• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2004년도 가을 학술발표회 논문집
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• pp.411-418
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• 2004

Using a level set method we develop a shape optimization method applied to energy flow problems in steady state. The boundaries are implicitly represented by the level set function obtainable from the 'Hamilton-Jacobi type' equation with the 'Up-wind scheme.' The developed method defines a Lagrangian function for the constrained optimization. It minimizes a generalized compliance, satisfying the constraint of allowable volume through the variations of implicit boundary. During the optimization, the boundary velocity to integrate the Hamilton-Jacobi equation is obtained from the optimality condition for the Lagrangian function. Compared with the established topology optimization method, the developed one has no numerical instability such as checkerboard problems and easy representation of topological shape variations.

• Journal of the Optical Society of Korea
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• 제19권4호
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• pp.397-402
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• 2015

In this paper, we propose a method used to measure the polarization state of a field with multiple polarization singularities (PSs), such as an array of PSs and PSs in vector speckle. A checkerboard is used to construct characteristic points, which makes it possible to calibrate the mismatches between pictures obtained during the rotation of a quarter-wave plate and a polarizer. Using this method a field with an array of PSs is measured. The experimental result is compared with the numerical simulation. We also carry out some data analysis. The comparison and analysis emphasize the necessity and feasibility of this method to measure the PSs.

• Nuclear Engineering and Technology
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• 제32권2호
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• pp.169-179
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• 2000

A detailed numerical analysis of the evolution of thermal stratification in a curved piping system in a nuclear power plant is performed. A finite volume based thermal-hydraulic computer code has been developed employing a body-fitted, non-orthogonal curvilinear coordinate for this purpose. The cell-centered, non-staggered grid arrangement is adopted and the resulting checkerboard pressure oscillation is prevented by the application of momentum interpolation method. The SIMPLE algorithm is employed for the pressure and velocity coupling, and the convection terms are approximated by a higher-order bounded scheme. The thermal-hydraulic computer code developed in the present study has been applied to the analysis of thermal stratification in a curved duct and some of the predicted results are compared with the available experimental data. It is shown that the predicted results agree fairly well with the experimental measurements and the transient formation of thermal stratification in a curved duct is also well predicted.

• 한국균학회지
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• 제23권2호통권73호
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• pp.153-160
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• 1995

담자균류의 하나인 잔나비걸상 자실체로부터 얻은 수성엑스의 항세균 시험과 항진균 시험을 액체배지 희석법으로 실시하고 naringenin과의 병용시험을 checkerboard assay 법으로 평가하였다. 항세균 시험결과 전반적으로 그람음성균보다 그람양성균에 대해 비교적 양호한 항균력을 나타내었으나 사용된 균주중 그람음성균인 Proteus vulgaris 78615는 MIC가 1.125 mg/ml로 가장 양호한 항균효과를 나타내었다. 11종의 균주에 대해 실시된 항진균 시험결과 Candida albicans, Fusarium spp. 그리고 Trichophyton mentagraphytes의 MIC가 7.5 mg/ml로 다른 균주에 대한 항진균 효과보다 두배 더 강한 효과를 나타내었다. naringenin과의 병용시험에서 Staphylococcus aureus ATCC 25923에 대하여 부분적 상승효과를 나타내었고, Klebsiella pneumoniae ATCC 10031과 Salmonella typhi ATCC 6229 두 균주에서 상가효과가 관찰되었다. 그리고 Bacillus subtilis ATCC 6633을 비롯한 7종의 균주에서 무관효과를 나타내었으며 길항효과는 관찰되지 않았다.

• 한국전산구조공학회논문집
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• 제26권4호
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• pp.241-246
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• 2013

본 논문에서는 밀도법 기반 위상 최적설계를 통해 얻어진 수치 결과를 바탕으로 CAD 모델을 구성하고 이를 3차원 프린터로 제작하여 실험적으로 최적설계를 검증하였다. 위상 최적설계 과정에서는 체커보드(Checkerboard) 현상이나 잔가지가 종종 나타나는데, 이는 최적설계 구조물을 실제로 제작함에 있어서 어려움을 준다. 이러한 문제점을 해결하기 위하여 민감도 필터링과 모폴로지 기법을 사용하였다. 엄밀한 검증을 위하여 수치 모델과 실험 모델의 부피율을 일치시켰다. 위상 최적설계를 포함한 다양한 설계에 대하여 실험을 통해 비교하여 최적설계 구조물이 가장 높은 강성을 가지고 있음을 확인하였으며 컴플라이언스에 대한 실험결과는 수치해석 값과 잘 일치함을 확인하였다.

