• 대한한의학회지
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• 제16권1호통권29호
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• pp.172-183
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• 1995

According to the literature surrey, we summarized the treatment and prescription for Su-Cheon(水喘), Hwa-Cheon(火喘) and Cardiac Asthma as follows. 1. The aim of treatment for Su-cheam(水喘) is I-Su-Hwa-Daw(利水火痰), Pynng-Cheon-Ick-Qi(平喘益氣) and Mokbangki-tang(木防己湯), Jungryuk daejosapye-tang(亭曆大棗瀉肺湯) Socheong ryong-tang(小靑龍湯), Gagamshinki-hwan(加減腎氣丸) and Shinbi-tang(神秘湯) are often used. 2. The sim of treatment for Hwa-Chean(火喘) is Cheong-Kuem-Kwang-Hwa(淸金降火祛痰) and Backho-tang(白虎湯) and Dodamtang-gamibang(導痰湯加味方) are useful. 3. In Oriental medicine, Sangmak-Sun(生脈散) and Sambutang-gamibang(參附湯加味方) for Ink-Qi-Ryum-Eum(益氣斂陰) and On-Yang-I-Su-Qi(溫湯利水化氣) are often used for cardiac asthma. 4. As the treatment for Su-Cheon(水喘), Hwa-Cheon(火喘), and cardiac asthma are Similar to, it is supposed to be need of careful differential diagnosis and treatment.

• 생약학회지
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• 제18권4호
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• pp.233-240
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• 1987

In order to investigate experimentally the clinical effects of Chungsimjeongchun-Tang that have been widely used for cardiac asthma, dyspnea and coughs secondary to the appoplexy and cardiac diseases, the water extract of Chungsimjeongchun-Tang was conducted to the effects on the anti-histamine action and respiratory system in mice, guinea-pigs, rabbits and cats. The following results of Chungsimieongchun-Tang were obtained. Spontaneous motility of the isolated ileum of mice and rabbits was strongly suppressed and contractions of the isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Anti-histamine action was noted. Antitussive action on the mechanically irritative cough in cats was recognized. Expectorant action on the leakage of dye in the respiratory tract of rabbits was also shown.

• 대한한방내과학회지
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• 제24권2_4호
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• pp.1093-1102
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• 2003

Congestive heart failure is a cardiac dysfunction that can't supply sufficient amount of blood. The disorder usually causes hypertension, ischemic cardiac disease and give rise to pulmonary congestion and pulmonary epileptic edema. The symptoms of the disease are dyspnea, palpitation, edema, etc. We treated a 82 year-old female patient who had severe dyspnea, nausea, and dizziness. At the point of differentiation of syndromes(辨證), the case was diagnosed as Su-Cheon(水喘) induced by Yang-deficiency of Both Spleen and Kidney(脾腎陽虛) and was administered Yerunpang(胃?湯). After two weeks of the treatment, we witnessed improvement in the symptoms of CHF and general depressed condition. This report describes the process and contents about the way the patient was treated.

• Tuberculosis and Respiratory Diseases
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• 제73권2호
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• pp.122-126
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• 2012

Plastic bronchitis is a rare disease characterized by marked airway obstruction, via the formation of large gelatinous or rigid airway cast. In Korea, there were a few case reports with plastic bronchitis not in adults, but in children. So we report a case of an adult who was diagnosed as plastic bronchitis with eosinophilic casts, with no history of atopic and cardiac disease.

• 동의생리병리학회지
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• 제17권2호
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• pp.363-367
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• 2003

Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine vasoaction, diabetes in oriental medicine. In this study, it was investigated that pear phenolic compound effects on cardiovascular system as blood pressure and renin and atrial natriuretic peptide(ANP) in plasma, Cardiac hypertrophy. The experiments were performed on Sprague Dawley rats, 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Animals were then divided into four groups, 5mg/Kg(PPC-A) 10mg/Kg(PPC-B) 15mg/Kg(PPC-c) and control group. Pear phenolic compound solution were supplied with them for 3weeks, a day's interval. The results are that The blood pressure was significantly decreased at 15days in PPC-A group than control group. The plasma ANP was increased in PPC-A and PPC-C group, and cardiac hypertrophy was significantly decrease in PPC-C group compared with control group.

