• Clinical and Experimental Reproductive Medicine
• /
• v.37 no.2
• /
• pp.159-168
• /
• 2010

Objective: The purpose of this study was to evaluate the correlation between the expression pattern of vascular endothelial growth factor (VEGF) in endometrium and the pathogenesis of endometriosis by investigating VEGF expression patterns and their difference between eutopic endometrium of patients with endometriosis and that of normal controls without endometriosis. Methods: Endometrial sections were obtained from 64 hysterectomy specimens from women under age of 40, who had undergone hysterectomies and had histological evidence of endometriosis, with stage 3 and 4 according to the revised American Society for Reproductive Medicine classification. As for controls, 37 sections were gained from women diagnosed as having cervical intraepithelial neoplasia (CIN) of the uterine cervix and without evidence of pelvic endometriosis or adenomyosis during their operation. The VEGF content was evaluated immunohistochemically in the eutopic endometrium from 64 patients with endometriosis and 37 normal controls. Histological semiquantitative score (H-score) was calculated and compared between study group and control group throughout the menstrual cycle. Results: There was no significant difference in the H-score of VEGF in the eutopic endometrium between patients with endometriosis and controls without endometriosis when compared according to the same phase of the cycle, although the H-score of the study group was significantly higher in the secretory phase than the proliferative phase. Conclusion: The VEGF expression in the eutopic endometrium of women with endometriosis was not different from that of women without endometriosis. This study suggests VEGF expression in eutopic endometrium is unlikely associated with the pathogenesis of endometriosis.

• Journal of Plant Biology
• /
• v.15 no.s
• /
• pp.1-32
• /
• 1972

In order to utilize for the prevention and preservation of the Han River from the environmental pollution the present studies were carried out to clarify the microflora and estimation of the water pollution levels of the Han River. In addition to the above regional and seasonal fluctuation of the phytoplankton was also examined. Samples of phytoplankton were collected from 6 stations in the South Han River during the period from December, 1971 to October, 1972. The results obtained during the present studies are as follows: 1. The phytoplankton samples collected from 6 stations, Yeoju, Hajapo-ri, Yangpyeong, Daruraegi, Giduwon and Paldang were identified and classified by Engler's classification system(1954). It resulted in 2 phylum, 2 classes, 7 orders, 10 families, 29 genera, 137 species, 1 sub-species, 49 varieties, 6 forma and 2 variety-forma. The total numbers of phytoplankton identified were 195 species, of which 7 families, 27 species, 26 varieties, 4 forma and 2 variety-forma are new to Korea, that of 54 species are first described in Korea. 2. In lower area of the Han River it is found 53 species from Paldang and in middle area it is found 114 species from Giduwon, 95 species from Daruraegi, 66 species from Yangpyeong, 71 species from Hajapori and 81 species from Yeoju. In standpoint of seasonal fluctuation of phytoplankton, the total numbers of the plankton is more abundant in summer than in winter season and it shows bimodal pattern. 3. As compared with previous data which obtained from 30 stations covering estuary to upper area, both South and North Han River, during the period from 1965-1972 it is shown that 10 species of the South Han River and 11 species of the North Han River are found throughout all seasons. Among the above species two are common in both area. In the other hand it is found that 9 species in spring season and 6 species in fall season in the South Han River and 10 species in spring, 23 species in summer, 4 species in fall and 15 species in winter season in the North Han River shows their seasonal fluctuation in this area. Among the seasonal occurrence of phytoplankton 10 species were consider to be indicator for the estimation of biological water pollution levels. 4. According to Fjerdingstad's water pollution level system (1963) the total numbers of 1, 230 species which have been collected from the Han River since 1965 includes 27 species of phytoplankton as indicator; 3 species of blue-green algae, 20 species of diatom, and 4 species of green-algae. 5. With 27 indicator species new estimation of water pollution level system was arranged for water pollution in the Han River. 6. The lower part of the central area of the Han River indicates mesosaprobic. In central area of the Han River shows mesosaprobic and oligosaprobic, but predominant in mesosaporobic. And it is indicated that mesosaprobic, oligosaprobic, and polysaprobic factors mixed up in the North Han River. Compare with their water pollution level in the South and North Han River, with author's new system, it is estimated that North Han River is more polluted than South Han River. 7. The reason why North Han River is more polluted suggested that the selfpurification action was limited by their circulation speed. The rapid speed of water in the North Han River is mainly caused by their topography and water-drainage from waterpower plant. In conclusion the central area of the Han River consist of mesosaprobe zone, as a part with oligosaprobe zone. But the presence of polysaprobe zone in the North Han River gives us many problems in future for the nationa development programme and natural conservation in this area.

