• Bulletin of the Korean Chemical Society
• /
• v.32 no.3
• /
• pp.867-872
• /
• 2011

For the prolonged delivery and sustained release rates of low molecular weight drugs, poly(lactic-co-glycolic acid) (PLGA) microparticles containing the drug SKL-2020 have been investigated. On increasing polyvinyl alcohol (PVA) concentration (from 0.2% to 5%), the size of microparticles decreased (from $48.02{\mu}m$ to $10.63{\mu}m$) and more uniform size distribution was noticeable due to the powerful emulsifying ability of PVA. A higher drug loading (from 5% to 20%) caused a larger concentration gradient between 2 phases at the polymer precipitation step; this resulted in decreased encapsulation efficiency (from 34.19% to 25.67%) and a greater initial burst (from 61.71% to 70.05%). SKL-2020-loaded PLGA microparticles prepared with different fabrication conditions exhibited unique release patterns of SKL-2020. High PVA concentration and high drug loading led to an initial burst effect by rapid drug diffusion through the polymer matrix. Since PLGA microparticles enabled the slow release of SKL-2020 over 1 week in vitro and in vivo, more convenient and comfortable treatment could be facilitated with less frequent administration. It is feasible to design a release profile by mixing microparticles that were prepared with different fabrication conditions. By this method, the initial burst could be repressed properly and drug release rate could decrease.

• Journal of Food Hygiene and Safety
• /
• v.35 no.6
• /
• pp.602-606
• /
• 2020

This study was designed to investigate the dynamic behaviors of phages against Salmonella enterica subsp. enterica serovar Typhimurium ATCC 19585 (STWT), S. Typhimurium KCCM 40253 (STKCCM), ciprofloxacin-induced S. Typhimurium ATCC 19585 strains (STCIP), and S. Typhimurium CCARM 8009 (STCCARM). Phages, including PBST-10, PBST-13, PBST-32, PBST-35, P-22, and P-22 B1 had narrow host ranges. The adsorption rates of all phages ranged from 47 to 85%, 58 to 95%, and 61 to 93%, respectively, against STWT, STKCCM, and STCIP, while the lowest adsorption rates ranged from 14 to 36% against STCCARM. The phage burst sizes were from 43 to 350, 37 to 530, 66 to 500, and 24 to 500 plaque-forming units (PFUs) per infected STWT, STKCCM, STCIP, and STCCARM, respectively. The STCIP strain was effectively inhibited by all phages at the early of incubation period. These results provide useful information for better understanding the phage behaviors against antibiotic-resistant and antibiotic-sensitive pathogens.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.18 no.7
• /
• pp.980-988
• /
• 1993

In this paper, performance of 8-ISDN traffic for the buffer size which is requested of important parameters in switch/multiplexer of B-ISDN with multimedia traffic is analyzed. Multimedia traffic is modeled as a traffic, which is composed of poisson distribution traffic and burst traffic with exponential/geometric ON time duration(Burst duration) Performance of traffic which is modeled as a multimedia traffic is analysed and buffer size, can provide the high quality service, is presented for the cell loss probability. It is simulated using event scheduling approach method which is provided by simulation package, PC SIMSCRIPT II.5. Simulation program is composed of PREAMBLE, MAIN, INITIAL, ARRIVAL, DEPARTURE and STOP·SIM modules. Specially, in case of mixed traffic simulation, ARRIVAL module is composed of ARRIVAL I and ARRIVAL II, and cells are generated independently by each module.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.20 no.1
• /
• pp.107-112
• /
• 2020

We analyze the flow aggregate (FA) based network delay guarantee framework, with generalized minimal interleaved regulator (IR) initially suggested by IEEE 802.1 time sensitive network (TSN) task group (TG). The framework has multiple networks with minimal IRs attached at their output ports for suppressing the burst cascades, with FAs within a network for alleviating the scheduling complexity. We analyze the framework with various topology and parameter sets with the conclusion that the FA-based framework with low complexity can yield better performance than the integrated services (IntServ) system with high complexity, especially with large network size and large FA size.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1996.04a
• /
• pp.282-282
• /
• 1996

The purpose of this study was to prepare the nifedipine dry elixir (NDE) and coated nifedipine dry elixir (CNDE) containing nifedipine ethanol solution for improving the dissolution rate and bioavailability of nifedipine. NDE containing nifedipine and ethanol in wall materials of dextrin was prepared using a spray-dryer and then NDE was coated with eudragit acrylic resin to make CNDE. Shape and size of the NDE and CNDE were monitored by scanning electron micrograph and laser particle size analyzer In vitro dissolution tests were performed in simulated gastric and intestinal fluid. Bioavailability of NDE and CNDE were compared with drug powder suspension and commercial soft capsule after oral administration of the preparations to rats. NDE and CNDE are spherical in shape. Cross-sectional view of dry elixirs indicates the large inter cavity containing ethanolic drug solution in shell. Geometric mean diameter of NDE and CNDE is about 6.64 and 8.70 $\mu\textrm{m}$, respectively. Drug dissolution rate within first 5 min from NDE increased dramatically irrespective of dissolution medium. However, CNDE showed a particularly retarded dissolution rate in pH 1.2 simulated gastric fluid compared with NDE. The bioavailability of nifedipine in the NDE was increased dramatically compared with drug powder suspension. CNDE reduced initial burst-out plasma peak compared with NDE. CNDE as a sustained release delivery system could reduce the initial burst-out plasma peak due to controlling the release rate of nifedipine from NDE and maintain the effective plasma level over a longer period within therapeutic window with enhanced bioavailability of nifedipine.