• 한국식품영양과학회지
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• 제32권5호
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• pp.700-705
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• 2003

배에서 추출된 pectin과 사과에서 추출된 pectin의 3주간 투여가 2K1C 고혈압 흰쥐의 일간 혈압 변화, 혈장 renin, ANP 변화 및 cardiac hypertrophy 변화를 관찰한 결과 다음과 같은 결론을 얻었다. 일간 혈압변화에서 대조군에 비하여 AP-A군의 15일째에 유의한 감소를 보였고, 19일째에 한계적으로 유의한 감소를 나타내었으며, AP-B군의 8일째와 15일째에 유의한 감소를 나타내었으며, AP-C군의 15일째에 한계적으로 유의한 감소를 나타내었다. 또한 대조군에 비하여 PP-A군은 모든 기간 동안 유의성을 나타내지 않았으며, PP-B군의 8일째와 15일째에 유의한 감소를 나타내었으며, PP-C군의 15일째에 유의한 감소를 나타내었다. 혈장 renin변화에 있어서 대조군에 비하여 apple pectin이 투여된 군에서는 모두 유의한 변화가 없었으며, pear pectin이 투여 된 PP-B군에서 한계적으로 유의한 감소를 나타내었다. 혈장 ANP 변화에 있어서 대조군에 비하여 apple pectin이 투여된 군에서는 모두 유의한 변화가 없었으며, pear pectin이 투여된 PP-B군에서 유의한 증가를 나타내었다. Cardiac hypertrophy 변화에 있어서 대조군에 비하여 apple pectin이 투여된 군에서는 모두 유의한 변화가 없었으며, pear pectin이 투여된 PP-C군에서 유의한 감소를 나타내었다.

• Toxicological Research
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• 제14권2호
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• pp.183-191
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• 1998

It has been reported that 50~70% of child asthma, bronchial asthma in adult, and allergic rhinitis are caused by house dust mite. The antigen extracted from house dust mite has been used for effective treatment against allergic diseases and for clinical test. This house dust mite antigen has been entirely imported from abroad. However, the composition and content of all the antigen imported vary from a brand to other brand. Thus, we need to standardize the composition and content of the antigen by developing it domestically. We proceeded pre-clinically general pharmacological test and toxicological test that are required for the eventual human use by utilizing the house dust mite cultured in Korea. In order to obtain information on general pharmacological tests such as its toxic signs in tissues or organs which are mainly affected, we examined the effect of house dust mite on the tensions of the isolated tissues and heart rates of cardiac muscle by recording with force displacement transducer of polygragh (Glass Model 7). We determined lethality of antigen extracted from house dust mite in mice and guinea pigs. We examined acute and subacute toxicity by administrating house dust mite extract of 500, 100, 20 times of the expected clinical dose. In male and female mice and guinea pigs, given a sigle intraperitoneal dose of antigen, $LD_{50}$ values were over 5.0 $\textrm{m}{\ell}$/kg, respectively. In animals administrated with house dust mite, there were no significant change of clinical symptom, body weight, food consumption, water consumption, eye examinations, urinalysis, blood biochemistry, and histopathological examinations in any animals tested. We found no toxic effect of this house dust mite. These results show that the house dust mite cultured by us could be used in the development of medicine against allergic diseases caused by the antigen of house dust mite.