• 한국약용작물학회지
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• 제22권6호
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• pp.504-509
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• 2014

Methicillin-resistant Staphylococcus aureus (MRSA) is a substantial contributor to morbidity and mortality. In search of a natural products capable of inhibiting this multidrug resistant bacteria, we have investigated the antimicrobial activity of brazilein (BRZ) isolated from Caesalpinia sappan L. (Leguminosae) against 8 different strains of Staphylococcus aureus (S. aureus). New antimicrobial activity was found using the minimum inhibitory concentrations (MICs), broth dilution as well as checkerboard method. Against the 8 strains, the minimum inhibitory concentrations of BRZ were in the range of $62.5-500{\mu}g/mL$. From those results we performed the checkerboard test to determine the synergism of BRZ in combination with Hygromycin-b (HgB) against 4 strains. The combined activity of BRZ and HgB against 4 strains resulted in a fractional inhibitory concentrations index (FICI) ranging from 0.18-0.5. The effect of BRZ with HgB was found to be synergistic. We found that BRZ reduced the MICs of HgB. BRZ and HgB could lead to the development of new combination antibiotics against MRSA infection.

• 한국측량학회지
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• 제36권2호
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• pp.43-50
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• 2018

영상을 기반으로 하는 3차원 위치결정에서 카메라는 핵심적인 요소이며 이러한 카메라의 내부적인 특성을 제대로 결정하는 카메라 캘리브레이션 작업은 대상물의 3차원 좌표를 결정하기 위해서 필수적으로 선행되어야 할 과정이다. 본 연구에서는 캘리브레이션을 위한 체크보드의 크기와 형태에 영향을 받지 않고 반자동으로 카메라의 내부표정요소를 결정하는 방법론을 제안하였다. 제안한 방법론은 쿼터니언을 이용한 외부표정요소 추정, 캘리브레이션 타겟의 인식, 번들블록조정을 통한 내부표정요소 매개변수 결정으로 구성되어 있다. 체스보드 형태의 캘리브레이션 타겟을 이용하여 내부표정요소를 결정한 후 소규모 3차원 모형에 대한 3차원 위치를 결정하였으며 검사점을 이용한 정확도 평가를 통해서 수평위치와 수직위치 오차는 각각 약 ${\pm}0.006m$와 ${\pm}0.007m$를 얻을 수 있었다.

• Archives of Pharmacal Research
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• 제12권2호
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• pp.114-118
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• 1989

The effects of intraperitoneal injection of cephradine in a dose of 75 mg/kg and netilmicin in dose of 50 mg/kg and their combination on creatinine and urea serum levels of rabbits were studied as well as the antipseudomonal activity against three multiresistant clinicial isolates. The antibacterial activity was investigated by two methods: Checkerboard titration method and time-kill studies. Finally, the antibacterial activity of the sera obtained from the rabbits receiving the used drugs in the previous regimen was studied using time-kill study method against Pseudomonas aeruginosa isolates. Results obtained from this study indicated that both creatinine and urea serum levels of the rabbits receiving both drugs were not significantly different from those of the rabbits receiving either cephradine or netilmicin alone. At the same time the in vitro antibactrial activity (either of the prepared solutions of the used drugs and their combination or of the sera obtained from the rabbits receiving these drugs as mentioned before) showed a synergistic effect against the tested strains of Pseudomonas aeruginosa

• 한국통신학회논문지
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• 제35권12C호
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• pp.1010-1019
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• 2010

This article presents a PDE-based interpolation algorithm to effectively reproduce high resolution imagery. Conventional PDE-based interpolation methods can produce sharp edges without checkerboard effects; however, they are not interpolators but approximators and tend to weaken fine structures. In order to overcome the drawback, a texture enhancement method is suggested as a post-process of PDE-based interpolation methods. The new method rectifies the image by simply incorporating the bilinear interpolation of the weakened texture components and therefore makes the resulting algorithm an interpolator. It has been numerically verified that the new algorithm, called the PDE-based image interpolator (PII), restores sharp edges and enhances texture components satisfactorily. PII outperforms the PDE-based skeleton-texture decomposition (STD) approach. Various numerical examples are shown to verify the claim.

• Journal of Mechanical Science and Technology
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• 제18권2호
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• pp.253-261
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• 2004

A simple and effective filtering method to control the member size of an optimized structure is proposed for topology optimization. In the present approach, the original objective sensitivities are replaced with their relative values evaluated within a filtering area. By adjusting the size of the filtering area, the member size of an optimized structure or the level of its topological complexity can be controlled even within a given finite element mesh. In contrast to the checkerboard-free filter, the present filter focuses on high-frequency components of the sensitivities. Since the present filtering method does not add a penalty term to the objective function nor require additional constraints, it is not only efficient but also simple to implement. Mean compliance minimization and eigenfrequency maximization problems are considered to verify the effectiveness of the present approach.