• Genomics & Informatics
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• 제20권4호
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• pp.44.1-44.13
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• 2022

Brugada syndrome (BS) is an autosomal dominant inheritance cardiac arrhythmia disorder associated with sudden death in young adults. Thailand has the highest prevalence of BS worldwide, and over 60% of patients with BS still have unclear disease etiology. Here, we performed a new viral metagenome analysis pipeline called VIRIN and validated it with whole genome sequencing (WGS) data of HeLa cell lines and hepatocellular carcinoma. Then the VIRIN pipeline was applied to identify viral integration positions from unmapped WGS data of Thai males, including 100 BS patients (case) and 100 controls. Even though the sample preparation had no viral enrichment step, we can identify several virus genes from our analysis pipeline. The predominance of human endogenous retrovirus K (HERV-K) viruses was found in both cases and controls by blastn and blastx analysis. This study is the first report on the full-length HERV-K assembled genomes in the Thai population. Furthermore, the HERV-K integration breakpoint positions were validated and compared between the case and control datasets. Interestingly, Brugada cases contained HERV-K integration breakpoints at promoters five times more often than controls. Overall, the highlight of this study is the BS-specific HERV-K breakpoint positions that were found at the gene coding region "NBPF11" (n = 9), "NBPF12" (n = 8) and long non-coding RNA (lncRNA) "PCAT14" (n = 4) region. The genes and the lncRNA have been reported to be associated with congenital heart and arterial diseases. These findings provide another aspect of the BS etiology associated with viral genome integrations within the human genome.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2006년도 학술발표회 논문집
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• pp.1931-1934
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• 2006

The accuracy impact of using high-order Boussinesq-type model as compared to the typical order model is examined in this paper. The multi-layer model developed by Lynett and Liu(2004a) is used for simulating of wave breaking over a step region. The overall comparisons between the two-layer model and the hydraulic experiments are quite good. The one-layer model overshoals the wave near the breakpoint, while the two-layer model shoals at a rate more consistent with the experimental data.

• 한국해안해양공학회:학술대회논문집
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• 한국해안해양공학회 1996년도 정기학술강연회 발표논문 초록집
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• pp.137-139
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• 1996

It is known that under storm waves, beach will respond by eroding material from the beach Ace and the formation of longshore bar(s) in the vicinity of breaking point. This breakpoint bar is believed to have the effect of slowing down beach erosion by dissipating incoming wave energy and retarding offshore sediment transport. Recently, artificial bin are being proposed as beach protective measures based on this reasoning. (omitted)

• 정보과학회 논문지
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• 제41권10호
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• pp.832-837
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• 2014

프로그램의 로딩 속도는 프로그램이 요청하는 디스크 블록을 미리 읽어 들임으로써(프리페칭) 향상시킬 수 있다. 그러나 기존의 프리페칭 관련 기법들은 특정 프로그램에 최적화된 경우를 제외하면 상당한 오버헤드를 보여주었다. 특히 요청블록을 정확히 추적하는데 어려움이 있었다. 어떤 블록들은 여러 시퀀스(단위시간 내에 추적된 블록들)에 나타날 수 있고 두 접근 시퀀스가 동일 하더라도 버퍼 캐시에 의해서 접근 시간과 수집되는 블록 정보가 다를 수 있기 때문에 분석이 까다롭다. 본 논문에서는 소프트웨어적 접근 방법으로 새로운 범용 워크로드 프리페칭 기법을 제안한다. 제안하는 프리페칭 기법은 브레이크 포인트를 프로그램의 적재 적소에 배치함으로써 요청 블록의 상관관계 정보를 수집하고, 이를 바탕으로 프리페칭을 수행한다. 상용 하드디스크를 이용한 실험 결과, 불필요한 오버헤드가 감소되었으며 기동 시간은 평균 30%, 로딩은 평균 15% 단축되었음을 확인하였다.

• Current Research on Agriculture and Life Sciences
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• 제15권
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• pp.83-91
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• 1997

페놀성 화합물들은 단백질이나 금속 이온들과 결합하는 성질을 지녀 식품분야에서는 영양 저해물질 혹은 갈변의 원인물질로 알려져 있으며 또 이들물질이 상수원에 유입시 염소와 결합하여 악취나 발암물질을 형성하는 등 환경적으로 유해한 물질로 알려져 있다. 그러나 최근에는 이들 물질들의 항미생물 효과, 항암효과 등이 밝혀짐에 따라 유용한 물질로 이용될 가능성이 매우 높아졌다. 이들 물질들의 제거 또는 회수는 곧 유해물질의 제거 혹은 유용성분의 분리의 의미가 된다. 따라서 본 실험에서는 연속식 고정층 흡착을 다성분계 페놀산 용액에서 행하여 실제 흡착공정에 적용시 필수적인 자료인 파과곡선 및 파과점을 nonlinoar curve fitting방법을 이용하여 산정하였다. 흡착질의 종류가 증가할수록 파과곡선의 적합성은 점점 낮아졌으며 흡착속도에 있어서는 gallic acid가 가장 빨리 파과점을 지나고 ferulic acid, p-coumaric acid의 순으로 나타났다. 이들 결과로부터 다성분계에서의 연속식 고정층 흡착은 흡착제와 흡착질간의 ionic strength와 흡착질간의 분자량의 차이가 흡착량과 파과속도에 영향을 미치는 것으로 생각된다.