• Tuberculosis and Respiratory Diseases
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• 제85권3호
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• pp.205-220
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• 2022

This study aimed to describe the prevalence of comorbidities associated with chronic obstructive pulmonary disease (COPD) and their relation with relevant outcomes. A systematic review based on the PRISMA methodology was performed from January 2020 until July 2021. The MEDLINE, Lilacs, and Scielo databases were searched to identify studies related to COPD and its comorbidities. Observational studies on the prevalence of comorbidities in COPD patients and costs with health estimates, reduced quality of life, and mortality were included. Studies that were restricted to one or more COPD pain assessments and only specific comorbidities such as osteoporosis, bronchitis, and asthma were excluded. The initial search identified 1,409 studies and after applying the inclusion and exclusion criteria, 20 studies were finally selected for analysis (comprising data from 447,459 COPD subjects). The most frequent COPD comorbidities were: hypertension (range, 17%-64.7%), coronary artery disease (19.9%-47.8%), diabetes (10.2%-45%), osteoarthritis (18%-43.8%), psychiatric conditions (12.1%-33%), and asthma (14.7%-32.5%). Several comorbidities had an impact on the frequency and severity of COPD exacerbations, quality of life, and mortality risk, in particular malignancies, coronary artery disease, chronic heart failure, and cardiac arrhythmias. Comorbidities, especially cardiovascular diseases and diabetes, are frequent in COPD patients, and some of them are associated with higher mortality.

• Journal of Chest Surgery
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• 제28권12호
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• pp.1150-1154
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• 1995

Pneumomediastinum[Mediastinal emphysema is characterized by the presence of air in the mediastinum, and classified as spontaneous[occurring without obvious cause or secondary[caused by a trauma or artificial ventilation . To study the clinical evaluation of pneumomediastinum, data were obtained from 20 patients. The incidences of spontaneous pneumomedisastinum were 5 and those of secondary pneumomedistinum were 15 cases. The mean age was 21.2$\pm$3.4 years[$\pm$SD in spontaneous pneumomediastinum and 44.1$\pm$20.0 years[$\pm$SD in secondary pneumomediastinum. There were 16 male and 4 female patients. The common presenting compliants were retrosternal pain in 19 patients[95% , dyspnea in 12[60% , and hoarsness in 2[10% . The predisposing factors were asthma,excessive exercise and vomiting in spontaneous pneumomediastinum;trauma, artificial ventilation, tracheostomy, the rupture of trachea or esophagus in secondary pneumomediastinum. The physical findings were subcutaneous emphysema in 17 patients[85% , Hamman`s sign in 11 patients[55% and decreased cardiac dullness in 2 patients[10% . Spontaneous pneumomediastinums were managed conservatively, however, surigical procedures were needed in secondary pneumomediastinums. There was no recurrence, but one patinet died of tension pneumomedistinum. We concluded that spontaneous pneumomediastinum is uncommon, usually benign, and self-limited and secondary pneumomedistinum due to trauma or artificial ventilation is more increasing, and necessitates the early, aggressive intervention.

• 대한간호학회지
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• 제33권1호
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• pp.87-94
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• 2003

Purpose: The purpose of this study was to identify the factors influencing Symptoms of Stress in patients with chronic illness. Method: Data were collected by questionnaires from 1,748 patients with chronic disease in General Hospital in Seoul. Chronic diseases of were cardiac disease including hypertension, peptic ulcer, pulmonary disease included COPD and asthma, DM, and chronic kidney disease. The data were analyzed using descriptive statistics, pearson correlation coefficients, and stepwise multiple regression. Result: 1. The level of symptoms of stress was moderate(M=2.17). 2. The score of symptoms of stress showed significantly positive correlation with the score of mood state(r=.58, p=.00), perceived stress(r=.57, p=.00), and ways of coping(r=.33, p=.00). The symptoms of stress showed significantly negative correlation with the score of social support(r=-.37, p=.00) and self-esteem(r=-.19, p=.00). 3. The most powerful predictor of symptoms of stress was mood state and the variance explained was 34%. A combination of mood state, ways of coping, perceived stress, social support, and duration of illness account for 45% of the variance in symptoms of stress of the patients with chronic illness. Conclusion: This study suggest that mood state, ways of coping, perceived stress, and social support are significantly influencing factors on symptoms of stress of the patients with chronic illness.