20. Results: The item mean score for family support was 21.01 and job stress was 98.89. There was a statistically significant negative correlation between family support and job stress (r=-.12). The level of job stress differed according to age (p=.014), duration of career (p=.013), department area (p<.001), position (p=.005), work duty form (p<.001), family member (p=.021), burden (p=.031), marital status (p=.001) and satisfaction (p<.001). Conclusion: Family support is needed to reduce job stress. Also, job satisfaction improvement programs and effective working systems should be developed to decrease the nurse's workplace stress.

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