• Journal of Genetic Medicine
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• v.10 no.2
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• pp.88-93
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• 2013

Alexander disease (ALXD) is a rare demyelinating disease of the white matter of the brain that is caused by a mutation in the glial fibrillary acidic protein (GFAP) gene. The overexpression of GFAP in astrocytes induces a failure in the developmental growth of the myelin sheath. The neurodegenerative destruction of the myelin sheath of the white matter is accompanied by an accumulation of abnormal deposits of Rosenthal fibers in astrocytes, which is the hallmark of ALXD. The disease can be divided into four groups based on the onset age of the patients: neonatal, infantile, juvenile, or adult. Early-onset disease is more severe, progresses rapidly, and results in a shorter life span than late-onset cases. Magnetic resonance imaging and genetic tests are mostly used for diagnostic purposes. Pathological tests of brain tissue for Rosenthal fibers are definitive diagnostic methods. Therapeutic strategies are being investigated. Ceftriaxone, which is an enhancer of glial glutamate transporter (GLT-1) expression, is currently in clinical trials for the treatment of patients with ALXD. To date, there are no clinically available treatments. The cause, pathology, pathophysiology, inheritance, clinical features, diagnosis, and treatment of ALXD will be reviewed comprehensively.

• Journal of Society of Preventive Korean Medicine
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• v.25 no.3
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• pp.25-37
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• 2021

Objectives : To investigate the effectiveness of Korean Medicine services use on the all-cause mortality and incidence of Parkinson's disease(PD) in elderly patients with chronic disease based on the National Health Insurance Service Corhort Database (elderly), called as the NHIS-senior. Methods : This study was a retrospective cohort analysis conducted using the NHIS-senior. Patients with chronic diseases over 65 years old who were not diagnosed PD during 2007-2009 were identified. The case group was defined as patients who used both Korean Medicine and Western Medicine services and the control group consisted of patients who used Western Medicine service only. The all-cause mortality and incidence of PD was analyzed using the Cox proportional hazard model after a propensity score matching(PSM) with a 1:1 ratio. Results : After PSM, the cohort included 47,546 subjects (23,773 in the case group, 23,773 in the control group). Sex, age, comorbidity, severity of disability, and neurology medical service utilization were adjusted in both groups. The mortality was 0.668 times (95% C.I.: 0.646-0.690) lower in the case group than the control group, which was statistically significant (p<0.001). The incidence of PD was 1.051 times (95% C.I.: 0.962-1.148) higher in the case group than the control group, which was not statistically significant(p=0.272). Conclusion : It was not obvious that the use of both Korean Medicine service and Western Medicine services for prevention of PD is benefitial than using only Western Medicine. But it would be possible that using both Korean Medicine and Western Medicine services decreases the mortality than using Western Medicine alone.

• Journal of Haehwa Medicine
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• v.9 no.1
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• pp.661-689
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• 2000

We came to the conculsion after considering all of information from many kinds of books on the cause, pathogenesis and treatment of Flaccidity-syndrome. The results were as follows : 1. Flaccidity-syndrome means limb-relaxation due to muscle atony that isn't able to constraction. It's begun as mild degree from extremities, in some cases ended to quadriplegia or expire. 2. Cause factor and pathogenesis of Flaccidity-syndrome is various. After Lung fluid consuption caused by heat-evil was refered in The Yellow Emperor's Canon of Internal Medicine. They were refered as cause factor that Main channel asthenia, excess of sexual intercourse, wetness-evil, heat-evil gets into the interior, asthenia of the spleen and stomach. Since Ming Dynasty, It's classified to wetness-heat evil, wetness-phlegm, deficiency of vital energy, deficiency of blood, deficiency of yin, blood stasis and indygestion, etc. 3. In the view of treatment of Flaccidity-syndrome, Yangming was selected in The Yellow Emperor's Canon of Internal Medicine, and it's been mean to clear away wetness-heat evil located at Yangming. In the method of acupuncture it was same on the base, and many skills have been used that electronic acupuncture, point-injection theraphy, acupuncture point block, catgut implantaion at acupuncture point, cutaneous acupuncture, auriculo-acupuncture and head acupuncture by the through post generation. 4. Flaccidity-syndrome was defined to weak, disuse and non-pain. Beacause it was non-pain, so medicine to expel wind-evil was prevented to use. But through post generation Flaccidity-syndrome has been treated that is able to cause pain or numness as arthralgia-syndrome. Therefore there is tendency that medicine to expel wind-evil is capable within pathological basement of Flaccidity-syndrome in recent. 5. In the view of west-medicine, Flaccidity-syndrome is diplegia or quadriplegia with sensory disorder, muscle atropy in some cases. And there are spinal disease, peripheral nerve disease, muscular disease, nerve-muscle copula disease. The symptoms are able to amyotomia, numness, sensory disorder, pain.

