• 한국산업정보학회논문지
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• 제7권1호
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• pp.66-74
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• 2002

판매되는 제품에 대한 보증비용은 소비자의 사용정도에 관계없이 일정하다고 가정한다. 하지만 현실적으로는 소비자들에 따라 사용 정도가 서로 다를 수 있다. 사용정도와 예방보수 형태는 보증비용 책정에 중요한 역할을 할 수 있다. 따라서, 본 논문에서는 소비자에 따라 사용정도가 다르고 예방보수 정책의 형태가 서로 다른 경우에 대한 제품의 기대보증 비용을 산출할 수 있는 새로운 보증비용 모형을 제시했다.

• 한국수소및신에너지학회논문집
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• 제3권2호
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• pp.1-7
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• 1992

수소압축기를 조합한 금속수소화물 히트펌프를 설계하여 이의 성능을 평가할 수 있는 새로운 모델을 제시하고 이를 실험결과와 비교 평가 하였다. 또한 본 모델에서는 카르노사이클에 단열압축과정을 도입하여 여러 조업관수가 성능계수에 미치는 영향을 검토하고 아울러 열역학 제 2법칙에 의한 비가역과정을 도입하므로써 보다 정확한 조업특성을 파악하도록 했다.

• 대한전기학회논문지:전력기술부문A
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• 제48권5호
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• pp.517-523
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• 1999

The Start-up transformers or on-site stand-by transformers are installed for the start-up and shut-down of generator and emergency status in unclear power plant. The on-site power supply configuration using these transformers must be detemined by considering configuration requirements, site characteristics, reliability and availability severely because it is remarkably important for safety and benefit of plant. The start-up or stand-by power supply configuration has been determined considering only safety requirements and construction cost up to now in Korea. I study various reliability estimating methods for the prediction of availability, and estimate the unavailability for the start-up power supply system of two 1,000㎿ unclear power plants. I also detemine the reliability and unavailability and unavailavility of equipment, system and configuration using FTA method.

• Journal of Information Technology Applications and Management
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• 제13권4호
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• pp.1-12
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• 2006

Many software reliability growth models(SRGM) have been proposed since the software reliability issue was raised in 1972. The technology to estimate and grow the reliability of developing S/W to target value during testing phase were developed using them. Most of these propositions assumed the S/W debugging testing efforts be constant or even did not consider them. A few papers were presented as the software reliability evaluation considering the testing effort was important afterwards. The testing effort forms which have been presented by this kind of papers were exponential, Rayleigh, Weibull, or logistic functions, and one of these 4 types was used as a testing effort function depending on the S/W developing circumstances. I propose the methology to evaluate the SRGM using least square estimator and maximum likelihood estimator for those 4 functions, and then examine parameters applying actual data adopted from real field test of developing S/W.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 추계학술발표대회 및 bio-venture fair
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• pp.77-80
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• 2000

Various analytical methods such as electron microscopy, quinone analysis, and 16S rDNA sequencing studies were used to investigate the microbial communities and to identify the microorganisms responsible for enhanced biological phosphorus removal (EBPR) in an anaerobic/aerobic sequencing batch reactor (SBR) fed with acetate. Electron photomicrographs showed that oval-shaped microorganisms of about $0.7\;{\sim}\;1\;{\mu}m$ in diameter dominated the microbial sludge. These microorganisms contained polyphosphate granules and glycogen inclusions, which suggests that they are a kind of phosphorus accumulating organism. Quinone and 16S rRNA sequence analyses showed that the members of Proteobacteria beta subclass were the most abundant species, which were affiliated with the Rhodocyclus-likes group. Phylogenetic analysis revealed that the two dominating clones of the beta subclass were most distantly related to Propionivibrio dicarboxylicus DSM 5885 and Rhodocyclus tenuis DSM 109 with about 95% and 96% sequence similarity, respectively. Therefore, it was concluded that the oval-shaped organisms related to the Rhodocyclus-likes group are likely to be responsible for biological phosphorus removal in SBR operation supplied with acetate.

• Advances in materials Research
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• 제13권3호
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• pp.195-202
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• 2024

Aluminum alloy is a material that is frequently used in the aerospace and transportation industries due to its high mechanical and corrosion resistance qualities. Unfortunately, aluminum alloys are prone to corrosion, limiting their application in some harsh situations such as when submerged in aqueous environments. The purpose of this study is to investigate how anodizing can increase the corrosion resistance of 6061 Aluminum alloy. The anodizing process was carried out using two different parameters which are voltage (5V, 10V, 15V) and electrolyte sulfuric acid (H₂SO₄) concentration (0.3M, 0.5M) for 1 hour. The anodized samples were performed using several analyses such as X-ray diffraction (XRD) analysis, morphology analysis, and corrosion test. From this study, it is found that the difference in anodizing parameters affects the corrosion resistance of the samples. Sample anodized at 15V, 0.5M gives the best corrosion resistance.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2867-2870
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• 2016

