• BMB Reports
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• v.52 no.1
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• pp.86-108
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• 2019

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.

• Women's Health Nursing
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• v.14 no.4
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• pp.314-322
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• 2008

Purpose: Dysmenorrhea is one of the most common gynecologic complaints of young women. This study investigated the changes in the menstrual cycle during test evaluations according to perfectionism and testing anxiety among high school girls in order to provide information for care of dysmenorrhea. Method: Data collection was done from July 14 to 18, 2008 by self administered questionnaires with 300 high school girls. Result: The subjects experienced amenorrhea(35.3%), changes in the menstrual cycle(66.3%), changes in menstrual duration(50.0%), changes in amount of menstruation(47.7%), and increases in menstrual pain during testing evaluations. There were significant differences in changes of menstrual patterns, physical symptoms, and menstrual pain during test evaluations between a high perfectionist group and low perfectionist group. Also, there were significant differences in changes of menstrual patterns, physical symptoms, and menstrual pain during test evaluations between a high testing anxiety group and low testing anxiety group. Perfectionism and testing anxiety showed a positive relationship with changes in menstrual patterns, physical symptoms, and menstrual pain. Conclusion: As perfectionism and testing anxiety seem to contribute to changes in the menstrual cycle during test evaluations, school health-care providers should screen routinely for dysmenorrhea and give more attention to health education on this topic to girls.

• Hwankyungkyoyuk
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• v.15 no.1
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• pp.101-114
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• 2002

This study is an ethnographic case study aiming at understanding the environmental education (EE) classes of 'Discretionary Activity' which has recently been introduced into Korean middle school curricula. To show the characteristics of the classes, researcher described the phenomena unique to two schools. Two middle school teachers were included in this study as research participants. Qualitative approaches were used to understand the status quo of school environmental education, teachers's perspectives on EE and their expectations for learners' changes. Data were gathered using the methods of participant observation during two school terms and in-depth interview with two teachers and nine students. Ethnographic analysis/interpretation methods such as domain analysis were used to analyze the data. To verify the research methodology and conclusions, triangulation, members checking and peers debriefing were used. Research questions emerging through the circulative research process include 1) what are the teachers' perspectives on EE and how do the teachers' perspectives affect their EE teaching? 2) what are the teachers' expectations for learners' changes and how are teachers/researcher able to perceive learners' changes? Two research participants have different life experiences and perspectives on environment and EE. The perspectives had influence on the selection of the contents and the styles of their teaching. Teachers' expectations for learners' changes were also different according to the styles of the teaching.

• Clinics in Shoulder and Elbow
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• v.7 no.1
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• pp.5-9
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• 2004

Purpose: To identify associated findings in glenohumeral joint in rotator cuff tear and evaluate its clinical significance, we examined minor and major changes during arthroscopic or mini open repair. Materials & Methods: We reviewed 66 patients of rotator cuff tear treated from March, 2001 to January, 2004. Of 38 cases of small to medium tear, average age was 53 years old and involved in dominant arm in 27 cases. Of 28 cases of large to massive tear, average age was 58 years old and involved in dominant arm in 26 cases. Minor and major associated changes of the glenohumeral joint were evaluated in the tendon of biceps long head, biceps pulley, cartilage of the glenoid and humeral head, labrum and synovium. Results: Minor changes in biceps tendon were in 35% of cases, biceps pulley in 18%, cartilage of humeral head in 27%, cartilage of glenoid in 18%, labrum in 38%, and synovium in 42%. Major changes in biceps tendon were in 6% of cases, biceps pulley in 35%, arthritis of humeral head in 3%, arthritis of glenoid in 2%, labrum in 6%, and synovium in 21 %. Major changes in biceps tendon were 5% in Group I and 7% in Group Ⅱ(p>0.05) and in biceps pulley, 18% and 57% in each (P<0.05). Minor changes of arthritis were prevalent in glenoid cartilage and major changes were more prevalent in humeral head. There were no differences in minor changes of labrum and synovium, but major changes were more prevalent in Group Ⅱ. Conclusion: The prevalence of intraarticular associated changes of rotator cuff tear were 63% in synovium, 54% in labrum, 53% in biceps pulley, 41% in biceps tendon, 30% in humeral head and 20% in glenoid cartilage in order. Major changes of biceps pulley, humeral head, labrum and synovium were more prevalent in Group Ⅱ.

