• Macromolecular Research
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• 제14권1호
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• pp.94-100
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• 2006

Although the peripheral nerve system has a relatively good regenerating capacity compared to the central nerve system, peripheral nerve repair remains a clinical challenge as restoration of normal nerve function is highly variable. Synthetic tubular nerve conduits were designed as an alternative repair method in order to replace the need for an isograft. These nerve conduits guide regenerating axons from the proximal toward the distal end, maintain within growth-promoting molecules released by the nerve stumps, and protect regenerating axons from infiltrating scar tissue. In this work, we prepared cinnamoylated alginate (CA)-collagen-chitosan nerve conduit using the lyophilization method to generate a controllable parallel channel in the center and then investigated its influence on peripheral nerve regeneration in an animal study. At 12 weeks after implantation, histological study showed that tissue cable was continuously bridging the gap of the sciatic nerve in all rats. Our newly developed nerve conduit is a promising tool for use in peripheral nerve regeneration and provides a suitable experimental model for future clinical application.

• 대한수의학회지
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• 제26권2호
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• pp.195-199
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• 1986

The papillary tubercles (PTs) developed on the splenic capsule of normal Landrace pigs were collected and their histological structures were observed with light microscope. The results were summarized as follows : 1. The external features of the PTs were smooth spherical or oval form protruded on the splenic capsules. On cross section of PTs, the shapes were predominantly round or elliptical single follicular form, and were often multifollicular and irregular form in some PTs. 2. The PTs were interposed into the splenic capsule. Therefore the peripheral boundary of PT was consisted of splenic capsular tissue and this tissue was covered with mesothelium, The basal tissues of PT were consisted of thick connective tissue and smooth muscle of splenic capsule, and capsular foramen for transport tract between splenic parenchyma and the PT was found at the center of the basal boundary of PT. 3. The basal region of PT was composed of parenchyma and this tissue was the splenic red pulp but the central and peripheral regions of PT contained much more erythrocytes than in the splenic parenchymae. 4. The splenic parenchymae adjoining to PT contained more erythrocytes than in other splenic parenchymal regions and parallel fixed cells directed to the capsular foramen.

• The Korean Journal of Physiology and Pharmacology
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• 제20권4호
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• pp.325-332
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• 2016

Resveratrol, a phytoalexin, is reported to activate AMP-activated protein kinase (AMPK) in vascular cells. The blood-brain barrier (BBB), formed by specialized brain endothelial cells that are interconnected by tight junctions, strictly regulates paracellular permeability to maintain an optimal extracellular environment for brain homeostasis. The aim of this study was to elucidate the effects of resveratrol and the role of AMPK in BBB dysfunction induced by lipopolysaccharide (LPS). Exposure of human brain microvascular endothelial cells (HBMECs) to LPS ($1{\mu}g/ml$) for 4 to 24 hours week dramatically increased the permeability of the BBB in parallel with lowered expression levels of occluding and claudin-5, which are essential to maintain tight junctions in HBMECs. In addition, LPS significantly increased the reactive oxygen species (ROS) productions. All effects induced by LPS in HBVMCs were reversed by adenoviral overexpression of superoxide dismutase, inhibition of NAD(P) H oxidase by apocynin or gain-function of AMPK by adenoviral overexpression of constitutively active mutant (AMPK-CA) or by resveratrol. Finally, upregulation of AMPK by either AMPK-CA or resveratrol abolished the levels of LPS-enhanced NAD(P)H oxidase subunits protein expressions. We conclude that AMPK activation by resveratrol improves the integrity of the BBB disrupted by LPS through suppressing the induction of NAD(P)H oxidase-derived ROS in HBMECs.

