• Journal of Chest Surgery
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• 제35권1호
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• pp.1-10
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• 2002

배경 : 관상동맥 결찰법에 의한 만성 심부전 모델은 실험 사망률이 비교적 높음에도 불구하고 임상적 연관성때문에 지속적인 연구 대상이 된다. 특히 대동물에서 만성 심부전 모델 확립은 소동물에서는 검증할 수 없는 기계 또는 생물학적 순환보조시스템의 연구분석에 대단히 유용하게 사용될 수 있다 이런 관점에서 본연구는 양에서 homonymous artery(사람의 좌전하행지에 해당)와 diagonal branch를 순차적으로 결찰 하는 방법으로 신뢰성 있는 만성 심부전 모델을 확립하고자 하였다. ·재료 및 방법: 모두 9마리의 Corridale 양을 사용하였다. 2마리 양에서 homonymous artery 와 diagonal branch를 동시에 결찰 하였고 7마리에서는 homonymous artery와 diagonal branch를 1시간 간격으로 결찰 하였다. 좌전 개흉술로 심장을 노출시킨 후 심첨부에서 기저부까지의 거리를 기준으로 하여 심첨부에서 40% 위치에서 homonymous artery를 결찰 하였다. diagonal branch는 homonymous artery와 동일한 위치에서 결찰 하였다. 관상동맥 결찰 전, homonymous artery 결찰 후,그리고 diagonal branch 추가 결찰 후 각각 동맥압, 심전도, 그리고 thermodilution catheter로 중심정맥압, 폐동맥압, 폐동맥쐐기압, 심박출량을 측정하였다. 같은 시점에 초음파 검사를 통해 좌심실 이완말기 크기, 좌심실수축말기 크기, 좌심실 구혈률, 좌심실 벽두께, 좌심실 구획단축률과 좌심실 벽운동을 분석하였다. 실험 동물은 2개월 또는 3개월 사육한 뒤 같은 분석 과정을 거친 후 희생시켰다. 실험양의 심장은 적출하여 병리조직학적 검사를 하였다. 결과 Homonymous artery 와 diagonal branch를 동시에 결찰 한 2마리는 결찰 직후 모두 사망하였다. 반면 homonymous artery 와 diagonal branch를 순차적으로 결찰 한 7마리는 모두 생존하였는데 이중 5마리는 2개월 그리고 2마리는 3개월 사육후 심장을 적출하였다. 결찰 2~3개월 후 양에서 중심정맥압, 폐동맥압, 폐동맥쐐기압, 좌심실 이완말기 및 수축말기 크기의 유의한 증가가 관찰되었다(p<0.05) 반면 homonymous artery 결찰 직후에는 동맥압의 유의한 감소(p<0.05)가 diagonal branch의 추가 결찰 후에는 동맥압, 심박출량의 감소 및 폐동맥쐐기압의 유의한 증가가 관찰되었다(p<0.05). 좌심실 벽운동은 결찰 직후부터 다양한 정도의 anteroseptal akinesia또는 dyskinesia가 관찰되었다. 적출 심장의 병리 분석 결과 주위와 잘 구별되는 섬유화 경색 부위가 관찰되었다. 결론: 양에서 homonymous artery와 diagonal branch를 순차적으로 결찰하는 방법으로 신뢰성 있는 만성 심부전 모델을 확립할 수 있었다.

• Journal of Computational Design and Engineering
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• 제1권2호
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• pp.116-127
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• 2014

This paper aims to review methods for computing orthogonal projection of points onto curves and surfaces, which are given in implicit or parametric form or as point clouds. Special emphasis is place on orthogonal projection onto conics along with reviews on orthogonal projection of points onto curves and surfaces in implicit and parametric form. Except for conics, computation methods are classified into two groups based on the core approaches: iterative and subdivision based. An extension of orthogonal projection of points to orthogonal projection of curves onto surfaces is briefly explored. Next, the discussion continues toward orthogonal projection of points onto point clouds, which spawns a different branch of algorithms in the context of orthogonal projection. The paper concludes with comments on guidance for an appropriate choice of methods for various applications.

