• Korean Journal of Radiology
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• 제21권5호
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• pp.526-536
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• 2020

Objective: This study aimed to evaluate the clinical benefits and risks of CT-guided percutaneous transthoracic needle lung biopsies (PTNBs) in patients with a suspected pulmonary infection. Materials and Methods: This study included 351 CT-guided PTNBs performed in 342 patients (mean age, 58.9 years [range, 17-91 years]) with suspected pulmonary infection from January 2010 to December 2016. The proportion of biopsies that revealed the causative organism for pulmonary infection and that influenced patient's treatment were measured. Multivariate analyses were performed to identify factors associated with PTNB that revealed the causative organism or affected the treatment. Finally, the complication rate was measured. Results: CT-guided PTNB revealed the causative organism in 32.5% of biopsies (114/351). The presence of necrotic components in the lesion (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.1-2.7; p = 0.028), suspected pulmonary tuberculosis (OR, 2.0; 95% CI, 1.2-3.5; p = 0.010), and fine needle aspiration (OR, 2.5; 95% CI, 1.1-5.8; p = 0.037) were factors associated with biopsies that revealed the causative organism. PTNB influenced patient's treatment in 40.7% (143/351) of biopsies. The absence of leukocytosis (OR, 1.9; 95% CI, 1.0-3.7; p = 0.049), presence of a necrotic component in the lesion (OR, 2.4; 95% CI, 1.5-3.8; p < 0.001), and suspected tuberculosis (OR, 1.7; 95% CI, 1.0-2.8; p = 0.040) were factors associated with biopsies that influenced the treatment. The overall complication rate of PTNB was 19% (65/351). Conclusion: In patients with suspected pulmonary infection, approximately 30-40% of CT-guided PTNBs revealed the causative organism or affected the treatment. The complication rate of PTNB for suspected pulmonary infection was relatively low.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.8.1-8.2
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• 2016

A simple linear model to test the hypothesis based on one-on-one relationship has been used to find the causative factors of diseases. However, we now know that not just one, but many factors from different systems such as chemical exposure, genes, epigenetic changes, and proteins are involved in the pathogenesis of chronic diseases such as diabetes mellitus. So, with availability of modern technologies to understand the intricate nature of relations among complex systems, we need to move forward to the future by taking complex systems model.

• Geosciences Journal
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• 제22권6호
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• pp.1053-1067
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• 2018

This paper uses a probability-based approach to study the spatial relationships between landslides and their causative factors in the Mingchukur area, Bostanlik districts of Tashkent, Uzbekistan. The approach is based on digital databases and incorporates methods including probability analysis, spatial pattern analysis, and interactive mapping. First, an object-oriented conceptual model for describing landslide events is proposed, and a combined database of landslides and environmental factors is constructed by integrating various databases within a unifying conceptual framework. The frequency ratio probability model and landslide occurrence data are linked for interactive, spatial evaluation of the relationships between landslides and their causative factors. In total, 15 factors were analyzed, divided into topography, hydrology, and geology categories. All analyzed factors were also divided into numerical and categorical types. Numerical factors are continuous and were evaluated according to their $R^2$ values. A landslide susceptibility map was constructed based on conditioning factors and landslide occurrence data using the frequency ratio model. Finally, the map was validated and the accuracy showed the satisfactory value of 83.3%.

• 한국지진공학회논문집
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• 제25권6호
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• pp.233-240
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• 2021

The stochastic method is applied to simulate strong ground motions at seismic stations of seven metropolises in South Korea, creating an earthquake scenario based on the causative fault of the 2016 Gyeongju earthquake. Input parameters are established according to what has been revealed so far for the causative fault of the Gyeongju earthquake, while the ratio of differences in response spectra between observed and simulated strong ground motions is assumed to be an adjustment factor. The calculations confirm the applicability and reproducibility of strong ground motion simulations based on the relatively small bias in response spectra between observed and simulated strong ground motions. Based on this result, strong ground motions by a scenario earthquake on the causative fault of the Gyeongju earthquake with moment magnitude 6.5 are simulated, assuming that the ratios of its fault length to width are 2:1, 3:1, and 4:1. The results are similar to those of the empirical Green's function method. Although actual site response factors of seismic stations should be supplemented later, the simulated strong ground motions can be used as input data for developing ground motion prediction equations and input data for calculating the design response spectra of major facilities in South Korea.

• 대한수의학회지
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• 제39권6호
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• pp.1126-1140
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• 1999

Renal failure is one of the main causes of economic impacts in the poultry industry and complex syndrome with different severity of clinical signs caused by multiple nephropathogenic factors such as infectious bronchitis viral infection and excess salt and calcium in diet. To evaluate the correlation between severity of renal failure and the causative nephropathogenic factors, one-day-old specific pathogen free chicks were treated with either single causative factor or multiple causative factors described as above. Each group was designed as control for non-treated control, IB for infectious bronchitis virus (IB virus) infection, IBHNa for IB virus infection with high diet salt, IBHCa for IB virus infection with high diet calcium, IBHNC for IB virus infection with high diet salt and calcium, HNa for high diet salt, HCa for high diet calcium and HNC for high diet salt and calcium. Chickens were inoculated with IB virus at 1-day-old and remained on their respective diets until 21 day of age. The high dietary salt feeding groups such as IBHNa, IBHNC, HNa, HNC increased water intake, watery diarrhea, general subcutaneous edema and the high dietary calcium feeding groups such as IBHCa and IBHNC showed severe visceral gout. Two more than treated groups caused high mortality in comparison with the single treated groups. IB virus exposure significantly increased urate deposition and lymphocytic interstitial nephritis. Especially urate deposition dramatically increased when excess diet calcium was combined together. In excess diet salt treated groups enlarged edematous kidneys were observed and hypertrophy of glomeruli were showed. These results suggest that IB virus enhanced the incidence and severity on chicken renal failure clearly related to the quantity of salt and calcium.

