• 대한한방내과학회지
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• 제25권4호
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• pp.306-317
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• 2004

Background & Object : Dyspepsia for which no organic causes are disclosed is referred to as functional dyspepsia. Functional dyspepsia is here studied in connection with a biopsychosocial model. From the aspect of individual response to external environment, in connection with stress response, functional dyspepsia is studied by both the psychology department and the internal medicine departments. The disease is taken as approachable from the aspect of internal injury due to seven emotions and stress as differentiated by Oriental medicine. Materials and Methods : Targeted at 223 patients underwent medical checks and endoscopy at Kangnam Korean Hospital, Kyunghee University. They agreed to join this clinical experiment. Stress response inventory, GARS (global assessment of recent stress scale), GSRS (gastrointestinal symptom rating scale), diagnostic scores for Ki-depression, and Spleen Disease Differentiation of Syndromes were all measured and evaluated. The test group was comprised of functional dyspepsia patients. The control group was comprised of nonsymptomatic chronic gastritis patients who were found to suffer from chronical gastritis in endoscopy and thus could be diagnosed with functional dyspepsia if symptoms would arise, but did not complain of subjective symptoms. Results showed these corelations: Functional dyspepsia patients were found to have more serious Ki-depression compared to nonsymptomatic chronic gastritis patients. The more serious Ki-depression the more serious the dyspepsia symptoms. The higher the stress response inventory the more serious the dyspepsia. Deficiency of spleen Eum, and Deficiency and Sinking of spleen Gi were found to coincide with serious Ki-depression.

• Biomolecules & Therapeutics
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• 제23권1호
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• pp.53-59
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• 2015

In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin $E_2$ ($PGE_2$) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive factor and inhibition of Helicobacter pylori (H. pylori) colonization known as a cause of chronic gastritis, gastric ulcer, and gastric cancer. Liriodendrin exhibited higher $PGE_2$ level than rebamipide used as a positive control group at the dose of $500{\mu}M$. It was also exhibited acid-neutralizing capacity (10.3%) and $H^+/K^+$-ATPase inhibition of 42.6% ($500{\mu}M$). In pylorus-ligated rats, liriodendrin showed lower volume of gastric juice ($4.38{\pm}2.14ml$), slightly higher pH ($1.53{\pm}0.41$), and smaller total acid output ($0.47{\pm}0.3mEq/4hrs$) than the control group. Furthermore liriodendrin inhibited colonization of H. pylori effectively. In vivo test, liriodendrin significantly inhibited both of HCl/EtOH-induced gastritis (46.9 %) and indomethacin-induced gastric ulcer (46.1%). From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.

• 한국식품영양과학회지
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• 제44권6호
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• pp.800-808
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• 2015

천연 생리활성 물질 탐색 연구의 일환으로 삼백초로부터 위염 억제 물질을 추출하여 효능을 검정하였다. 삼백초 추출물 0.25~2 g/kg B.W.를 마우스에 경구 투여한 결과 1.5 g/kg B.W. 미만 투여량의 급성독성 실험에서 안정성을 나타내었으며 $LD_{50}$은 1.81 g/kg B.W.였다. 삼백초 추출물 0.5 g/kg B.W.를 마우스에 경구 투여한 만성독성 실험에서는 13주간의 투여기간 동안 독성이 없는 것으로 나타났다. 위염을 유발시키기 전에 삼백초 추출물을 250 및 500 mg/kg B.W. 농도로 미리 섭취시킨 결과 위출혈 및 위부종과 세포손상이 농도 의존적으로 감소하였다. 또한 사이토카인의 발현도 억제되었다. 따라서 삼백초 추출물은 스트레스성 위염에 의한 출혈 및 세포손상을 농도 의존적으로 억제하는 효과가 있으며, 그 mechanism은 염증성 사이토카인의 발현 억제에 의한 것이라 생각되었다.

• 약학회지
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• 제49권3호
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• pp.237-243
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• 2005

Present study was performed for the development of a new supplementary product with gastroprotective effect. The preliminary screening were conducted for the effects of HCl-ethanol-induced gastric lesions in rats. Samples were aloe gel, active hexose correlated compound (AHCC) mentioned that have GI protective property and pulmuone healthy aloe gel (PHAG) that mixture of natural products from Pulmuone company. Aloe gel significantly inhibited HCl-ethanol-induced gastric lesions at the oral dose of 5 ml/kg. AHCC showed the strongest effectiveness at the oral dose of 1,200 mg/kg. PHAG also showed the significant effects at the oral dose of 10, 20 g/kg. In pylorus ligated rats, the treatments of aloe gel, AHCC and PHAG showed decrease in the volume of gastric secretion and acid output. And aloe gel, AHCC and PHAG significantly suppressed the aspirin-induced ulcer and chronic ulcer in pylorus ligated rats. The treatments of aloe gel and PHAG significantly reduced acetic acid-induced ulcer at the oral dose of 5 ml/kg and 10 g/kg for 12 days. In this study; we have found that PHAG had significant improvement in acute gastritis and ulcer at the dose of 20 g/kg and in chronic gastritis and ulcer at the dose of 10 g/kg. Also we evaluated the anti-bacterial activity against H. pylori treated with aloe gel, AHCC and PHAG. PHAG had a equivalent anti bacterial activity with ampicillin against H. pylori at the dose of 1 g/kg.

