• Journal of Microbiology and Biotechnology
• /
• v.10 no.6
• /
• pp.753-758
• /
• 2000

Human leptin is identified as a 16kDa (146 amino acids) protein secreted from adipocytes which influences body weight homeostasis. In order to produce active leptin, the human obese gene coding for leptin was expressed in Bacillus subtilis WB600 strain which is deficient in six extracellular proteases. The recombinant leptin was produced in a culture supernatant, and in a culture supernatant, it was contained as high as 48% for total proteins. After simple purification steps, which consisted of ammonium sulfate precipitation and anion-exchange column chromatography, 2.3 mg of leptin with a purity greater than 95% was obtained from the 0.51 culture with the recovery yield of 38.3%. The purified leptin showed the correct folding structure with one disulfied bond.

• Journal of the Korean Society for Precision Engineering
• /
• v.21 no.8
• /
• pp.164-170
• /
• 2004

The skin movement artifacts are referred to as the relative motion of skin with respect to the motion of underlying bones. This is of great importance in joint biomechanics or internal kinematics of human body. This paper describes a novel experiment that measures the skin movement of a hand based on MR(magnetic resonance) images in conjunction with surface modeling techniques. The proposed approach consists of 3 phases: (1) MR scanning of a hand with surface makers, (2) 3D reconstruction from the MR images, and (3) registration of the 3D models. The MR images of the hand are captured by 3 different postures. And the surface makers which are attached to the skin are employed to trace the skin motion. After reconstruction of 3D models from the scanned MR images, the global registration is applied to the 3D models based on the particular bone shape of different postures. The results of registration are then used to trace the skin movement by measuring the positions of the surface markers.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.29 no.6
• /
• pp.411-414
• /
• 2018

In this paper, we propose a radar image extraction scheme for frequency modulated continuous wave radar-based human motion indication. We extracted three-dimensional(3D) range-velocity-angle spectra and generated three micro-profile images by compressing the 3D images in all three directions in every frame. Furthermore, we used body echo suppression to make use of the weak reelection such as in hands and arms. By applying the complete images to classifiers, various human motions can be indicated.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.22 no.12
• /
• pp.1116-1123
• /
• 2011

In this paper, we studied the propagation of the radio wave in the human body for WBAN system and proposed the path-loss models applicable in the MICS and ISM frequency band. Human Tissues are composed of complicate organ. So it is difficult to measure to insert the probe in human body. Accordingly, the equations were modelled by electromagnetic analysis using the numerical phantom based on the real human. The numerical analysis used XFDTD 6.5 of Remcom co. in commercial software based on the Finite-Difference Time-Domain method. Human body model used a standard adult Korean model developed by ETRI. The proposed channel models will be very helpful to design the WBAN system.

• Tuberculosis and Respiratory Diseases
• /
• v.73 no.6
• /
• pp.336-341
• /
• 2012

Primary effusion lymphoma (PEL) is a rare type of lymphoma that arises in the body cavity without detectable masses. It is associated with human herpes virus-8 (HHV-8), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV). Recently, PEL unrelated to viral infection has been reported and it has been termed HHV-8 unrelated primary effusion lymphoma-like lymphoma (HHV-8 unrelated PEL-like lymphoma). Here, we report a case of HHV-8 unrelated PEL-like lymphoma in an 80-year-old woman. Chest X-ray and computed tomography revealed left-sided pleural effusion. Pleural effusion analysis and mediastinoscopic biopsy showed atypical cells that had originated from the B cells. The cells were positive for CD20 and bcl-2, but negative for CD3, CD5, CD21, CD30, CD138, epithelial membrane antigen, and HHV-8. Serological tests for HIV and EBV were negative. Considering the patient's age, further treatments were not performed. She has shown good prognosis without chemotherapy for more than 18 months.

