Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Peripheral Nerve Regeneration Through Nerve Conduit Composed of Alginate-Collagen-Chitosan

  • Kim, Sang-Wan (Department of Polymer Science and Engineering, Sungkyunkwan University, IBEC, Seoul National University) ;
  • Bae, Hong-Ki (Department of Polymer Science and Engineering, Sungkyunkwan University, IBEC, Seoul National University) ;
  • Nam, Hye-Sung (Department of Polymer Science and Engineering, Sungkyunkwan University, IBEC, Seoul National University) ;
  • Chung, Dong-June (Department of Polymer Science and Engineering, Sungkyunkwan University, IBEC, Seoul National University) ;
  • Choung, Pill-Hoon (Department of Oral and Maxillofacial Surgery, Seoul National University)
  • Published : 2006.02.01
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Abstract

Although the peripheral nerve system has a relatively good regenerating capacity compared to the central nerve system, peripheral nerve repair remains a clinical challenge as restoration of normal nerve function is highly variable. Synthetic tubular nerve conduits were designed as an alternative repair method in order to replace the need for an isograft. These nerve conduits guide regenerating axons from the proximal toward the distal end, maintain within growth-promoting molecules released by the nerve stumps, and protect regenerating axons from infiltrating scar tissue. In this work, we prepared cinnamoylated alginate (CA)-collagen-chitosan nerve conduit using the lyophilization method to generate a controllable parallel channel in the center and then investigated its influence on peripheral nerve regeneration in an animal study. At 12 weeks after implantation, histological study showed that tissue cable was continuously bridging the gap of the sciatic nerve in all rats. Our newly developed nerve conduit is a promising tool for use in peripheral nerve regeneration and provides a suitable experimental model for future clinical application.

Keywords

References

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