• Title/Summary/Keyword: cap

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Purification and Chemical Properties of Anti-complementary Polysaccharide from Capsici Fructus (고추의 항보체 다당의 정제와 특성)

  • Ra, Kyung-Soo;Yamada, Haruki;Sung, Ha-Jin;Cyong, Jong-Chol;Yang, Han-Chul
    • Applied Biological Chemistry
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    • v.32 no.4
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    • pp.378-385
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    • 1989
  • Water-soluble crude polysaccharide (CAP-0) obtained from the Capsici Fructus(the fruits of Capsium annuum L.) showed a potent anti-complementary activity. The anti-complementary activity did not change by pronase digestion of CAP-0, but decreased by the periodate oxidation. CAP-0 was fractionated into four polysaccharide fractions, CAP-1,2,3 and 4, by the addition of cetyltrimethylammonium bromide. CAP-1, showing the highest anti-complementary activity, was refractioned by anion-exchange chromatography to give three major fractions(CAP-1-III, IV and V). CAP-1-III was shown to have low anti-complementary activity, but CAP-1-IV and V had high activity. CAP-1-III and IV were purified on Sephadex G-100 to give each two fractions(CAP-1-IIIa and IIIb, CAP-1-IVa and IVb), respectively. From the results of gel filtration and electrophoresis, these four fractions and CAP-1-V were found to be homogeneous polysaccharides. High molecular polysaccharies(M.W. CAP-1-IIIa 70,000, IVa 195,000, V 140,000) showed relatively higher anti-complementary activity than low molecular polysaccharides(CAP-1-IIIb and IVb).

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Settlement analysis of pile cap with normal and under-reamed piles

  • Kumar, Madisetti Pavan;Raju, P. Markandeya;Jasmine, G. Vincent;Aditya, Mantini
    • Computers and Concrete
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    • v.25 no.6
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    • pp.525-535
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    • 2020
  • The use of pile foundations has become more popular in recent years, as the combined action of the pile cap and the piles can increase the bearing capacity, reduce settlement, and the piles can be arranged so as to reduce differential deflection in the pile cap. Piles are relatively long, slender members that transmit foundation loads through soil strata of low bearing capacity to deeper soil or rock strata having a high bearing capacity. In this study analysis of pile cap with considering different parameters like depth of the pile cap, width and breadth of the pile cap, type of piles and different types of soil which affect the behaviour of pile cap foundation is carried out by using Finite Element Software ANSYS. For understanding the settlement behaviour of pile cap foundation, parametric studies have been carried out in four types of clay by varying pile cap dimensions with two types of piles namely normal and under-reamed piles for different group of piles. Furthermore, the analysis results of settlement and stress values for the pile cap with normal and under-reamed piles are compared. From the study it can be concluded that settlement values of pile cap with under-reamed pile are less than the settlements of pile cap with normal pile. It means that the ultimate load bearing capacity of pile cap with under-reamed piles are greater than the pile cap with normal piles.

Effect of Dietary Capsaicin on Proto-oncogenes Expression in Various in Mice (식이 Capsaicin이 마우스의 주요 장기조직에서의 Proto-oncogenes Expression에 미치는 영향)

  • 김정미;한인섭;김병삼;유리나
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.25 no.6
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    • pp.1024-1030
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    • 1996
  • Capsaicin (8-methyl-N-vanillyl-6-nonenamide: CAP) is a mai or ingredient of hot pepper that has been used as a spicy food additive, preservative, and medicine. In this study, we evaluated the effect of dietary CAP on the selected proto-oncogene(c-jun, c-myc, H-ras, erbB, p53) expressions in various tissues of mice. Male ICR mice were divided into four groups and fed the experimental diets containing CAP at the levels of 0, 5, 20 and 100ppm for four weeks. Steady state RNA levels in various tissues were measured by slot blot hybridization assay. C-jun expression level was enhanced in stomach tissue from mice fed 20ppm CAP and significantly reduced from mice fed 100ppm CAP. The c-jun expression levels were differentially altered in organ-specific manner, Tumor suppressor gene p53 expression level appeared to be slightly increased in the liver from mice fed 20ppm CAP. These results suggested that dietary CAP differentially modulates c-jun and p53 expression in various organs.