• Journal of The Korean Society of Clinical Toxicology
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• v.7 no.2
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• pp.69-76
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• 2009

Purpose: Various electrocardiogram (ECG) changes can occur in patients with acute organophosphate poisoning (OPP) and may be associated with the clinical severity of poisoning. The present study aimed to evaluate the extent and frequency of ECG changes and cardiac manifestations, and their association with acute OPP clinical severity. Methods: Seventy-two adult patients admitted to our emergency department with a diagnosis of acute OPP were studied retrospectively. ECG changes and cardiac manifestations at admission were evaluated. ECG changes between respiratory failure (RF) group and no respiratory failure (no RF) groups were compared. Results: Prolongation of QTc interval (n=40, 55.6%) was the most common ECG change, followed by sinus tachycardia (n=36, 50.0%). ST-T wave changes such as ST segment elevation or depression and T wave change (inversion or non-specific change) were evident in 16 patients (22.2%). Prolongation of QTc interval was significantly higher in the RF group compared with the no RF group (p=0.03), but was not an independent predictor for RF in acute OPP (OR; 4.00, 95% CI; 0.70-23.12, p=0.12). Conclusion: While patients with acute OPP can display ECG changes that include prolongation of QTc interval, sinus tachycardia, and ST-T wave changes at admission, these changes are not predictors of respiratory failure.

• Journal of Fisheries and Marine Sciences Education
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• v.26 no.2
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• pp.257-269
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• 2014

The purpose of this study was to investigate the change of perceptions of students', parents', teachers' on creativity and character education at the model school for creativity and character education. This study used pre and post tests to examine the effects of creativity and character education on students, parents, and teachers. The results were as follows. Firstly, operating model school for creativity and character education brought about the statistically meaningful changes of students' perception on creativity and character education. However, the changes seemed that the level of their perception on creativity and character education was not rational as the average is about 3.5 point. Secondly, operating model school for creativity and character education brought about the statistically meaningful changes of parents' perception on creativity and character education. However, the changes seemed that the level of their perception on creativity and character education was not rational as the average was about 3.5 point like their children. thirdly, operating model school for creativity and character education brought about the statistically meaningful changes of teachers' perception on creativity and character education. The changes seemed that the level of their perception on creativity and character education was rational as the average was about 4.5 point unlike their students and school parents. Fourthly, it seemed that the perception on creativity and character education showed a difference among students, school parents, and teachers.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.6 no.1
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• pp.10-17
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• 1997

It is pointed out that the color of composite resin is changing according to it's ploymerization and this color change is a harmful effect for the clinical satisfacion of composite resin restoration. The purpose of this study was to compare the changes of color of newly developed composite resins between before and after exposure of activating light. Five Compostie resins (8 shades) were employed: Palfique Estelite(UL, U, DY, G ; Tokuyama), Photo Clearfil A (US : Kuraray), Photo Clearfil Bright (US ; Kuraray), GC Graft LC(A3 ; GC), Silux Plus(U; 3M), Tristirnulus values of each material were determined before and after curing-light exposure by using a Micro Multi Photometer (MMP-1001, Nihon Denshoku Kogyo). The values were transformed into $L^*\;a^*\;b^*$ system and color changes of the resins were evaluated by the changes of $L^*$, $a^*$ and $b^*$ values for the individual shades. In addition, the effects of resin thickness and background color on color changes were also studied The finding were as follows: 1. Color changes of $L^*$, $a^*$ and $b^*$ values were recognized due to the light exposure for all products. The $b^*$ values of Palfique Estelite showed negligible changes for all shades. 2. The $b^*$ values were affected strongly by the background color, especially when decreasing the brightness on the background color.(Request original article reprints to Dr. Aoshima)

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.46 no.6
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• pp.385-392
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• 2020

