• 한국방사선학회논문지
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• 제13권5호
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• pp.713-720
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• 2019

본 연구의 목적은 컴퓨터단층 혈관조영술에서 혈관 직경을 정확하게 측정할 수 있는 새로운 측정 방법인 상대적 측정법의 기초연구 자료를 제공하고자 한다. 비이온성 요오드 조영제를 자체 제작한 관류 팬텀에 일정한 속도로 흐르게 한 후 컴퓨터단층 혈관조영술 검사를 시행하였다. 원시 데이터를 얻은 후 다중평면재구성 및 최대강도투사법으로 영상을 재구성하였고 장비 사에서 제공하는 거리측정 장치를 사용하여 팬텀의 직경을 측정하였다. 측정법은 고식적 측정법과 본 연구에서 제안하는 상대적 측정법을 사용하였다. 관류팬텀의 평균 직경은 다중평면재구성기법과 최대강도투사법 모두에서 상대적 측정법이 기존 측정법 보다 실측에 더 가깝게 나타났다(34% VS 24%, p<0.05). 하지만 두 가지 측정법 모두 실측보다 여전히 확대된 결과를 나타내고 있음을 확인하였다. 따라서 상대적 측정 방법에 대한 추가 연구가 필요한 실정이며, 이에 본 연구가 기초 자료를 제공할 수 있을 것이라 사료된다.

• Journal of Nutrition and Health
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• 제53권6호
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• pp.570-582
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• 2020

본 연구는 상지추출물과 stilbene 화합물인 MSA, ORT의 항비만 효능을 비교 분석하고자 식이성 비만 마우스 모델을 이용하여 HFD에 실험물질을 첨가한 식이를 13주 동안 급여하였다. 연구결과, 실험물질들의 항비만 효능은 ORT, ME, MSA, MW군 순이었으며, 특히 ME와 ORT의 급여는 고지방식이에 의한 체중 및 체지방 증가, 혈당 증가, 이상지질혈증 및 지방간 개선에 있어 양성대조군인 GC군과 비슷한 효과를 보였다. 향후 관련 기작 규명 및 안전성 확보, 그리고 최대 유효성 도출을 위한 추출 조건 확립 및 용량 검증 등의 연구가 수행된다면 체중조절용 기능성 식품으로의 개발을 기대해 볼 수 있을 것으로 사료된다.

• 대한한방내과학회지
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• 제41권6호
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• pp.967-983
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• 2020

Objective: This study was performed to investigate the effect of Acanthopanax sessiliflorum Cheonghyeol plus (ASCP) on NF-κB and MAPK signaling and vascular adhesion factors associated with dyslipidemia in human umbilical vein endothelial cells (HUVECs). Methods: We measured the scavenging activity of DPPH radical and ABTS radical by ASCP in HUVECs. We measured the protein expression levels of NF-κB, IκBα, ERK, JNK, and p38 after treatment of HUVECs with TNF-α. We measured the expression levels of MCP-1, ICAM-1, and VCAM-1 mRNA and of MCP-1, ICAM-1, and VCAM-1 biomarkers after treatment of HUVECs with TNF-α. Results: The DPPH and ABTS radical scavenging activity of ASCP increased in a concentration-dependent manner. NF-κB, IκB, ERK, p38 protein expression levels decreased following ASCP treatment at all concentrations compared to untreated control HUVECs. JNK protein expression levels decreased in ASCP-treated HUVECs compared to untreated controls at concentrations of 100 ㎍/mL. MCP-1 mRNA expression level decreased with ASCP treatment ≥200 ㎍/mL compared to the control. ICAM-1 and VCAM-1 mRNA expression levels decreased at all concentrations compared to the control. MCP-1 protein expression level was reduced compared to the control at concentrations ≥200 ㎍/mL, ICAM-1 protein expression level was reduced compared to the control at concentrations ≥100 ㎍/mL, and VCAM-1 protein expression level was reduced at all concentrations. Conclusions: These results suggest that ASCP has an antioxidative and hypolipidemic effect and that ASCP could treat and prevent dyslipidemia, atherosclerosis, and cardio-cerebrovascular diseases.

