• The Journal of Korean Physical Therapy
• /
• v.26 no.2
• /
• pp.130-135
• /
• 2014

Purpose: The purpose of this study was to examine the impairments of body structures, activity limitation, and participation restriction. In addition, we wanted to provide basic data on correlation between impairments of body structures, activity, and participation in Disabled Persons Living at Home. Methods: After selection of 128 people with physical disabilities more than the third level and brain damage disabilities living at home, we conducted testing for impairments of body structures, activity, and participation, according to the ICF checklist. Results: Impairments of body structures was highest in the upper and lower extremity. 2) Mobility, domestic life, and self care were more limited. 3) Also, the structure related to movement showed correlation with mobility, domestic life, and self care. Conclusion: We observed differences in participation and activities of persons with disabilities Living at Home depending on the impairments of body structures. After thorough review of the status of Disabled Persons Living at Home, we decided to appropriate support and social services.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 1999.10a
• /
• pp.387-394
• /
• 1999

Artificial Neural Network (ANN) is a computational model inspired by the structure and operations of the brain. It is massively parallel system consisting of a large number of highly interconnected and simple processing units. The purpose of this paper is to verify the applicability of ANN to predict experimental results through the use of measured experimental data. Although there have been accumulated data based on hysteretic characteristics of structural element with cyclic loading tests, it is difficult to directly apply them for the analysis of elastic and plastic response. Thus, simple models with mathematical formula such as Bi-Linear Model, Ramberg-Osgood Model, Degrading Tri Model, Takeda Model, Slip type Model, and etc, have been used. To verify the practicality and capability of this study, ANN is adapted to several models with mathematical formula using numerical data To show the efficiency of ANN in nonlinear analysis, it is important to determine the adequate input and output variables of hysteretic models and to minimize an error in ANN process. The application example is Beam-Column joint test using the ANN in modeling of the linear and nonlinear hysteretic behavior of structure.

• Journal of the Korean Magnetic Resonance Society
• /
• v.16 no.2
• /
• pp.147-161
• /
• 2012

Human melanocortin-4 receptor (hMC4R) among MC-Rs, expressed in the brain, is in charge of the control on energy homeostasis and food intake. The structure and function of human MC4R have been studied to understand their essential function and roles. To investigate the structure and function, it is necessary to prepare sufficient amounts of proteins. However, their expression and purification is demanding and time-consuming due to their innate insoluble and toxic properties. The heterozygous mutations of hMC4R, exchange of Asp 90 to Asn located in second transmembrane, cause severe obesity in human. To obtain purified hMC4R wt-TM2 for structural studies, it was first over-expressed and purified by fast protein liquid chromatography (FPLC) and then solution NMR studies were performed to get high-resolution spectra. In here, we established optimized purification scheme to get more purified target peptide.

• Biomolecules & Therapeutics
• /
• v.28 no.2
• /
• pp.145-151
• /
• 2020

Alzheimer's disease (AD) is a devastating neurodegenerative disease and a major cause of dementia in elderly individuals worldwide. Increased deposition of insoluble amyloid β (Aβ) fibrils in the brain is thought be a key neuropathological hallmark of AD. Many recent studies show that natural products such as polyphenolic flavonoids inhibit the formation of insoluble Aβ fibrils and/or destabilize β-sheet-rich Aβ fibrils to form non-cytotoxic aggregates. In the present study, we explored the structure-activity relationship of naturally-occurring biflavonoids on Aβ amyloidogenesis utilizing an in vitro thioflavin T assay with Aβ1-42 peptide which is prone to aggregate more rapidly to fibrils than Aβ1-40 peptide. Among the biflavonoids we tested, we found amentoflavone revealed the most potent effects on inhibiting Aβ1-42 fibrillization (IC₅₀: 0.26 µM), as well as on disassembling preformed Aβ1-42 fibrils (EC₅₀: 0.59 µM). Our structure-activity relationship study suggests that the hydroxyl groups of biflavonoid compounds play an essential role in their molecular interaction with the dynamic process of Aβ1-42 fibrillization. Our atomic force microscopic imaging analysis demonstrates that amentoflavone directly disrupts the fibrillar structure of preformed Aβ1-42 fibrils, resulting in conversion of those fibrils to amorphous Aβ1-42 aggregates. These results indicate that amentoflavone affords the most potent anti-amyloidogenic effects on both inhibition of Aβ1-42 fibrillization and disaggregation of preformed mature Aβ1-42 fibrils.