Objectives: This study evaluates soft tissue changes of the upper lip and nose after maxillary setback with orthognathic surgery such as Le Fort I or anterior segmental osteotomy. Materials and Methods: All 50 patients with bimaxillary protrusion and skeletal Class II malocclusion underwent Le Fort I or anterior segmental osteotomy with backward movement. Soft and hard tissue changes were analyzed using cephalograms collected preoperatively and 6 months postoperatively. Results: Cluster analysis on the ratios shows that 2 lines intersected at 4 mm point. Based on this point, we divided the subjects into 2 groups: Group A (less than 4 mm, 27 subjects) and Group B (more than 4 mm, 23 subjects). Also, each group was divided according to changes of upper incisor angle (≥4°=A1, B1 or <4°=A2, B2). The correlation between A and B groups for A'/ANS and Ls/Is (P<0.001) was significant; A'/A (P=0.002), PRN/A (P=0.043), PRN/ANS (P=0.032), and St/Is (P=0.010). Variation of nasolabial angle between the two groups was not significant. There was no significant correlation of vertical movement and angle variation. Conclusion: The ratio of soft tissue to hard tissue movement depends on the amount of posterior movement in the maxilla, showing approximately two times higher rates in most of the midface when posterior movement was greater than 4 mm. The soft tissue changes caused by posterior movement of the maxilla were little affected by angular changes of upper incisors. Interestingly, nasolabial angle showed a different tendency between A and B groups and was more affected by incisal angular changes when horizontal posterior movement was less than 4 mm.

• Journal of the Korean Society of Earth Science Education
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• v.4 no.1
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• pp.32-42
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• 2011

The purpose of this study is to provide meaningful basic materials for organizing a science curriculum in future by analyzing the status and changes of contents about astronomical phenomena in textbooks according to the changes of the science curriculum of elementary school. A main target of analysis is science textbooks of elementary school in curriculums from 1st to 7th. For the analysis, the analytic frame based on contents in astronomy textbooks of teachers colleges and colleges of education was used. The result of the analysis is as in the following. First, astronomy accounted for average about 7% of all pages of textbooks in all of science curriculums. The 1st educational curriculum had the most learning quantity of 10.40%, and the 6th curriculum had the least quantity of 4.39%. These results show that astronomy was not a small part and was considered important in each science curriculum of elementary school considering that earth science accounted for 17-26% of all pages in elementary school science curriculum. Second, the things that have been dealt with in common in all science curriculums from 1st to 7th of elementary school are the shape of the earth, the rotation and the revolution of the earth, the occurrence of the seasons, the apparent motion of the sun, the status and motion of the moon, the movement of a star, the brightness and distance of a star, constellations, the sun, planets and others. These contents are expected to be dealt with continuously as basic contents to organize astronomy regardless of the changes of curriculum. Third, in science curriculum of elementary school, astronomical phenomena based on life experiences regarding the earth, the moon and the sun are mainly dealt with in the first and the second grade. Contents requiring principles-understanding and research are dealt with in the fifth and sixth grade. These results show that elementary school science curriculum dealing with astronomy reflects the developmental stages of students and considers principle of learning possibility.

• Journal of the Korean Society of Costume
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• v.57 no.6 s.115
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• pp.17-31
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• 2007

Fashion of one period is symbolic and figurative means of expression reflecting spirit, ideology, emotion and aesthetic values of that period. Designs of school uniforms fer girls also went through changes in various shapes along with changes in sociocultural and philosophical backgrounds in each period. Thus, in this study, in examining girls' school uniforms, how girls' school uniforms have evolved with what kind of design characteristics was observed along with process of historical changes, and investigation was made on realistic conditions of girls school uniforms since 1996 when active advancements in school uniform design were started. Also, through examination of girls' school uniform designs from homepage of large student uniform companies and catalogues, characteristics of girls' school uniforms after 1996 were observed. On the result, we could know that girl's school uniforms from 1996 to 2006 were designed in various forms compared to those of the past time and changing Arends of the era were reflected on the school uniform designs. Narrow waistline, shorter blouse, changes in the length of jacket and skirt showed that current school uniform designs pursue the fashionable and trendy designs unlike those of the past times that were uniform and strict. This study include organizing characteristics of girls' school uniform designs by each period, providing fundamental and realistic data for clothes manufacturing and marketing activities through analysis on designs of girls' school uniforms since 1996, and providing directions for future school uniform designs.