• Journal of Yeungnam Medical Science
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• 제33권1호
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• pp.1-7
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• 2016

The two distinctive clinical features of varicella-zoster virus (VZV) are varicella (chickenpox) by primary infection and zoster (singles) by the reactivation of latent infection. In addition to the two typical clinical symptoms mentioned above, diverse clinical manifestations have been reported as a result of VZV reactivation, including chronic radicular pain without rash, visual loss, facial palsy, dysphagia, sore throat, odynophagia, otalgia, hearing loss, dizziness, headache, hemiplegia, etc. Most of these symptoms are derived from neuropathy and vasculopathy of affected nerves and arteries. Diagnosis of VZV disease can be difficult if there is no appearance of a skin rash during development of atypical symptoms. In addition to natural infection, vaccination and anti-viral agent treatment have influenced the changes of epidemics and clinical presentations of varicella and zoster. In this article, diverse clinical manifestations caused by VZV reactivation, particular without skin rash, are reviewed.

• 한방안이비인후피부과학회지
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• 제10권1호
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• pp.349-356
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• 1997

an acute, unilateral, self-limited inflammatory disease of cerebral ganglia and the ganglia of posterior nerve roots and peripheral nerves in a segmented distribution, caused by the chickenpox virus, and characterized by groups of small vesicles in the cutaneous areas along the course of affected nerves, and associated with neuralgic pain. three case of herpes zoster has severe post herpetic neuralgia. these patients has been treated with westernmedicine. But they could not expect to improve condition. We exprienced three cases of herpes zoster that have a result of effect with oriental treatment and lazer threaphy.

• Pediatric Infection and Vaccine
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• 제22권2호
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• pp.55-62
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• 2015

목적: 고위험군 환자에서 수두 바이러스 접촉 후 예방 요법으로 수두 면역 글로불린을 투여한다. 수두 면역 글로불린으로 국내에서는 VZIG, 미국에서는 VariZIG$^{(R)}$을 사용한다. 2013년 7월 미국 질병관리본부에서 수두 바이러스 노출 후 VariZIG$^{(R)}$ 투여를 최대 10일까지로 연장하여도 수두 예방 효과가 있음을 발표하였다. 본 연구에서 저자들은 수두 노출 후 96시간 이내에 VZIG 투여 군과 96시간 이후 투여 군에서 수두 예방 효과를 비교하고자 하였다. 방법: 삼성서울병원에서 2001년 1월부터 2012년 12월 사이에 VZIG이 투여된 환자들을 대상으로 후향적 차트 분석을 통해 평가하였다. 결과: 전체 91명의 환자에서 57명(62.6%)은 남자였고 연령의 중앙값은 5.91세였다. 39명(42.9%)은 병원 내에서 수두 바이러스에 노출되었다. 기저 질환은 고형 종양 41.8%, 혈액 종양 40.7%이었고 그 외 다른 질환이 17.5%이었다. 전체 환자 중에서 45명(49.5%)은 조혈모세포 이식 환자였다. 74명(81.3%)이 수두 바이러스 노출 후 96시간 이내에 VZIG을 투여 받았다. 수두 바이러스 노출 후 96시간 이내에 VZIG이 투여된 군과 96시간 이후에 투여된 군에서 수두 발생은 뚜렷한 차이가 없었다(2.7% vs. 5.9%, P=0.4664). 효소면역분석법 검사에서 수두 항체가 음성인 환자는 22명이었고, 이 환자들에서 수두 바이러스 노출 후 96시간 이내에 VZIG이 투여된 군과 96시간 이후에 투여된 군에서 수두 발생은 뚜렷한 차이가 없었다(6.6% vs. 0%, P=0.667). 결론: 본 연구에 의하면 수두 노출 후 96시간 이전에 VZIG 투여군과 96시간 이후에 VZIG 투여군 사이에 수두 발생을 예방하는데 차이가 없었으나, 향후 더 많은 환자수에서 추가 연구가 필요할 것으로 사료된다.

