• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.11
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• pp.24-35
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• 2012

In this paper, we propose a dynamic lane control scheme with a traffic predictor module and a rate controller for reconciling with commercial optical PHY modules in energy efficient optical Ethernet systems. The commercial high speed optical Ethernet system capable of 40/100Gbps employs 4 or 10 multiple optical transceivers over WDM or multiple optical links. Each of the transceivers is always turned on even if the link is idle. To save energy, we propose the dynamic lane control scheme. It allows that several links may be entirely turned off in a low traffic load and frames are handled on the remaining active links. To preserve the byte order even if the number of active links may be changed, we propose a rate controller to be sat on the reconciliation sublayer. The main role of the controller is to insert null byte streams into the xGMII of inactive lanes. For the PHY module, the null input streams corresponding to inactive lanes will be disregarded on inactive PMDs. It is very handy to implement the rate controller module with MAC in FPGA without any modification of commercial PHYs. It is very crucial to determine the number of active links based on the fluctuated traffic load, we provide a simple traffic predictor based on both the current transmission buffer size and the past one with different weighting factors for adapting to the traffic load fluctuation. Using the OMNET++ simulation framework, we provide several performance results in terms of the energy consumption.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2002.11a
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• pp.345-352
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• 2002

무선 인터넷을 이용하는 사용자는 정보의 양의 따른 시간적 통신비용의 증가 문제로 개인화 에이전트가 사용자의 관심에 따라 서비스를 제공하는 기능과 맞춤화된 정보를 제공하는 기능, 지식 기반 방식으로 정보를 예측하는 기능을 가지기를 바라고 있다. 본 논문에서는 이와 같이 무선 인터넷을 사용하는 사용자를 위한 PDA 개인화 에이전트 시스템을 구축하고자 한다. PDA 개인화 에이전트 시스템 구축을 위해 프로파일 기반의 에이전트 엔진과 사용자 프로파일을 이용한 지식기반 방식을 사용한다. 사용자가 웹페이지에서 행하는 행위들을 모니터링하여 사용자가 관심 가지는 문서를 파악하고 정보 검색을 통해 얻어진 문서를 분석하여 사용자 각각의 관심 문서로 나누어 서비스하게 된다. 모니터링 되어진 문서를 효과적으로 분석하기 위해 unsupervised clustering 기계학습 방식인 Cobweb을 이용한다. unsupervised 기계 학습은 conceptual 방식을 이용하여 검색되어진 정보를 사용자의 관심 분야별로 clustering한다. 클러스터링을 통해 얻어진 결과를 다시 기계학습을 통해 사용자 관심문서에 대한 프로파일을 생성하게 된다. 이렇게 만들어진 프로파일을 룰(Rule)로 만들어 이를 기반으로 사용자에게 서비스하게 된다. 이러한 룰은 사용자의 모니터링 결과로 얻어지기 때문에 주기적으로 업데이트하게 된다. 제안하는 시스템은 인터넷신문이나 웹진 등에서 사용자들에게 뉴스를 전달하기 위한 목적으로 생성하는 뉴스문서를 특정 대상으로 선정하였고 사용자 정보를 이용한 검색을 실시하고 결과로 얻어진 정보를 정보 분류를 통해 PDA나 휴대폰을 통해 사용자에게 제공한다. 상품을 검색하기 위한 검색노력을 줄이고, 검색된 대안들로부터 구매자와 시스템이 웹상에서 서로 상호작용(interactivity) 하여 해를 찾고, 제약조건과 규칙들에 의해 적합한 해를 찾아가는 방법을 제시한다. 본 논문은 구성기반 예로서 컴퓨터 부품조립을 사용해서 Template-based reasoning 예를 보인다 본 방법론은 검색노력을 줄이고, 검색에 있어 Feasibility와 Admissibility를 보장한다.매김할 수 있는 중요한 계기가 될 것이다.재무/비재무적 지표를 고려한 인공신경망기법의 예측적중률이 높은 것으로 나타났다. 즉, 로지스틱회귀 분석의 재무적 지표모형은 훈련, 시험용이 84.45%, 85.10%인 반면, 재무/비재무적 지표모형은 84.45%, 85.08%로서 거의 동일한 예측적중률을 가졌으나 인공신경망기법 분석에서는 재무적 지표모형이 92.23%, 85.10%인 반면, 재무/비재무적 지표모형에서는 91.12%, 88.06%로서 향상된 예측적중률을 나타내었다.ting LMS according to increasing the step-size parameter $\mu$ in the experimentally computed. learning curve. Also we find that convergence speed of proposed algorithm is increased by (B+1) time proportional to B which B is the number of recycled data buffer without complexity of compu