• 보건행정학회지
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• 제30권4호
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• pp.479-492
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• 2020

Background: As the prevalence of hypertension is increasing in Korea, the government is seeking policy actions to manage patients with hypertension more efficiently. In this paper, we aimed to identify factors associated with the use of medical care at hospitals among outpatients with hypertension. Methods: We analyzed a total of 15,040 cases of 3,877 outpatients with hypertension obtained from the Korea Medical Panel database from 2010 to 2016. The dependent variable was whether a patient with hypertension visited a hospital or not; and independent variables were the patient's various socio-demographic, health-related, and heath-status characteristics. We conducted a generalized linear mixed model analysis with logit link for all the cases and then conducted it stratified by gender. Results: As a result of a multivariable analysis, women were less likely than to visit at a hospital (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.32-0.61) and people aged 65 years and older than those aged less than 65 years (OR, 0.71; 95% CI, 0.57-0.89). Residents in Busan, Ulsan, and Gyeongnam were more likely than those in than Seoul, Gyeonggi, Incheon, and Jeju to visit a hospital (OR, 1.40; 95% CI, 1.05-1.86). The likelihood of visiting a hospital was high in people belonging to a group of: the highest level of annual household income (OR, 1.73; 95% CI, 1.30-2.29); Medical care aid recipients (OR, 1.94; 95% CI, 1.34-2.83); people having three or more complex chronic diseases (OR, 1.59; 95% CI, 1.19-2.11); people having diabetes (OR, 1.81; 95% CI, 1.41-2.32); or people having ischemic heart disease or cerebrovascular disease (OR, 6.80; 95% CI, 5.28-8.76). Also, we found that factors associated with the use of medical care at hospitals among outpatients with hypertension differed between genders. Conclusion: A variety of factors seem to be associated with the use of medical care at hospitals among outpatients with hypertension. Future research needs to find a way to help patients with hypertension visit an appropriate medical institution between clinics and hospitals.

• 한국응용과학기술학회지
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• 제38권1호
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• pp.60-74
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• 2021

본 연구의 목적은 고혈압 및 당뇨병을 진단 받은 성인의 뇌졸중 및 심근경색증의 조기 증상 인지 정도를 파악하고 비인지와 관련된 요인을 분석하기 위함이다. 2017년 지역사회건강조사 원시자료를 활용하여, 40세 이상 성인 12,277명의 자료를 분석하였다. 뇌졸중 및 심근경색증의 조기 증상 인지율은 각각 53.6%와 46.8%였다. 뇌졸중 및 심근경색증 조기 증상 비인지 요인을 평가하기 위해 로지스틱 분석을 수행하였다. 고혈압 관리 교육, 혈압 수치 및 당화혈색소 수치 인식은 다변량 분석에서 인구사회학적 변수를 보정한 후에도 뇌졸중 조기 증상 비인지와 유의한 관련이 있었다. 혈압 수치 및 당화혈색소 수치 인식은 심근경색증 조기 증상 비인지와 유의한 관련이 있었다. 그러므로 고혈압과 당뇨병을 모두 관리해야 하는 고위험군에 대한 홍보 촉진 및 교육 강화 등 심뇌혈관질환 조기 증상 인지 수준 개선을 위한 중재 및 전략의 개발이 요구된다.

• 한국융합학회논문지
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• 제13권3호
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• pp.67-75
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• 2022

