• Tuberculosis and Respiratory Diseases
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• v.70 no.1
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• pp.21-27
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• 2011

Background: Although the gold standard method for research trials on epidermal growth factor receptor (EGFR) mutations has been direct sequencing, this approach has the limitations of low sensitivity and of being time-consuming. Peptide nucleic acid (PNA)-mediated polymerase chain reaction (PCR) clamping is known to be a more sensitive detection tool. The aim of this study was to compare the detection rate of $EGFR$ mutation and EGFR-tyrosine kinase inhibitor (TKI) responsiveness according to $EGFR$ mutation status using both methodologies. Methods: Clinical specimens from 112 NSCLC patients were analyzed for $EGFR$ mutations in exons 18, 19, 20, and 21. All clinical data and tumor specimens were obtained from 3 university hospitals in Korea. After genomic DNA was extracted from paraffin-embedded tissue specimens, both PNA-mediated PCR clamping and direct-sequencing were performed. The results and clinical response to $EGFR$-TKIs were compared. Results: Sequencing revealed a total of 35 (22.9%) mutations: 8 missense mutations in exon 21 and 26 deletion mutations in exon 19. PNA-mediated PCR clamping showed the presence of genomic alterations in 45 (28.3%) samples, including the 32 identified by sequencing plus 13 additional samples (6 in exon 19 and 7 in exon 21). Conclusion: PNA-mediated PCR clamping is simple and rapid, as well as a more sensitive method for screening of genomic alterations in $EGFR$ gene compared to direct sequencing. This data suggests that PNA-mediated PCR clamping should be implemented as a useful screening tool for detection of $EGFR$ mutations in clinical setting.

• Transactions on Electrical and Electronic Materials
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• v.16 no.6
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• pp.308-311
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• 2015

V₂O₅/Mn₃O₄/Nb₂O₅ codoped zinc oxide varistor ceramics were sintered at a temperature range as low as 875~950℃. The voltage clamping characteristics of V₂O₅/Mn₃O₄/Nb₂O₅ codoped zinc oxide varistor ceramics were investigated at a pulse current range of 1~50 A. The sintering temperature had a significant effect on clamp voltage ratio, which exhibits surge protection capabilities. The varistor ceramics sintered at 875℃ exhibited the best clamping characteristics, in which the clamp voltage ratio was 2.69 at a pulse current of 50 A. The varistor ceramics sintered at 900℃ exhibited the highest electrical stability, where = 3,824 V/cm (initial 3,909 V/cm), and E_{1 mA/cm²} = 27 (initial 39) after application of a pulse current of 100 A.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.11
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• pp.1827-1836
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• 1997

In this paper, the clamping type forging of helical gears has been investigated. Clamping type forging is an operation in which the product is constrained to extrude sideways through an orifice in the container wall. Punch is cylindrical shaped. The punch compresses a cylindrical bilet placed in a die insetr. As a consequence the material flows in a direction perpendicular to that of punch movement. The forging has been analysed by using the upper-bound method. A kinematically admissible velocity field has been developed, wherein, an involute curve has been introduce to re4present tooth profile of the gear. Numerical calculations have been carried out to investigate the effects of various parameters, such as module, number of teeth, helix angle, friction factor and initial height of billet on the forging of helical gears. Some firgiing experiments were catrried out with aluminium alloy to show the validity of the analysis. Good agreement was found between the predicted values of the forging load and obtained from the experimental results.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.16 no.2
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• pp.81-87
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• 2017

The pipe connection process using a clamping ring is used for joining small pipes in the refrigerator and air-conditioner industries instead of the brazing process, which induces inevitable thermal deformation in the pipes. However, few studies have been carried out on the process to select optimal parameters in joining pipes, and studies on the relation between the process parameters of the connection and connecting force of the joint have not been conducted. In this study, the connection process of pipes with the clamping ring was modeled using the finite element method (FEM) and analyzed to obtain the contact stress distribution between the pipes with which the connecting force of the joint was estimated. Considering the characteristics of pipe connection, the process was modeled and simulated in a two-dimensional axisymmetric solution domain. With the numerical model, the effect of ring shape on the connection was studied by adding a projection to the end of a ring or changing the length of a ring. The results of the analyses revealed that the contact stress distribution could be predicted with the suggested model. The effect of the ring shape was also presented. The effect of any combination of process parameters could be easily estimated through the related analyses.

