• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.97-102
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• 2013

Objective: The aim of this study was to develop an automated computer-aided diagnostic system for diagnosis of thyroid cancer pattern in fine needle aspiration cytology (FNAC) microscopic images with high degree of sensitivity and specificity using statistical texture features and a Support Vector Machine classifier (SVM). Materials and Methods: A training set of 40 benign and 40 malignant FNAC images and a testing set of 10 benign and 20 malignant FNAC images were used to perform the diagnosis of thyroid cancer. Initially, segmentation of region of interest (ROI) was performed by region-based morphology segmentation. The developed diagnostic system utilized statistical texture features derived from the segmented images using a Gabor filter bank at various wavelengths and angles. Finally, the SVM was used as a machine learning algorithm to identify benign and malignant states of thyroid nodules. Results: The SVMachieved a diagnostic accuracy of 96.7% with sensitivity and specificity of 95% and 100%, respectively, at a wavelength of 4 and an angle of 45. Conclusion: The results show that the diagnosis of thyroid cancer in FNAC images can be effectively performed using statistical texture information derived with Gabor filters in association with an SVM.

• The Journal of Korean Academic Society of Nursing Education
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• v.13 no.2
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• pp.284-291
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• 2007

Purpose: Even though the breast is not removed, women with a breast conservative operation(BCO) are suffering from the psychosocial distress comparable with mastectomies. The purpose of this study was to identify how clinical nurses view essential nursing problems and nursing approaches to post operative breast cancer experiences. Method: To identify the clinical nurses's interpretation, they were asked to respond to a case involving a woman struggling with breast cancer. The nurses' responses were analyzed using a manifest content analysis strategy to determine themes in problem identification and nursing care strategies. Result: The clinical nurses recognized that most of the patient's experiences originated from a psycho-social problem. Fifteen nurses(83%) interpreted the breast cancer woman's experience derived from her psychosocial problem. They identified the most effective nursing approaches for breast cancer women following surgery as counseling and providing information. Conclusion: In conclusion, the results revealed that a psychosocial skill including an empathic communication skill is essential for excellent nursing in post operative patient care.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.239-243
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• 2016

This article investigates ethical challenges cancer patients face in the end stages of life including doctors' responsibilities, patients' rights, unexpected desires of patients and their relatives, futile treatments, and communication with patients in end stages of life. These patients are taken care of through palliative rather than curative measures. In many cases, patients in the last days of life ask their physician to terminate their illness via euthanasia which has many ethical considerations. Proponents of such mercy killing (euthanasia) believe that if the patient desires, the physician must end the life, while opponents of this issue, consider it as an act of murder incompatible with the spirit of medical sciences. The related arguments presented in this paper and other ethical issues these patients face and possible solutions for dealing with them have been proposed. It should be mentioned that this paper is more human rational and empirical and the views of the legislator are not included, though in many cases human intellectual and empirical comments are compatible with those of the legislator.

• Asian Oncology Nursing
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• v.6 no.1
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• pp.66-75
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• 2006

Purpose: The present study was to identify the levels of stress and coping and their relationship in mothers of children with cancer. Methods: A total of 124 mothers were recruited from a university hospital from June 1, to August 31, 2004. Parental Stress Scale developed by Miles and Carter (1983), and the Coping Behavior Patterns developed by McCubbin (1979) were used. Data were analyzed using SAS PC+ 8.0 program. Results: The mean score for the stress level in the mothers of the children with cancer was 195.6 from the range of 0-250. The mean score for the level of coping stress by the mothers of children with cancer was 121.8 from the range of 0-165. The level of coping stress was particularly high when the relationship with their husband was good, and when they felt hope for the children's health status. Conclusions: The most stressful element to the mothers of the children with cancer was the 'treatment and the nursing process for the children.' The frequently used coping methods were 'communication with other parents in the same situation' and 'consultation with the expert.'

