• The Journal of Korean Medicine
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• v.22 no.2
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• pp.109-119
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• 2001

Objective : There are many reports that acupuncture has thermoregulatory effects on human and animals. To investigate the effect and mechanism of antipyretic action of acupuncture, we observed the body temperature and cytokine expressions in the hypothalamus of rats. Methods : Lipopolysaccharide (LPS, i.p., 2.5mg/kg) was injected to conscious rats (Sprague-Dawley, male, n=4l) to cause hyperthermia and simple needling (stainless steel, 0.25 mm o.d., 5 mm insertion for 10 sec with no manipulation) was performed bilaterally with the measurement of rectal temperature. Next, we sacrificed rats to remove brain and determined the level of mRNA for interleukin-6 (IL-6), $interleukin-1{\beta}{\;}(IL-1{\beta})$, interleukin-2 (IL-2) and $interferon-{\gamma}{\;}(IFN-{\gamma})$ in the hypothalamus by using reverse transcriptase-polymerase chain reaction (RT-PCR). Resul1s : Needling on forepaw (acupoint HT8) and needling on hindpaw (acupoint BL66 and acupoint LR2) significantly inhibited LPS-induced fever of rats (P<0.01, 10 min after treatment respectively), but same treatment on proximal tail (non-acupoint) did not cause any change on fever. The levels of IL-6 and $IL-1{\beta}$ mRNA in the hypothalamus was significantly enhanced by LPS-injection, while the level of IL-6 and $IL-1{\beta}$ mRNA was markedly reduced after treatment on BL66 (P<0.01). Treatment on forepaw reduced it slightly, but not significantly. Equivalent stimulation on proximal tail did not cause any changes. Conclusions : Our results indicate that acupuncture stimulation on various body parts has differential thermoregulatory effects on LPS-induced fever of rats with site-specificity. And, we suggest that its antipyretic action might be accompanied with the suppression of hypothalamic production of pro-inflammatory cytokine of immune system, IL-6 and $IL-1{\beta}$.

• Journal of dental hygiene science
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• v.23 no.4
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• pp.296-301
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• 2023

Background: Periodontal disease is a major cause of tooth loss in adults and is a representative oral disease commonly suffered by most people around the world. Mainly the proliferation of Gram-negative bacteria and secreted virulence factors cause an inflammatory response and destroy periodontal tissue. Gossypetin, isolated from Hibiscus sabdariffa L, is known to have various pharmacological effects, including antibacterial and anticancer activities. We aimed to confirm the anti-inflammatory effect of gossypetin through interleukin-6 (IL-6) regulation in human gingival fibroblasts (HGFs) stimulated with lipopolysaccharide (LPS) of Porphyromonas gingivalis, a major cause of adult periodontitis. Methods: CCK-8 assay was performed to confirm the concentration-dependent cytotoxicity of gossypetin against HGFs. The secretion level and mRNA expression of IL-6, an inflammation-related cytokine, and the effect of gossypetin on these in HGFs stimulated with P. gingivalis LPS were confirmed by ELISA and qRT-PCR analysis, respectively. Results: Up to a concentration of 100 µM gossypetin with or without P. gingivalis LPS, the survival rate for HGFs was maintained at over 95% and showed no toxicity. ELISA and qRT-PCR analysis results showed that P. gingivalis LPS increased IL-6 secretion and mRNA levels in HGFs compared to the control group. However, this increase in IL-6 was significantly down-regulated by gossypetin treatment in a dose-dependent manner. In particular, 80 µM gossypetin inhibited IL-6 production to the level of the control group. Conclusion: These results indicated that gossypetin attenuated IL-6 production in HGFs stimulated by P. gingivalis LPS, which may ultimately suppress the inflammatory response in periodontal tissue. Therefore, gossypetin may have potential as a natural ingredient for the prevention and treatment of periodontal disease.