• 한국통신학회논문지
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• 제16권6호
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• pp.556-565
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• 1991

A가 nxn 삼중대각행렬인 선형방정식 Ax=b를 WZ분해 알고리즘을 이용하여 해석하고 이 알고리즘을 CAM Systolic Array 로 구현했다. 그리고 이 어레이를 평가하기위하여 LU분해 알고리즘을 제시하고 이를 W, D, Z분해 알고리즘과 비교 고찰한 결과 LU분해 알고리즘 보다 WZ분해 알고리즘이 1/4정도 가까운 시간으로 실행시간이 단축될 수 있었다. CAM Systolic Array에서 실행되는 각 단계를 1 time stpe으로 가정하면 2n+1 times이 필요하고 CAM의 데이타 워드는 메트릭스 원소의 값과 행번호, 연산의 형태 및 상태에 관한 정보를 포함하고 pipeline식으로 각 프로세서를 systolic processing하므로서 중앙제어가 필요없고, data brodcasting도 피할 수 있다.

• Journal of Plant Biology
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• 제30권4호
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• pp.225-247
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• 1987

Meiosis and postmeiotic mitosis in Boletus rubinellus were examined ultrastructurally. Meriosis occurred at the apex of the basidium. A sausage-shaped spindle pole body(SPB) was observed along with the presence of synaptonemal complexes during pachytene and a diglobular SPB was present on late pachytene or diplotene nuclei. During metaphase I, the monoglobular SPB at the spindle pole was surrounded bya membrane and the nuclear enveloope was discontinuous. At anaphase I, the chromosomes became better defined and formed a central spindle. The nucleolus was extruded from the nucleus. During anaphase I, the SPB was excluded from the chromosomal region by a membrane and both poles were fully separated to opposite sides of the basidial wall. In meiosis II, the two nuclei divided synchronously and the spindles were parallel. The spindles were smaller than in meiosis I, while the SPB was approximately the same size as that of the similar stage in meiosis I. During anaphasetelophase II, the SPB was surrounded by a cap of endoplasmic reticulum (ER) that delimited it from the spindle. The postmeiotic interphase nuclei migrated to the mid-region of the basidium before migration to the spores. The SPB at this stage was diglobular. A postmeiotic mitosis occurred within the basidiospore, and the plane of the spindle was obique to the long axis of the spore. The spindle and SPB were smaller than at meiosis I and there were fewer nonchromosomal microtubules. At anaphase, the nucleolus was present inside the nuclear envelope but lateral to the spindle.

• 한국표면공학회지
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• 제52권6호
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• pp.357-363
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• 2019

We investigated a synthesis yield and diameter distribution of single-walled carbon nanotubes (SWNTs) with respect to the growth position in a horizontal chemical vapor deposition (CVD) chamber. Thin films and line-patterned Fe films (0.1 nm thickness) were prepared onto ST-cut quartz substrates as catalyst to compare the growth behavior. The line-patterned samples showed higher growth density and parallel alignment than those of the thin film catalyst samples. In addition, line density of the aligned SWNTs at central region of the chamber was 7.7 tubes/㎛ and increased to 13.9 tubes/㎛ at rear region of the CVD chamber. We expect that the enhanced amount of thermally decomposed feedstock gas may contribute to the growth yield enhancement at the rear region. In addition, the lamina flow in the chamber also contribute to the perfect alignment of the SWNTs based on the value of gas velocity, Reynold number, and Knudsen coefficient we employed.

• 한국지하수토양환경학회지:지하수토양환경
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• 제19권3호
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• pp.66-81
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• 2014

A Fortran program was developed to determine the optimal locations of an artificial recharge well. Three objective functions were considered: (1) maximizing the recovery rates, (2) maximizing the injection rates, and (3) minimizing the coefficient of variation of the increased pumping rates. We also suggested a new aggregate objective function which combined the first and the third objective functions. The model results showed that locating the injection well inside the cluster of pumping wells was desirable if either the recovery or the injection rate was taken into account. However, the injection well located outside the cluster evenly increased the pumping rates in existing pumping wells. Therefore, for clustered pumping wells, installing an injection well at the center or the upstream of the pumping wells seems beneficial. For linear arrangement of pumping wells parallel to the constant head boundary, locating the injection well in the upstream was recommended. On the contrary, in case of the linear arrangement perpendicular to the constant head boundary, the injection well installed on both sides of the central part of the pumping wells was preferable.