• Korean Journal of Adult Nursing
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• v.25 no.1
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• pp.33-40
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• 2013

Purpose: The purpose of this study was to explore conflict resolution styles, marital intimacy and family functions among breast cancer patients and their spouses. Methods: The subjects were total 126 participants. Breast cancer patients who completed chemotherapy and or radiation along with their spouses. Data were collected using questionnaires with questions about conflict resolution styles, marital intimacy and family functions. Results: There were no differences between breast cancer patients and their spouses in verbal aggression, avoidance of conflict resolution styles and family functions. As patients reported using positive conflict resolution styles the spouse-perceived marital intimacy and family functions were higher. Those patients who perceived marital intimacy as lower they also reported more verbal aggression and avoidance. As breast cancer patients perceived family functions increasing, their spouses perception of both intimacy and family function increased. Conclusion: As these results, it should be considered as basic data to develop family intervention programs such as positive communication and effective stress management and improving of conflict resolution, intimacy and family functions among breast cancer patients and their spouses.

• Journal of the Korean Society of Visualization
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• v.18 no.3
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• pp.84-89
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• 2020

Cancer cells secrete angiogenic factors, and nearby vasculatures make new blood vessels essential for cancer development and metastasis in response to these soluble factors. Many efforts have been made to elucidate cancer-endothelial cell interactions in vitro. However, not much is known due to the lack of a suitable co-culture platform. Here, we introduce a 3D printing-based microfluidic system that mimics the in vivo-like cancer-endothelial cell interactions. The tumoroids and endothelial cells are co-cultured, physically separated by porous fibrin gel, allowing communication between two cell types through soluble factors. Using this microfluidic system, we were able to visualize new vessel formation induced by tumoroids of different origins, including liver, breast, and ovary. We confirmed that the ovarian tumoroids most induced angiogenesis while the other two cancer types suppressed it. Utilization of the proposed co-culture platform will help the researchers unveil the underlying mechanisms of the dynamic interplay between tumor and angiogenesis.

• Rapid Communication in Photoscience
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• v.1 no.2
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• pp.50-50
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• 2012

• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.69.1-69.1
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• 2004

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.695-701
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• 2014

The main objective of palliative treatment for cancer patients has been to maintain, if not improve, the quality of life (QoL). There is a lack of local data on satisfaction and QoL among cancer patients receiving palliative treatment in Malaysia. This study covers patients with incurable, progressive cancer disease receiving palliative treatment in a teaching hospital in Kuala Lumpur, comparing the different components of QoL and correlations with patient satisfaction. A cross-sectional survey using Malay validated SF36 QoL and PSQ-18 (Short Form) tools was carried out between July 2012 -January 2013 with 120 cancer patients receiving palliative treatment, recruited into the study after informed consent using convenient sampling. Results showed that highest satisfaction were observed in Communication Aspect ($50.6{\pm}9.07$) and the least in General Satisfaction ($26.4{\pm}5.90$). The Mental Component Summary ($44.9{\pm}6.84$) scored higher when compared with the Physical Component Summary ($42.2{\pm}7.91$). In this study, we found that patient satisfaction was strongly associated with good quality of life among cancer patients from a general satisfaction aspect (r=0.232). A poor significant negative correlation was found in Physical Component (technical quality, r=-0.312). The Mental Component showed there was a poor negative correlation between time spent with doctor (r=-0.192) and accessibility, (r=-0.279). We found that feeling at peace and having a sense of meaning in life were more important to patients than being active or achieving good physical comfort. More studyis needed to investigate patients who score poorly on physical and mental component aspects to understand their needs in order to achieve better cancer care.

• Natural Product Sciences
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• v.5 no.2
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• pp.88-92
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• 1999

Inhibition of gap junction-mediated intercellular communication (GJIC) has been considered as an important factor in the tumor promotion phase of carcinogenesis. Recovery effects of natural products on gap junctional intercellular communication are measured by scrape-loading and dye transfer method using Lucifer yellow after administration of phorbol-12-myristate-13-acetate (PMA) on WBF344 cells. Among tested natural products, the hexane fraction and subfractions (F-01 and F-04) of Setaria italica were relatively effective for recovery of GJIC. The hexane fraction of Setaria italica $(EC_{25},\;12.14\;{\mu}g/ml)$ and subfractions $(F-01:EC_{50},\;10.74\;{\mu}g/ml;EC_{25},\;1.58\;{\mu}g/ml,\;F-04:EC_{50},\;11.03\;{\mu}g/ml;\;EC_{25},\;3.12\;{\mu}g/ml)$ revealed dose-dependent recovery effects on GJIC. Our data show GJIC activity measurement by Lucifer yellow spread on cells can be an effective tool for the screening of natural products with possible cancer chemopreventive effects.