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http://dx.doi.org/10.3961/jpmph.15.046

Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review  

Bae, Jong-Myon (Department of Preventive Medicine, Jeju National University School of Medicine)
Kim, Eun Hee (Department of Preventive Medicine, Jeju National University School of Medicine)
Publication Information
Journal of Preventive Medicine and Public Health / v.48, no.5, 2015 , pp. 225-230 More about this Journal
Abstract
Objectives: The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT) and breast cancer risk in Korean women. Methods: We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR) with 95% confidence intervals (CIs) were calculated using random effect models. Results: One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%), a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556). Conclusions: These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.
Keywords
Breast neoplasms; Risk factors; Hormone replacement therapy; Meta-analysis;
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1 Santen RJ, Allred DC, Ardoin SP, Archer DF, Boyd N, Braunstein GD, et al. Postmenopausal hormone therapy: an Endocrine Society scientific statement. J Clin Endocrinol Metab 2010;95(7 Suppl 1):s1-s66.   DOI
2 Chang HJ, Jee BC. Postmenopausal hormone therapy and breast cancer. J Korean Soc Menopause 2008;14(2):81-108 (Korean).
3 Kim Y, Choi JY, Lee KM, Park SK, Ahn SH, Noh DY, et al. Dosedependent protective effect of breast-feeding against breast cancer among ever-lactated women in Korea. Eur J Cancer Prev 2007;16(2):124-129.   DOI
4 Lee JB, Kim LS. Hormone replacement therapy and breast cancer: the situation in Korea. J Breast Cancer 2010;13(3):237-241.   DOI
5 Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288(3):321-333.   DOI
6 Chlebowski RT, Hendrix SL, Langer RD, Stefanick ML, Gass M, Lane D, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative randomized trial. JAMA 2003;289(24):3243-3253.   DOI
7 Chlebowski RT, Anderson GL. Menopausal hormone therapy and cancer: changing clinical observations of target site specificity. Steroids 2014;90:53-59.   DOI
8 Chlebowski RT, Anderson GL. Changing concepts: menopausal hormone therapy and breast cancer. J Natl Cancer Inst 2012;104(7):517-527.   DOI
9 Sprague BL, Trentham-Dietz A, Cronin KA. A sustained decline in postmenopausal hormone use: results from the National Health and Nutrition Examination Survey, 1999-2010. Obstet Gynecol 2012;120(3):595-603.   DOI
10 Bae JM. On the benefits and harms of mammography for breast cancer screening in Korean women. Korean J Fam Pract 2014;4(1):1-6 (Korean).
11 DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin 2014;64(1):52-62.   DOI
12 Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013;63(1):11-30.   DOI
13 Shin HR, Joubert C, Boniol M, Hery C, Ahn SH, Won YJ, et al. Recent trends and patterns in breast cancer incidence among Eastern and Southeastern Asian women. Cancer Causes Control 2010;21(11):1777-1785.   DOI
14 Perry CS, Otero JC, Palmer JL, Gross As. Risk factors for breast cancer in East Asian women relative to women in the West. Asia Pac J Clin Oncol 2009;5(4):219-231.   DOI
15 Bae JM. Narrative reviews. Epidemiol Health 2014;36:e2014018.
16 Cho HJ, Joo WH, Kim YN, Bae JM, Nam CM. Cohort effects of female breast cancer incidence in Korea. J Health Inform Stat 2014;39(2):32-43 (Korean).
17 Jung KW, Won YJ, Kong HJ, Oh CM, Cho H, Lee DH, et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2012. Cancer Res Treat 2015;47(2):127-141.   DOI
18 Bae JM. Two hypotheses of dense breasts and viral infection for explaining incidence of breast cancer by age group in Korean women. Epidemiol Health 2014;36:e2014020.
19 Bae JM. Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis. Epidemiol Health 2015;37:e2015005.   DOI
20 Methley AM, Chew-Graham C1, Campbell S, Cheraghi-Sohi S. Experiences of UK health-care services for people with Multiple Sclerosis: a systematic narrative review. Health Expect 2014. doi: 10.1111/hex.12228.   DOI
21 Greenhalgh T, Heath I. Measuring quality in the therapeutic relationship--part 1: objective approaches. Qual Saf Health Care 2010;19(6):475-478.   DOI
22 Bae JM, Lee EJ, Guyatt G. Citrus fruit intake and stomach cancer risk: a quantitative systematic review. Gastric Cancer 2008;11(1):23-32.   DOI
23 Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002;21(11):1539-1558.   DOI
24 Park IH, Ko K, Joo J, Park B, Jung SY, Lee S, et al. High volumetric breast density predicts risk for breast cancer in postmenopausal, but not premenopausal, Korean women. Ann Surg Oncol 2014;21(13):4124-132.   DOI
25 Do MH, Lee SS, Jung PJ, Lee MH. Intake of fruits, vegetables, and soy foods in relation to breast cancer risk in Korean women: a case-control study. Nutr Cancer 2007;57(1):20-27.   DOI
26 Park SB, Shin HR, Lee SY. A population-based cohort study of HRT use and breast cancer in Korea. Asia Pac J Public Health 2012;24(2):415-422.   DOI
27 Lee EJ, Suh SW, Lee WK, Lee HS. Reproductive factor and food intake pattern influencing on the breast cancer risk in Daegu Gyungbuk area, Korea. Korean J Nutr 2007;40(4):334-346 (Korean).
28 Do MH, Lee SS, Jung PJ, Lee MH. Food intake and breast cancer risk: a case-control study. Korean J Nutr 2001;34(2):165-175 (Korean).
29 Shin A, Kim J, Lim SY, Kim G, Sung MK, Lee ES, et al. Dietary mushroom intake and the risk of breast cancer based on hormone receptor status. Nutr Cancer 2010;62(4):476-483.   DOI
30 Kim BK, Choi YH, Song YM, Park JH, Noh HM, Nguyen TL, et al. Bone mineral density and the risk of breast cancer: a case-control study of Korean women. Ann Epidemiol 2014;24(3): 222-227.   DOI
31 Kim MK, Kim JH, Nam SJ, Ryu S, Kong G. Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study. Nutr Cancer 2008;60(5):568-576.   DOI
32 Cho YA, Kim J, Park KS, Lim SY, Shin A, Sung MK, et al. Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status. Eur J Clin Nutr 2010;64(9):924-932.   DOI
33 Study Group of Menopause. Clinical characteristics of breast cancers diagnosed in Korean women on hormone therapy. J Korean Soc Menopause 2009;15(3):172-177 (Korean).
34 Bae JM. The necessity of an observational study on the interactions between allergic history and citrus fruit intake for the prevention of pancreatic cancer. Epidemiol Health 2015;37:e2015028.   DOI
35 Cho MK, Park HM. The national use of hormonal therapy in postmenopausal women in 2010. J Korean Soc Menopause 2011;17(3):150-154 (Korean).   DOI
36 Chung YJ, Kim MR, Jeong HW, Yoon BK, Lee BS, Kang BM, et al. Changing Korean menopausal women's awareness on hormone therapy: 7-years after Women's Health Initiative study. J Korean Soc Menopause 2012;18(2):94-99 (Korean).   DOI