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.4
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• pp.378-388
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• 2008

Flash memory has been attracting attention as the next mass storage media for mobile computing systems such as notebook computers and UMPC(Ultra Mobile PC)s due to its low power consumption, high shock and vibration resistance, and small size. A storage system with flash memory excels in random read, sequential read, and sequential write. However, it comes short in random write because of flash memory's physical inability to overwrite data, unless first erased. To overcome this shortcoming, we propose an SSD(Solid State Disk) architecture with two novel features. First, we utilize non-volatile FRAM(Ferroelectric RAM) in conjunction with NAND flash memory, and produce a synergy of FRAM's fast access speed and ability to overwrite, and NAND flash memory's low and affordable price. Second, the architecture categorizes host write requests into small random writes and large sequential writes, and processes them with two different buffer management, optimized for each type of write request. This scheme has been implemented into an SSD prototype and evaluated with a standard PC environment benchmark. The result reveals that our architecture outperforms conventional HDD and other commercial SSDs by more than three times in the throughput for random access workloads.

• Korean Journal of Veterinary Service
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• v.39 no.3
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• pp.141-149
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• 2016

Changes in the Leydig cell from pre-puberty to adulthood were studied in Korean native cattle. Eight groups of male cattle aged 14, 17, 20, 25, 30, 35, 40 and 104 weeks (n=7 cattle per group) after birth were used. The purpose of this study was to obtain quantitative information on the Leydig cell of the Korean native cattle during postnatal development. Testes of cattle were fixed by perfusion using a fixative containing 2.5% glutaraldehyde in cacodylate buffer, processed and embedded in Epon-araldite. Using $1{\mu}m$ section stained with methylene blue-azure II, qualitative and quantitative (stereological) morphological studies were performed. The average diameter of seminiferous tubules gradually increased with age from 14 ($75.56{\mu}m$) to 104 weeks ($298.9{\mu}m$). The volume density of the seminiferous tubules increased with age from 54.2% at week 14 to 76.9% at week 104. The volume density of the interstitium represents 45.52% at week 14. This proportion progressively diminishes during development to reach a value of 23.14% at week 104. The volume density of Leydig cells decreased almost linearly from 14 (20.71%) to 104 weeks (5.28%). The absolute volume of Leydig cells per testis increased significantly from 14 to 104 weeks. The number of Leydig per testis have almost linearly increased from 14 to 104 weeks. The average volume of a Leydig cell reached maximum size by 104 weeks ($2553{\mu}m^3$). These data suggested development of Leydig cell can be classified as the fetal and immature adult Leydig cells (14~35 weeks), and the adult Leydig cells (40~104 weeks).

• Proceedings of the Korean Society of Toxicology Conference
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• 2006.11a
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• pp.65-74
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• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• Korean Chemical Engineering Research
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• v.43 no.1
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• pp.110-117
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• 2005

In this work, solid-state inclusion complex powders of itraconazole and $2-hydroxypropyl-{\beta}-cyclodextrin(HP-{\beta}-CD)$ were produced by a supercritical anti-solvent (SAS) process. In order to evaluate the degree of complexation, the thermal behavior of the microparticulate complexes was investigated using differential scanning calorimetry. The experimental results obtained for the solubility and dissolution rate of the microparticulate inclusion complexes in a buffer solution of pH 1.2 showed that the complexation of itraconazole with $HP-{\beta}-CD$ results in a significant increase in the solubility and dissolution rate of itraconazole. The particle size of the SAS-produced inclusion complexes was dramatically reduced ($<0.1-0.5{\mu}m$) compared with untreated itraconazole ($30-50{\mu}m$) and $HP-{\beta}-CD$ ($50-100{\mu}m$). The solubility of itraconazole was increased with the increase of pressure at a constant temperature to ca. $758.6{\mu}g/mL$ in an aqueous medium of pH 1.2. The dissolution rate of itraconazole was observed to be significantly improved and about 90% of itraconazole was found to be dissolved within 5-10 min.

