• Computers and Concrete
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• v.28 no.6
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• pp.585-603
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• 2021

The validation based on the experimental data demonstrates that the concrete strength under triaxial compression (TC) is overestimated by Lubliner-Oller strength criterion (SC) but underestimated by Lubliner-Lee SC in ABAQUS. Moreover, the discontinuous derivatives of failure criterion exists near the unexpected breakpoints. Both resulted from the piecewise linear meridians of the original Lubliner SC with constants γ. Following the screen for the available failure criteria to determine the model parameter γ of Lubliner SC, Menétrey-Willam SC (MWSC) is considered the most promising option with a reasonable aspect ratio Kc but no other strength values required and only two new model parameters introduced. The failure surface of the new Lubliner SC based on MWSC (Lubliner-MWSC) is smooth and has no breakpoints along the hydrostatic pressure (HP) axis. Finally, predicted results of Lubliner-MWSC are compared with other concrete failure criteria and experimental data. It turns out that the Lubliner-MWSC can represent the concrete failure behavior, and MWSC is the optimal choice to improve the applicability of the concrete damaged plasticity model (CDPM) under TC in ABAQUS.

• Journal of computational fluids engineering
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• v.3 no.2
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• pp.1-8
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• 1998

We make use of cubic B-spline interpolation function in two cases: heat conduction and fluid flow problems. Cubic B-spline test function is employed because it is superior to approximation of linear and non-linear problems. We investigated the accuracy of the numerical formulation and focused on the position of the breakpoints within the computational domain. When the domain is divided by partitions of equal space, the results show poor accuracy. For the case of a heat conduction problem this partition can not reflect the temperature gradient which is rapidly changed near the wall. To correct the problem, we have more grid points near the wall or the region which has a rapid change of variables. When we applied the unequally spaced breakpoints, the results show high accuracy. Based on the comparison of the linear problem, we extended to the highly non-linear fluid flow problems.

• Journal of the military operations research society of Korea
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• v.18 no.2
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• pp.96-113
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• 1992

A time-varying nonhomogeneous poisson process approximation of the nonexponential stochastic Lanchester model is defined and evaluated over a range of combat parameters including initial force sizes. breakpoints. and interkilling random variables. The proposed approximation is far excellent and takes much less CPU time than the existing models. The sensitivity analysis was peformed to evaluate the efficiency of the proposed model and three recommended factors are suggested to guide the combat operators.

• Bulletin of the Korean Chemical Society
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• v.32 no.3
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• pp.857-862
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• 2011

Kinetic studies of the reactions of N-methyl-Y-${\alpha}$-bromoacetanilides with substituted X-benzylamines have been carried out in dimethyl sulfoxide at $25.0^{\circ}C$. The Hammett plots for substituent X variations in the nucleophiles (log $k_N$ vs ${\sigma}_X$) are slightly biphasic concave upwards/downwards, while the Bronsted plots (log $k_N$ vs $pK_a$) are biphasic concave downwards with breakpoints at X = H. The Hammett plots for substituent Y variations in the substrates (log $k_N$ vs ${\sigma}_Y$) are biphasic concave upwards/downwards with breakpoints at Y = H. The cross-interaction constant $\rho_{XY}$ values are all negative: $\rho_{XY}$ = -0.32 for X = Y = electron-donating; -0.22 for X = electron-withdrawing and Y = electron-donating; -1.80 for X = electron-donating and Y = electronwithdrawing; -1.43 for X = Y = electron-withdrawing substituents. Deuterated kinetic isotope effects are primary normal ($k_H/k_D$ > 1) for Y = electron-donating, while secondary inverse ($k_H/k_D$ < 1) for Y = electronwithdrawing substituent. The proposed mechanisms of the benzylaminolyses of N-methyl-Y-${\alpha}$-bromoacetanilides are a concerted mechanism with a five membered ring TS involving hydrogen bonding between hydrogen (deuterium) atom in N-H(D) and oxygen atom in C = O for Y = electron-donating, while a concerted mechanism with an enolate-like TS in which the nucleophile attacks the ${\alpha}$-carbon for Y = electronwithdrawing substituents.

• Journal of Genetic Medicine
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• v.19 no.1
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• pp.14-21
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• 2022

Complex chromosome rearrangements (CCRs) are structural chromosomal rearrangements involving at least three chromosomes and more than two breakpoints. CCR carriers are generally phenotypically normal but related to higher risk of recurrent miscarriage and having abnormal offspring with congenital anomalies. However, most of CCR carriers are not aware of their condition until genetic analysis of either abortus or affected baby or parental karyotyping is performed. Herein, we present the case that CCR carrier patients can be identified by preimplantation genetic testing of preimplantation embryos. An infertile male patient with severe oligoasthenoteratozoospermia was diagnosed balanced reciprocal translocation, 46,XY,t(3;11) (p26;p14) at first. After attempting the first preimplantation genetic testing for structural rearrangement (PGT-SR) cycle, we found the recurrent segmental gain or loss on 21q21.3-q22.3 of five out of nine embryos. As a result of karyotype re-analysis, the patient's karyotype showed a balanced CCR involving chromosomes 3, 11, and 21 with three breakpoints 3p26, 11p14, and 21q21. The patient underwent two PGT-SR cycles, and a pregnancy was established after the transfer of an euploid embryo in the second cycle. Amniocentesis confirmed that the baby carried normal karyotype without mosaicism. At 37 weeks gestation, a healthy girl weighting 3,050 g was born.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.125-126
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• 2006

NimbleGen has developed strategies to use its high-density oligonucleotide microarray platform (385,000 probes per array) to map both promoter binding sites and copy number variation at very high-resolution in the human genome. Here we describe a genome-wide map of active promoters determined by experimentally locating the sites of transcription imitation complex binding throughout the human genome using microarrays combined with chromatin immunoprecipitation. This map defines 10,567 active promoters corresponding to 6,763 known genes and at least 1,196 un-annotated transcriptional units. Microarray-based comparative genomic hybridisation (CGH) is animportant research tool for investigating chromosomal aberrations frequently associated with complex diseases such as cancer, neuropsychiatric disorders, and congenital developmental disorders. NimbleGen array CGH is an ultra-high resolution (0.5-50 Kb) oligo array platform that can be used to detect amplifications and deletions and map the associated breakpoints on the whole-genome level or with custom fine-tiling arrays. For whole-genome array CGH, probes are tiled through genic and intergenic regions with a median probe spacing of 6 Kb, which provides a comprehensive, unbiased analysis of the genome.

