• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4877-4881
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• 2013

Background: The aim of the study was to assess the knowledge about HPV and HPV vaccines and attitudes towards vaccination among the females aged 9-24 years in Turkey. Materials and Methods: Self-administered questionnaires were filled out individually by the participants covering demographic information, knowledge about HPV infection and HPV vaccines, attitudes towards vaccination, and the perceptions of them about their parental attitudes about vaccination. Results: Of the 408 subjects participating in the study, 41.6% (n=170) had heard of HPV. Thirty-three percent (n=136) knew the causal relationship between HPV and cervical cancer. Only 27.9% (n=114) of them knew that HPV vaccines can prevent cervical cancer. Eleven percent (n=46) of the females participating in the study were willing to be vaccinated, and only 1.4% (n=6) were already vaccinated at the current time. The main reason listed among the participants who were not willing to be vaccinated was lack of information. Conclusions: Awareness and knowledge of Turkish female adolescents and young women about HPV, relation with cervical cancer and prevention of cervical cancer by Pap smear and vaccine are still limited. If the most important barrier to vaccination, which is reported as lack of information, were to be addressed, it would greatly impact the decision-making and vaccine acceptance.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.837-845
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• 2014

Background: Overweight and obesity are recognized as major drivers of cancers including breast cancer. Several cytokines, including interleukin-6 (IL-6), IL-10 and lipocalin 2 (LCN2), as well as dysregulated cell cycle proteins are implicated in breast carcinogenesis. The nuclear, casein kinase and cyclin-dependent kinase substrate-1 (NUCKS-1), is a nuclear DNA-binding protein that has been implicated in several human cancers, including breast cancer. Objectives: The present study was conducted to evaluate NUCKS-1 mRNA expression in breast tissue from obese patients with and without breast cancer and lean controls. NUCKS-1 expression was correlated to cytokine profiles as prognostic and monitoring tools for breast cancer, providing a molecular basis for a causal link between obesity and risk. Materials and Methods: This study included 39 females with breast cancer (G III) that was furtherly subdivided into two subgroups according to cancer grading (G IIIa and G IIIb) and 10 control obese females (G II) in addition to 10 age-matched healthy lean controls (G I). NUCKS-1 expression was studied in breast tissue biopsies by means of real-time PCR (RT-PCR). Serum cytokine profiles were determined by immunoassay. Lipid profiles and glycemic status as well as anthropometric measures were also recorded for all participants. Results: IL-6, IL-12 and LCN2 were significantly higher in control obese and breast cancer group than their relevant lean controls (p<0.05), while NUCKS-1 mRNA expression was significantly higher in the breast cancer group compared to the other groups (p<0.05). Significant higher levels of IL-6, IL-12, and LCN2 as well as NUCKS-1 mRNA levels were reported in G IIIb than G IIIa, and positively correlated with obesity markers in all obese patients. Conclusions: Evaluation of cytokine levels as well as related gene expression may provide a new tool for understanding interactions for three axes of carcinogenesis, innate immunity, inflammation and cell cycling, and hope for new strategies of management.

• 한국산학기술학회논문지
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• 제21권9호
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• pp.283-290
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• 2020

본 연구는 미충족 의료 경험과 삶의 질 관련 측정지표 간 인과관계를 실증하는 데 목적을 두었다. 이 두 변수간 인과관계 검증을 위해 본 연구는 한국의료패널의 부가조사 원자료를 가공하여 분석을 실시하였다. 삶의 질과 관련된 측정지표로는 운동능력, 자기관리, 일상 활동, 통증/불편, 불안/우울, 주관적 건강상태의 6개 변수를 투입해 선형회귀분석을 실시하였다. 본 연구의 분석 결과 미충족 의료 경험은 본 연구에 투입한 6가지의 삶의 질 하위변수 모두에 통계적으로 유의한 부(-)적 영향을 미치는 것을 확인할 수 있었다. 아울러 선형회귀분석을 통해 도출된 β값을 활용해 상대적 영향력의 크기를 검토한 결과 통증/불편, 주관적 건강상태, 불안/우울, 일상 활동, 운동능력, 자기관리의 순으로 차별적 영향 수준을 나타내는 것을 알 수 있었다. 이러한 분석 결과에 기초해 삶의 질적 수준 향상에 기여하기 위한 미충족 의료에 대한 정책 대응방안으로서 보건과 복지의 실무 연계 강화와 관련한 실무적 시사점을 제언하였다.