• Journal of Korean Society of Forest Science
• /
• v.42 no.1
• /
• pp.39-54
• /
• 1979

Such stream characteristics as the numbers, lengths, orders of stream channels, and drainage density are the essential elements for the analysis of drainages in planning of watershed management in a drainage basin. The drainage net is the pattern of tributaries and master streams in a drainage basin as declineated on a planimetric map. Stream order is a measure of the position of a stream in the hierarchy of tributaries. Density of the drainage is given by the quotient of the cumulative length of stream and the total drainage area. Drainage density then is simply a length per unit of area. In this study, the Anyang-cheon upper-watershed is selected for the survey and analysis of the stream system and drainage density in view point of the useful collection of data for effective watershed management planning. The Anyang-cheon upper-watershed is consisted of about 12,600 hectars of drainage area including the 13 Sub-stream. Total length of the Stream (as described in the Stream Law) in the survey area is measured as much as 71.2km, and that of the Small-stream as descrived in the Saemaul Stream Survey Book (1972) is calculated as 43,010 meters. Besides of this lengths, measured about 43,410 meters of the Small-stream and about 71,900 meters of the Torrential valley through this study. The range of the drainage density among the 13 Sub-streams having sub-watershed is analysed as from 14.79 to 24.10, and average value of drainage density in the entire watershed is calculated as 18.21 in case of including the length of the Torrential valley and 12.50 in case of excluding the same. It is required that the standard classification system in classifing for the characteristics of identification among the Stream, Sub-stream, Small-stream, Torrent, and Torrential valley must be satisfied through joint study of the authorities concerned.

• Journal of Yeungnam Medical Science
• /
• v.14 no.2
• /
• pp.359-369
• /
• 1997

We studied the expression of the cell surface antigen associated with myeloid and lymphoid leukemias on bone marrow or peripheral blood blast cells from 153 leukemic patients including 61 cases of acute myelogenous leukemias(AML), 46 of acute lymphocytic leukemias(ALL) and 12 of acute leukemias. They were analyzed by direct or indirect immunofluorescence method for reactivity with the monoclonal antibodies to B cells(CD10, CD19, SmIg), T cells(CD2, CD5, CD7, CD3, CD4, CD8), myeloid antigen(CD13, CD14, CD33, CD61) and a nonspecific antigen, HLA-DR. Lymphoid associated markers detected on AML is CD7 32.8%, CD10 14.8%, CD5 13.1%, CD2 6.6% and CD19 1.6%. TdT was positive in 4.9% of AMLs. Hybrid leukemias were 8 cases out 61 AML cases and were mainly composed of monocytic lineage, M4 and M5a. Myeloid markers detected in ALL were CD13 2.2% and CD33 2.2%. In this study, immunologically classified ALLs were composed of 65.2% of CALLA (+) B precursor type, 10.9% of CALLA (-) B precursor pattern, 8.7% of T cell type, 2.2% of B cell type, 4.5% of mixed lymphoid lineage(B&T), 2.2% of undifferentiated leukemia, and 6.5% of hybrid leukemia. Twelve cases of acute leukemias ware finally diagnosed to be 5 cases of hybrid leukemia, 3 cases of B lineage, 3 case of T lineage and 1 case of mixed lymphoid(B&T) leukemia. In summary, we think the best method for typing acute leukemias is by using a combination of FAB classification and immunophenotying.