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Comparison of Immune Responses to the PCV2 Replicase-Capsid and Capsid Virus-Like Particle Vaccines in Mice

  • Jung, Bo-Kyoung;Kim, Hye-Ran;Lee, Young-Hyeon;Jang, Hyun;Chang, Kyung-Soo
    • Journal of Microbiology and Biotechnology
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    • v.29 no.3
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    • pp.482-488
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    • 2019
  • Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome (PMWS) in pigs. Replicase (Rep) proteins are considered essential for viral replication. Capsid (Cap) protein is the primary immunogenic protein that induces protective immunity. Little is known about comparison on the immunogenicity of PCV2 Rep and Cap fusion protein and Cap protein. In the present study, recombinant baculoviruses expressing the Rep-Cap fusion protein (Bac-Rep-Cap) and the Cap protein (Bac-Cap) of PCV2 were constructed and confirmed with western blot and indirect fluorescence assay. Immunogenicities of the two recombinant proteins were tested in mice. The titers of antibodies were determined with a PCV2-specific enzyme-linked immunosorbent assay (ELISA) and a serum neutralization assay. The $IFN-{\gamma}$ response of immunized mice was measured by ELISA. The mice immunized with the Bac-Rep-Cap and Bac-Cap successfully produced Cap-specific immunoreaction. The mice immunized with the Bac-Cap developed higher PCV2-specific neutralizing antibody titers than mice injected with the Bac-Rep-Cap. $IFN-{\gamma}$ in the Bac-Rep-Cap group was increased compared to those in the Bac-Cap group. Vaccination of mice with the Bac-Rep-Cap showed significantly decreased protective efficacy compared to the Bac-Cap. Our findings will indubitably not only lead to a better understanding of the immunogenicity of PCV2, but also improved vaccines.

An Experimental Study of the Effect of Pile Cap on Behaviors of Group Piles (모형실험을 통한 사질토 지반에서의 무리말뚝 거동에 대한 상부기초 접촉 효과 연구)

  • 이수형;진봉근;정충기
    • Proceedings of the Korean Geotechical Society Conference
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    • 1999.03a
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    • pp.259-266
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    • 1999
  • In case that pile cap is in direct contact with underlying soil, the bearing mechanism for pile groups, including direct bearing effect of cap and its induced influence on pile-soil-cap interaction, should be properly considered. In this paper, the effects of pile caps on behaviors of pile groups in sandy soils were investigated by model tests, which consist of tests on 3 by 3 pile groups with/without contact on subsoil, single pile with/without contact and cap as a shallow foundation. Also, the influences of pile spacing in group piles on contact effects were investigated. The test results showed that the load carrying capacity of pile cap was large enough not to be ignored. However, the interaction effects due to contact between cap and subsoils were not revealed obviously in working load range. And in the design of pile groups, the bearing effect of pile cap when contacted with subsoils, can be reflected by simply summing up load settlement behaviors of each cap and group piles without contact.

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Influence of Pile Cap On The Behaviors of End Bearing Pile Groups (말뚝캡이 선단지지 무리말뚝의 지지거동에 미치는 영향)

  • 최영석;이수형;정충기;김명모
    • Proceedings of the Korean Geotechical Society Conference
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    • 2000.11a
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    • pp.245-252
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    • 2000
  • Model tests on free standing pile groups and piled footings with varying a pile spacing in two layered soils are carried out. The influence of pile cap on the behaviors of end bearing pile groups is analyzed by comparing the bearing behavior in piled footings with those in a single pile, a shallow footing(cap alone) and free standing pile groups. From the test results, it is found that the bearing characteristics of cap-soil-pile system are related with load levels and pile spacings. Before yield, the bearing resistance by cap is not fully mobilized, however, as the applied load increases, the bearing resistance of cap approaches to that of cap alone and settlement hardening occurs after yield due to the compaction caused by the contact pressure between cap and soil. By the cap-soil-pile interaction, shaft friction and point resistance of piles considerably increase with dependency of pile spacings. In two layered soil, the increasing effect of dilatancy in dense sandy soil adjacent to pile tips, increases the point resistance of pile.

