• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2611-2614
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• 2013

Aims: To explore efficacy and side effects of intrapleural or intraperitoneal lobaplatin for treating patients with malignant pleural or peritoneal effusions. Methods: Patients in Jiangsu Cancer Hospital and Research Institute with cytologically confirmed solid tumors complicated with malignant pleural effusion or ascites were enrolled into this study. Lobaplatin (20-30 $mg/m^2$) was intrapleurally or intraperitoneally infused for patients with malignant pleural effusion or ascites. Results: From 2012 to 2013, intrapleural or intraperitonea lobaplatin was administered for patients with colorectal or uterus cancer who were previous treated for malignant pleural effusion or ascites. Partial response was achieved for them. Main side effects were nausea/vomiting, and bone marrow suppression. No treatment related deaths occurred. Conclusion: Intrapleural or intraperitoneal infusion of lobaplatin is a safe treatment for patients with malignant pleural effusion or ascites, and the treatment efficacy is encouraging.

• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4251-4256
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• 2015

Background: Exposure to cigarette may affect human health and increase risk of a wide range of diseases including pulmonary diseases, such as chronic obstructive pulmonary disease (COPD), asthma, lung fibrosis and lung cancer. However, the molecular mechanisms of pathogenesis induced by cigarettes still remain obscure even with extensive studies. With systemic view, we attempted to identify the specific gene modules that might relate to injury caused by cigarette smoke and identify hub genes for potential therapeutic targets or biomarkers from specific gene modules. Materials and Methods: The dataset GSE18344 was downloaded from the Gene Expression Omnibus (GEO) and divided into mouse cigarette smoke exposure and control groups. Subsequently, weighted gene co-expression network analysis (WGCNA) was used to construct a gene co-expression network for each group and detected specific gene modules of cigarette smoke exposure by comparison. Results: A total of ten specific gene modules were identified only in the cigarette smoke exposure group but not in the control group. Seven hub genes were identified as well, including Fip1l1, Anp32a, Acsl4, Evl, Sdc1, Arap3 and Cd52. Conclusions: Specific gene modules may provide better understanding of molecular mechanisms, and hub genes are potential candidates of therapeutic targets that may possible improve development of novel treatment approaches.

• Molecules and Cells
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• 제37권5호
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• pp.383-388
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• 2014

Renal cell carcinoma (RCC) is associated with a high frequency of metastasis and only few therapies substantially prolong survival. Honokiol, isolated from Magnolia spp. bark, has been shown to exhibit pleiotropic anticancer effects in many cancer types. However, whether honokiol could suppress RCC metastasis has not been fully elucidated. In the present study, we found that honokiol suppressed renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties. In addition, honokiol inhibited tumor growth in vivo. It was found that honokiol could upregulate miR-141, which targeted ZEB2 and modulated ZEB2 expression. Honokiol reversed EMT and suppressed CSC properties partly through the miR-141/ZEB2 axis. Our study suggested that honokiol may be a suitable therapeutic strategy for RCC treatment.

• 대한예방한의학회지
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• 제22권1호
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• pp.69-80
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• 2018

Objectives : This paper examines the effects of Particulate Matter on human bodies and the possibility of treating them with Chinese or Korean medicines. Methods : This paper categorizes the diseases caused by Particulate Matter, as well as the causes, pathology, prevention methods, and effectiveness of treatments by Chinese and Korean medicines. Based on these results, it analyzes whether such diseases can be managed by Chinese and Korean medicine. Results : Particulate Matter is known to affect respiratory organs, skin, circulatory system, nervous system, gestational diabetes, and other parts of the human body. While studies show evidence that treatments by Chinese and Korean medicines can reduce symptoms of some diseases and improve bodily functions that are damaged by Particulate Matter, there is no statistically significant evidence that they can provide fundamental treatments nor treat irreversible damages. Conclusion : Currently, there is no definite evidence that Chinese and Korean medicine can treat symptoms and diseases caused by Particulate Matter. Therefore, some Korean medicine doctors' arguments that Korean medicine is effective in treating such diseases are problematic, and thus, there is a need for much research in this field.

• 대한한방내과학회지
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• 제39권3호
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• pp.323-337
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• 2018

Objective: The purpose of this research is to investigate Chinese clinical studies of the treatment of hiccup after stroke with herbal medicine. Methods: We used the China National Knowledge Infrastructure (CNKI) database to search for clinical studies about using herbal medicine to treat hiccup after stroke. Results: Nineteen clinical articles Until August 31, 2017 were analyzed. The most commonly used herbal prescription was Xuanfudaizhe-tang (旋覆代?湯). According to analysis, the most commonly used medical herbs were Haematitum (代?石), Inulae Flos (旋覆花), and Pinelliae Tuber (半夏). Clinical symptoms, total incidence rate of adverse reaction, recurrence rate, symptom improvement time, patient satisfaction comparison, and dietary status improvement were used to evaluate the treatments. The effective rate of the treatment group was 86.0-97.8%, significantly higher than control group in all papers. Side effects occurred much less frequently in the treatment group than in the western medicine control group. Conclusion: The treatment of hiccup after stroke with herbal medicine was shown to be highly effective in 19 studies. Additional well-designed clinical trials are needed; this study can be used as a basis for further research regarding the treatment of hiccup after stroke.