• Journal of Home Health Care Nursing
• /
• v.4
• /
• pp.5-22
• /
• 1997

The purpose of the study was to development an information delivery system for the home nursing service, to demonstrate and to evaluate the efficiency of it. The period of research conduct was from September 1996 to August 31, 1997. At the 1st stage to achieve the purpose, Firstly Assessment tool for the patients with cerebral vascular disease who have the first priority of HNS among the patients with various health problems at home was developed through literature review. Secondly, after identification of patient nursing problem by the home care nurse with the assessment tool, the patient's classification system developed by Park (1988) that was 128 nursing activities under 6 categories was used to identify the home care nurse's activities of the patient with CAV at home. The research team had several workshops with 5 clinical nurse experts to refine it. At last 110 nursing activities under 11 categories for the patients with CVA were derived. At the second stage, algorithms were developed to connect 110 nursing activities with the patient nursing problems identified by assessment tool. The computerizing process of the algorithms is as follows: These algorithms are realized with the computer program by use of the software engineering technique. The development is made by the prototyping method, which is the requirement analysis of the software specifications. The basic features of the usability, compatibility, adaptability and maintainability are taken into consideration. Particular emphasis is given to the efficient construction of the database. To enhance the database efficiency and to establish the structural cohesion, the data field is categorized with the weight of relevance to the particular disease. This approach permits the easy adaptability when numerous diseases are applied in the future. In paralleled with this, the expandability and maintainability is stressed through out the program development, which leads to the modular concept. However since the disease to be applied is increased in number as the project progress and since they are interrelated and coupled each other, the expand ability as well as maintainability should be considered with a big priority. Furthermore, since the system is to be synthesized with other medical systems in the future, these properties are very important. The prototype developed in this project is to be evaluated through the stage of system testing. There are various evaluation metrics such as cohesion, coupling and adaptability so on. But unfortunately, direct measurement of these metrics are very difficult, and accordingly, analytical and quantitative evaluations are almost impossible. Therefore, instead of the analytical evaluation, the experimental evaluation is to be applied through the test run by various users. This system testing will provide the viewpoint analysis of the user's level, and the detail and additional requirement specifications arising from user's real situation will be feedback into the system modeling. Also. the degree of freedom of the input and output will be improved, and the hardware limitation will be investigated. Upon the refining, the prototype system will be used as a design template. and will be used to develop the more extensive system. In detail. the relevant modules will be developed for the various diseases, and the module will be integrated by the macroscopic design process focusing on the inter modularity, generality of the database. and compatibility with other systems. The Home care Evaluation System is comprised of three main modules of : (1) General information on a patient, (2) General health status of a patient, and (3) Cerebrovascular disease patient. The general health status module has five sub modules of physical measurement, vitality, nursing, pharmaceutical description and emotional/cognition ability. The CVA patient module is divided into ten sub modules such as subjective sense, consciousness, memory and language pattern so on. The typical sub modules are described in appendix 3.

• Journal of Life Science
• /
• v.19 no.9
• /
• pp.1328-1332
• /
• 2009

Anisakidosis is caused by anisakid nematodes (family Anisakidae) larvae which can cause not only direct tissue damage but also a severe allergic response related to excretory-secretion products. Lots of different species of anisakid larvae, including Anisakis simplex, Contracaecum, Goezia, Pseudoterranova, and Hysterothylacium, cause the anisakidosis. But it is difficult to diagnosis the species of larvae since the morphologies of larval anisakid nematodes are almost indistinguishable. In order to diagnosis the differential infections of larval anisakid nematodes, polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) of 18S rDNA - was conducted. Three major species of anisakid larvae including A. simplex, C.ontracaecum spp, and Goezia spp. were collected from mackerel (Scomber japonicus), mullet (Mugil cephalus), founder (Paralichthys olivaceus), eel (Astroconger myriaster) and red sea bream (Pagrus major). PCR amplified 18S rDNA from each species of anisakid larvae was digested with eight restriction enzymes including Taq I, Hinf I, Hha I, Alu I, Dde I, Hae III, Sau96 I, and Sau3A I. The original sizes of PCR amplified 18S rDNA were 2.0Kb in both anisakid larvaes and Goezia. Restrction enzymes including Hinf 1, Alu 1, Hha I, Dde 1 and Hae III cut differently and distinguished the A. simplex and Contracaecum type C'. However, Contracaecum type A showed two different restriction enzyme cutting patterns by Taq 1, Hinf I, Alu 1, and Dde 1. One of the patterns was the same as those of A. simplex, Contracaecum type C' and Goezia and the other was unique. These results suggest that PCR-RFLP pattern by Hinf 1, Alu 1, Hae I, Dde 1 and Hae III can be applied to differential diagnosis of human infection with A. simplex and Contracaecum type C'. Contracaecum type A needs further study of classification by morphological characteristics and genetic analysis.