• Journal of Power Electronics
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• v.18 no.2
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• pp.395-406
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• 2018

Marine controlled-source electromagnetic transmitters (MCSETs) are important in marine electromagnetic exploration systems. They play a crucial role in the exploration of solid mineral resources, marine oil, and gas and in marine engineering evaluation. A DC-DC controlled-source circuit is typically used in traditional MCSETs, but using this circuit in MCSETs causes several problems, such as large voltage ringing of the high-frequency diode, heating of the insulated-gate bipolar transistor (IGBT) module, high temperature of the high-frequency transformer, loss of the duty cycle, and low transmission efficiency of the controlled-source circuit. This paper presents a clamping-diode circuit for MCSET (CDC-MCSET). Clamping diodes are added to the controlled-source circuit to reduce the loss of the duty ratio and the voltage peak of the high-frequency diode. The temperature of the high-frequency diode, IGBT module, and transformer is decreased, and the service life of these devices is prolonged. The power transmission efficiency of the controlled-source circuit is also improved. Saber simulation and a 20 KW MCSET are used to verify the correctness and effectiveness of the proposed CDC-MCSET.

• Journal of the Korean Society for Nondestructive Testing
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• v.33 no.2
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• pp.154-159
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• 2013

In this paper, the effect of bolt clamping force and form accuray of contact surface between mirror and mount on mirror surface was studied. Normally, mirror used in reflecting optical system was assembled with mount by bolts or adhesive. In this case, the tension caused by bolt clamping force or adhesive force may distort the mirror surface. Also, form accuracy error of the contact surface have a negative impact on wrenched mirror surface which assembled by bolts or adhesive. In this study, stress and distorted displacements on mirror surface were analyzed according to the different contact surface form accuracies and bolt clamping forces by using the finite element analysis method.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.06a
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• pp.1790-1795
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• 2000

The purpose of this papery is to introduce a new spacer damper's design for the bundle transmission lines network. It has the design, the main characteristics and advantage of this new kind of spacer damper. To reply to this problems, France, Japan and other countries had developed through many years a spacer damper with an automatic system. While the automatic clamping device are free of maintenance such as fatigue Break and aeolian vibration, imported price are so high. Now it is necessary to design, manufacture and certificate these automatic clamping device spacer damper.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• v.5B no.4
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• pp.343-349
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• 2005

This paper proposes a novel zero-voltage-switching (ZVS) Push-pull DC-DC Converter for high input voltage and high power applications. This topology utilizes two switches in series to replace one switch in conventional push-pull converter, and two clamping diodes are introduced. The voltage stress of the switches is the input voltage, and the switches can realize ZVS with the use of the leakage inductance of the transformer. Furthermore, secondary full-wave rectifier with a clamping capacitor is used to eliminate the voltage oscillation and spike of the rectifier diodes due to the reverse recovery. Therefore, the electromagnetic interference is reduced effectively. The operation principle of the proposed converter is analyzed theoretically. The output characteristic, ZVS condition and design principle of the clamping capacitor are discussed. Experimental results obtained from a 270V input 2kW prototype with $95.8\%$ high efficiency confirms the design.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.19 no.6
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• pp.614-619
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• 2009

The STW(servo track writing) system which is the process of writing servo signals on disks before assembling in drives uses the spindle motor-chuck mechanism to realize low cost because the spindle motor-chuck mechanism has merit which can simultaneously write multi-disk by piling up disks in hub. Therefore, when the spindle motor-chuck mechanism of horizontal type operates in high rotation speed it is necessary to reduce the effect of RRO(repeatable run-out) and NRRO(non-repeatable run-out) to achieve the high precision accuracy of nano-meter level during the STW process. In this paper, we analyzed that the slip in assembly surfaces can be caused by the mechanical tolerance and clamping force in hub-chuck mechanism and can affect NRRO performance. We designed springs for centering and clamping considering centrifugal force by the rotation speed and assembly condition. The experimental result showed NRRO performance improves about 30 % than case of weak clamping force. The result shows that the optimal design of the spindle motor-chuck mechanism can effectively reduce the effect of NRRO and RRO in STW process.

• Journal of the Korean Magnetics Society
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• v.26 no.2
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• pp.55-61
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• 2016

This study proposes the design algorithm of an electromagnetic linear actuator with a divided coil excitation system, such as the colenoid (COL) system, using the equivalent magnetic circuit (EMC) method. Nowadays, the clamping device is used to hold workpiece in the electrically driven chucking system and is needed to produce a huge clamping force of 40 kN like hydraulic system. The design algorithm for electromagnetic linear actuator can be obtained using the EMC method. At first, the parameter map is used to decide the slot width ratio in the initial design. Next, to make the magnetic flux density uniform at each pole, the pole width is adjusted by the pole width adjusting algorithm with EMC. When the dimensions of the electromagnetic linear actuator are decided, the clamping force is calculated to check the desired clamping force. The design results show that it can be used to hold a workpiece firmly instead of using a hydraulic cylinder in a chucking system.