• Journal of Pharmaceutical Investigation
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• v.26 no.1
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• pp.33-41
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• 1996

In order to study the effect of phenobarbital(PB) on the hepatic transport of diltiazem(DTZ), $Ca^{2+}$ channel blocker, we used isolated hepatocytes of rat which was intraperitoneally pretreated with phenobarbital sodium(75 mg/kg) for four days once a day. For the isolation of rat liver cells, a modification of the two step procedure of Seglen was used. DTZ was dissolved in incubation buffer to the final DTZ concentrations of 200, 400, 600, 800 and 1000 ng/ml in order to elucidate the uptake characteristics of DTZ by hepatocytes. Reactions were stopped at 10, 20, 30, 45, 60, 90, 120 and 300 sec. The initial velocity was determined by disappearance of diltiazem in the hepatocyte suspension. On the other hand, to determine the effect of PB on the in vitro hepatic intrinsic clearance of DTZ we obtained the metabolism rates of DTZ in the control and the PB-pretreated rat hepatocyte at various time intervals. According to pretreatment with PB, the size of hepatocyte and the amount of protein per $10^6$ cells were significantly (p<0.01) increased from $26.92{\pm}0.1364\;m$ to $35.31{\pm}1.00\;m$ and from $468{\pm}6.5\;{\mu}g/10^6$ cells to $628.8{\pm}12.1{\mu}g/10^6$ cells, respectively. In the case or hepatic uptake of diltiazem, $K_m$ was not different in the normalization by cell numbers and increased from $2.90\;{\mu}M\;to\;13.89\;{\mu}M$ in the normalization by protein amount. $V_max$ was increased regardless of normalization by protein amount and cell numbers, from $1.21\;{\mu}mole/min \;{\cdot}\;mg\;protein\;to\;3.96\;{\mu}mole/min\;{\cdot}\;mg\;protein\;and\;from\;2.38\;{\mu}mole/min\;{\cdot}\;10^6\;cells\;to\;2.83\;{\mu}mole/min\;{\cdot}\;10^6\;cells$, respectively. The in vitro hepatic intrinsic clearance of DTZ was significantly (p<0.01) increased from $0.640{\pm}0.038\;ml/mim\;{\cdot}\;10^6\;cells\;to\;2.385{\pm}0.212\;ml/min\;{\cdot}\;10^6\;cells$ due to PB-pretreatment. These results suggest that the uptake of DTZ by hepatocyte is extremely fast and PB enhances the hepatic intrinsic metabolic clearance of DTZ.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.8
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• pp.1239-1244
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• 2003

Microcapsules were prepared by coacervation method using acetone/liquid paraffin system to control the ripening of kimchi. Eudragit E100, which was soluble at below pH 5.0 in aqueous solution, was used to make microcapsules to be sensitive to acidity of kimchi. The microcapsules with Eudragit E100 containing grapefruit seed extract (GFSE) showed the highest yield of 92.13%, the size of microcapsules was decreasing as increasing the amount of aluminium stearate, a dispersing agent. Morphology of the microcapsules determined by scanning electron microscopy showed spherical forms. GFSE, encapsulated antimicrobial agents, was quickly released at acidic buffer (pH 4,5,6) within 1 storage day. However, 70% of encapsulated GFSE in Eudragit E100 microcapsules was continuously released at pH 7 till 3 days, and it was sustained till 9 days. Characteristics of kimchi containing microcapsules of GFSE were analysed with ripening period. Decease of pH in kimchi was retarded with the added GFSE microcapsules till 2 days of fermentation, but GFSE did not affect pH in kimchi after 3 days. Total numbers of microorganisms and lactic acid microorganisms in kimchi were decreased with increasing the amount of the added GFSE microcapsules, however, the effect of controlled released GFSE from pH sensitive Eudragit E100 microcapsules was hard to detect. These results suggest the possibility of pH sensitive microcapsules for high qualify of kimchi.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2002.05a
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• pp.140-148
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• 2002