• The korean journal of orthodontics
• /
• v.9 no.1
• /
• pp.39-65
• /
• 1979

The purpose of this study was to investigate the pattern of irregularities of teeth in various malocclusion groups. The subjects consist of 803 out-patients (355 males, and 448 females) in department of Orthodontics of S.N.U. Hospital, Yonsei University, and Kyunghi University Hospital. The results were as follows. 1. The proportions of subjects on the basis of Angle's Classification were 39.2% (42.2% male, and 57.8% fomale) in class I malocclusion, 29.0% (44.6% male, and 55.4% female) in class II. div. 1., 3.5%(46.4% male, and 53.6% female) in class II. div. 2., 28.3%(46.3% male, and 53.7% female) in class III. 2. Considering all the subjects, the percentage of teeth crowding was 67.8% (45.0% male, and 55.0% female). In class I malocclusion, the percentage of Crowding was 70.8%(43.5% male, and 56.5% female) with higher frequency in upper anterior teeth than in lower anterior. 3. The percentage of Maxillary anterior diastema was 25.6% (45.6% male, and 54.4% female) on the whole. In class II. div. 1. malocclusion, the percentage was 28.8% (46.3% male, and 53.7% female) and in class III, the percentage was 19.8% (46.7% male, and 53.3% female). Thus, frequency of maxillary anterior distema, was comparatively higher in class II. div. 1. than in class III. 4. The percentage of high canine was 25.1% (53.2% male, and 46.8% female) on the whole, and was 86.0% male and 76.6% female in right side, 73.0% male and 72.3% female in left side. In calss II. div. 2., the percentage was 53.6% (46.7% male, and 53.3% female ). In class II. div. 1., the percentage was 16.7% (46.2% male, and 53.8%) with higher frequency in class II. div.2. 5. The percentage of deep overbite was 23.0% (43. 2% male, and 56.8% female) on the whole. Ia class 11. div. 2., and in clas sll. div. 1., its were 89.3%(48.0% male and 52.0% female), 54.5% (40.9% male, and 59.1% female) respectively. This result can be considered as one of the characterics of Angle's class 11 malocclusion group. 6. The percentage of spacing was 23.0% (36.8% male, and 63.2% female) on the whole, In class II. div. 1., and in class II. div. 2., its were 26.1% (44.3% male, and 55. 7% female), 7.1% (50.0% male, and 50.0% female) respectively. 7. The percentage of open bite was 14.3% (42.6% male, and 57.4% female) on the whole with higher rate on the anterior part. It rated 17.6%(50. 0% male, and 50.0% female) in class III, but none in class II. div. 2. 8. The percentage of crossbite was 22.5% (55.8% male, and 44.2% female) on the whole, with higher frequency on the anterior part than on the posterior part. In Angle's class III, it rated as much as 55.1% (57.6% male, and 42.4% female). 9. The percentage of edge-to-edge bite was 20.4% (47.6% male, and 52.4% female) with higher frequency on anterior part than on posterior part. 10. The percentage of irregularities of teeth in various malocclusion groups, was 21.5% (24.8% maxillary, and 18.1% mandible) in crowding, 20.8% (23.5% maxillary, and 18.0% mandible) in rotation, 10.7% (10.6% maxillary, and 10.8% mandible) in cross bite, 9.5% (11.8% maxillary, and 7.3% mandible) in spacing, 8.5% (8.5% maxillary, and 8.5% mandible) in edge-to-edge bite, 8.1% (8.3% maxillary, 7.8% mandible) in open bite. Crowding teeth, spacing teeth, and rotating teeh were more prevalent in anterior part than in posterior part. Cross bite teeth and edge-to-edge bite teeth were more prevalent in class III malocclusion than in another.

• Korean Journal of Environmental Agriculture
• /
• v.26 no.4
• /
• pp.343-350
• /
• 2007

Three different experiments were carried out to investigate the runoff and erosion losses of endosulfan from sloped-field by rainfall. The mobility of endosulfan and which phase it was transported by were examined in adsorption study, the influence of rainfall pattern and slope degree on the pesticide loss were evaluated in simulated rainfall study, and the pesticide losses from soybean-grown field comparing with bare soil were measured in field lysimeter study. Adsorption parameter (K) of endosulfan ranged from 77 to 131 by adsorption method and K values by the desorption method were higher than those by the adsorption method. By the SSLRC's classification for pesticide mobility endosulfan was classified as non-mobile class ($K_{oc}>4,000$). Runoff and erosion loss of endosulfan by three rainfall scenarios ranged from 3.4 to 5.6%and from 4.4 to 15.6%of the amount treated. Endosulfan residues were mainly remained at the top 5 cm of soil depth after the simulated rainfall study. Pesticide loss in case of 30%-slope degree ranged from 0.6 to 0.9 times higher than those in case of 10%-slope degree. The difference of pesticide runoff loss was related with its concentration in runoff water and the difference of pesticide erosion loss would related closely with the quantity of soil eroded. Endosulfan losses from a series of lysimeter plots in sloped land by rainfall ranged from 5 to 35% of the amount treated. The erosion rate of endosulfan from soybean-plots was 66% of that from bare soil plots. The effect of slope conditions was not great for runoff loss, but was great for erosion loss as increasing to maximum $4{\sim}12$ times with slope degree and slope length. The peak runoff concentration of endosulfan in soybean-plots and bare soil plots ranged from 8 to 10 and from 7 to $9{\mu}gL^{-1}$ on nine plots with different slope degree and slope length. Therefore the difference of the peak runoff concentrations between bare soil plots and soybean-plots were not great.

