• Molecules and Cells
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• v.26 no.1
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• pp.5-11
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• 2008

Stalled DNA replication forks activate specific DNA repair mechanism called post-replication repair (PRR) pathways that simply bypass DNA damage. The bypassing of DNA damage by PRR prevents prolonged stalling of DNA replication that could result in double strand breaks (DSBs). Proliferating cell nuclear antigen (PCNA) functions to initiate and choose different bypassing pathways of PRR. In yeast, DNA replication forks stalled by DNA damage induces monoubiquitination of PCNA at K164, which is catalyzed by Rad6/Rad18 complex. PCNA monoubiquitination triggers the replacement of replicative polymerase with special translesion synthesis (TLS) polymerases that are able to replicate past DNA lesions. The PCNA interaction motif and/or the ubiquitin binding motif in most TLS polymerases seem to be important for the regulation of TLS. The TLS pathway is usually error-prone because TLS polymerases have low fidelity and no proofreading activity. PCNA can also be further polyubiquitinated by Ubc13/ Mms2/Rad5 complex, which adds an ubiquitin chain onto monoubiquitinated K164 of PCNA. PCNA polyubiquitination directs a different PRR pathway known as error-free damage avoidance, which uses the newly synthesized sister chromatid as a template to bypass DNA damage presumably through template switching mechanism. Mammalian homologues of all of the yeast PRR proteins have been identified, thus PRR is well conserved throughout evolution. Mutations of some PRR genes are associated with a higher risk for cancers in mice and human patients, strongly supporting the importance of PRR as a tumor suppressor pathway.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.22 no.5
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• pp.1069-1078
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• 2012

It is known that memory has been frequently a target threatening the computer system's security while attacks on the system utilizing the memory's weakness are actually increasing. Accordingly, various memory protection mechanisms have been studied on OS while new attack techniques bypassing the protection systems have been developed. Especially, buffer overflow attacks have been developed as attacks of Return to Library or Return-Oriented Programing and recently, a technique bypassing the countermeasure against Return-Oriented Programming proposed. Therefore, this paper is intended to suggest a detection mechanism at binary level by analyzing the procedure and features of Jump-Oriented Programming. In addition, we have implemented the proposed detection mechanism and experimented it may efficiently detect Jump-Oriented Programming attack.

• Proceedings of the KIEE Conference
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• 2003.10b
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• pp.247-250
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• 2003

To get more realistic wind turbine torque characteristic, it is important to consider many parameters about wind turbine system. One of them is the tower effect which is occurred when a blade is bypassing the wind turbine tower and influences shaft torque fluctuation. In this paper, to emulate the similar torque performance of wind turbine, the wind turbine simulation and experiment with torque fluctuation by blade tower effect are implemented and verified. The simulation model is based on MATLAB Simulink.

• 한국생물공학회:학술대회논문집
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• 2000.04a
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• pp.215-218
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• 2000

Aspergillus oryzae is a filamentous fungus classified in the group Aspergillaceae Ascomycetes. It is an important microorganism for industrial production of enzymes and fermented food productions. The genetic transformation system in A. oryzae was used to protoplast mediated transformation with PEG/$CaCl_2$. When the protoplast was used, the regeneration efficiency was decreased and then transformation frequence was also effected. In this study, fungal transformation was carried out by bypassing the protoplast isolation step, changing enzymes, such as hemicellulase and celluclast, and decreasing the culturing time for the increment of the transformation efficiency. 83 transformants/10ug of DNA with hemicellulase were obtained, compared with less than 10 transformants with novozyme234 and celluclast.