• 한국경영과학회지
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• 제25권4호
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• pp.15-25
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• 2000

In this paper, we introduce a point-to-multipoint minimum cost flow problem with convex and demand splitting. A source node transmits the traffic along the tree that includes members of the point-to-multipoint connection. The traffic is replicated by the nodes only at branch points of the tree. In order to minimize the sum of arc costs, we assume that the traffic demand can be splitted and transmitted to destination nodes along different trees. If arc cost is linear, the problem would be a Steiner tree problem in networks eve though demand splitting is permitted. The problem would be applied in transmitting large volume of traffic from a serve to clients in Internet environments. Optimality conditions of the problem are presented in terms of fair tree routing. The proposed algorithm is a finite terminating algorithm for $\varepsilon$-optimal solution. convergence of the algorithm is obtained under monotonic condition and strict convexity of the cost function. Computational experiences are included.

• Journal of applied mathematics & informatics
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• 제26권5_6호
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• pp.1169-1183
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• 2008

In this paper, a method to find the weighted possibilistic variance and moments about the mean value of fuzzy numbers via applying a difuzzification using minimizer of the weighted distance between two fuzzy numbers is introduced. In this way, we obtain the nearest weighted point with respect to a fuzzy number, this main result is a new and interesting alternative justification to define of weighted mean of a fuzzy number. Considering this point and the weighted distance quantity, we introduce the weighted possibilistic mean (WPM) value and the weighted possibilistic variance(WPV) of fuzzy numbers. This paper shows that WPM is the nearest weighted point to fuzzy number and the WPV of fuzzy number is preserved more properties of variance in probability theory so that it can simply introduce the possibilistic moments about the mean of fuzzy numbers without problem. The moments of fuzzy numbers play an important role to estimate of parameters, skewness, kurtosis in many of fuzzy times series models.

• The Korean Journal of Pain
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• 제9권1호
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• pp.105-108
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• 1996

Localized or radiating pain in the arm and shoulder joint may result after faulty alignment causing compression or tension on nerves, blood vessels, or supporting soft tissues. The critical site of faulty alignment is the quadrangular space in the axilla bounded by the teres major, teres minor, long head of triceps, and humerus. The axillary nerve emerges through this space to supply the deltoid and teres minor. The activity of the trigger point on teres minor compressing the axillary nerve causes pain to develop through the area of sensory distribution of cutaneous branch of the axillary nerve. Relieving compression on the axillary nerve and suprascapular nerve is the key point to relieving the pain. Spasm of the supraspinatus and infraspinatus compressing the suprascapular nerve caused pain to develop in the shoulder joint and scapular area. We treated those patients experiencing such pain with local anesthetic infiltration or I-R laser stimulation on the identified trigger points.

• 대한전기학회논문지
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• 제31권7호
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• pp.11-17
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• 1982

In this paper, a reliable and convenient evaluation method for the adequacy of any radial distribution line's voltage drop is proposed for improvement of the voltage regulation of the distribution line under operation. Using the voltage measurement of the first load branch point and the last point on the given distribution line its average line voltage drop and the line voltage drop variance by pure load variation are computed. And by these values and allowable or required line drop from proper voltage regulation view point, present adequency index and operation improvement index of the line drop are newly introduced for the evaluation of the given distribution line's voltage regulation. As a result of application to the 4 cases of study, the proposed method is proved to be reliable and convenient.

• Structural Engineering and Mechanics
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• 제18권2호
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• pp.195-209
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• 2004

By means of the two-dimensional basic equations of transversely isotropic magneto-electro-elastic media and the strict differential operator theorem, the general solution in the case of distinct eigenvalues is derived, in which all mechanical, electric and magnetic quantities are expressed in four harmonic displacement functions. Based on this general solution in the case of distinct eigenvalues, a series of problems is solved by the trial-and-error method, including magneto-electro-elastic rectangular beam under uniform tension, electric displacement and magnetic induction, pure shearing and pure bending, cantilever beam with point force, point charge or point current at free end, and cantilever beam subjected to uniformly distributed loads. Analytical solutions to various problems are obtained.