• Journal of Preventive Medicine and Public Health
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• 제40권2호
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• pp.95-101
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• 2007

Focusing on complex diseases of public health significance, strategic issues regarding the on-going Korean Genome Cohort were reviewed: target size and diseases, measurements, study design issues, and follow-up strategy of the cohort. Considering the epidemiologic characteristics of Korean population as well as strengths and drawbacks of current research environment, we tried to tailor the experience of other existing cohorts into proposals for this Korean study. Currently 100,000 individuals have been participating the new Genome Cohort in Korea. Target size of de novo collection is recommended to be set as between 300,000 to 500,000. This target size would allow acceptable power to detect genetic and environmental factors of moderate effect size and possible interactions between them. Family units and/or special subgroups are recommended to parallel main body of adult individuals to increase the overall efficiency of the study. Given that response rate to the conventional re-contact method may not be satisfactory, successful follow-up is the main key to the achievement of the Korean Genome Cohort. Access to the central database such as National Health Insurance data can provide enormous potential for near-complete case detection. Efforts to build consensus amongst scientists from broad fields and stakeholders are crucial to unleash the centralized database as well as to refine the commitment of this national project.

• Bulletin of the Korean Chemical Society
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• 제11권5호
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• pp.427-430
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• 1990

Cholesteryl aniline ($C_{33}H_{51}N$) is monoclinic, space group $P2_1$, with a = 9.020(3), b = 6.000(1), c = 27.130(9)${\AA},\;{\beta} = 98.22(2)^{\circ}$, Z = 2, Dc = 1.06 g/cm$^3$ and Dm = 1.04 g/cm$^3$. A diffraction data set was collected with Mo-$K_{\alpha}$ radiation (${\lambda} = 0.7107 {\AA}$) on a diffractometer with a graphite monochromator to a maximum 2${\theta}$ value of 50$^{\circ}$, by the ${\omega}-2{\theta}$ scan technique. The coordinates of the non-hydrogen atoms and their anisotropic temperature factors were refined by full-matrix least-squares methods to final R of 0.058. In cholesteryl group, bond distances were normal except in tail part, where high thermal vibration resulted in apparent shortening of the C-C distances. The crystal structure consists of bilayers of thickness $d_{001} = 27.13 {\AA}$, in each of which there is the tail to tail arrangement of molecules aligned in the unit cell with their long axes approximately parallel to the [104] axis. The two halves of the double layer are related to each other by the screw axis.

• Steel and Composite Structures
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• 제21권6호
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• pp.1265-1285
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• 2016

This paper presents experimental results of advanced investigation carried out on the beams reinforced with Glass Fiber Reinforced Polymer (GFRP) rebar and stirrups. Twelve beams reinforced with GFRP and one beam with steel reinforcement of size $230{\times}300{\times}2000mm$ were investigated. Longitudinal reinforcement, shear span and spacing of stirrups were the main variables to form the set. In advanced testing three types of strain gauges for steel, composite and concrete surface were applied to observe strain/stress development against the applied load. Live data were recorded from four strain gauges applied on stirrups, one at center on longitudinal reinforcement, two on the concrete surface and central deflection during the test. Although the focus of the paper was mainly on the behavior of GFRP shear reinforcement, other parallel data were observed for the completeness of the test. Design recommendations of ISIS Canada Design Manual (2007), Japan Society of Civil Engineers (1997) and American Concrete Institute (ACI-440.1R-06) were reviewed. Shear design predictions were compared with experimental results in which it was observed that all the three standards provided conservative predictions. However, ACI found most efficient compare to other two there is room to improve the efficiency of the recommendations.