• The Journal of the Korea Contents Association
• /
• v.17 no.10
• /
• pp.463-471
• /
• 2017

There is a world of unconscious that works when creating story contents. The unconscious layer of the abyss has the artist goes on the path of creating a common story structure without knowing because the human race is connected. It is monomyth and is now used as an important authoring tool. Analyzing the structure of the silent film "A trip to the Moon" made before the discovery of it, we can still find the frame of monomyth. Although this film is an intuitive imagination of the inspiration received from four contemporary works, the monomyth has been completely revealed.. This means it's still working regardless of area or time. That's why the story that was created in a modern short time has the same structure as the myth that passed down for a long time because there is archetype of story in human collective unconscious. This archetype determines the way the story. The human brain is not infinitely free to imagine but that it can be applied to the surface along the path of the archetype. Good story contents is less likely to succeed if it does not follow the path proposed by the archetype within our collective unconscious.

• Journal of Technologic Dentistry
• /
• v.34 no.4
• /
• pp.345-352
• /
• 2012

Purpose: The age-hardening mechanism of an Au-Ag-Cu-Pt-Zn alloy for crown and bridge fabrication was investigated by means of hardness test, X-ray diffraction study and field emission scanning electron microscopic observation. Methods: Before hardness testing, the specimens were solution treated and then were rapidly quenched into ice brine, and were subsequently aged isothermally at $400-450^{\circ}C$ for various periods of time in a molten salt bath and then quenched into ice brain. Hardness measurements were made using a Vickers microhardness tester. The specimens were examined at 15 kV using a field emission scanning electron microscope. Results: By the isothermal aging of the solution-treated specimen at $450^{\circ}C$, the hardness increased rapidly in the early stage of aging process and reached a maximum hardness value. After that, the hardness decreased slowly with prolonged aging. However, the relatively high hardness value was obtained even with 20,000 min aging. By aging the solution-treated specimen, the f.c.c. Au-Ag-rich ${\alpha}_0$ phase was transformed into the Au-Ag-rich ${\alpha}_1$ phase and the AuCu I ordered phase. Conclusion: The hardness increase in the early stage of aging process was attributed to the formation of lattice strains by the precipitation of the Cu-rich phase and then subsequent ordering into the AuCu I-type phase. The decrease in hardness in the later stage of aging process was due to the release of coherency strains by the coarsening of tweed structure in the grain interior and by the growth and coarsening of the lamellar structure in the grain boundary. The increase of inter-lamellar space contributed slightly to the softening compared to the growth of lamellar structure toward the grain interior.

• Journal of the Economic Geographical Society of Korea
• /
• v.4 no.2
• /
• pp.37-56
• /
• 2001

Regarding human capital development and the competitive advantage of regional economies, the transfer of local university graduates to the local labor market is a very important factor. This study aims to investigate the employment structure of university graduates and spatial patterns of their jobs, and the job search strategies to enter the employment system with a case study of Chonnam National University graduates. Because of the lagged industrial structure and peripheral location of Kwangju/Chonnam Province, the employment rate of the university graduates is generally lower than a national average. And there is a strong tendency of the concentration of job places on the metropolitan areas on the one hand, and on the Kwangju/chonnarn and Capital region of Korea on the other. University graduates in searching for jobs especially prefer spatial mobility toward job opportunities In other regions to promoting the flexibility of job qualifications to meet labor market demands. Based on the results of the study, we can identify a process of so-called train drains'in both quantitative and qualitative terms, and conclude that the role of the Chonnam National University in promoting regional development potentials and local labor market conditions is Quite restrictive.