• Journal of Preventive Medicine and Public Health
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• v.45 no.1
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• pp.21-28
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• 2012

Objectives: The aim of this study was to investigate whether a medium to high degree of total physical activity and indoor physical activity were associated with reduced all-cause and cardiovascular mortality among elderly Korean women. Methods: A prospective cohort study was done to evaluate the association between physical activity and mortality. The cohort was made up of elderly (${\geq}65$ years of age) subjects. Baseline information was collected with a self-administered questionnaire and linked to death certificates retrieved from a database. Cox proportional hazard models were used to estimate the hazard ratios (HRs) with 95% confidence interval (CI) levels. Results: Women who did not suffer from stroke, cancer, or ischemic heart disease were followed for a median of 8 years (n=5079). A total of 1798 all-cause deaths were recorded, of which 607 (33.8%) were due to cardiovascular disease. The group with the highest level of total physical activity and indoor physical activity was significantly associated to a reduced all-cause mortality (HR, 0.60; 95% CI, 0.51 to 0.71 and HR, 0.58; 95% CI, 0.50 to 0.67, respectively) compared to the group with the lowest level of total physical activity and indoor physical activity. Additionally, the group with the highest level of total physical activity and indoor physical activity was significantly associated to a lower cardiovascular disease mortality (HR, 0.53; 95% CI, 0.40 to 0.71 and HR, 0.51; 95% CI, 0.39 to 0.67, respectively) compared to the group with the lowest level of total physical activity and indoor physical activity. Conclusions: Our study showed that regular indoor physical activity among elderly Korean women has healthy benefits.

• Journal of Chest Surgery
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• v.27 no.5
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• pp.402-406
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• 1994

Behcet`s disease is a rare systemic disease of unknown cause and it is a progressive disorder with episodes of activity and remission. The major features are oral and genital ulceration and skin and eye lesions. Pulmonary involvement is rare, and we have experienced a 38 year old female patient who had undergone right lower lobe lobectomy due to extensive, rapidly growing pulmonary thromboemboli and pseudoaneurysm in pulmonary artery.

• Journal of Korean Medical classics
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• v.30 no.1
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• pp.111-133
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• 2017

Objectives : Dryness pathogen, which is one of six pathogenic factors, causes dryness diseases. Currently, the theory on dryness disease is composed of external dryness and internal dryness. External dryness, in turn, is composed of cool dryness and warm dryness. However, these categorizations and their symptoms bear ambiguity for many reasons. Therefore, this paper aims to review various texts in order to study the special features of dryness pathogen and dryness disease. Methods : Texts that deal with dryness pathogen and dryness disease were studied. Most texts are comprised of dissertations and historical medical texts, therefore, CNKI and The Sikuquanshu's databases, and Traditional Chinese Medical(TCM) book webdatabases were utilized. Materials are listed in chronological order, and their main points regarding dryness pathogen and dryness disease are compared. Results & Conclusions : It is difficult to accept the assertion that dryness pathogen does not lead to external dryness. Dryness does not have the elements of chill and fever in itself. Dryness's elements of chill and fever are determined in the ways they combine with each individual element. Moreover, the symptoms of chill and fever on dryness disease are subject to the host's body type. External dryness and internal dryness cannot be discussed within an identical premise. Whereas the dryness in external dryness signifies the cause of a disease, the dryness in internal dryness is the consequence of a disease. In other words, internal dryness revolves around cause of disease and external dryness revolves around the mechanic of disease. It's difficult to determine whether these diseases are caused by dryness or wetness in Autumn. There is an understanding which integrates these together through the Yunqi theory, but it is imperfect.