• The Plant Pathology Journal
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• 제18권3호
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• pp.115-120
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• 2002

Xanthomonas axonopodis pv. glycines, the causal agent of bacterial pustule of soybean, induces hypersensitive response (HR) in a non-host plant, hot pepper (Capsicum annuum). A wild-type strain (8ra) and its non-patho-genic mutant (8-13) of X. axonopodis pv. glycines were inoculated into the pepper leaf tissues and their subcellular responses to the bacterial infections were examined by electron microscopy. Intrastructural changes related to HR were found in the leaf tissues infected with 8ra from 8 h after inoculation, characterized by separation of plasmalemma from the cell wall, formation of small vacuoles and vesicles, formation of cell wall apposition, and cellular necrosis. No such responses were observed in the tissues infected with the mutant. In 8ra, the bacterial cells were attached to the cell walls, with the cell wall material dissolved into and appearing to encapsulate the bacterial cells. The bacterial cells later became entirely embedded in the cell wall material. On the other hand, in 8-13, the bacterial cells were usually not attached tightly to the plant cell wall, and no or poor encapsulation of the bacteria by the wall material occurred, although these were encircled by rather loose wall materials at the later stages.

• 한국응용곤충학회지
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• 제7권
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• pp.77-81
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• 1969

오이덩굴쪼김병에 대한 Carbamisol. NCS, Similuton, Soill, Captan, Difolatan, Grand 및 소석회등의 토양소독효과를 침지법, Zentmyer법, pot 및 포장시험 등으로 시험한 결과 다음과 같다. 1. 침적법에서는 공시된 약제중 소석회를 제외하고는 모두 살균효과가 있었다. 그러나 Zentmyer의 drench법에서는 Grand 유제와 Similuton을 제외하고는 모두 살과균효가 없었다. 2. Pot시험에서는 Grand 유제가 가장 효과적이었고 그 다음이 Similuton 및 oxysporum의 수도 Grand 유제를 처리한 구가 타약제구에 비하여 현저하게 적었다. 3. 포장시험에서의 오이덩굴쪼기병에 대한 약제의 효과는 화합물의 종류에 따라 차이가 있는데, 공시된 살균제중 Grand유제가 가장 효과적이었으며 다음으로 Difolatan이 효과적이었다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2895-2899
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• 2016

Background: Increasing breast cancer (BC) incidence rates have been reported from India; causal factors for this increased incidence are not understood and diagnosis is mostly in advanced stages. Trivandrum exhibits the highest BC incidence rates in India. This study aimed to estimate trends in incidence by age from 2005-2014, to predict rates through 2020 and to assess the stage at diagnosis of BC in Trivandrum. Materials and Methods: BC cases were obtained from the Population Based Cancer Registry, Trivandrum. Distribution of stage at diagnosis and incidence rates of BC [Age-specific (ASpR), crude (CR) and age-standardized (ASR)] are described and employed with a joinpoint regression model to estimate average annual percent changes (AAPC) and a Bayesian model to estimate predictive rates. Results: BC accounts for 31% (2681/8737) of all female cancers in Trivandrum. Thirty-five percent (944/2681) are <50 years of age and only 9% present with stage I disease. Average age increased from 53 to 56.4 years (p=0.0001), CR (per $10^5$ women) increased from 39 (ASR: 35.2) to 55.4 (ASR: 43.4), AAPC for CR was 5.0 (p=0.001) and ASR was 3.1 (p=0.001). Rates increased from 50 years. Predicted ASpR is 174 in 50-59 years, 231 in > 60 years and overall CR is 80 (ASR: 57) for 2019-20. Conclusions: BC, mostly diagnosed in advanced stages, is rising rapidly in South India with large increases likely in the future; particularly among post-menopausal women. This increase might be due to aging and/or changes in lifestyle factors. Reasons for the increased incidence and late stage diagnosis need to be studied.

• 대한간호학회지
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• 제49권4호
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• pp.472-485
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• 2019

Purpose: This study aimed to develop and evaluate the effectiveness of an adapted health literacy self-management intervention for elderly cancer patients undergoing chemotherapy. Methods: The intervention in this study was systematically developed through the six stages of Intervention Mapping Protocol and was based on Fransen et al's causal pathway model. A quasi-experimental trial was conducted on a total of 52 elderly patients (26 in an experimental group and 26 in a control group) undergoing chemotherapy in Korea. The intervention consisted of seven sessions over 5 weeks. The experimental tool for this study was an adapted health literacy self-management intervention, which was designed to promote a reduction in the symptom experience and distress of elderly cancer patients through the promotion of self-management behavior. To develop efficient educational materials, the participants' health literacy was measured. To educate participants, clear communication and the teach-back method were used. In addition, for the improvement of self-efficacy, four sources were utilized. For the promotion of self-management behavior, five self-management skills were strengthened. Data were collected before and after the intervention from June 4 to September 14, 2018. The data were analyzed with SPSS/WIN 21.0. Results: Following the intervention, self-management knowledge and behavior and, self-efficacy significantly improved in experimental group. Symptom experience and distress decreased in the experimental group compared to the control group. Conclusion: The self-management intervention presented in this study was found to be effective in increasing self-management knowledge and behavior and, self-efficacy, and ultimately in reducing symptom experience and distress for elderly patients undergoing chemotherapy.