• International Area Studies Review
• /
• v.13 no.3
• /
• pp.93-119
• /
• 2009

The purpose of this paper is to analyze the world rice market through structure and conduct frameworks utilizing annual data from 1970 to 2007. The world rice market has been unstable for much of the period post-World War II, with prices volatile and the availability of supplies uncertain. Therefore, analysis of the structure and conduct of the world rice market can provide information to better formulate the direction of future policies. Also, this paper will describe the effects of total production, export rice price, market concentration, and real exchange rate for exporting countries on total export rice volume. On basis of the expected results, the international rice market possesses market power with respects to static calculation and hypothesis test, and it will be demonstrated that exporting countries' currency crucially affects the exporting quantity and market power of those same exporting countries.

• Korean Journal of Cognitive Science
• /
• v.27 no.2
• /
• pp.159-219
• /
• 2016

Mathematical ability is important for academic achievement and technological renovations in the STEM disciplines. This study concentrated on the relationship between neural basis of mathematical cognition and its mechanisms. These cognitive functions include domain specific abilities such as numerical skills and visuospatial abilities, as well as domain general abilities which include language, long term memory, and working memory capacity. Individuals can perform higher cognitive functions such as abstract thinking and reasoning based on these basic cognitive functions. The next topic covered in this study is about individual differences in mathematical abilities. Neural efficiency theory was incorporated in this study to view mathematical talent. According to the theory, a person with mathematical talent uses his or her brain more efficiently than the effortful endeavour of the average human being. Mathematically gifted students show different brain activities when compared to average students. Interhemispheric and intrahemispheric connectivities are enhanced in those students, particularly in the right brain along fronto-parietal longitudinal fasciculus. The third topic deals with growth and development in mathematical capacity. As individuals mature, practice mathematical skills, and gain knowledge, such changes are reflected in cortical activation, which include changes in the activation level, redistribution, and reorganization in the supporting cortex. Among these, reorganization can be related to neural plasticity. Neural plasticity was observed in professional mathematicians and children with mathematical learning disabilities. Last topic is about mathematical creativity viewed from Neural Darwinism. When the brain is faced with a novel problem, it needs to collect all of the necessary concepts(knowledge) from long term memory, make multitudes of connections, and test which ones have the highest probability in helping solve the unusual problem. Having followed the above brain modifying steps, once the brain finally finds the correct response to the novel problem, the final response comes as a form of inspiration. For a novice, the first step of acquisition of knowledge structure is the most important. However, as expertise increases, the latter two stages of making connections and selection become more important.

• Animal cells and systems
• /
• v.1 no.2
• /
• pp.317-321
• /
• 1997

Tau protein is one of the microtubule-associated proteins in the mammalian brain. In Alzheimer's disease, tau protein is immobilized in the somatodendritic compartment of certain nerve cells, where it forms a part of the paired helical filament (PHF). To understand the role of tau protein in the formation of PHF, a recombinant human tau protein expressed in Escherichia coli and five synthetic peptide fragments (peptide 1 to peptide 5), corresponding to the C-terminal region of tau protein, were prepared and their ability in self-assembly to form filamentous structures was examined. The recombinant human tau protein formed short rod-like structures in 0.1M MES buffer containing 1 mM $MgCI_2$, while a synthetic peptide fragment 1 containing 55 amino acid residues could assemble into a lot of long filamentous structures in water and particularly twisted helical structures in 0.1M MES buffer containing 1 mM $MgCI_2$. This suggests that the C-terminal region possesses a filament-forming ability and may be related to the formation of the helical structure by providing a powerful filament-forming driving force.