• Korean Institute of Interior Design Journal
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• v.17 no.5
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• pp.141-149
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• 2008

This study aims to understand functional spaces within university dormitory, examine the influences of residential environment factors and personal characteristics on users' satisfaction through what parameters and probability among these parameters and seek improvement methods for dormitory users to live at dormitory as the best residential space through causal analysis of residential space uses at university dormitory based on such a probability. Research methods include theoretical research of architectural space characteristics of university dormitory facilities through literature survey, analysis of satisfaction with spaces and their uses through questionnaire and causal analysis of each residential environment factor after making route model using data obtained from the results of analysis. The results of this study are as follows. Factors affecting residents' satisfaction with cultural activities of residential environment factors are safety, territoriality, interior finishing and complexity and those affecting residents' educational activities are safety and amenity of space. Residential function space of university dormitory must have spatial planning that social activities including individual and small group culture and educational activities from the view of spatial territoriality and flexibility based on safety and amenity and facilities related to continuity and connection of common space and unit residential space should be decentralized rather than centralized.

• Textile Coloration and Finishing
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• v.32 no.4
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• pp.232-238
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• 2020

Duck down is a feather of waterfowl and is used as an accessory for bedding products such as evil, pillow and outdoor sleeping bags due to its soft and bulky characteristics. Down is used mainly for winter outdoor such as padding and jumpers because of its excellent thermal insulation effect. Down wear is known as a product with high added value. Down is processed and sanitized because a large amount of oil and fat, bacteria, dust, insects, and soil are mixed. In particular, if the proper amount of oil and fat is not removed, it may cause odor or bacteria, and since the fishy smell peculiar to down and harmful VOCs (toluene, benzene, etc.) are released, there is a need to suppress the occurrence of bacteria through the provision of antibacterial function. In this study, we investigated the substances that cause the fishy odor of down, and confirmed the effect on the deodorization and antibacterial properties of down according to processing agents and processing conditions in order to impart deodorant and antibacterial properties to down.

• Journal of the Korea Institute of Building Construction
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• v.23 no.4
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• pp.417-428
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• 2023

The demolition of domestic infrastructures mirrors other significant construction initiatives in presenting a markedly high accident rate. A comprehensive investigation into the origins of such accidents is crucial for the prevention of future incidents. Upon detailed inspection, the causes of demolition construction accidents are multifarious, encompassing unsafe worker behavior, hazardous conditions, psychological and physical states, and site management deficiencies. While statistics relating to demolition construction accidents are consistently collated and reported, there exists an exigent need for a more foundational cause categorization system based on accident type. Drawing from Heinrich's Domino Theory, this study classifies the origins of accidents(unsafe behavior, unsafe conditions) and human errors(human factors) as per the type of accidents experienced during demolition construction. In this study, a three-step model of QFD-FMEA(Quality Function Deployment - Failure Mode Effect Analysis) is employed to systematically categorize accident causes according to the types of accidents that occur during demolition construction. The QFD-FMEA method offers a technique for cause classification at each stage of the demolition process, including direct causes(unsafe behavior, unsafe environment), and human errors(human factors) through a tri-stage process. The results of this accident cause classification can serve as safety knowledge and reference checklists for accident prevention efforts.

• Journal of the Korean Home Economics Association
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• v.47 no.10
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• pp.13-28
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• 2009

The purpose of this study is to analyze environment-friendly consumption behaviors and consumption value of adolescent consumers, and to analyze the effects of environmental knowledge, environment and experience, perception of environment, the awareness of consumption and environmental pollution, and consumption value on environment-friendly consumption behaviors of them. The data were collected by 999 adolescent consumers in Jeju Province. Data were analyzed by frequency, percentage, t-test, one-way ANOVA and Scheffe’s multiple range test using SPSS 12.0 Program . The results are as follows. Economy had the most cause and effect influence on environment-friendly purchasing behaviors, followed by experience of environmental activities, eco-friendliness, esthetic sense, enjoyment, and awareness of consumption and environmental pollution. Regarding the environmentfriendly consumer behavior, economy is the most influential factor, followed by eco-friendliness, awareness of consumption and environmental pollution, experience of environmental activities, environmental knowledge and monthly average allowance. Eco-friendliness had the most cause and effect influence on environment-friendly disposal behavior, followed by awareness of consumption and environmental pollution, economy and experience of environmental activities.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.671-676
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• 2005