컴퓨터를 통해 편리한 생활을 추구해온 인간들은 전자상거래 분야에서도 이러한 욕구를 충족시키기 위해 자동협상이라는 기능을 요구하게 되었다. 지능형 에이전트를 이용한 자동협상은 인간의 거래협상 업무의 부담을 많은 부분을 덜어주고 있어 자동협상 에이전트에 관한 연구들이 활성화되고 있다 소비자간 전자상거래에서는 다수의 자동협상 에이전트 연구들이 경매시장에서의 자동협상에 초점을 맞추고 있는데 반해, 가격 이외의 여러 거래속성을 갖는 상품에 대한 제안기반 협상시장에서의 자동협상 에이전트에 관한 연구들이 최근에 활발히 이루어지고 있다. 본 연구에서는 소비자간 전자상거래에서 거래속성의 변화에 따라 개인의 효용가치의 차이를 이용한 다속성 상품의 제안기반 협상시장이 가져야할 특성에 대해 연구하고, 이를 기반으로 자동 거래협상을 수행에 필요한 거래속성 변화에 따른 소비자 개인의 선호체계를 표현하기 위한 방법을 개발하였다. 그리고 이러한 자동 거래협상을 공정하게 수행하기 위해 협상시장이 가져야할 특징과 프로토콜을 제안하고 시장운영 에이전트 시스템의 구조를 설계하였다. 마지막으로 이러한 분산형 시장구조를 갖는 제안기반의 협상시장에 참여하는 사용자 에이전트 시스템이 최적의 거래상대와 최적의 거래안을 찾기 위한 탐색방법을 구체적으로 개발하였다. 본 연구의 결과를 통하여 소비자간 전자상거래에서 구매자 뿐만 아니라 판매자도 협상결과에 따른 거래로 얻어지는 자신의 효용을 극대화할 수 있는 공정한 협상시장을 운영할 수 있을 뿐만 아니라 사용자들도 손쉽게 자신의 협상 선호체계를 쉽게 표현하고, 표현된 선호체계를 반영한 자동 거래협상을 수행할 수 있을 것 이다. 기존의 UN/EDIFACT표준을 사용하고 있는 EDI환경과 기존 VAN 방식의 EDI 중계 시스템과 연동되며, 향후 관세청의 XML/EDI 표준 시행을 미리 대비하는 선도연구로서 자리매김이 된다. 본 연구에서는 개발된 XML/EDI 통관시스템은 향후, 서비스의 최대 걸림돌이 되어왔던 값비싼 EDI 사용료의 부담에서 벗어날 수 있게 할 것이며, 저렴한 EDI구축/운영 비용으로 전자문서교환의 활성화와 XML이 인터넷 기반의 문서유통 표준으로 자리매김할 수 있는 중요한 계기가 될 것이다.재무/비재무적 지표를 고려한 인공신경망기법의 예측적중률이 높은 것으로 나타났다. 즉, 로지스틱회귀 분석의 재무적 지표모형은 훈련, 시험용이 84.45%, 85.10%인 반면, 재무/비재무적 지표모형은 84.45%, 85.08%로서 거의 동일한 예측적중률을 가졌으나 인공신경망기법 분석에서는 재무적 지표모형이 92.23%, 85.10%인 반면, 재무/비재무적 지표모형에서는 91.12%, 88.06%로서 향상된 예측적중률을 나타내었다.ting LMS according to increasing the step-size parameter $\mu$ in the experimentally computed. learning curve. Also we find that convergence speed of proposed algorithm is increased by (B+1) time proportional to B which B is the number of recycled data buffer without

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.49 no.4
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• pp.17-22
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• 2012

Convolution filtering methods have been widely applied to various digital signal processing fields for image blurring, sharpening, edge detection, and noise reduction, etc. According to their application purpose, the filter mask size or shape and the mask value are selected in advance, and the designed filter is applied to input image for the convolution processing. In this paper, we proposed an image processing acceleration method for the convolution processing by using two-dimensional Look-up table (LUT) and overlap-region buffering technique. First, based on the fixed convolution mask value, the multiplication operation between 8 or 10 bit pixel values of the input image and the filter mask values is performed a priori, and the results memorized in LUT are referred during the convolution process. Second, based on symmetric structural characteristics of the convolution filters, inherent duplicated operation region is analysed, and the saved operation results in one step before in the predefined memory buffer is recalled and reused in current operation step. Through this buffering, unnecessary repeated filter operation on the same regions is minimized in sequential manner. As the proposed algorithms minimize the computational amount needed for the convolution operation, they work well under the operation environments utilizing embedded systems with limited computational resources or the environments of utilizing general personnel computers. A series of experiments under various situations verifies the effectiveness and usefulness of the proposed methods.