• Korean Journal of Acupuncture
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• v.26 no.4
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• pp.173-182
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• 2009

Objectives : The aim of this study was to show the rationale of point-selection on the methods of acupuncture and moxibustion in the Essence of life section(in the Naegyeong Chapter) of the Donguibogam. Methods : First, We summarized the cause of each disease in the Essence of life section(in the Naegyeong Chapter) of the Donguibogam. Then, we explained the rationale of acupuncture point-selection referring to the cause of disease, physiology of the Oriental medicine, other uses of each acupuncture points in the Donguibogam, character of each acupuncture points, flow of meridian pathways and specific acupuncture points etc. Results and Conclusions : Total 12 acupuncture points were used in the Essence of life section(in the Naegyeong Chapter) of the Donguibogam. Most of acupuncture points were specific acupuncture points. But, some rationale of acupuncture point-selection were explained by the cause of disease, physiology of the Oriental medicine, other uses of each acupuncture points in the Donguibogam, flow of meridian pathways etc.

• Korean Journal of Acupuncture
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• v.24 no.2
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• pp.45-59
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• 2007

Objectives : The aim of this study was to show the rationale of point-selection on the methods of acupuncture and moxibustion in the Qi section(in the Naegyeong chapter) of the Donguibogam. Methods : First, We summarized the cause of each disease in the Qi section(in the Naegyeong chapter) of the Donguibogam. Then, We explained the rationale of acupuncture point-selection referring to the cause of disease, physiology of the Oriental medicine, other uses of each acupuncture points in the Donguibogam, character of each acupuncture points, flow of meridian pathways and specific acupuncture points etc. Results and Conclusions : Total 37 acupuncture points were used in the Qi section(in the Naegyeong chapter) of the Donguibogam. Most of acupuncture points were specific acupuncture points. but, some rationale of acupuncture point-selection were explained by the cause of disease, physiology of the Oriental medicine, other uses of each acupuncture points in the Donguibogam, flow of meridian pathways etc.

• Korean Journal of Acupuncture
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• v.24 no.4
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• pp.1-12
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• 2007

Objectives : The aim of this study was to show the rationale of point-selection on the methods of acupuncture and moxibustion in the Phlegm section(in the Naegyeong chapter) of the Donguibogam. Methods : First, We summarized the cause of each disease in the Phlegm section(in the Naegyeong chapter) of the Donguibogam. Then, We explained the rationale of acupuncture point-selection referring to the cause of disease, physiology of the Oriental medicine, other uses of each acupuncture points in the Donguibogam, character of each acupuncture points, flow of meridian pathways and specific acupuncture points etc. Results and Conclusions : Total 9 acupuncture points were used in the Phlegm section(in the Naegyeong chapter) of the Donguibogam. Most of acupuncture points were specific acupuncture points. But, some rationale of acupuncture point-selection were explained by the cause of disease, physiology of the Oriental medicine, other uses of each acupuncture points in the Donguibogam, flow of meridian pathways etc.

• Korean Journal of Acupuncture
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• v.25 no.1
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• pp.61-71
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• 2008

Objectives : The aim of this study was to show the rationale of point-selection on the methods of acupuncture and moxibustion in the Rhinological section(in the Oehyeong chapter) of the Dong Ui BO Gam. Methods : First, We summarized the cause of each disease in the Rhinological section(in the Oehyeong chapter) of the Dong Ui BO Gam. Then, We explained the rationale of acupoint-selection referring to the cause of disease, physiology of the Oriental medicine, other uses of each acupoints in the Dong Ui BO Gam, character of each acupoints, flow of meridian pathways and specific acupoints etc. Results and Conclusions : Total 15 acupoints were used in the Rhinological section(in the Oehyeong chapter) of the Dong Ui BO Gam. Most of acupoints were specific acupoints. But, some rationale of acupoint-selection were explained by the cause of disease, physiology of the Oriental medicine, other uses of each acupoints in the Dong Ui BO Gam, flow of meridian pathways etc.