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http://dx.doi.org/10.7314/APJCP.2012.13.5.1877

Inhibition of Breast Cancer Metastasis Via PITPNM3 by Pachymic Acid  

Hong, Ri (Department of Breast, the First School of Clinical Medicine, Zhejiang Chinese Medical University)
Shen, Min-He (Department of Oncology, the First School of Clinical Medicine, Zhejiang Chinese Medical University)
Xie, Xiao-Hong (Department of Breast, the First School of Clinical Medicine, Zhejiang Chinese Medical University)
Ruan, Shan-Ming (Department of Oncology, the First School of Clinical Medicine, Zhejiang Chinese Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.5, 2012 , pp. 1877-1880 More about this Journal
Abstract
Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3.
Keywords
Breast cancer; metastasis; MDA-MB-231; PITPNM3; pachymic acid;
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