• Journal of the Korean Institute of Telematics and Electronics S
• /
• v.35S no.5
• /
• pp.1-10
• /
• 1998

Satellite communication is getting more important in the coming 21st century because of its wide areas sevice capability, ease of access, and fast channel establishment. As such, satellite communication networks will be the basis of the global communication system in cooperation with the ground ATM networks. In this paper, we consider an efficient transmission methodology of ATM cells over the satellite communication channel. We first analyze possible bottlenecks and performance deterioration factors in the case, and then propose an enhanced cell trasmission mechanism. In order to use satellite channel for ATM cell transmission, the application of complicated channel coding is inevitable. However, the forwared error control such as convolutional encoding brings forth burst errors, which calls for the application of some kind of interleaving mechanism to randomize the burst errors at the receiver. Another aspect which should b econsidered in satellite communication system is the inherent transmission delay, which can be very considered in satellite communication system is te inherent transmission delay, which can be very critical to the delay-sensitive ATM traffic. Therefore, we propose that the processing delay at the block interleaving stage should be controlled propose a variable-size block interleaving mechanism which utilizes the predicted transmission delay for each traffic in the queues of the transmitter. According to the computer simulation, the proposed mechanism could improve the overall performance by drastically reducing the ATM cell drop rate owing to the excessive transmission delay.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.23 no.4
• /
• pp.21-27
• /
• 2019

Composite motor cases fabricated by the filament winding method are structurally weak in the dome when they are required to withstand the internal pressure of the combustion gas. In this study, a finite element analysis is conducted to compare the burst pressure of a composite dome according to the variation of the pressure distribution ratio(PDR). The performance of the composite motor case was compared quantitatively by calculating the stress on the inner and outer dome surfaces and metal boss volume. As a result, the critical point of the failure mode was observed at a PDR between 2.5 and 3.0. A design at a PDR of 2.5­-3.5 can reduce the weight of metal boss without fluctuation in the burst pressure of the combustion motor case. Moreover as the design reference value changes according to the dome shape and opening size, further analysis and testing are necessary.

• Bulletin of the Korean Space Science Society
• /
• 1995.04a
• /
• pp.21-21
• /
• 1995

The structures of 17GHz microwave burst for bipolar sunspots have investigated. which included the effects of the projected shapes of radio sources as they traverse across the solar disk using a magnetic loop employing a model of solenoid coils. An ensemble of high-energy electrons confined in the loop be assumed. The projected brightnesls distributions of gyrosynchrotron emission in x- and o-modes are computed and converted into total intensity and circular polarization difference at 17GHz for various heliocentric distances using numerical integration of the transfer equation along the line of sight. The results of computations at 17GHz for optical thin case will be presented. and the effects of the orientation of the loop will be discussed in detail, as well as the effect of size, position, Structure, and polarization of the emission. Also the results of the various physical P8lrameters such as the strength of magnetic field. high and low energy cut-off of accelerated electrons. spectral index and density of electrons will be preslmted. After comparing the results of model calculation with observations. we found that the observations can be well explained in terms of a loop model and its projection effect.effect.

• Korean Journal of Microbiology
• /
• v.39 no.2
• /
• pp.118-122
• /
• 2003

To develop vector plasmid for the bacteriophage P2-P4 system which is a useful experimental tool for the study of viral capsid assembly, we constructed a new P4-derived vector plasmid starting from P4 ash8 sid71 With recombinant DNA technology, a portion of P4 genome was deleted and tetracyclin resistance gene (terR) was introduced into P4 genome to give P4 selectivity. Resulting P4 ash8(sid71) terR was 12.09 kb long and could be converted to a viable bacteriophage with P2 infection. The burst size of induced bacteriophage form of P4 ash8(sid71) terR was determined. The CsCl buoyant equilibrium density gradient experiment of new P4 derivative suggested the upper limit of packaging capacity in P2-size head.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.26 no.4
• /
• pp.562-570
• /
• 2022

The supply expansion of 5G services and personal smart devices has caused the sharp increase of data traffic and the demand of various services. Again, these facts have resulted in the huge demand of network bandwidth. However, existing network technologies using electronic signal have reached the limit to accommodate the demand. Therefore, in order to accept this request, optical internet has been studied actively. However, optical internet still has a lot of problems to solve, and among these barriers a very urgent issue is to develop QoS technologies. Hence, in order to achieve service differentiation between classes in optical internet, especially in OBS network, a new QoS method automatically tuning the size of data bursts is proposed in this article. Especially, the algorithm suggested in this article is based on fiber delay line.