Background: Endometrial cancer is the most common gynecological malignancy among females worldwide, approximately 320,000 women being diagnosed with the disease each year and 76,000 dying. To date, there is limited knowledge of endometrial cancer in Malaysia. Objectives: To identify the epidemiological profile and prognostic factors of survival. Materials and Methods: A list of endometrial cancer patients in 2000-2011 was obtained from the hospital Record Department. Only cases confirmed by histopathology examination were included. We excluded those with incomplete medical records or referral cases. Simple and multiple Cox regression approaches were used for data analysis. Results: Only 108 cases were included with a mean (SD) age of 62.7 (12.3) years, with 87.0% Malay ethnicity. Grade of cancer was: 29.1% grade 1, 43.7% grade 2 and 27.2% grade 3. The majority of patients had non-endometrioid type (60.2%), with myometrial invasion (82.2%) and lymphovascular invasion (57.3%). The significant prognostic factors were age (HR 1.05; 95% CI: 1.02, 1.08, p=0.002) and having lymphovascular invasion (HR 2.15; 95% CI: 1.08, 4.29; p=0.030). Conclusions: Endometrial cancer patients should be diagnosed earlier to reduce the risk of mortality. The public should be given education on the signs and symptoms of the disease.

• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.78-85
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• 2011

Background and Objectives : The aim of this study was to investigate anti-inflammatory and anti-oxidant effects of Hyunggaeyungyo-tang(HYT) on RAW 264.7 cells. Material and Methods : Two types of experiments were implemented for this study: first, the experiment to study the anti-oxidant effect of HYT using riboflavin; second, in vitro experiment to investigate the suppression of NF-${\kappa}$B activation using RAW 264.7 cells (I${\kappa}$B kinase and induce nitric oxide synthase mRNA expression) Results : 1. The anti-oxidant effects of HYT was dose-dependantly increased. 2. The RAW 264.7cells were treated with LPS for 1 hours prior to the addition of indicated concentrations(0.4,-1.0mg/$m\ell$) of HYT, and the cells were further incubated for 24 hours. The LPS-induced IKK & iNOS mRNA expression were dose-dependantly decreased in HYT treated RAW 264.7cells. Conclusion : The results suggest that HYT is significantly effective in the treatment of inflammation through the suppression of NF-${\kappa}$B activation and iNOS production.

• Journal of Microbiology and Biotechnology
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• 제33권1호
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• pp.43-50
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• 2023

Fungal keratitis is a refractory kind of keratopathy. We attempted to investigate the antiinflammatory role of thymol on Aspergillus fumigatus (A. fumigatus) keratitis. Wound healing and fluorescein staining of the cornea were applied to verify thymol's safety. Mice models of A. fumigatus keratitis underwent subconjunctival injection of thymol. The anti-inflammatory roles of thymol were verified by hematoxylin-eosin (HE) staining, slit lamp observation, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting. In contrast with the DMSO group, more transparent corneas and less inflammatory cells infiltration were detected in mice treated with 50 ㎍/ml thymol. Thymol downregulated the synthesis of TLR4, MyD88, NF-kB, IL-1β, NLRP3, caspase 1, caspase 8, GSDMD, RIPK3 and MLKL. In summary, we proved that thymol played a protective part in A. fumigatus keratitis by cutting down inflammatory cells aggregation, downregulating the TLR4/ MyD88/ NF-kB/ IL-1β signal expression and reducing necroptosis and pyroptosis.

• IMMUNE NETWORK
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• 제4권4호
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• pp.237-243
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• 2004

Background: The normal functions of the cell cycle inhibitor p16INK4a are frequently inactivated in many human cancers. Over 80% of hepatocellular carcinoma (HCC) cases lack a functional p16/Rb pathway. p16/Rb pathway, as well as p53 pathway, is considered as one of key components of tumor suppression. Methods: To study the roles of p16INK4a in HCC, a stable cell line expressing exogenous p16 was generated from SNU-449 hepatocellular carcinoma cells lacking endogenous p16, and suppression subtractive hybridization (SSH) was performed in parallel with the control cells. Results: 1) SSH identifies fibronectin (FN1), crystallin ${\alpha}B$ (CRYAB), Rac1, WASP, RhoGEF, and CCT3 as differentially-expressed genes. 2) Among the selected genes, the up-regulation of FN1 and CRYAB was confirmed by Northern blot, RT-PCR and by proteomic methods. Conclusion: These genes are likely to be associated with the induction of stress fiber and stabilization of cytoskeleton. Further studies are required to clarify the possible role of p16 in the signal transduction pathway.