의료정보는 의료기기뿐만 아니라 카메라 등의 기기로부터 다양하게 생성된다. 최근 의료빅데이터 수집 및 관리에서부터 환자의 상태분석을 위한 의료인공지능 제품 및 관련 융합기술들이 급격히 증가하고 있지만, 실용화까지의 절차들이 산재되어 있어 실적용에 어려움을 겪고 있다. 본 논문에서는 의료인공지능 기술 연구, 개발 및 실용화 절차를 간소화하고, 관련 산업 발전 가속화를 위한 지능형 병원정보시스템 모델을 제안한다. 제안한 모델은 의료기관에서 (1)다양한 기기로부터 환자 데이터의 실시간 관리, (2)의료인공지능 기술 개발에 특화된 데이터 정제 및 관리, (3)개발된 의료인공지능 기술의 실시간 적용을 통합 지원한다. 이를 이용하여 환자모니터링기기로부터 실시간 생체데이터 수집 및 의료인공지능 특화 데이터 생성 사례와 기 개발된 카메라 기반 환자 보행분석 및 뇌MRA 기반 뇌혈관질환분석 기술의 구체적 적용사례를 소개한다. 제안한 모델을 기반으로 인공지능 개발에 필요한 데이터의 보안성 증대 및 일관된 인터페이스의 플랫폼화를 통한 실용화 증대로 병원정보시스템 개선에 활용되기를 기대한다.

• Journal of Ginseng Research
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• 제46권4호
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• pp.515-525
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• 2022

Background: The incidence of ischemic cerebrovascular disease is increasing in recent years and has been one of the leading causes of neurological dysfunction and death. Ginsenoside Rg1 has been found to protect against neuronal damage in many neurodegenerative diseases. However, the effect and mechanism by which Rg1 protects against cerebral ischemia-reperfusion injury (CIRI) are not fully understood. Here, we report the neuroprotective effects of Rg1 treatment on CIRI and its possible mechanisms in mice. Methods: A bilateral common carotid artery ligation was used to establish a chronic CIRI model in mice. HT22 cells were treated with Rg1 after OGD/R to study its effect on [Ca²⁺]_i. The open-field test and poleclimbing experiment were used to detect behavioral injury. The laser speckle blood flowmeter was used to measure brain blood flow. The Nissl and H&E staining were used to examine the neuronal damage. The Western blotting was used to examine MAP2, PSD95, Tau, p-Tau, NOX2, PLC, p-PLC, CN, NFAT1, and NLRP1 expression. Calcium imaging was used to test the level of [Ca²⁺]_i. Results: Rg1 treatment significantly improved cerebral blood flow, locomotion, and limb coordination, reduced ROS production, increased MAP2 and PSD95 expression, and decreased p-Tau, NOX2, p-PLC, CN, NFAT1, and NLRP1 expression. Calcium imaging results showed that Rg1 could inhibit calcium overload and resist the imbalance of calcium homeostasis after OGD/R in HT22 cells. Conclusion: Rg1 plays a neuroprotective role in attenuating CIRI by inhibiting oxidative stress, calcium overload, and neuroinflammation.

• Journal of Korean Neurosurgical Society
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• 제65권6호
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• pp.816-824
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• 2022

Objective : Emergency superficial temporal artery to middle cerebral artery (STA-MCA) anastomosis in patients with large vessel occlusion who fails mechanical thrombectomy or does not become an indication due to over the time window can be done as an alternative for blood flow restoration. The authors planned this study to quantitatively measure the degree of improvement in cerebral perfusion flow using perfusion magnetic resonance imaging (MRI) after bypass surgery and to find out what factors are related to the outcome of the bypass surgery. Methods : For a total of 107 patients who underwent emergent STA-MCA bypass surgery with large vessel occlusion, the National Institute of Health stroke scale (NIHSS), modified Rankin score (mRS), infarction volume, and hypoperfusion area volume was calculated, the duration between symptom onset and reperfusion time, occlusion site and infarction type were analyzed. After emergency STA-MCA bypass, hypoperfusion area volume at post-operative 7 days was calculated and analyzed compared with pre-operative hypoperfusion area volume. The factors affecting the improvement of mRS were analyzed. The clinical status of patients who underwent emergency bypass was investigated by mRS and NIHSS before and after surgery, and changes in infarct volume, extent, degree of collateral circulation, and hypoperfusion area volume were measured using MRI and digital subtraction angiography (DSA). Results : The preoperative infarction volume was median 10 mL and the hypoperfusion area volume was median 101 mL. NIHSS was a median of 8 points, and the last normal to operation time was a median of 60.7 hours. STA patency was fair in 97.1% of patients at 6 months follow-up DSA and recanalization of the occluded vessel was confirmed at 26.5% of patients. Infarction volume significantly influenced the improvement of mRS (p=0.010) but preoperative hypoperfusion volume was not significantly influenced (p=0.192), and the infarction type showed marginal significance (p=0.0508). Preoperative NIHSS, initial mRS, occlusion vessel type, and last normal to operation time did not influence the improvement of mRS (p=0.272, 0.941, 0.354, and 0.391). Conclusion : In a patient who had an acute cerebral infarction due to large vessel occlusion with large ischemic penumbra but was unable to perform mechanical thrombectomy, STA-MCA bypass could be performed. By using time-to-peak images of perfusion MRI, it is possible to quickly and easily confirm that the brain tissue at risk is preserved and that the ischemic penumbra is recovered to a normal blood flow state.