• 대한한방내과학회지
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• 제36권3호
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• pp.348-360
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• 2015

Objectives From observing the tongue of a patient, one can assess the health status; this method has been frequently used in traditional Korean Medicine (KM) clinics. In particular, KM posits that the color of the tongue is highly related to digestive functions. In this study, the color of tongue and heart rate variability (HRV) were compared between chronic dyspepsia (CD) patients and healthy subjects. Methods Healthy subjects and CD patients with functional dyspepsia (FD), gastroesophageal reflux disease (GERD), or chronic gastritis (CG) were enrolled for the study. Profile view images of the tongue were acquired by using a computerized tongue image acquisition system (CTIS). The color of the tongue body was extracted from the non-coated region on the tongue images. Results Color differences in CIE L*a*b* color space between the three sub-types of CD patients and healthy subjects were analyzed by using multiple linear regression analysis with age and sex as the factors. The variable b* was significantly lower in GERD patients than in the controls (p=0.017). Variable a* was significantly lower in CG than in the controls (p=0.03). No significant difference was seen between FD and controls. In GERD, the tongue body seems to be intense red in color; in CG, pale red. Frequency domain analysis showed that HF was significantly lower in GERD patients than in the controls (p=0.041). Conclusions The color of the tongue body and HF of HRV can be used for diagnosing digestive functions in health care.

• 약학회지
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• 제55권2호
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• pp.160-167
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• 2011

Cirsium japonicum var. ussuriense (CJ) is used as a folk medicine for diuretic, arthritis, dyspepsia, and bleeding in Korea. Until now, more than fifteen kinds of CJ were identified and among them, Cirsium japonicum var. nakaianum Nakai was selected as experimental material. Both that from The Medical Herb Garden of Seoul National University located at Gayang-dong, Koyang city and native that from a hillock near Dangjin, Chungnam were collected and analyzed to determine whether it is varied in efficacy on their habitats. Extracts and fractions of CJ had a strong effect of antibacterial activity on H. pylori and antioxidant effects. And the CJ from Garden and Dangjin were showed to be more efficient in acute gastritis through the HCl${\cdot}$ethanol-induced gastric lesion test and chronic gastritis through the indomethacin-induced gastric lesion test, respectively. This study proved that the effects of CJ are varied by their habitats. Also, these results suggest that the CJ has potentials for use as functional food and medicine.

• 대한수의학회지
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• 제49권1호
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• pp.79-83
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• 2009

A 6-year-old, spayed female Miniature Pinscher dog with chronic vomiting lasted for 7 weeks was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Physical examination, complete blood counts, serum chemistry, gastroscopy, upper gastrointestinal series, endoscopic biopsy and histopathological examination were performed for the diagnosis. The complete blood counts and serum biochemistry revealed no remarkable effect to the patient's general condition. Gastroscopy revealed erosion, erythema in mucosal surface of gastric lesions and endoscopic biopsy performed. No significant findings in upper gastrointestinal series were observed, and histopathologic examination revealed infiltration of lymphocyte in the gastric mucosa. Based on these findings, the dog was diagnosed with lymphocytic gastritis. The dog were treated by metronidazole and ranitidine with hypoallergenic diet, and then the patient showed no vomiting or other complications.

• 대한한방소아과학회지
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• 제18권1호
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• pp.139-152
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• 2004

Objective: The aim of this study was to find about relation between Chiljung(七情) and chronic recurrent abdominal pain in children. Methods: It was surveyed the oriental medical book concerning Chiljung(七情) and western medical book concerning Chronic recurrent abdominal pain. Results: Chronic recurrent abdominal pain which is common disorder in children is mostly functional abdominal pain due to stress. The Stress can be defined as spiritual factor which lead to imbalance of body homeostasis in medicine. In oriental medicine, it is considered as Chiljung(七情) disorder. The gastrointestinal disease due to stress are peptic ulcer, chronic gastritis, irritable bowel syndrome, chronic abdominal pain, vomitting etc. In oriental medicine pathology mechanism, it is considered as discord with liver and spleen, depression of spleen-energy. It comes within the category of depression. Children with chronic recurrent abdominal pain is dependent on parents and they have an introspective nature, compulsive idea which is intolerable for failure.

• Biomolecules & Therapeutics
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• 제20권2호
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• pp.239-244
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• 2012

This study examined the inhibitory effects of 4-guanidinobutyric acid (4GBA), an alkaloid, against gastric lesions by assessing the inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Acute and chronic gastritis were also observed using HCl/ethanol (EtOH) and indomethacin-induced gastric lesion models, respectively. 4GBA inhibited the growth of H. pylori in a dose dependent manner, and showed acid-neutralizing capacity. In the pylorus ligated rats, 4GBA decreased the volume of gastric secretion and gastric acid output slightly, and increased the pH. 4GBA at a dose of 100 mg/kg reduced the size of HCl/EtOH-induced gastric lesions (70.8%) and indomethacin-induced gastric lesions (38.8%). The antigastritic action of 4GBA might be associated with the acid-neutralizing capacity, anti-H. pylori action, and decreased volume of gastric secretion. These results suggest that 4GBA might be useful in the treatment and/or protection of gastritis.

• 한국임상수의학회지
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• 제31권2호
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• pp.108-111
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• 2014

7세 중성화된 암컷 고양이가 3개월 동안 지속된 간헐적인 구토 증상으로 진료 의뢰되었다. 혈액 검사와 진단영상학적 검사에서 비정상적인 소견은 관찰되지 않았다. 내시경 검사에서 위 동체 점막에 국소적인 미란이 관찰되었고, 해당 병변들에 대한 조직병리학적 검사를 통해 림프구성 위염으로 진단하였다. 프레드니솔론 투약 7일 후에 구토 및 식욕 부진 증상은 소실되었지만, 장기간 투약에 의한 부작용 발생 때문에 프레드니솔론 대신에 싸이클로스포린을 처방하였다. 환자의 상태는 개선되었고, 구토와 식욕부진은 더 이상 관찰되지 않았다. 본보는 만성 구토를 보이는 고양이 림프구성 위염에 있어 싸이클로스포린은 치료 약물로 적용 가능함을 시사한다.