Browse > Article

Strategy Considerations in Genome Cohort Construction in Korea  

Sung, Joo-Hon (Department of Preventive Medicine, Kangwon National University College of Medicine)
Cho, Sung-Il (Department of Epidemiology, Seoul National University School of Public Health)
Publication Information
Journal of Preventive Medicine and Public Health / v.40, no.2, 2007 , pp. 95-101 More about this Journal
Abstract
Focusing on complex diseases of public health significance, strategic issues regarding the on-going Korean Genome Cohort were reviewed: target size and diseases, measurements, study design issues, and follow-up strategy of the cohort. Considering the epidemiologic characteristics of Korean population as well as strengths and drawbacks of current research environment, we tried to tailor the experience of other existing cohorts into proposals for this Korean study. Currently 100,000 individuals have been participating the new Genome Cohort in Korea. Target size of de novo collection is recommended to be set as between 300,000 to 500,000. This target size would allow acceptable power to detect genetic and environmental factors of moderate effect size and possible interactions between them. Family units and/or special subgroups are recommended to parallel main body of adult individuals to increase the overall efficiency of the study. Given that response rate to the conventional re-contact method may not be satisfactory, successful follow-up is the main key to the achievement of the Korean Genome Cohort. Access to the central database such as National Health Insurance data can provide enormous potential for near-complete case detection. Efforts to build consensus amongst scientists from broad fields and stakeholders are crucial to unleash the centralized database as well as to refine the commitment of this national project.
Keywords
Cohort studies; Human genome; Genetic predisposition to disease; National Health Insurance; Republic of Korea; Follow-up studies; Biological specimen banks;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Willett WC, Blot WJ, Colditz GA, Folsom AR, Henderson BE, Stampfer MJ. Merging and emerging cohorts: not worth the wait. Nature 2007; 445(7125): 257-258   DOI   ScienceOn
2 Almasy L, Blangero J. Multipoint quantitativetrait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62(5): 1198-1211   DOI   ScienceOn
3 Sung JH. Years of life lost and health priority in Korea. Korean J Epidemiol 1997; 19(2):200-209 (Korean)
4 Peltonen L. GenomEUtwin: A strategy to identify genetic influences on health and disease. Twin Res 2003; 6(5): 354-360   DOI   ScienceOn
5 Kim HJ, Lee SM, Choi NK, Kim SH, Song HJ, Cho YK, Park BJ. Smoking and colorectal cancer risk in the Korean elderly. J Prev Med Public Health 2006; 39(2): 123-129 (Korean)   과학기술학회마을
6 Ollier W, Sprosen T, Peakman T. UK Biobank: from concept to reality. Pharmacogenomics 2005; 6(6): 639-646   DOI   ScienceOn
7 Triendl R. Japan launches controversial Biobank project. Nat Med 2003; 9(8): 982   PUBMED
8 Jee SH, Sull JW, Park J, Lee SY, Ohrr H, Guallar E, Samet JM. Body-mass index and mortality in Korean men and women. N Engl J Med 2006; 355(8): 779-787   DOI   ScienceOn
9 Murray CJ, Lopez AD, Jamison DT. The global burden of disease in 1990: summary results, sensitivity analysis and future directions. Bull World Health Organ 1994; 72(3): 495-509   PUBMED
10 Bentley DR. Genomes for medicine. Nature 2004; 429(6990): 440-445   DOI   PUBMED   ScienceOn
11 Yoo KY, Shin HR, Chang SH, Choi BY, Hong YC, Kim DH, Kang D, Cho NH, Shin C, and Jin YW for the Korean Genome Epidemiology Society. Genomic epidemiology cohorts in Korea: Present and the future. Asian Pac J Cancer Prev 2005; 6(3): 238-243   PUBMED
12 Ebrahim S, Sung J, Song YM, Ferrer RL, Lawlor DA, Davey Smith G. Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study. BMJ. 2006; 333(7557): 22   DOI   ScienceOn
13 Collins FS, Manolio TA. Merging and emerging cohorts: necessary but not sufficient.Nature 2007; 445(7125): 259   DOI   ScienceOn
14 Potter JD. Toward the last cohort. Cancer Epidemiol Biomarkers Prev 2004; 13(6): 895-897   PUBMED
15 Hakonarson H, Gulcher JR, Stefansson K. deCODE genetics, Inc. Pharmacogenomics 2003; 4(2):209-215   DOI   ScienceOn
16 Jun JK, Gwack J, Park SK, Choi YH, Kim Y, Shin A, Chang SH, Shin HR, Yoo KY. Fasting serum glucose level and gastric cancer risk in a nested case-control study. J Prev Med Pub Health 2006; 39(6): 493-498 (Korean)   과학기술학회마을
17 Ronningen KS, Paltiel L, Meltzer HM, Nordhagen R, Lie KK, Hovengen R, Haugen M, Nystad W, Magnus P, Hoppin JA. The biobank of the Norwegian mother and child cohort Study: A resource for the next 100 years. Eur J Epidemiol 2006; 21(8): 619-625   DOI   ScienceOn
18 건강보험심사평가원. 우리나라의 보험 청구자료의 진단명 정확도에 대한 연구 보고서. 건강보험평가원;2003.p.10-21
19 Collins. FS. The case for a US prospective cohort study of genes and environment. Nature 2004; 429(6990): 475-477   DOI   PUBMED   ScienceOn
20 Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30(1):97-101   DOI   ScienceOn
21 Terwilliger JD, Weiss KM. Confounding, ascertainment bias, and the blind quest for a genetic 'fountain of youth'. Ann Med 2003;35(7): 532-544   DOI   ScienceOn
22 Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in whole-genome association studies. Nature 2004;429(6990): 446-452   DOI   ScienceOn
23 Sung J, Cho SI, Lee K, Ha M, Choi EY, Choi JS, Kim H, Kim J, Hong KS, Kim Y, Yoo KY, Park C, Song YM. Healthy twin: A twinfamily study of Korea - Protocols and current status. Twin Res Hum Genet 2006; 9(6): 844-848   DOI   PUBMED
24 Manolio TA, Bailey-Wilson JE, Collins FS. Genes, environment and the value of prospective cohort studies. Nat Rev Genet 2006; 7(10): 812-820   DOI   ScienceOn
25 Glazier AM, Nadeau JH, Aitman TJ. Finding genes that underlie complex traits. Science 2002;298(5602): 2345-2349   DOI   PUBMED   ScienceOn