• 여성건강간호학회지
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• 제28권2호
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• pp.145-153
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• 2022

Purpose: This study aimed to investigate the influencing factors of breast cancer recurrence by comparing the risk factors and lifestyle patterns related to breast cancer in Korean women with and without recurrence. Methods: This cross-sectional survey comprised 241 Korean women diagnosed with breast cancer who had received follow-up treatment. Participants were recruited from a university hospital in Seoul and an online social media platform for breast cancer patients. Data were collected either via online or a paper survey, using a structured questionnaire that included general and disease-related characteristics and lifestyle behaviors. Data were analyzed using descriptive statistics, univariate analysis, and logistic regression. Results: Recurrence of breast cancer was influenced by four factors; childbirth experience, consumption of green/yellow vegetables, drinking behavior, and recovery from fatigue after sleep. Prevalence of recurrent breast cancer was associated with no childbirth experience (OR=2.29, p=.010), fewer green/yellow vegetables (OR=0.71, p=.008), drinking behavior (OR=0.24, p=.001), and a lower level of recovery from fatigue after sleep (OR=0.51, p<.001). Conclusion: Aside from having experienced childbirth, this study identified several modifiable factors that influence breast cancer recurrence. Increasing green/ yellow vegetable intake, alleviating fatigue, and reducing alcohol intake are important. Intervention strategies in clinical research and practice can be applied to address risk factors and reduce the prevalence of recurrent breast cancer.

• Journal of Korean Neurosurgical Society
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• 제51권2호
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• pp.94-97
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• 2012

Tumors that metastasize to the pituitary gland are unusual, and are typically seen in elderly patients with diffuse malignant disease. The most common metastases to the pituitary are from primary breast and lung cancers. We report a 65-year-old woman with pituitary metastasis from breast cancer who presented with recent-onset left progressive deterioration of visual acuity and visual field. The clinical diagnosis was made after brain and sellar magnetic resonance imaging showed a large sellar mass compressing the optic chiasm and invading the pituitary stalk. An otorhinolaryngology and neurosurgery team removed the tumor via a transsphenoidal approach, and this procedure obtained symptomatic relief. Postoperatively, metastasis from breast invasive ductal adenocarcinoma was confirmed histologically. We report this unusual case with a review of the relevant literature.

• Investigative Magnetic Resonance Imaging
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• 제20권1호
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• pp.9-26
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• 2016

The purpose of this paper is to show the radiologic features of various lesions appearing as skin thickening or enhancement under the breast MRI. And histopathologic results of the skin lesions were correlated. Radiologist must be familiar with normal appearance of the breast skin under the MRI and a wide variety of conditions may affect the skin of the breast.

• Radiation Oncology Journal
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• 제34권1호
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• pp.1-9
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• 2016

Overexpression of human epidermal growth factor receptor 2 (HER2) is found in about 20% of breast cancer patients. With treatment using trastuzumab, an anti-HER2 monoclonal antibody, systemic control is improved. Nonetheless, the incidence of brain metastasis does not be improved, rather seems to be increased in HER2-positive breast cancer. The mainstay treatment for brain metastases is radiotherapy. According to the number of metastatic lesions and performance status of patients, radiosurgery or whole brain radiotherapy can be performed. The concurrent use of a radiosensitizer further improves intracranial control. Due to its large molecular weight, trastuzumab has a limited ability to cross the blood-brain barrier. However, small tyrosine kinase inhibitors such as lapatinib, has been noted to be a promising agent that can be used as a radiosensitizer to affect HER2-positive breast cancer. This review will outline general management of brain metastases and will focus on preclinical findings regarding the radiosensitizing effect of small molecule HER2 targeting agents.

