• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
• /
• pp.255.2-255.2
• /
• 2003

Monoamine oxidase (MAO) is flavin-containing enzyme that catalyzes the oxidation of variety of amine-containing neurotransmitters such as catecholamines and serotonin to yield the corresponding aldehyde. Thus, MAO activity might play important roles in some pathological states of central nervous system diseases such as depression, alcoholism, and schizophrenia. (omitted)

• 웰빙융합연구
• /
• 제5권4호
• /
• pp.33-37
• /
• 2022

Purpose: This study aims to understand the trend and central concept of domestic researches on laughter therapy. For the analysis, this study used total 72 theses verified by inputting the keyword 'laughter therapy' from 2007 to 2021. Research design, data and methodology: This study performed the development and analysis of keyword co-occurrence network, analyzed the types of researches through topic modeling, and verified the visualized word cloud and sociogram. The keyword data that was cleaned through preprocessing, was analyzed in the method of centrality analysis and topic modeling through the 1-mode matrix conversion process by using the NetMiner (version 4.4) Program. Results: The keywords that most appeared for last 14 years were laughter therapy, depression, the elderly, and stress. The five topics analyzed in thesis data from 2007 to 2021 were therapy, cognitive behavior, quality of life, stress, and the elderly. Conclusions: This study understood the flow and trend of research topics of domestic laughter therapy for last 14 years, and there should be continuous researches on laughter therapy, which reflects the flow of time in the future.

• 한국지구과학회지
• /
• 제31권4호
• /
• pp.322-334
• /
• 2010

최근 30년간(1979-2008년) 한반도 주변($32-36^{\circ}N$, $122-132^{\circ}E$)에서 태풍이 약화될 때 한국에서 나타나는 시공간적 강수 특징을 분석하였다. 약화 유형은 온대저기압으로 약화되는 태풍(Weakened to Extratropical Cyclone, WEC)과 열대성 저압부로 약화되는 태풍(Weakened to Tropical Depression, WTD)으로 구분하였다. WEC의 경우, 강수량은 전국에 걸쳐 골고루 분포하였으며 남해안에서 가장 많았다. WTD의 경우, 강수량은 남해안에서 가장 많았지만 중부 및 내륙지역은 적었다. 두 경우의 강수량 차이는 Region 2(전라남도, 경상남도, 경상북도 남동부 지역, 제주도)에서는 거의 없었으며, Region 1(중부지방, 전라북도, 경상북도 내륙)에서는 WTD보다 WEC일 때 강수량이 더 많았다. 태풍이 한반도로 접근 할 때 WEC의 경우 태풍의 북서쪽에는 상층의 발달된 잠재소용돌이도와 하층의 온도골이 위치하고 있었으며, 태풍의 북동쪽에는 상층 제트 및 강한 상층 발산역이 위치하였다. 이는 태풍 전면에 경압교란과 비단열 과정을 발달시켰고 이로 인해 강수영역이 넓게 형성된 것으로 추측되었다. 그러나 WTD의 경우에서는 강한 잠재소용돌이도나 온도골, 상층제트가 태풍 주변에 나타나지 않았으며, 이로 인해 강수영역이 좁게 형성되었다.

• Journal of Hospice and Palliative Care
• /
• 제18권2호
• /
• pp.136-147
• /
• 2015

목적: 본 연구는 통합적 완화 돌봄 중재연구가 말기 암환자의 삶의 질에 미치는 효과 크기를 분석하기 위한 메타분석 연구이다. 방법: 말기 환자와 통합적 완화 돌봄 중재 및 연구 설계를 나타내는 용어들을 병합하여 PubMed, Cochrane Library CENTRAL, LWW (Ovid), CINAHL 및 국내 데이터 베이스에서 검색하였다. 논문의 질평가는 RCT 연구인 경우 RoB 도구를 사용하였으며, Non-RCT 연구인 경우는 RoBANS를 사용하였다. 중재의 효과크기는 Stata 10 프로그램으로 메타분석 하였다. 결과: 8편의 연구가 최종선정 되었으며, 총 대상자의 수는 356명이었다. 통합적 완화 돌봄 중재는 평균 6.5주, 5.6 세션으로 이루어졌으며, 한 세션당 평균 47.8분이 소요되었다. 효과는 동질성 및 하위그룹 분석을 실시하였다. 통합적 완화 돌봄 중재의 효과는 삶의 질(ES=1.83, P=0.018, $l^2=92%$), 영적 안녕(ES=0.78, P=0.040, $l^2=0$), 우울(ES=0.86, P<0.001, $l^2=32$) 및 불안(ES=0.69, P=0.041, $l^2=71.1$)에서 효과가 있었다. 그러나 말기암환자의 통증(ES=0.365, P=0.230, $l^2=69.8$)에는 효과가 없었다. 결론: 이상의 결과로 통합적 완화 돌봄 중재는 비록 통증은 완화시키지는 못했으나 우울과 불안을 감소시키고 영적 안녕과 삶의 질을 높이는 것으로 나타나, 통합적 완화 돌봄 중재는 말기암환자의 사회심리영적 차원의 삶의 질을 증진시킬 수 있다고 본다.