• Journal of Nutrition and Health
• /
• v.39 no.8
• /
• pp.733-741
• /
• 2006

The study was conducted to investigate the effects of dietary calcium and soy isoflavone on body fat and lipid metabolism in high fat-induced obesity. Four week old female C57/BL6J mice, known as a good model of diet-induced obesity, were fed low Ca and high fat diet for 6 weeks. After induced obesity, mice were divided into six groups according to diets varying calcium contents (0.1 or 1.5%) and genistein contents (0 or 500 or 1,000 ppm). Body weight, fat pad (perirenal fat and parameterial fat), adipocyte size, serum total lipid and total cholesterol were significantly decreased by both high Ca intake and genistein supplementation. However, the effect of genistein supplementation showed in low Ca-fed groups. Serum LDL-cholesterol and TG were significantly decreased by high Ca intake and genistein supplementation, respectively. In liver, lipogenic enzymes (fatty acid synthase and malic enzyme) activity and TG were significantly decreased by both high Ca intake and genistein supplementation. This inhibitory effect of genistein on lipogenic enzymes showed in low Ca-fed groups. But liver total cholesterol and total lipid were significantly decreased by high Ca intake and genistein supplementation, respectively. Fecal excretion of total lipid, total cholesterol and TG were significantly increased by high Ca intake, not by genistein supplementation. In conclusion, high calcium intake and genistein supplement may be beneficial for suppression of obesity through direct anti-adipogenesis by decreasing fat weight and size and indirect anti-lipo-genesis by inhibiting lipogenic enzymes activity and improving lipid profile.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.3 no.1
• /
• pp.85-92
• /
• 1997

To understand the dynamics of a drifting object, an analysis based on fluid dynamics theory is presented. A simplified analysis shows a consistency with the linear formula currently used for search and rescue mission. Also an experiment using miniatured human models has been conducted to study the drift characteristics of Person-in-Water. The tests were carried out at the water channel facility and the models were tested in different positions and styles. The measured drag coefficients for human body ranged over 0.4-1.2.

• Proceedings of the Korea Society for Simulation Conference
• /
• 1999.04a
• /
• pp.147-151
• /
• 1999

This paper extends and enhances the existing inverse kinematics technique using the concept of motion characteristic capturing. Motion characteristic capturing is not about measuring motion by tracking body points. Instead, it starts from pre-measured motion data, extracts the motion characteristics, and applies them in animating other bodies. The resulting motion resembles the originally measured one in spite of arbitrary dimensional differences between the bodies. Motion characteristics capturing is a new principle in kinematic motion generalization to process measurements and generate realistic animation of human being or other living creatures.

• The Journal of Korea Robotics Society
• /
• v.11 no.3
• /
• pp.183-192
• /
• 2016

Generating motion of center of mass for biped robots is a challenging issue since biped robots can easily lose balance due to limited contact area between foot and ground. In this paper, we propose force control method to generate high-speed motion of the center of mass for horizontal direction without losing balancing condition. Contact consistent multi-body dynamics of the robot is used to calculate force for horizontal direction of the center of mass considering balance. The calculated force is applied for acceleration or deceleration of the center of mass to generate high speed motion. The linear inverted pendulum model is used to estimate motion of the center of mass and the estimated motion is used to select either maximum or minimum force to stop at goal position. The proposed method is verified by experiments using 12-DOF torque controlled human sized legged robot.

• Korean Institute of Interior Design Journal
• /
• v.15 no.2 s.55
• /
• pp.56-64
• /
• 2006

From ancient times to today the formation of centrality in architecture has taken very important role as an organizing device. However after 19th century modem architecture focused on the universal aspect and homogeneity of space, and developed its own vocabulary through de-centralization. Since 1960's the reflections on de-humanized space of modem space have been evloved. As those movement has been understood seriously, the centrality can be changed to phenomenological one. And The phenomenological centrality maintains organic balance with its surroundings not trying to form a hierarchic system. So it shows human-oriented tendency and facilitates experiential movements of human body. And it also gives a sense of being. The phenomenological centrality is comprised of center, boundary, and two types of axis. The characteristics of phenomenological centrality can be analyzed as practical and meaningful center, visible boundary, experiential movement, and unexpectable encounters with spaces and nature.