• BMB Reports
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• 제40권2호
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• pp.196-204
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• 2007

Our previous study has shown that sodium selenite can cause apoptosis in acute promyelocytic leukemia-derived NB4 cells in a caspase-dependent manner, but the detailed mechanism is unknown. Here we demonstrate a requirement for extracellular signal-regulated protein kinase (ERK) in mediating sodium selenite -induced apoptosis in NB4 cell. Though no apparent elevation of ERK activity was observed during the apoptosis in NB4 cells caused by 20 μM sodium selenite treatment, PD98059 and U0126, specific chemical inhibitors of the MEK/ERK signaling pathway, were shown to strongly prevent the apoptosis process, while ERK activator TPA enhanced the process. It is also known that p38 MAPK inhibitor SB203580 and JNK inhibitor SP600125 had slight effects on apoptosis. Further study indicated that ERK exerted its proapoptotic effect only at the early stage of apoptosis and played an antiapoptotic role at the later stages. Taken together, our findings suggest that ERK plays an active role in mediating sodium seleniteinduced apoptosis in NB4 cells .

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1877-1880
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• 2012

Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3.

• 대한한방내과학회지
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• 제23권1호
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• pp.117-122
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• 2002

Objective : We conducted this study to analyze some of the trends of treatments from the recent Chinese medical journals and contribute them to the oriental medical experiments and clinical research for the future. Methods : By referring to the Chinese medical journals that were published in China from 1999 to March, 2002, we analyzed the effective rates on frequency, methods, medical treatment, and diseases. Result : The average effective rate was 90.93%, which was very high. Lately, there have been no big changes in the methods of treatment. The methods of coordinating stomach-Qi, supplying Yin element, replenishing bone marrow, tonifying essence of life, and removing blood stasis are used by means of reinforcing Qi, producing blood, tonilying spleen, and replenishing the kidney. Conclusions : The decreased in bone marrow and leucopenia, and the side effects of radiotherapy and chemotherapy were more effectively treated when we used Korean oriental medical treatments. In addition, more Korean oriental medical experiments and clinical studies are needed in Korea, in the future.

• 치위생과학회지
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• 제11권5호
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• pp.381-388
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• 2011

본 연구는 중국인 유학생을 대상으로 치과의료 이용 실태에 대해 조사함으로써 외국 유학생의 치과의료 이용에 대한 문제점을 개선하고 치과의료서비스 확충을 위한 기초자료를 제공하고자, 2011년 4월 1일부터 7월 15일까지 국내 8개 대학에 재학 중인 중국인 유학생을 대상으로 조사를 실시하여 다음과 같은 결과를 얻었다. 1. 국내 치과의료기관 이용 경험에 관한 질문에서 응답자의 14.4%가 국내에서 치과치료를 받은 경험이 있었으며, 이용한 치과의료기관 분류로는 치과의원이 52.5%로 가장 많았고, 치료받은 내용으로는 충치(충전)치료가 52.8%로 가장 많은 것으로 나타났다. 2. 국내 체류 중 치과치료를 받지 못한 경험에 대한 이유는 '비용이 부담스러워서'가 38.7%로 가장 많았으며, '시간이 없어서'라는 응답도 29.8%로 조사되었다. 3. 건강보험에 가입되어 있는 경우가 57.3%로 가입되어 있지 않은 경우보다 약간 많았으며, 건강보험의 필요성을 묻는 질문에서는 대부분 필요하다고 응답하였다. 또한, 건강보험에 가입한 경우 가입하지 않은 경우 보다 치과치료를 더 많이 받은 것으로 조사되었다(p<.001). 4. 치과의료 이용 만족도에서는 한국어 실력이 좋을수록 치료 만족도가 높은 것으로 조사되었으며(p<.01), 건강보험에 가입되어 있는 경우 가입하지 않은 경우보다 치료 만족도가 높았다(p<.05). 이러한 결과는 중국인 유학생의 효율적인 치과의료 이용을 위해서 유학생의 건강보험 가입에 관한 제도를 개선하고, 보건의료 관련 행정 지원이 필요할 것으로 사료된다.

• Molecules and Cells
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• 제40권8호
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• pp.542-549
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• 2017

Cardiomyocyte apoptosis is initiated by various cellular insults and accumulated cardiomyocyte apoptosis leads to the pathogenesis of heart failure. Excessive reactive oxygen species (ROS) provoke apoptotic cascades. Manganese superoxide dismutase (MnSOD) is an important antioxidant enzyme that converts cellular ROS into harmless products. In this study, we demonstrate that MnSOD is down-regulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury. Enhanced expression of MnSOD attenuates cardiomyocyte apoptosis and myocardial infarction induced by I/R injury. Further, we show that miR-23a directly regulates the expression of MnSOD. miR-23a regulates cardiomyocyte apoptosis by suppressing the expression of MnSOD. Our study reveals a novel model regulating cardiomyocyte apoptosis which is composed of miR-23a and MnSOD. Our study provides a new method to tackling apoptosis related cardiac diseases.