• 한국임상약학회지
• /
• 제27권4호
• /
• pp.267-275
• /
• 2017

Background and Objective: Whabyung is a Korean cultural disorder characterized by a combination of emotional stress and physical symptoms. Acupuncture, herbal medicines and other complementary medicinal treatments are used to treat the symptoms of whabyung. The purpose of this study is to investigate the effects of acupuncture treatment and herbal medicine treatments on anger, anxiety and depression of whabyung. Methods: Using PubMed, CENTRAL, AMED, MEDLINE, EMBASE, MEDLINE, CINAHL, Cnii, CNKI, J-SATGE, PsycArticles, KISS, KoreaMed, kmbase, NDSL, RISS, OASIS and Korean Traditional Knowledge Portal, articles published by March 2017 for whabyung or whabyung-related syndrome were searched. The quality of selected articles was evaluated using RoB and RoBANS. The effects of acupuncture and herbal medicines on anger, anxiety, and depression levels of whabyung patients were considered for meta-analyses. Results: Of the total 2408 articles retrieved from the database, 11 were finally selected and 4 articles were used for meta-analyses. Acupuncture reduced whabyung patients' anger and anxiety. Especially, the state anxiety was significantly reduced (effect size= -0.676, p= .026). Herbal medicine had effects on reducing anxiety and state anger while trait anger was increased without statistical significance. Conclusion: The present study showed the effectiveness of acupuncture and herbal medicines for whabyung patients in general. However, considering the limited availability of articles and the heterogeneity between them included for the meta-analysis, the results should be generalized with caution. In the future, more studies within the structure of evidence-based medicine need to be conducted to generate objective and valid evidences of korean medicine.

• 정신신체의학
• /
• 제20권2호
• /
• pp.135-138
• /
• 2012

기능성 위장관 장애(functional gastrointestinal disorder, FGID)의 생물학적 병태생리는 아직 명확하지 않은 실정이나 최근에 뇌-장관 축(brain-gut axis, BGA) 모델이 각광받고 있다. BGA 모델은 중추신경계(CNS)와 장관신경계(ENS)가 신경계, 신경내분비계, 신경면역계 등으로 밀접하게 연계되어 양방향성으로 항상성을 유지한다는 이론이다. 또한 BGA는 FGID에 대한 항우울제 효과의 이론적 근거를 제공한다. 저자들은 세로토닌 노르에프네프린 재흡수 차단제인 duloxetine이 목 이물감, 우울감을 보이는 환자와 상부 위장관 팽만감, 건강염려증적 불안을 보이는 환자에서 위장관 증상 및 정신의학적 증상에 효과적이었음을 경험하였다. 이에 두 증례보고를 통하여 BGA에 대해서 간략히 검토하고 duloxetine의 효과를 BGA의 측면에서 고찰하였다. 이 두 증례에서 duloxetine의 장관에서 뇌로의 영향(bottom-up regulation)으로는 세로토닌 수용체, 노르에피네프린 수용체 그리고 부신피질자극호르몬방출인자(CRF) 길항효과를 통해서 내장과민성(visceral hypersensitivity) 및 정신의학적 증상을 호전시키고, 뇌에서 장관으로의 영향(top-down regulation)으로는 우울과 불안을 호전시킴으로 위장관 증상에 영향을 미친 것으로 추정해 볼 수 있다.

• 대한간호학회지
• /
• 제44권5호
• /
• pp.471-483
• /
• 2014

Purpose: This study was done to evaluate the effects of dignity interventions on depression, anxiety and meaning of life in terminally ill patients. Methods: PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL and several Korean databases were searched. The main search strategy combined terms indicating dignity intervention, presence of terminal illness and study design. Methodological quality was assessed using Cochrane's Risk of Bias for randomized studies and Risk of Bias Assessment tool for non randomized studies. Data were analyzed by the RevMan 5.2.11 program of Cochrane Library. Results: Twelve clinical trials met the inclusion criteria with a total of 878 participants. Dignity intervention was conducted for a mean of 2.2 weeks, 2.8 sessions and an average of 48.7 minutes per session. Effect sizes were heterogeneous and subgroup analysis was done. Dignity interventions had a significant effect on depression (ES= -1.05, p<.001, $I^2$=15%) and anxiety (ES= -1.01, p<.001, $I^2$=0). For meaning of life, dignity interventions were effective (ES= -1.64, p=.005) and effect sizes were still heterogeneous. Conclusion: Results support findings that dignity interventions can assist terminal ill patients in reducing emotional distress and improving meaning of life. Further well-designed dignity studies will lead to better understanding of the effects of treatments on spiritual well-being.

