• Medical Lasers
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• 제10권3호
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• pp.170-175
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• 2021

Background and Objectives Cisplatin is an important chemotherapy drug for the treatment of head and neck cancer. Interstitial laser treatment (ILT) has cosmetic utility and is very important for maintaining the function of the head and neck after cancer treatment. This study examined the synergistic effects of locally injected cisplatin-epigel and high fever induced by an interstitial potassium titanyl phosphate (KTP) laser treatment on a xenografted human Heinz squamous cell carcinoma. Materials and Methods SNU-1041 (107 cells/0.1 ml) cells were xenografted into the back of nude mice by subcutaneous injection. The ILT group (n = 10) was treated with a KTP laser (1 J/mm³) through a cylindrical diffuser tip inserted into the tumor, monitoring the temperature at 43-45℃. In the combined treatment group (n = 10), local hyperthermia was induced by intratumoral injection of 100-200 ㎍ of cisplatin into a collagen-based gel carrier (cisplatin-epigel), which was released slowly four hours before ILT. After four weeks of follow-up, the treated tumors were evaluated for tumor remission and volume change. Results Eight (80%) of the combined group showed complete tumor remission at the four-week follow-up, whereas only three (30%) of the ILT group showed remission (30%) (p < 0.01). Conclusion The current study has shown the synergistic effects of a local cisplatin injection and high fever from ILT on a xenografted human Heinz squamous cell carcinoma.

• International Journal of Naval Architecture and Ocean Engineering
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• 제11권2호
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• pp.736-749
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• 2019

This paper employs computational tools to investigate the diffraction effects in regular head waves on the added resistance and wake on the propeller plane. The objective ships are a 66,000 DWT bulk carrier and a 3,600 TEU container ship. Fixed and free to heave and pitch conditions at design speed have been taken into account. Two-phase unsteady Reynolds averaged Navier-Stokes equations have been solved using the finite volume method; and a realizable k-ε model has been applied for the turbulent closure. The free surface is obtained by solving a VOF equation. The computations are carried out at the same scale of the model tests. Grid and numerical wave damping zones are applied to remove unwanted wave reflection at the boundaries. The computational results are analyzed using the Fourier series. The added resistances in waves at the free condition are higher than those at the fixed condition, which are nearly constant for all wavelengths. The wake velocity in waves is higher than that in calm water, and is accelerated where the wave crest locates on the propeller plane. When the vertical motion at the stern goes upward, the wake velocity also accelerated.

• International Journal of Naval Architecture and Ocean Engineering
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• 제11권2호
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• pp.723-735
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• 2019

This paper employs computational tools to investigate the cause of resistance reductions in calm water and waves of the sharp bow form compared to the blunt bow in 66,000 DWT bulk carriers. A more slender shape at the fore-shoulder without a bulbous bow is a prominent feature of the sharp bow. The blunt bow incorporates a bulbous shape. A two-phase unsteady Reynolds averaged Navier-Stokes equations have been solved; and a realizable k-ε model has been applied for the turbulent closure. The free-surface is obtained by solving a VOF equation. The computational results have been validated with model tests carried out at a towing tank. The pressure component of resistance in the sharp bow is reduced by 8.9% in calm water, and 6.4-12.7% in regular head waves. The frictional components of resistance in the sharp and blunt bows are largely the same.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 추계학술대회
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• pp.383-387
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• 2004

The Fuel Test Loop (FTL) consists of In-Pile Test Section (IPS) and Out-of-Pile System (OPS). The test condition in IPS such as pressure, temperature and quality of the main cooling water, can be controlled by the OPS. The FTL has been developed to be able to irradiate three pins to the core irradiation hole (IR1 hole) by considering for its utility and user's irradiation requirement. The IPS vessel assembly (IVA) consists of IPS head, outer pressure vessel, inner pressure vessel, inner assembly and test fuel carrier. The IVA is approximately 5.6 m long and fits within a 74 mm in diameter envelope over the full height of the chimney. Above the top of the chimney, the head of the IPS is enlarged to allow the closure flanges and pipe work connections. IVA was designed to test the CANDU and PWR nuclear fuel pin together. Specially, wished to minimize interference by nuclear fuel change in design and synthesize these items and shape design for IVA.

• Journal of Advanced Research in Ocean Engineering
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• 제4권2호
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• pp.53-65
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• 2018

The load condition significantly influences ship maneuverability in calm water. In this research, the effect of the load condition on turning performance of a very large crude oil carrier (VLCC) sailing in adverse weather conditions is investigated by an MMG-based maneuvering simulation method. The relative drift direction of the ship in turning to the wave direction is $20^{\circ}-30^{\circ}$ in ballast load condition (NB) and full load condition (DF) with a rudder angle $35^{\circ}$ and almost constant for any wind (wave) directions. The drifting displacement in turning under NB becomes larger than that under DF at the same environmental condition. Advance $A_d$ and tactical diameter $D_t$ become significantly small with an increasing Beaufort scale in head wind and waves when approaching, although $A_d$ and $D_t$ are almost constant in following wind and waves. In beam wind and waves, the tendency depends on the plus and minus of the rudder angle.

