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http://dx.doi.org/10.4048/jbc.2018.21.e51

New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis  

Han, Chang-chang (Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanchang University)
Wan, Fu-sheng (Department of Biochemistry and Molecular Biology, School of Basic Medicine, Nanchang University)
Publication Information
Journal of Breast Cancer / v.21, no.4, 2018 , pp. 354-362 More about this Journal
Abstract
Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To accommodate the occurrence of ERS, cells have evolved a highly conserved, selfprotecting signal transduction pathway called the unfolded protein response. Notably, ERS signaling is involved in the development of a variety of diseases and is closely related to tumor development, particularly in breast cancer. This review discusses recent research regarding associations between ERS and tumor metastasis. The information presented here will help researchers elucidate the precise mechanisms underlying ERS-mediated tumor metastasis and provide new directions for tumor therapies.
Keywords
Breast neoplasms; Endoplasmic reticulum stress; Neoplasm metastasis; Unfolded protein response;
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