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http://dx.doi.org/10.3746/jkfn.2003.32.5.700

The Effect of Pear Pectin on Blood Pressure, Plasma Renin ANP and Cardiac Hypertrophy in Hypertensive Rat Induced by 2K1C  

Na, Chang-Su (Dept. of Oriental Medicine, Dongshin University)
Yun, Dae-Hwan (Dept. of Oriental Medicine, Dongshin University)
Choi, Dong-Hee (Dept. of Oriental Medicine, Dongshin University)
Kim, Jeong-Sang (Dept. of Oriental Medicine, Dongshin University)
Cao, Chun-Hua (Dept. of Medicine, Chonbuk National University)
Eun, Jong-Bang (Dept. of Food Science and Technology, Chonnam National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.32, no.5, 2003 , pp. 700-705 More about this Journal
Abstract
Oriental pear was used as treatment of asthma, control of blood pressure tonic medicine vasoactio, diabetes in oriental medicine. In this study, it was investigated that pear pectin effects on cardiovascular system as blood pressure and renin and atrial natriuretic peptide (ANP) in plasma, cardiac hypertrophy. The experiments were performed on Sprague-Dawley rats, 2K1C hypertension model was prepared by constricting the left renal artery with a sliver clip. Animals were then divided into four groups, 5 mg/kg, 10 mg/kg, 15 mg/kg and the control, pear pectin and apple pectin solutions were supplied with them. The blood pressure was more decreased in pear pectin 10 mg/kg than in apple pectin. The plasma ANP was decreased in pear pectin 10 mg/kg, and renin was increased in same concentration of drug. Cardiac hypertrophy had a tendency to decrease in pear pectin 15 mg/kg, but was not statistically significant compared to control group.
Keywords
pear pectin; blood pressure; plasma renin & ANP; cardiac hypertophy; 2K1C;
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Times Cited By KSCI : 1  (Citation Analysis)
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