• BMB Reports
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• v.53 no.9
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• pp.458-465
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• 2020

Metastasis is the main culprit of the great majority of cancerrelated deaths. However, the complicated process of the invasion-metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and genomic integrity. Telomerase reverse transcriptase (TERT) exerts a series of fundamental functions that are independent of its enzymatic cellular activity, including proliferation, inflammation, epithelia-mesenchymal transition (EMT), angiogenesis, DNA repair, and gene expression. Accumulating evidence indicates that TERT may facilitate most steps of the invasion-metastasis cascade. In this review, we summarize important advances that have revealed some of the mechanisms by which TERT facilitates tumor metastasis, providing an update on the non-canonical functions of telomerase beyond telomere maintaining.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.10a
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• pp.191-194
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• 1995

The business of manufacturing is increasingly becomeing time-compresssing, precise and long-life oiented, owing to various needs form the consumers and harsh global competition. with the emergence of the layer laminate maunfacturing methods, it is possible to prototypes directly from 3D CAD and additive process, the production time and cost have shortened dramatically. However there are some problems like surface-step, dimensional deviation and warp. A newly developed powder casting is suitable for rapid-manufacturing metallic tools. Powder casting can serve as a promising repid tooling method because of high density charateristics and low dimensional shrinkage below 0.1% during sintering and infiltration. By this process, we have realized significant time savings bypassing the wait for prototype tooling and cost savings eliminating the expense of conventional prototype tooling process.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.26 no.8
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• pp.96-101
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• 2012

A surge protection device of the metal oxide varistor(MOV) has been commonly used for preventing electrical damage in many electronic equipments. The MOV has a property that leakage current is increased and might be permanently damaged when it is exposed continuously to the electrical stresses such as lightening surges. In this paper, we propose a novel surge protection circuit adopting a silicon controlled rectifier(SCR) in the traditional protection circuits using the MOV device simultaneously. When lightning surges are injected to the proposed circuit, the MOV lets the surge pulses bypassing through the ground at first up to the level that SCR begins to operate. Above the threshold level of turning on the SCR, the SCR operates bypasses large surge currents to the ground. Proposed circuit was verified with a leakage current experiment and PSpice circuit simulations under the repeated surge injection environment.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 1997.05a
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• pp.25-29
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• 1997

In many solute transport studies, either flux or resident concentration has been used. Choice of the concentration mode was dependent on the monitoring device in solute displacement experiments. It would be questionable, however. to accept the equivalency in the solute transport parameters between flux and resident concentrations in structured soils exhibiting preferential movement of solute. In this study, we investigate how they differ in the monitored breakthrough curves (BTCs) and transport parameters for a given boundary and flow condition by performing solute displacement experiments on a number of undisturbed soil columns. Both flux and resident concentrations have been simultaneously obtained by monitoring the effluent and resistance of the Horizontally-positioned TDR probes. The study reveals that soil columns having relatively high flux densities exhibited great differences in the degree of peak concentration and travel time of peak between flux and resident concentrations. The peak concentration in flux mode was several times higher than that in resident one. This was mainly due to the bypassing of solute through soil macropores.

• Nuclear Engineering and Technology
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• v.21 no.4
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• pp.302-307
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• 1989

Nuclide release through penetrations in radioactive waste container is analyzed. Penetrations may result from corrosion or cracking and may be through the container material or through deposits of corrosion products. The analysis deals with the resultant nuclide release, but not with the way these penetrations occur. Numerical illustrations show that mass transport from multiple holes can be significant and may approach the mass transfer rate calculated from bare waste forms. Although partially-failed containers may present an important long-term barrier to release of radionuclides, numerous small holes on a container surface have the potential of bypassing the effectiveness of these barriers.

• Journal of Power Electronics
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• v.10 no.1
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• pp.34-42
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• 2010

Reliability is an important issue in cascaded H-bridge converters (CHB converters) because they use a high number of power semiconductors. A faulty power cell in a CHB converter can potentially lead to expensive downtime and great losses on the consumer side. With a fault-tolerant control strategy, operation can continue with the undamaged cells; thus increasing the reliability of the system. In this paper, the operating principles and the control method for a CHB multilevel rectifier are introduced. The influence of various faults on the CHB converter is investigated. The method of fault diagnosis and the bypassing of failed cells are explained. A fault-tolerant protection strategy is proposed to achieve redundancy in the CHB rectifier. The redundant H-bridge concept helps to deal with device failures and to increase system reliability. Simulation results verify the performance of the proposed strategy.