• 한국인터넷방송통신학회논문지
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• 제23권2호
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• pp.119-129
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• 2023

수면 무호흡증은 고혈압, 뇌졸중, 심근경색, 우울증 및 인지기능 장애 등 다양한 2차 질환을 일으키며 심혈관 및 뇌혈관 질환의 발생 원인이 되기에 수면 무호흡의 조기 발견 및 지속적인 관리가 절실히 필요하다. 본 연구에서는 수면 중 호흡을 모니터링하기 위해 목의 기관 부위에서 호흡에 의한 미세한 진동을 검출할 수 있는 PVDF 필름 진동 센서를 이용하여 정상호흡과 수면 무호흡을 판단하는 웨어러블 디바이스를 개발하였다. 검출된 호흡음 데이터를 기반으로 호흡수, 무호흡 등의 변수들을 추출하였고 잡음 제거 알고리즘을 수립하여 잡음 신호가 있을 시에도 영향을 최소화하는 방법을 적용하였다. 또한 변동 문턱치 알고리즘을 수립하여 불규칙적인 호흡 패턴에서도 분석이 가능함을 확인하였다. 그 결과 분당 호흡수의 정확도는 98.7%이고 무호흡 횟수와 무호흡 지속 시간에 대한 개발기기와 수면다원검사의 결과를 비교한 결과 무호흡 횟수 측정 정확도는 92.6%, 무호흡 지속 시간의 정확도는 94.0%임을 확인하였다. 본 연구의 결과는 일상생활 중 가정에서 간편하고 정확하게 수면 정보를 모니터링하고 치료 경과를 확인할 수 있는 웨어러블 디바이스의 제품화로 이어져 수면장애의 관리에 큰 도움이 될 것이다.

• 대한한방내과학회지
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• 제44권2호
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• pp.167-177
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• 2023

Background: Pressure injuries are localized areas of damage to the skin and/or underlying tissue, usually over a bony prominence due to pressure. Cerebrovascular disease increases the risk of pressure injuries due to the immobility caused by physical paralysis. The general approach to managing a patient with pressure injuries should include pain relief, the treatment of the infection, optimizing nutritional intake, proper positioning, and contamination prevention. Nonetheless, the duration of treatment for pressure injuries varies from person to person. Case report: An 80-year-old female intracerebral hemorrhage patient developed a pressure injury. To improve the injury faster, a Radix Astragali pharmacoacupuncture solution was applied to the pressure sore. The pressure injury's width, length, and depth was assessed using a ruler, and the exudate amount and tissue types were assessed. The treatment was performed for 35 days. The rate at which the size of the pressure sore lessened increased since the Radix Astragali pharmacoacupuncture solution was applied to the pressure sore. In addition, the tissue type of the pressure injury improved, and the exudates decreased. There was no significant difference in the Pressure Ulcer Scale for Healing Tool 3.0, since the Radix Astragali pharmacoacupuncture solution was applied to the pressure injury. Conclusion: This clinical case study suggests that the Radix Astragali pharmacoacupuncture solution might be effective in speeding up the healing of pressure injuries.