• 대한수의학회지
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• 제39권6호
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• pp.1141-1150
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• 1999

Renal failure is one of the main causes of economic impacts in the poultry industry and complex syndrome with different severity of clinical signs caused by multiple nephropathogenic factors such as infectious bronchitis viral infection and excess salt and calcium in diet. To evaluate the correlation between severity of renal failure and the causative nephropathogenic factors, one-day-old specific pathogen free chickens were treated with either single causative factor or multiple causative factors described as above. Each group was designed as control for non-treated control, IB for infectious bronchitis virus (IB virus) infection, IBHNa for IB virus infection with high diet salt, IBHCa for IB virus infection with high diet calcium, IBHNC for IB virus infection with high diet salt and calcium, HNa for high diet salt, HCa for high diet calcium and HNC for high diet salt and calcium. Chickens were inoculated with IB virus at 1-day-old and remained on their respective diets until 21 day of age. Plasma $Na^+$, $Cl^-$, BUN, creatinine, calcium and uric acid values were examined. The results obtained were as follows ; IB virus and high dietary calcium combined treatment showed elevated plasma uric acid. BUN and creatinine values were not characteristic on chicken renal failure. But plasma uric acid values were increased according to renal lesion. Hypercalcemia and hyperuricemia did not induce urate deposition and mineralization in the kidney.

• 패션비즈니스
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• 제8권6호
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• pp.103-112
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• 2004

A Politician Appearance Acceptance Model (PAAM model) was formed and designed based on an analysis of how the electorate would accept a female politician. The PAAM model evaluated factors which influenced the voter's view of the female politician based on appearance. Causative factors were assessed that impacted acceptance based on appearance and analyzed whether voting was influenced by the appearance image; appearance image preferences for a female politician included the classic, dramatic, romantic and natural images. Through validations, the appearance image and competency had a causative factor that contributed to the acceptance of the politician image. The Classic Image demonstrated the strongest and most important image among the appearance images. As voters were more interested in the appearance image of a female politician, more emphasis and weight was on the appearance image during the voting selection process.

• 한국안전학회지
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• 제18권4호
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• pp.155-163
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• 2003

The intensity of industrial accidents has been increased while the number of industrial accidents has been decreased in theses days. It represents that we need safety guidelines based on personal attributes as well as physical attributes. This study tries to identify major causative factors for industrial accidents and to suggest an evaluation model based on personal attributes. Specifically, relationship between self-efficacy belief associated with industrial safety and other relative personal attributes has been analyzed. First, FGI(Focus Group Interview) was conducted to identify important personal attributes of industrial accidents. The questionnaire was prepared based on the results of FGI and was applied to identifying personal attributes. The relationship between personal attributes identified in this study and self-efficacy belief was assessed using fuzzy logic and fault tree analysis. The results of the assessment showed that self-efficacy belief was closely associated with industrial accidents. Specifically, workers with accident experience had higher level of self-efficacy beliefs than workers without accident experience.

• 대한지리학회:학술대회논문집
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• 대한지리학회 2005년도 춘계학술대회
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• pp.209-210
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• 2005

• Journal of Korean Neurosurgical Society
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• 제29권9호
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• pp.1222-1227
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• 2000

Objective : Vascular endothelial growth factor(VEGF), an endothelial cell specific cytokine, is a potent angiogenic growth factor implicated in the tumor angiogenesis and increases vascular permeability dramatically. Peritumoral brain edema(PTBE) occurs in 40-60% of meningiomas. Many causative factors have been investigated, but the mechanism of PTBE associate with meningioma is unclear. VEGF has been implicated as one of the causative factors of PTBE. This study was designed to determine whether the extent of VEGF expression is correlated with degree of PTBE in meningiomas. Methods : Meningioma tissue samples from 40 patients(7 men and 33 women, mean age $53{\pm}13years$) who underwent surgery were examined retrospectively for the expression of VEGF immunohistochemically. The extent of PTBE was estimated by using preoperative CT or MRI as an edema index(EI). In addition to VEGF, several causative factors including tumor size, location, histologic type, microvasculature(CD31) were compared with EI. Results : Twenty-six meningiomas demonstrated PTBE, and the other 14 did not. Of the 40 patients of meningiomas, 28 were positive(17 were 1+ and 11 were 2+) for VEGF. The EI increased significantly just as VEGF was strongly expressed(p=0.006). Microvascular proliferation was also closely correlated with the extent of peritumoral brain edema(p<0.05). Conclusion : These data suggest that VEGF expression and microvascular proliferation are closely correlated with PTBE in meningioma.