• 원예과학기술지
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• 제18권1호
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• pp.22-27
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• 2000

배를 캐나다 등 외국에 수출할 시는 수출 상대국의 검역요건에 맞추어 주어야 한다. 수출국 특히 캐나다에 수출되는 배의 검역상 문제점을 찾아 그 해결법을 제시하고자 수출 조건에서 수출 단계별 검역규제병해충을 조사하였다. 조사 결과 복숭아명나방과 복숭아순 나방이 발견되었으나 이들은 저온처리로 인하여 모두 사멸되었다. 해충은 복숭아심식나방류 유충이 과실로 이동되는 시기에 방제를 소홀히 한 생산지 과실에서 발견되었으므로 복숭아명나방 등 심식나방류 유충이 과실로 이동되는 시기에 예찰을 철저히 하여 적기방제 하는 것이 필요하다. 한편 병원균은 과실의 선과 작업과 이동할 때 생긴 압상, 자상 등 상처를 통하여 Penicillium sp. 및 Alternaria sp.의 부생균이 감염된 것이 발견되고 검역병원균은 발견되지 않았다. 그러나 이들 병원균도 비록 비검역병원균이라고 하지만 부패과실이 일정비율 초과할 경우 수출자가 수입자에게 이를 보상하여야 하므로 수출배 중 외피가 얇은 황금배 등은 수확 후 운송과정과 선과장 선과 작업 중에 특별한 주의가 요구된다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.257-261
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• 2016

Cancer causes cells to avoid death while being the second cause of death in the world itself. Damaged cells in the absence of apoptosis will increasingly amplify their inefficient genome. Of the two main apoptosis inducing pathways in cells, the first has p53 protein as the main initiating factor in the cascade. According to research results this protein s mutated in 50% of cancers and sointerest has cooncentrated on the second pathway that features death receptors. Among these receptors TRAIL1/DR5 is especially expressed in cancer cells. So targeting such receptors can initiate the apoptotic cascade in cells. Interestingly by substitution of activating ligands with antibodies as agonists, we could efficiently turn on the apoptosis pathway. First of all, three small peptides from the DR5 protein extracellular domain were synthesized and injected with two different kind of adjuvants (Fround and liposomal encapsulation) separately into mice at 15 day intervals. As a result, liposomal peptides induced the immune system more efficient than Frounds adjuvant and at the end point the antibodies which were obtained from liposomal peptide injection induced much more effective death. Liposomal formol could be used as an adjuvant in immunization utilizing small peptides. They carry, protect and deliver peptides very efficiently. In addition, small peptides of a certain size from the extracellular domain of DR5 proteins not only can induce immune system but also produce antibodies playing a remarkable anti-cancer roles against breast cancer cells (MCF-7).

• 한국재료학회지
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• 제24권2호
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• pp.73-80
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• 2014

Ink-jet printing technology has been widely attractive due to its facility for direct and fine printing on various substrates. Recent studies have focused on expanding the application of ink-jet printing technology from general consumer use and design companies to the prototype production of precision parts and parts manufacturing. The use of ink-jet printing technology in decorated tableware, tiles, and other ceramic products also has many advantages. The printing process is fast and can be adaptable to various kinds of objects because there is no direct contact point between the printer and the substrates to be printed. For application to ceramic product decoration, inks containing highly dispersed inorganic nano-pigments are required. Here we report the synthesis and characterization of blue $CoAl_2O_4$ nanopigment for ink-jet printing. Blue ceramic ink based on the obtained $CoAl_2O_4$ pigment was prepared by dissolving $CoAl_2O_4$ pigment in a mixed solution of ethylene glycol and ethanol with volume ratios of 7:3 and 8:2, respectively, to obtain the appropriate viscosity for ink-jet printing. The ink solution contained 15 wt% of $CoAl_2O_4$ pigment and Cetyltrimethyl ammonium bromide(CTAB) and Sodium dodecyl sulfate(SDS) as dispersive agents. The prepared blue ceramic ink was stably jetted and formed a sphere-shaped droplet from an ink-jet printer.