• 한국콘텐츠학회논문지
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• 제21권3호
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• pp.561-566
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• 2021

학교는 감염병 발생 시 광범위하게 확산될 우려가 높은 집단이며, 학생들의 건강과 학습권을 저해할 수 있으므로 체계적인 관리와 신속한 대응이 필요하다. 본 연구는 초·중·고 학생들에게 흔히 발생하는 감염병의 현황을 파악하여 감염병의 위협으로부터 학생과 교직원을 보호하고 정상적인 학교 기능을 유지하기 위한 기초자료를 제공하기 위해 실시하였으며, 조사 대상으로는 세종시를 선정하였다. 3대 감염병은 인플루엔자, 수두, 수족구병으로서, 3대 감염병 모두 급성 바이러스성 감염병으로 분류되며 전파속도가 빠르고 전파력이 강한 특징이 있어 집단 생활을 하는 학생들에게는 치명적인 결과를 초래할 수 있다. 연구자료는 교육부 교육행정정보망인 나이스(NEIS)의 2019년도 감염병 보고자료를 활용하였고, 전국 초·중·고등학교에서 매주 보고된 현황 자료를 활용하여 분석하였으며, 연구방법으로는 전국과 세종시 감염병 발생 현황 비교, 각 학교급별 발생 현황 비교, 감염병 항목별 발생 현황 비교, 시기별 감염병 현황 분석을 실시하였다. 3대 감염병 발생 현황 조사 결과는 세종시 뿐만 아니라 전국 학교감염병의 감염병을 관리하는데 기초자료로 사용되어, 향후 학교감염병 관리 대책 수립에 활용할 수 있도록 기대한다.

• Pediatric Infection and Vaccine
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• 제14권2호
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• pp.188-193
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• 2007

대상포진 수막염은 대상포진 후 발생할 수 있는 신경학적 합병증으로 주로 면역 기능이 저하된 상태의 환자에게서 발생한다. 저자들은 면역 기능이 정상인 환아에서 피부 병변 없이, 수두 백신 접종을 한 경우 드물게 발생하는 대상포진 수막염 2례를 경험하였기에 보고하는 바이다.

• Clinical and Experimental Pediatrics
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• 제57권12호
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• pp.538-541
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• 2014

Varicella is usually considered to be a benign disease in healthy children; however, serious complications can occur such as necrotizing fasciitis and toxic shock syndrome. We describe a 38-month-old girl with necrotizing fasciitis and streptococcal toxic shock syndrome following varicella. She was previously healthy and vaccinated against varicella at 12 months of age. She had been diagnosed with varicella three days prior to presenting at our facility; she developed fever, vomiting, and painful swelling on her left flank. Her skin lesions worsened, she became lethargic, and had episodes of hypotension and coagulopathy. Necrotizing fasciitis on the left abdominal wall, buttocks, and left thigh was diagnosed by magnetic resonance imaging, and group A Streptococcus was isolated from a tissue culture. She was diagnosed as necrotizing fasciitis and streptococcal toxic shock syndrome, and successfully treated with repeated surgical debridement and fasciotomy, in addition to intensive antibiotics. Our experience suggests that necrotizing fasciitis in patients with varicella should be considered to be a rare complication even with widespread vaccine use. Early diagnosis and intensive treatment are required to prevent a fatal outcome.

• Journal of Microbiology and Biotechnology
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• 제25권2호
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• pp.268-273
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• 2015

The fluorescent-antibody-to-membrane-antigen (FAMA) test is regarded as the "gold standard" to detect protective antibodies to varicella-zoster virus (VZV) because of its high sensitivity and specificity. Because the classic FAMA test uses an infectious virus for detection of antibodies to VZV, it is labor-intensive, and also requires special equipment for handling the virus. For this reason, we attempted to develop a simple and safe FAMA assay. Because VZV glycoprotein E (gE) is one of the major VZV glycoproteins, we used the gE protein for the FAMA test (gE FAMA). Here, we demonstrate that overexpression of gE in HEK293T cells can be used to measure antibodies in human serum, and that gE FAMA titers are closely correlated with gpEIA ELISA data. These results indicate that our gE FAMA test has the potential to measure antibodies to VZV.