• 한국기계가공학회지
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• 제11권1호
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• pp.1-6
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• 2012

The polishing of silicon wafers has an important role in semiconductor manufacturing. Generally, getting a flat surface such as a mirror is the purpose of the process. The wafer surface roughness is affected by many variables such as the characteristics of the carrier head unit, operation, speed, the pad and slurry temperature. Optimum process conditions for experimental temperature, pH value, down-force, slurry ratio are investigated, time is used as a fixed factor. This study carried out a series of experiments at varying platen, chuck rpm and oscillation cpm taking particular note of the difference between the rpm and the affect it has on the surface roughness. In this experiment determine the optimum conditions for polishing silicone wafers.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2007년도 추계학술대회
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• pp.114-115
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• 2007

As a carrier of malaria and sneak of blood, mosquitoes are regarded as an unpleasant insect. However, there are novel phenomena that happen inside a mosquito. Among them, we focused on the blood sucking function of a female mosquito. The main objective of this study was to investigate the mosquito's pumping mechanism in order to resolve the problem encountered when we inject or transport biologic fluids into a micro-chip. To analyze the pumping mechanism, we visualized the blood sucking process inside a female mosquito. Flow characteristics of blood flow in a proboscis were investigated experimentally using a micro-PIV velocity field measurement technique. The anatomical variation of head, thorax, abdomen which work as pumps and valves, was visualized using the syncrotron X-ray micro-imaging technique.

• 한국진공학회지
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• 제8권3A호
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• pp.249-255
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• 1999

Deposition characteristics of Cu thin films using Ar carrier gas and $H_2$ processing gas at various working pressures and substrate temperatures were investigated. Also, effects of $H_2$ pretreatment using plasma at $200^{\circ}C$ of substrate temperature and 0.6 Torr of chamber pressure were stdied. Cu thin films were deposited on TiN/Si substrate at working pressure of 0.5~1.5 Torr, substrate temperatures of 140~$240^{\circ}C$ with (hface)Cu(tmvs). Substrates were pretreated by $H_2$ plasma, and Cu films deposited in situ using twofold shower head. The purity, electrical resistivity, thickness, surface morphology, optical properties of the deposited Cu films were measured b the AES, four point probe, stylus profiler, SEM,. and the uv-visible spectrophotometer. This study suggests that $H_2$ plasma is an effective method for enhancing deposition rate and for producing high quality copper thin films.

• 한국산업융합학회 논문집
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• 제26권6_3호
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• pp.1197-1204
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• 2023

Ti-alloy, a high-strength alloy material among the materials used in aircraft that are trending toward lighter weight, is classified as a difficult-to-cut material that requires a lot of energy for cutting. Cutting in a high-temperature environment is considered one means of making this possible, and various studies have been conducted on it. In particular, research on LAM (Laser Assisted Machining (LAM)), which utilizes laser heating of the cutting area, is being actively conducted. Before processing of the milling cutter begins, the temperature is raised locally by the laser irradiated through the laser head carrier, and the resistance during milling is reduced. Therefore, in this paper, in order to derive such conditions, we performed heat transfer analysis according to transfer conditions and compared it with actually applied test data to use it to establish appropriate processing conditions.

• 생명과학회지
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• 제17권11호
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• pp.1562-1570
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• 2007

본인들은 주류생산 부산물인 주박을 이용한 친환경적인 비료를 개발하고자 한다. 본 시험에 사용된 주박에는 잔존 알코올함량이 평균 5-8%이며, 주요성분으로 6.04% 총질소량, 42.59% 총탄수화물량, 1.01% 유용 인산량, 73.42% 유기물량, 7.72% $K_2O$, 1.35% CaO와 0.53% MgO을 함유하고 있었다. 주박은 980 units/g의 ${\alpha}-amylase$, 300 units/g의 glucoamylase와 1,800 units/g의 산성 protease활성을 나타내어 비교적 높은 수준의 효소 활성을 나타내었다. 토양으로부터 분리한 미생물 중 항 진균활성이 우수한 근권세균인 Bacillus subtilis KMU-13을 분리, 생화학적 특성과 16s rDNA 분석에 의하여 Bacillus subtilis KMU-13으로 동정했다. 식물병원성 진균인 Botrytis cinerea KACC 40573, Sclerotinia sclerotiorum KACC 41065, Fusairum of oxysporum KACC 40052, Pythium aphanidermatum KACC 40156, Phytophthora capsici KACC 40476와 Glomerella cingulata KACC 40299에 대하여 높은 항 진균활성을 나타내었다. 시제품은 동결건조 주박을 직접 시제품으로 사용하는 시제품 1과 동결건조 주박 20%, 담체 70%, B. subtilis KMU-13의 배양액 9.7%, 미량원소 0.3%를 혼합하여 시제품 2를 제작했다. 시제품 1과 시제품 2의 상추를 이용한 포장 재배시험에 대한 비료효과 및 토양이화학성 변화를 조사한 결과, 3요소비료, 퇴비 및 석회를 시용한 관행구에 비해 수확기의 엽장, 엽폭, 엽수 및 생체중량 등이 증가하였으며, 토양 이화학성의 변화는 거의 없었다.