• The korean journal of orthodontics
• /
• v.33 no.1 s.96
• /
• pp.63-72
• /
• 2003

Over the Past decades, the number of Patients seeking orthodontic treatment has increased markedly with socioeconomic development and change of recognition on appearance. The purpose of this study was to provide an epidemiologic data base related to the orthodontic treatment need. We could take an adequate information regarding the characteristics of orthodontic patients, and the changing trends about treatment mordality. Distrubution and treands were Investigated in 676 patients who had been examined and diagnosed at Department of orthodontics, Dental Hospital, Seoul National University from January to June in 1992 and 2002. 1. Sex distribution of patients changed from 1:2.1 to 1:1.5 (male female). 2. In 2002, are distribution had shown $7\~12$ year-old group being the largest$(32.0\%)$ and percentage of $19\~24,\;13\~18,\;over\;25,\;4\~6,\;0\~3$ year-old group were $24.0\%,\;21.6\%,\;14.2\%,\;5.8\%,\;2.4\%$ respctively. Compared with data in 1992, the number of adult patients highly increased. 3. With regard to Angle classification, each percentage of Class I, Class II div 1, Class II div 2, and Class III malocclusion were $25.0\%,\;20.9\%,\;3.4\%,\;and\;48.1\%$ respectively in 2002. 4. Geographic distribution showed that most of the patients visited $(37.0\%)$ lived in northeast of Seoul in 2002. 5. Mandibular prognathism showed the highest percentage in chief complaints. The percentages of crowding and facial asymmetry were $14.2\%\;and\;11.8\%$ in 2002. Patients with facial asymmetry increased significantly. 6. Percentages of patients treated with fixed appliance and orthognathic surgery were $38.0\%\;and\;25.0\%$ in 2002. Patients needed to observe the growth pattern comprised $13.0\%$ with increasing trends. The use of chin cap reduced and the percentage of ortognathic surgery and growth observation increased significantly.

• Radiation Oncology Journal
• /
• v.15 no.4
• /
• pp.321-329
• /
• 1997

Purpose : It is well known that the risk of lymph nodes metastases to head and neck cancers are influenced by the location and size of the Primary tumor. as well as the degree and types of histological differentiation. However, data on the statistical analyses of lymph node metastases from the head and neck cancers among Korean Population are not available at present. In order to obtain current status of such data, we have analyzed cancer patients at the department of radiation oncology, korea universityhospital for radiation treatment. Materials and Methods : We have evaluated nine-hundred and ninetyseven (997) head and neck cancer Patients who visited to the Department of radiation oncology, between November 1981 to December 1995. After careful physical examinations and CAT scan, Patients were divided into two groups, those with positive lymph node metastases and with negative lymph node metastases. The nodal status were classified according to the TNM system of American Joint Committee on Cancer (AJCC) Besults : Four-hundred and sixteen Patients out of the 997 patients were lymph node positive $(42\%)$ and 581 patients were lymph node negative $(58\%)$ when they were first presented at the department of radiation oncelogy. According to the AJCC classification, the distribution of positive lymph node is as follow: Nl:106 $(25.5\%),\;N2a:100\;(24\%),\;N2b:68\;(16.4\%),\;N2c:69\;(16.6\%),\;3:73\;(15\%).$ respectively. The frequency of lymph node metastases according to the primary sites is as follow : larynx 283 $(28.5\%)$, paranasal sinuses: 182 $(18\%),\;oropharynx:144\;(14.5\%)\;nasopharynx:122(12\%),\;oral\;cavity\;92\;(9\%),\;hypopharynx:71\;(7\%),\;falivary\;gland:58\;(6\%)$ unknown primary:31 $(3\%),\;skin:\;14(2\%)$,. The most frequent Primary site for the positive Iymph node metastases was nasopharynx $(71\%)$ followed by hypopharynx $(69\%),\;oropharynx\;(64\%),\;oral\;cavity\;(39\%)$ The most common histologic type was squamous cell carcinoma (652/997: $65.4\%$). followed by malignant lymphoma $(109/997:11\%)$. Conclusion : Statistical results of lymph node metastases from head and neck cancer at our department were very similar to those obtained from other countries. It is concluded that the location of Primary cancer influences sites of metastases on head and neck, and stage of the primary cancer also influences the development of metastatic lesions. Since the present study is limited on the data collected from one institute. further statistical analyses on Korean cancer Patients are warrented.