• Journal of Yeungnam Medical Science
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• 제24권2호
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• pp.339-343
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• 2007

Varicella is a contagious infection in childhood disease typically affecting children aged 2-8 years and usually follows benign outcome. In the adult, clinical presentation is more severe and more commonly associated with complications. Varicella pneumonia, although rare, is a potentially life-threatening complication that should be suspected in any adult with varicella and respiratory symptoms. We report a case of varicella pneumonia in immunocompetent patient. The characteristic radiographic findings consisted of diffuse scattered coarse nodular infiltrations, less than 1cm sized, with ground glass opacity and consolidation in both lung fields. The patients was started on intravenous acyclovir. The chest radiograph performed 2 weeks later showed complete resolution of the pulmonary lesions.

• 한국의사학회지
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• 제23권1호
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• pp.77-104
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• 2010

In July 2008, I obtained a copy of "Hanbang Eihak Gangseupseo" through Uibangseowon. It was recorded that the book was compiled by Seong Ju-bong and reviewed by Ji Seok-young. According to previous studies, this book was the lecture book that was used in teaching Traditional Korean Medicine in Daejeon, Chungcheongnam-do. This book gave insight to the system and curriculum of the school for Traditional Korean Medicine in Daejeon, Chungcheongnam-do. It also exhibited the academic characteristics of Traditional Korean Medicine in the Period of Japanese Occupation and the medical viewpoint of Seong Ju-bong. The summary is as follows: First, an independent School for Traditional Korean Medicine was run in Daejeon, Chungcheongnam-do, with reasonable curriculums and systematic textbooks. Second, the medical viewpoint and treatment methods of Huang Yuan-Yu of Qing Dynasty was actively introduced. Then it was reorganized for the society and stimulated the progress of Traditional Korean Medicine. Third, while absorbing Chinese Medicine, it still inherited our heritage of Traditional Korean Medicine Especially, Seong Ju-bong's original opinions and clinical experiences are shown in surgery, gynecology and pediatrics. Fourth, in a break from the past, when Chinese culture could not be introduced due to diplomatic problems between Joseon and Qing, efforts were made to overcome limitations of lagging behind by adopting and educating Warm Disease study. Fifth, while working side by side with Ji Seok-young who introduced the modern Western Medicine through vaccination, it still searched for a traditional Korean medical treatment for chickenpox. I hope that the report of my findings through reading "Eihak Gangseupseo" could make up for the fact that the medical history during the colonial period is scarce.

• Archives of Plastic Surgery
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• 제37권2호
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• pp.143-147
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• 2010

Purpose: Nostril stenosis is an uncommon deformity that develops as a consequence of smallpox, chickenpox, tuberculosis, syphilis, congenital malformations etc. There have been several studies on the surgical techniques to treat it. However, it is difficult to maintain the result for a long time. The goal of this study is to evaluate the use of Wplasty, perialar flap as an operative techniques and expansion exercise using Foley catheter as a method to keep the patency of nostril. Methods: This is a retrospective review of the senior surgeon's (Y.L.) patients who underwent W-plasty and a perialar flap. Patients treated from 2005 to 2009 were reviewed and the postoperative results were evaluated. Average patient age was 24 years, ranged from 1 to 61 years, average follow-up period was 27.5 months, ranged from 3 to 77 months. The mild deformity was released with an incision and expansion by the ballooning of a Foley catheter and corrected by W-plasty only. However, a severe deformity required an additional procedure including perialar flap transposition. During the postoperative period, the patients maintained a nasal stent and exercise using a Foley catheter to prevent recurrence. Results: Five cases of nostril stenosis in four patients were treated using this technique. One case was corrected with W-plasty only, but four cases were more severe and were corrected with W-plasty and a perialar flap. There were no perioperative complications. The patients were satisfied with the results and retained a good shape during the follow-up periods. Conclusion: Nostril stenosis can be corrected with W-plasty and a perialar flap. A perialar flap is added if W-plasty is unable to correct the deformity. A postoperative nasal stent and expansion with a Foley catheter can help in preventing recurrences.