• 수산경영론집
• /
• 제24권2호
• /
• pp.17-53
• /
• 1993

Pusan is the largest fishing port in Korea, and deals with more than I million ton of fish catches annually, including catches of coastal and off-shore fisheries as well as those of deep-sea fishery. However, it hen had no fishing port facilities specialized fer deep-sea fishery since it started 30 years ago. Economic and physical losses resulting from this have teen enormous. Although fishing port facilities are a part of infra-structures built by Governments, the construction of them has been delayed due to financial difficulties of Central or local governments. To overcome this harsh situation to which deep-sea fishery cooperations faced, some cooperations have decided to construct fishing port facilities including fish-pier specialized for deep-sea fishery in Gamcheon port. The construction expenses of these facilities were financed by private funds to which they themselves jointly contributed. As a result, a fish-[pier, which has the capacity of serving one fishing vessel of 10, 000 ton or four of 5, 000 ton or four of 1, 000 ton at the same time, will be opened in here by 1994. The paper examines the master plan to revitalize the deep-sea fisheries industry in a deep depression with the opening of these physical facilities. The framwork of the plan is pursued in two different aspects, which are both hardware and software. In a hardware aspect, the plan in to develop Pusan into a city which is suitable for one of the best fishing ports in the world. That is, it is to develop the city into a place famous for sightseeing as well as the distribution and processing of fish-products centering around fish-piers. On the other hand, in a software aspet, it is regarding improvement of the distribution system of fish-products. One way to do that is to make up some deficiencies of the current system of a producers' joint sale. And the other is to establish an exchange of fish-products futures. Through these institutions, we could abrsorb speculative funds, which would otherwise be invested in speculation on fish-products, into productive investment opportunities, We believe that if the plan is realized, the deep-sea fishery in Korea will revive from a long-tasted depression and make progress to become one of the mai industries of Korea.

• 동의생리병리학회지
• /
• 제34권3호
• /
• pp.117-125
• /
• 2020

The purpose of this review is to confirm whether Soyo-san (Xiaoyao-san) and its modifications is effective on alleviating clinical symptoms in chronic fatigue syndrome (CFS) patients. We collected clinical trials (randomized controlled trial, quasi-randomized controlled trial, controlled clinical trial) to investigate the effects of Soyo-san and its modifications on general symptoms, fatigue, depression and anxiety in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, Embase, CNKI, CQVIP, Wanfang, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found studies to conform with prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified based on the interventions in experimental and control group. Eight randomized controlled trials and one controlled clinical trial (total 921 participants) were eligible and their results were synthesized in the meta analysis. The synthesis showed a considerable effect of Soyo-san and its modifications on improvement of general symptoms (relative risk 0.27 [95% CI 0.19 to 0.39], Z=7.03, P<0.00001; I2=0%) and fatigue severity (SMD -1.20 [95% CI -1.46 to -0.93], Z=8.78, P<0.00001; I2=52%) in CFS patients, while Effect on depression and anxiety were inconclusive. We found that Soyo-san and its modifications were effective for improvement of general symptoms and fatigue severity in CFS post-treatment.

• 대한임상독성학회지
• /
• 제19권2호
• /
• pp.133-138
• /
• 2021

Glufosinate-containing herbicides is a non-selective herbicide commonly used worldwide. As the use of them increased gradually since paraquat was banned in 2012, the number of suicides by their ingestion is also increasing continuously. Complications of glufosinate-containing herbicide poisoning include various central nervous system (CNS) toxicities such as convulsions, loss of consciousness, memory impairment, and respiratory depression, which may be accompanied by hemodynamic changes such as bradycardia and hypotension. However, it is very rare that arrhythmias other than bradycardia occurred and Takotsubo cardiomyopathy was combined due to cardiotoxicity. A 71-year-old female patient was transferred to our hospital after ingesting 500 mL of glufosinate-containing herbicide and receiving 5 L of gastric lavage at a local hospital. A few hours later, she presented stuporous mentality, respiratory depression, and convulsions, and was accompanied by hypotension and bradycardia. On the second day of admission, electrocardiogram (ECG) showed bradycardia and QTc prolongation with hemodynamic Instability. Accordingly, we conducted the early treatment with continuous renal replacement therapy (CRRT) and the application of temporary cardiac pacemaker. An echocardiogram demonstrated decreased ejection fraction (EF) and Takotsubo cardiomyopathy on the third day of admission. Then, she was discharged safely with conservative treatment. At the follow-up after 1 year, Takotsubo cardiomyopathy, EF and QTc prolongation were recovered on echocardiogram and ECG. Because cardiac toxicity after glufosinate-containing herbicide poisoning may cause life-threatening consequences, caution is required while treating the patient. Therefore, if electrocardiogram changes are seen in the elderly with a large amount of glufosinate herbicide ingestion, additional cardiac function test through echocardiography should be concerned, and early treatment through CRRT or artificial cardiac pacing should be considered.