• Journal of Genetic Medicine
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• 제11권1호
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• pp.16-21
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• 2014

A 31-year-old woman, who was pregnant with twins, underwent chorionic villus sampling because of increased nuchal translucency in one of the fetuses. Cytogenetic analysis showed a normal karyotype in the fetus with increased nuchal translucency. However, the other fetus, with normal nuchal translucency, had a derivative X chromosome (der(X)). For further analysis, fluorescence in situ hybridization (FISH) and additional molecular studies including fragile X analysis were performed. FISH analysis confirmed that the Y chromosome was the origin of extra segment of the der(X). The X-chromosome breakpoint was determined to be at Xq27 by FMR1 CGG repeat analysis, and the Y-chromosome breakpoint was determined to be at Yq11.23 by the Y chromosome microdeletion study. To predict the fetal outcome, the X-inactivation pattern was examined, and it revealed non-random X inactivation of the der(X). To the best of our knowledge, the identification of an unbalanced Xq;Yq translocation at prenatal diagnosis has never been reported. This study was performed to identify precise breakpoints and the X-inactivation pattern as well as to provide the parents with appropriate genetic counseling.

• 패션비즈니스
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• 제13권2호
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• pp.78-86
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• 2009

When scouring and contraction finishing at $90^{\circ}C$ using Relaxer or Rotary Washer contraction and weight loss ratio in warp and weft directions were excellent. Also surface state of fabric after drying or sanding treatment was excellent without crease. Low melting polyester fabric showed a complete melting bond by heat setting(P/S) at above $160^{\circ}C$. The alkali hydrolysis reaction of polyester showed the breakpoint in the weight loss behavior test, polyester yarn showed a breakpoint ranging from 25% to 28%. This is due to the difference of the hydrolysis rate between regular polyester and soluble polyester. Initially the soluble polyester was eluted and micro-fibrillized 5 times faster than a regular polyester. At a later time, a regular polyester was reduced weight to impart a proper flexibility and drape property to the fabric. As a result of surface sanding finishing, the surface of interior fabric showed a surface state most stabilized when using Mesh No. 220 in mono 0.2d after elution finishing. When the rotation direction of sanding roller was pro-, pro-, pro-, and retro-direction, a directional effect of tuft was not shown, a writing effect as suede was exhibited and a surface state was even. Sublimation fastness was 3-4 class for polyester and 2-4 class for nylon. Light fastness 3-4 class after lapse of 100 hours and 2-4 class after lapse of 160 hours. Abrasion fastness was 3-4 class on wet and 4-5 class on dry Laundry fastness was 2-4 class. As such, the abrasion fastness is slightly reduced upon wetting and the use thereof for interior is excellent, whereas laundry fastness is slightly lowered.

• Membrane and Water Treatment
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• 제10권1호
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• pp.45-55
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• 2019

Climate change has significantly affected the rainfall characteristics which can influence the pollutant build-up and wash-off patterns from the catchment. Therefore, this study explored the influence of varying rainfall characteristics on urban and agricultural runoff pollutant export using statistical approaches. For this purpose, Mann-Kendall and Pettitt's test were applied to detect the trend and breakpoint in rainfall characteristics time series. In addition, double mass curve and correlation analysis were used to drive the relationship between rainfall-runoff and pollutant exports from both catchments. The results indicate a significant decreased in total rainfall and average rainfall intensity, while a significant increased trend for antecedents dry days and total storm duration over the study periods. The breakpoint was determined to be 2013 which shows remarkable trend shifts for total rainfall, average rainfall intensity and antecedents dry days except total duration. Double mass curve exhibited a straight line with significant rainfall-runoff relationship indicates a climate change effect on both sites. Overall, higher pollutant exports were observed at both sites during the baseline period as compared to change periods. In agricultural site, most of the pollutants exhibited significant (p< 0.05) association with total rainfall, average rainfall intensity and total storm duration. In contrast, pollutants from urban site significantly correlated with antecedent dry days and average rainfall intensity. Thus, total rainfall, average rainfall intensity and total duration were the significant factors for the agricultural catchment while, antecedents dry days and average rainfall intensity were key factors in build-up and wash-off from the urban catchment.

• 전자공학회논문지SC
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• 제41권5호
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• pp.9-18
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• 2004

본 논문에서는 펄스레이더를 이용한 차량검지 알고리즘을 제안하였다. 제안된 알고리즘은 likelihood개념을 이용한 likelihood ration를 통해 하나의 펄스신호에서 분류위치를 추출하고 추출된 분리점을 기준으로 신호를 분리, 간략화 하였다. 이렇게 처리 된 펄스신호에서 연속된 신호의 유클리드거리를 이용하여 단순 군집 탐색 알고리즘에 의해 차량을 검지하였고, 실험을 통해 제안된 알고리즘의 유용성을 확인하였다.

• 환경위생공학
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• 제14권1호
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• pp.11-16
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• 1999

This study was performed to investigate THMs formation by chloramination as a secondary disinfection in drinking water distribution system. As the $Cl_2/NH_3-N$ ratio increased from 1:1 to 4:1, the THMs concentration had actually no change in the breakpoint curve of pH 6, 7. At pH 8, THMs level was not augmented at between 1:1 and 5:1. In the $Cl_2/NH_3-N$ ratio of more than 5:1 and 6:1 respectively, THMs level was raised. Only the chloroform of THMs was insignificantly detected by both preformed chloramine and preammoniation applications, which was probably attributed to the stoichiometrically unstable equilibrium in the preparation of chloramine, whereas $CHCl_3$, $CHCl_2Br$ and $CHClBr_2$ of THMs were found in the application of free chlorine. However it turned out that the THMs levels by chloramine was incomparably inferior to that of free chlorine.