• Journal of Breast Cancer
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• 제21권4호
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• pp.354-362
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• 2018

Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To accommodate the occurrence of ERS, cells have evolved a highly conserved, selfprotecting signal transduction pathway called the unfolded protein response. Notably, ERS signaling is involved in the development of a variety of diseases and is closely related to tumor development, particularly in breast cancer. This review discusses recent research regarding associations between ERS and tumor metastasis. The information presented here will help researchers elucidate the precise mechanisms underlying ERS-mediated tumor metastasis and provide new directions for tumor therapies.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10313-10317
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• 2015

Background: The purpose of the article was to analyze the years of potential life lost (YPLL) of women who died from breast and cervical cancer in the State of Paran$\acute{a}$, Southern Brazil. This was a temporal trend study (2000 to 2010) about the coefficients of mortality and the years of potential life lost in women aged 20 to 70 years. Materials and Methods: Data were obtained through the database of the Department of the Unified Health System (DATASUS) and the National Mortality Information System. Results: There was a loss of 125.075 YPLL due to breast cancer, with an average of 11.370 YPLL. Regarding cervical cancer, the figure obtained was 91.625 YPLL from 2000 to 2010, with an average of 8.329 YPLL. Increased risk of death from breast cancer was observed for women aged 50 to 59 years, with a significant increase among those in the age group from 40 to 49 years. There was an increased rate of cervical cancer among women 40 to 69 years. Conclusions: The risk of death grows with increasing age, being higher from 40 years. Prevention is paramount for both cancers. Thus, preventive measures are required and a reassessment of political strategies should be adopted.

• 종양간호연구
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• 제12권4호
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• pp.280-288
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• 2012

Purpose: The aim of this study was to analyze the differences in psychosocial adjustment between younger (age${\leq}50$) and older (age>50) breast cancer survivors, and to explore the role of sociodemographic and disease-related variables in predicting psychosocial adjustment between younger and older breast cancer survivors. Methods: A total of 262 women participated in this study. A self-reported questionnaire, the Psychosocial Adjustment to Illness Scale-Self Report Korean version (PAIS-SR Korean version), was used. Data were analyzed with SAS/WIN 9.1 for descriptive statistics using the t-test, ANOVA, and stepwise multiple regression. Results: The psychosocial adjustment score of younger breast cancer survivors was significantly higher than that of older breast cancer survivors. Significant predictors influencing psychosocial adjustment in younger breast cancer survivors were marital state, menopausal cause, immune therapy, and self-help group, and these predictors account for 48% of the variance in psychosocial adjustment. Significant predictors influencing psychosocial adjustment in older breast cancer survivors were stage of cancer, monthly income, marital state, and menopausal cause. These predictors accounted for 35% of the variance in psychosocial adjustment. Conclusion: The findings indicate the importance of counseling and educational programs to improve the psychosocial adjustment according to breast cancer survivors' age.

• Archives of Plastic Surgery
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• 제39권5호
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• pp.448-451
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• 2012

One of the techniques for augmentation mammaplasty is the procedure using implants. Even though this technique has been used for many years, there are still several controversial issues to be discussed and overcome for patient safety. In this review article, capsular contracture, leak or rupture of the implants, possible systemic disease, relation with breast cancer, and recent problems with Poly Implant Prothese implants are described and discussed.

• Journal of Preventive Medicine and Public Health
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• 제48권5호
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• pp.225-230
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• 2015

Objectives: The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT) and breast cancer risk in Korean women. Methods: We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models. Results: One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556). Conclusions: These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.

• Perspectives in Nursing Science
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• 제11권1호
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• pp.39-48
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• 2014

Purpose: This study investigated the effects of an education program integrating self-efficacy theory and narratives on self-efficacy, knowledge, and resilience in women with breast cancer. Methods: This study employed a nonequivalent control group posttest only design. A 3-day program consisting of sessions in which participants shared their experiences of breast cancer, lectures on breast cancer, and breast self-examinations was implemented. Data were collected using self-reported questionnaires in 2013. Results: The mean age of participants was $50.8{\pm}5.3$; approximately half (52.8%) had Stage II breast cancer at the time of diagnosis. The results showed that the levels of self-efficacy, knowledge, and resilience were significantly higher in the experimental group than in the control group (p<.05). Conclusion: The results of the study suggest that programs integrating self-efficacy theory and narratives would be effective in promoting resilience as well as self-efficacy and knowledge in women with breast cancer. Further studies are needed to identify the effects of such education programs for people with other types of cancer or chronic illnesses.