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http://dx.doi.org/10.4046/trd.2012.73.6.336

A Case of Human Herpes Virus-8 Unrelated Primary Effusion Lymphoma-Like Lymphoma Presented as Pleural Effusion  

Kim, Kyung Ho (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine)
Lee, Ji-Hyun (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine)
Jeong, Hye Cheol (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine)
Kim, Gun-Woo (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine)
Song, Sang Hee (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine)
Jung, So-Young (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine)
Kim, Gwang Il (Department of Pathology, CHA Bundang Medical Center, CHA University College of Medicine)
Kim, Eun Kyung (Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.73, no.6, 2012 , pp. 336-341 More about this Journal
Abstract
Primary effusion lymphoma (PEL) is a rare type of lymphoma that arises in the body cavity without detectable masses. It is associated with human herpes virus-8 (HHV-8), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV). Recently, PEL unrelated to viral infection has been reported and it has been termed HHV-8 unrelated primary effusion lymphoma-like lymphoma (HHV-8 unrelated PEL-like lymphoma). Here, we report a case of HHV-8 unrelated PEL-like lymphoma in an 80-year-old woman. Chest X-ray and computed tomography revealed left-sided pleural effusion. Pleural effusion analysis and mediastinoscopic biopsy showed atypical cells that had originated from the B cells. The cells were positive for CD20 and bcl-2, but negative for CD3, CD5, CD21, CD30, CD138, epithelial membrane antigen, and HHV-8. Serological tests for HIV and EBV were negative. Considering the patient's age, further treatments were not performed. She has shown good prognosis without chemotherapy for more than 18 months.
Keywords
Lymphoma, Primary Effusion; Herpesvirus 8, Human; Pleural Effusion;
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