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Design of Cap Inspection Algorithm of Fuse Cap (퓨즈 캡의 검사를 위한 알고리즘 설계)

  • Ban, Gi-Jong;Won, Young-Jin;Lim, Seung-Ha
    • 전자공학회논문지 IE
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    • v.47 no.4
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    • pp.28-33
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    • 2010
  • In this paper, we proposed to the inspection algorithm for cap, Electric fuse is an over current and circuit protection device which is occurred in electric & electronic appliance. Also the fuse are protection the second hazard at arc etc. Fuse are interest regarding a safety increased. Consequently, the fuse came to be very important. Cap inspection algorithm is designed for the cap of fuse. CCD camera is monitering the solder of cap distribution map. The conditioning of fuse cap; suming all searching data with non solder area. the area is bigger reference data then the cap is bad cap.

Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy

  • Xiaofeng Dai;Jiale Wu;Lianghui Lu;Yuyu Chen
    • Biomolecules & Therapeutics
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    • v.31 no.5
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    • pp.496-514
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    • 2023
  • Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous design of CAP devices and their parameter configurations. These factors have substantially hindered the clinical use of CAP as an oncotherapy. It is thus imperative to clarify the tumour types responsive to CAP, the experimental models available for CAP-associated investigations, CAP administration strategies and the mechanisms by which CAP exerts its anticancer effects with the aim of identifying important yet less studied areas to accelerate the process of translating CAP into clinical use and fostering the field of plasma oncology.

Effect of Pile Cap Flexibility on the Response of Pile Group Supported Column (교대를 지지하는 군말뚝의 캡강성효과)

  • Jeong, Sang-Seom;Won, Jin-Oh;Kim, Young-Ho
    • Journal of the Korean Geotechnical Society
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    • v.23 no.9
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    • pp.39-49
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    • 2007
  • The load deformation behavior of the cap-pile-soil system is investigated, based on numerical analysis. Special attention is given to consideration of pile cap flexibility. Rigid pile cap analysis and flexible cap analysis were conducted for comparison. A numerical method that takes into account the coupling between the rigidities of the piles, the cap, and the column has been introduced to analyze the response of pile group supported columns. The prediction of the lateral loads and bending moments in the pile cap is much more conservative for a flexible cap than for a rigid cap.

A Strategy for Activating Spatial Data Community : A Case of the NSDI CAP(Cooperative Agreements Program) in U.S. (공간정보 커뮤니티 활성화 방안 연구 : 미국 NSDI의 CAP 사례를 중심으로)

  • Kim, Ho-Yong;Nam, Kwang-Woo
    • Journal of the Korean Association of Geographic Information Studies
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    • v.14 no.1
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    • pp.26-39
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    • 2011
  • This paper reviews the strategy of activating spatial data community and its impacts, focusing on the Cooperative Agreements Program(CAP) of National Spatial Data Infrastructure(NSDI), established by Federal Geographic Data Committee(FGDC) in U.S. to facilitate cooperative data sharing. After thoroughly reviewing the 20 research categories followed by 350 cases, supported by CAP for the last decade, it turned out that since NSDI issued "Future Directions Initiative" in 2004, the CAP adopted all components of NSDI as CAP categories in attempting to reinforce the partnership rather than mainly deploying standardized meta-data. Also, CAP has been utilized as a means to enforce the role of NSDI as spatial data user and provider as well, recognizing that the spatial data community is essence for expandable and sustainable NSDI. Implementing CAP resulted in the sound structure of spatial data marketplaces increasing spatial data demand and promoting the relevant business due to diverse users.