• The Journal of Korean Association of Computer Education
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• v.10 no.6
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• pp.91-105
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• 2007

The Hough transform is a popular method for ellipse detection from image. But the method wastes time and memory space severely. And the existing methods for elliptical arc segmentation are very sensitive to noise or detect improper breakpoints. In this paper a fast method is proposed for the segmentation and detection of elliptical arcs from digital curve using its area. Experimental results show that the proposed method segments and detects elliptical arcs from noisy curves and the average of the distance errors between the fitted arc and given curve is within a threshold.

• Atmosphere
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• v.33 no.2
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• pp.73-104
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• 2023

Over the past 60 years, Korean numerical weather prediction (NWP) has advanced rapidly with the collaborative effort between the science community and the operational modelling center. With an improved scientific understanding and the growth of information technology infrastructure, Korea is able to provide reliable and seamless weather forecast service, which can predict beyond a 10 days period. The application of NWP has expanded to support decision making in weather-sensitive sectors of society, exploiting both storm-scale high-impact weather forecasts in a very short range, and sub-seasonal climate predictions in an extended range. This article gives an approximate chronological account of the NWP over three periods separated by breakpoints in 1990 and 2005, in terms of dynamical core, physics, data assimilation, operational system, and forecast application. Challenges for future development of NWP are briefly discussed.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2001.10a
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• pp.61-86
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• 2001

All cancers are caused by abnormalities in DNA sequence. Throughout life, the DNA in human cells is exposed to mutagens and suffers mistakes in replication, resulting in progressive, subtle changes in the DNA sequence in each cell. Since the development of conventional and molecular cytogenetic methods to the analysis of chromosomal aberrations in cancers, more than 1,800 recurring chromosomal breakpoints have been identified. These breakpoints and regions of nonrandom copy number changes typically point to the location of genes involved in cancer initiation and progression. With the introduction of molecular cytogenetic methodologies based on fluorescence in situ hybridization (FISH), namely, comparative genomic hybridization (CGH) and multicolor FISH (m-FISH) in carcinomas become susceptible to analysis. Conventional CGH has been widely applied for the detection of genomic imbalances in tumor cells, and used normal metaphase chromosomes as targets for the mapping of copy number changes. However, this limits the mapping of such imbalances to the resolution limit of metaphase chromosomes (usually 10 to 20 Mb). Efforts to increase this resolution have led to the "new"concept of genomic DNA chip (1 to 2 Mb), whereby the chromosomal target is replaced with cloned DNA immobilized on such as glass slides. The resulting resolution then depends on the size of the immobilized DNA fragments. We have completed the first draft of its Korean Genome Project. The project proceeded by end sequencing inserts from a library of 96,768 bacterial artificial chromosomes (BACs) containing genomic DNA fragments from Korean ethnicity. The sequenced BAC ends were then compared to the Human Genome Project′s publicly available sequence database and aligned according to known cancer gene sequences. These BAC clones were biotinylated by nick translation, hybridized to cytogenetic preparations of metaphase cells, and detected with fluorescein-conjugated avidin. Only locations of unique or low-copy Portions of the clone are identified, because high-copy interspersed repetitive sequences in the probe were suppressed by the addition of unlabelled Cotl DNA. Banding patterns were produced using DAPI. By this means, every BAC fragment has been matched to its appropriate chromosomal location. We have placed 86 (156 BAC clones) cytogenetically defined landmarks to help with the characterization of known cancer genes. Microarray techniques would be applied in CGH by replacement of metaphase chromosome to arrayed BAC confirming in oncogene and tumor suppressor gene: and an array BAC clones from the collection is used to perform a genome-wide scan for segmental aneuploidy by array-CGH. Therefore, the genomic DNA chip (arrayed BAC) will be undoubtedly provide accurate diagnosis of deletions, duplication, insertions and rearrangements of genomic material related to various human phenotypes, including neoplasias. And our tumor markers based on genetic abnormalities of cancer would be identified and contribute to the screening of the stage of cancers and/or hereditary diseases

• Journal of Institute of Control, Robotics and Systems
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• v.20 no.4
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• pp.474-479
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• 2014

LEON3 is a 32-bit synthesizable processor based on the SPARC V8. It can be connected to AMBA 2.0 bus and has a 7- stage pipeline, IEEE-754 FPU and 256[KB] cache. It can be easily implemented using FPGA and used for a SoC design. DSU which comes with LEON3 can be used to control and monitor the operation of LEON3. And DSU makes it easy to set a debugging environment for the development of both hardware and software for an embedded systems based on LEON3. This paper presents the summary of the debugging tool for LEON3 based embedded systems. The debugging tool can initialize the target hardware, find out how the target hardware is configured, load application code to a specified memory space and run that application code. To provide users a debugging environment, it can set breakpoints and control the operation of LEON3 correspondingly. And function call trace is one of key functions of the debugging tool.