In this study, we investigated the antioxidant effect of extract from Monascus pillosus, on the human wild-type p53 and p21 expressing A549 lung epithelial cell line and MCF-7 mammary adenocarcinoma cell line stimulated by NO. $P21^{waf/cip1}$ was identified as a gene induced in senescent cells. It is a cyclin-dependent kinase inhibitor and has been shown to cause cell cycle arrest and apoptosis. While p53-regulated stimulation of p21 appears to be central for the permanent growth-arrest, the role of p21 in p53-triggered cell death is unclear. Low dose of sodium nitroprusside (SNP) induced the development of senescence associated with increased expression of p53 and p21 in A549 cells. Inhibition of p21 transactivating activity requires high level correlates with the amount of p53 necessary to cause cell death. Association of p21 and p53 results in inhibition of p21-stimulated transcription. This requires a higher p53 level than is necessary for transcriptional activation of endogenous p53-responsive gene but correlates well with the level of p53 necessary to cause cell death. Exposure to W-1 inhibited oxidative stresses-induced senescence-like arrest, resulting in a significant reduction in p53 and p21 steady state levels. These results suggest that p53 and p21 play a central role in the onset of senescence. Thus, it is important to emphasize control of oxidative balance in tumor prevention and aging.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.1
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• pp.114-122
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• 2001

Leg weakness in pigs is one of the most serious problems in the pig industry. Leg weakness is responsible for an increase in the rate of culling of breeding pigs, which results in economic loss in the pig industry. Many researchers have investigated the cause of leg weakness, and that of osteochondrosis, in pigs, as well as in other mammals. For evaluating leg weakness, subjective scoring criteria have been applied, but the scoring systems varied widely. Subjective scoring systems have also been used in evaluating osteochondrosis lesions in leg joints. The lesions were scored optically, radiographically and histologically. Leg weakness and osteochondrosis are to some extent heritable traits. The heritability of leg weakness and joint lesion scores was found to range from 0.01 to 0.42. Leg weakness and osteochondrosis are associated with production traits (lean percentage and back fat depth). Nutritional aspects of leg weakness and osteochondrosis have also been extensively studied. Although the energy level of the diet may affect leg weakness and osteochondrosis, other nutritional factors seem to have very little effect. Confinement conditions also have an effect on leg weakness and osteochondrosis. Although studied extensively, the cause and etiology of leg weakness and osteochondrosis remain uncertain. It could be that there are multiple causes of leg weakness.

• Journal of Families and Better Life
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• v.26 no.5
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• pp.333-354
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• 2008

This study aimed to investigate the role of domain-specific causal mechanism information and domain-general conditional probability in young children's causal reasoning on psychology and biology. Participants were 121 3-year-olds and 121 4-year-olds recruited from seven childcare centers in Seoul, Kyonggi Province, and Busan. After participants watched moving pictures on psychological and biological phenomena, they were asked to choose appropriate cause and justify their choices. Results of this study were as follows: First, young children made different inferences according to domain-specific causal mechanisms. Second, the developmental level of causal mechanisms has a gap between psychology and biology, and biological knowledge was proved to be separate from psychological knowledge during the preschool period. Third, young children's causal reasoning was different depending on the interaction effect of domain-specific mechanisms and domain-general conditional probability: children could make more inferences based on domain-specific causal mechanisms if conditional probability between domain-appropriate cause and effect was evident. To conclude, it can be inferred that the role of domain-specific causal mechanisms and domain-general conditional probability is not competitive but complementary in young children's causal reasoning.

• Journal of Information Technology Applications and Management
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• v.23 no.3
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• pp.71-86
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• 2016

This paper proposes a new software quality model composed of a hierarchy of software quality views and three software quality characteristics models. The software view hierarchy is composed of two levels : end view and means view at the first level, contingency view and intrinsic view as sub-views of means view. Three software quality characteristics models are activity quality characteristics model, contingency quality characteristics model, and intrinsic quality characteristics model, which correspond to end view, contingency view, and intrinsic view respectively. This paper also reclassifies characteristics of ISO/IEC 25000 series SQuaRE's software product quality model according to the proposed software quality model. The results illustrate clearly the shortcomings of SQuaRE's product quality model and how to overcome them. First of all, most of SQuaRE's product characteristics should be redefined and conceptually clarified according to the views on which they are really rested. Much more characteristics should be supplemented too. After that, rigorous empirical researches will become relevant. Causal relationships between activity quality characteristics and characteristics of means view should be empirically researched.