• 디지털융복합연구
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• 제19권7호
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• pp.371-377
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• 2021

본 연구는 스포츠 경기의 특성에 따른 스포츠 감정 유형을 분석하였다. 이를 위해 2018년 아시안게임 중, 대한민국 대표팀이 출전한 축구 7경기, 야구 6경기를 선정한 후, 이에 대한 소셜 네트워크 서비스 상 기사와 그 댓글을 조사대상으로 선정하였다. Python을 이용하여 수집된 댓글은 전문가 회의를 통해 해당 감정을 분석하였다. 스포츠 경기의 승패, 상대 팀의 수준 및 대한민국 대표팀의 경기력에 따른 스포츠 감정을 분석한 결과, 첫째, 승패와 상대 팀 수준은 특정한 유형의 스포츠 감정을 형성한다고 보기 어려웠다. 둘째, 스포츠 경기의 경기력은 좋다는 평가를 받을 경우 만족, 열광, 기쁨 등의 긍정적 감정을, 나쁘다는 평가를 받을 경우 실망, 분노, 창피의 부정적 감정을 형성하였다. 셋째, 스포츠 경기와 연관된 사회·문화적 배경이나 해당 경기의 특정한 사건 또한 스포츠 감정의 유형에 영향을 미쳤다. 추후, 본 연구에서 다루지 못한 다양한 스포츠 경기의 특성을 추가하여 보다 많은 스포츠 경기를 대상으로 분석하는 연구가 필요할 것이다.

• 한국융합학회논문지
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• 제13권5호
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• pp.53-60
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• 2022

본 연구는 강원도 일개 대학 치위생과 학생을 239명을 대상으로 치위생과 상생 방안 마련을 위해, 접근 동기와 회피 동기, 디지털 사용 인식을 통한 구조모형의 인과관계를 파악하는 것이다. 통계 방법은 SPSS Statistics 24.0 프로그램과 AMOS 21.0을 이용하였다. 구조방정식 모델 분석 결과 접근 동기는 디지털 사용 인식과 수업 만족도에 유의하게 나타났다. 또한, 디지털 사용인식은 수업 만족도에 유의하게 나타났고, 수업 만족도는 학과 만족도와 학과 추천에 유의하게 나타났다. 마지막으로 학과 만족도는 학과 추천에 유의하게 나타났다. 즉, 치위생(학)과의 상생 방안은 디지털 수업의 융합 확대이다. 문제 해결을 위해서는 학교에서는 실기 수업을 위한 수업 자재의 확충 시설 구축 및 교수법을 강구할 필요가 있다.

• 한국과학교육학회지
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• 제29권8호
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• pp.861-873
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• 2009

이 연구에서는 비유 만들기 활동을 도입한 크로마토그래피 개념 학습에서 과학영재들이 만든 비유의 유형과 대응 오류 유형 및 비유 만들기 활동에 대한 인식을 조사하였다. 서울시 4개 교육청의 중학교 2학년 과학영재 68명의 학생을 대상으로 하였다. 연구 결과, 과학영재들은 대부분 구체적이고 일상적인 상황에 기초하여 글과 그림으로 비유를 표현하였고, 목표 개념의 기능적 속성과 인과 관계를 포함시켜 부연 설명하였다. 자신이 만든 비유 중 가장 좋은 비유로는 목표물과 비유물 사이의 유사점이 가장 많거나 구조와 원리가 비슷한 비유를 선택하는 학생들이 많았으며, 비유 소재로는 주로 '학교생활'을 사용하였다. 선택한 비유에 대한 대응 검사 결과, 많은 과학영재들이 '대응 불이행', '과잉 대응' 등의 오류를 범하는 것으로 나타났다. 또한, 과학영재들은 비유 만들기 활동에 대해 긍정적으로 인식하는 것으로 나타났다. 이 연구 결과는 과학영재들을 위한 교육프로그램으로 적용할 수 있는 비유 만들기 수업 모형의 개발을 위한 기초정보로 활용될 수 있을 것이다.